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      • 비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

        박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

        저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

      • KCI등재
      • KCI등재

        납착 방법이 치과용 금속의 성상에 미치는 영향에 관한 연구

        김철형,송영균,이종혁 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

        연구 목적: 본 연구는 치과영역에서 많이 사용되는 비귀금속 합금인 니켈-크롬 합금을 산소-아세틸렌 불꽃 납착법과 적외선 용접법을 이용해 용접하고 용접부 및 그 주변을 광학 현미경과 EPMA (Electron Probe Micro Analyzer, 전자미세현미분석기)를 통해 관찰하여 용접방법이 금속의 성상(性狀)에 미치는 영향을 조사하였다. 연구 재료 및 방법:니켈-크롬 합금을 이용하여 3.0 mm 직경, 30 mm 길이의 시편을 제작하였다. 시편은 산소-아세틸렌 불꽃 납착법, 적외선 용접법의 두 개의 그룹으로 분류하였다(n = 4). 시편을 low-speed disc로 자른 후 각각을 산소-아세틸렌 토치와 적외선 용접기를 이용해 용접하였다. 용접과 마무리 후에 시편을 광학현미경으로 용접부, 5 mm 떨어진 지점, 10 mm 떨어진 지점의 3개 부위에서 관찰하고EPMA를 이용하여 분석하였다. 결과: 광학 현미경 관찰 결과 용접부에서는 두 방법 모두 다수의 파절선이 관찰되었고, 10.0 mm 떨어진 거리에서는 두 방법 모두 시편의 표면에서 파절선이 발견되지 않았으나 5.0 mm 떨어진 거리에서는 적외선 용접법에서는 시편의 표면이 다소 거칠기는 했으나 파절선은 발견되지 않았고 산소-아세틸렌 불꽃 납착 표면에서는 다수의 파절선이 관찰되었다. EPMA분석에서 적외선 용접법에 의한 방법에서는 용접부위, 5.0 mm 떨어진 부위, 10.0 mm 떨어진 부위 모두에서 시편 금속의 구성성분 비율이 제조사의 구성성분 비율과 10.0%이내의 오차를 나타내었고, 산소-아세틸렌 불꽃 납착법에서는 5.0, 10.0 mm에서는 시편금속의 구성성분이 10.0%이내의 오차를 나타내었으나, 납착 부위에서는 Ni만이 검출되어 적외선 용접법과는 차이를 나타내었다. 이와 같은 분석결과를 살펴 볼 때 적외선 용접을 시행한 시편의 구성 성분이 모금속의 성분과 유사한 것을 알 수 있었다. 결론: 이상의 결과로 산소-아세틸렌 불꽃 납착법보다 적외선 용접법을 이용할 때, 금속의 결함 및 성분의 변화가 적어서 좀 더 우수한 금속 보철물의 제작이 가능할 것으로 사료된다. PURPOSE. The purpose of this study was to compare Ni-Cr alloy property of gas-oxygen torch soldering and infrared welding using optical microscope and Electron Probe Micro Analyzer (EPMA). MATERIALS AND METHODS. Ni-Cr alloys were casted for specimens. Specimens had 3.0 mm diameter, 30.0 mm length and were divided into two groups. Each group had 4 specimens. One group was for gas-oxygen torch soldering and the other was infrared welding. Specimens were cut with low-speed disc and soldered each other with gas-oxygen torch and infrared machine. After soldering and polishing, specimens were observed at 3 points (soldering point, 5 mm distance point, 10 mm distance point) with optical microscope and analyzed 3 points (soldering point, 5 mm distance point, 10 mm distance point with EPMA. RESULTS. The results of this study were as follows: 1. The observation of gas-oxygen torch soldering at 10 mm distance point under the optical microscope was not founded any specific surface properties, but some crack lines were observed at 5 mm distance and soldering point. 2. There were no crack lines were founded at the observation of infrared welding at 10 mm distance and 5 mm distance points under the optical microscope. However, at the 5 mm distance, the surface was not smooth enough compared with at 10 mm distance point. Some crack lines were observed at the welding point as well. 3. In the EPMA analysis of the gas-oxygen torch soldering, the component of Ni was increased by 4.5%, Cr was increased by 7.5% than that of the Ni-Cr alloy at the 10.0 mm distance. At the 5 mm distance, the component of Ni was decreased by 6.1%, Mo was increased by 9.0% than that of the Ni-Cr alloy but Cr was equally shown at the 5.0 mm distance. Only Ni was shown at the soldering point. 4. In the EPMA analysis of the infrared welding, the component of Ni was increased by 9.1%, Cr was increased by 0.4% than that of the Ni-Cr alloy but Al was equal at the 10.0 mm distance. At the 5 mm distance, the component of Ni was increased by 4.7%, Cr was increased by 4.7% and Al was increased by 0.1% than that of the Ni-Cr alloy. At the welding point, the component of Ni was increased by 8.8%, Cr was increased by 8.2% than that of the Ni-Cr alloy. CONCLUSION.From these results, at the 5 mm distance from the soldering point, the surface of the infrared welding was more smoother than that of the gas-oxygen torch soldering. On the EPMA analysis, the component of the specimens with infrared welding was more similar than that of the gas-oxygen torch soldering compared with the component of the Ni-Cr alloy.

      • 폴리아미드/폴리스티렌 블렌드의 결정화 거동에 대한 상용화의 영향

        홍인철,김형일 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

        폴리아미드-6(PA), 스틸렌-무수말레인산 공중합체(SMA), 폴리스텔린(PS)를 포함하는 일련의 블렌드계에서 상용화가 분산상인 결정성 고분자 PA의 결정화 거동에 미치는 영향을 조사하였다. PA의 결정화 거동은 PA의 말단 아민기와 SMA의 산무수물기간의 축합반응을 통한 상용화 정도에 따라 크게 영향을 받았다. 블렌드에서 SMA의 함량이 증가할수록 분산상 PA의 결정화 진행이 지연되었다. 이는 계면에서 PA에 연계된 SMA분자의 운동성으로 인하여 PA의 정상적인 결정화 온도에서 PA분자의 결정격자위치로 이동하는데 방해를 받았기 때문이었다. A series of blends containing polyamide-6(PA), styrene-maleic anhydride copolymer(SMA) and polystyrene(PS) have been prepared to study the effect of compatibilization on the crystallization behavior of the dispersed semicrystalline component PA. The crystallization behavior of PA depended largely on the extent of compatibilization via the condensation reaction between the terminal amine group of PA and anhydride group of SMA. As the content of SMA was increased, the crystallization of the dispersed PA was retarded. It was because the reduces mobility of SMA which was linked to PA at the interface prevented the PA molecule from moving into a crystal lattice position at the normal crystallization temperature.

      • 중성자 방사화분석에 의한 조선시대 청·백자 분류연구

        姜炯台,李澈,諸元穆 漢陽大學校 環境科學硏究所 1989 環境科學論文集 Vol.10 No.-

        조선시대 자기의 특성화를 위하여 중성자방사화분석법으로 15개의 미량성분원소 (Sm,Ga,K,La,Ce,Yb,Th,Hf,Na,Cs,Sc,Rb,Fe,Co,Eu) 함량을 결정하였다. 데이타의 수학적 처리법으로서 선형판별식분석법을 사용하였다. 이 선형판별식분석법으로서 자기의 분류에 유용한 변수를 선정한 다음 재차 선형결합방식으로 분류규칙을 구하였다. 판별점수로서 평면상에 도시한 결과 경기도 광주군 상번천리5호, 상번천리9호 및 도수리 청·백자의 분류효율은 각각 12/15,15/15,10/10이었다. Data on the concentration of Sm,Ga,K,La,Ce,Yb,Th,Hf,Na,Cs,Sc,Rb,Fe,Co and Eu obtained by neutron activation analysis have been used to characterize Korean porcelain by multivariate analysis. A combination of analytical data by means of statistical linear discriminant analysis(SLDA) has resulted in removal of redundant variables, optimal linear combination of meaningful variables and formulation of classification rules. The plot in the first-to-second discriminant scores has shown that the three distinct territorial regions exist among porcelains of Kyungkido Sangbunchulli No. 5, Sangbunchulli No. 9 and Dosuri, with respective efficiencies of 12/15,15/15 and 10/10.

      • 현대사회와 낭만적 자아 : T.S. Eliot의 시적 체험 T.S.Eliot's Poetic Experience

        정형철 釜山外國語大學 文化硏究所 1991 比較文化硏究 Vol.3 No.-

        The liberal humanist ideology based on the view of the Self as a Cartesian cogito or a transcendental essence has seriously been undermined since the early 20th century when individualism was challenged under centralized control. Modernism, including T.S Eliot's poetics, was a literary response to the post-liberal social condition in which individuality (interior authenticity), rather than individualism, was more emphasised. In this thesis, we read Eliot's earlier poems expressing the flight of alienated individuals who regressively long for the past organic fedualistic society, being unable to have genuine relation with others. We also read his later poems expressing the desire to return to the theocentric order by means of private purgation. We found that his poems, on the whole, embodied his poetic spirit in pursuit of the existential authenticity of the Self. It should be noted that Eliot's thocentric attitude itself, ironically, enough, is a form of anti-humanism. Eliot's tlleocentric anti-humanism, however, is different from the language-centered anti-humanism of recent Post-Structualism.

      • 해체 비평 연구

        정형철 부산외국어대학 1985 논문집 Vol.3 No.-

        Among new literary theories and critical methods which have multiplied from the sixties, Deconstructionism or Deconstructive Criticism is sharply attacking the critical hegemony of New Criticism. New Criticism, which was formed by the conservative ideology of liberal humanism, has been gradually displaced by new modes of critical practice from the sixties when liberal humanism itself became doubtful. The limits of New Criticism lies in its reification of literature. In other words, New Criticism regards a literary text as an autonomous artifact devoid of concrete social context and prefers meaning(signified) to language(signifier). Deconstructive Criticism based on Jacques Derrida's "metaphysics of absence" denies reification or mystification of literature. According to Derrida, the tradition of Western way of thought has been based on the premise that language is subservient to the outside referent. He denied this logocentrism and made a new term, "difference" in order to mean both "to differ" and "to defer". Influenced by Derrida's view of language, so-called Yale school composed of his followers, such as Paul de Man, J.Hillis Miller, Geoffrey Hartman and Harold Bloom, is preoccupied with the epistemology of poetic language. Deconstructive Criticism of Yale school reduces poetic language that has been regarded as the product of individual genius to the result of the grammatical pattern. Even though its self-reflexive attitude toward language is radical, Deconstructive Criticism also has the limits in that it reduces the problem of historical realities to the problem of everyday language we use.

      • KCI등재후보

        정신분열병 환자의 사회기능에 대한 올란자핀과 정형적 항정신병약물의 효과비교

        김철권,정형모,최병무 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

        Objectives : The purpose of this study was to compare the social functioning between schizophrenic patients treated with olan-zapine and those with typical antipsychotics. Methods : Fifty-seven schizophrenic patients with acute exacerbation entered consecutively to olanzapine treatment (N=33) or typical antipsychotic treatment (N=24). The assessment of social functioning and symptoms were made at 3 time points : at the time of admission (baseline), 6 months and 12 months after starting medications. Social functioning and symptoms were examined using the Korean version of Social Adjustment Scale II-Revised Version (KSAS n-RV) and the Positive and Nega-tive Syndrome Scale (PANSS). Results : After 6-months and 12-months treatments, olanzapine treatment group showed significantly improved PANSS total scores (p=.02), Positive scores (p=.04), negative scores (p=.01), and KSAS II-RV total score (p=.004), instrumental role (p= .002), social leisure (p= .03), Personal well-being subarea scores (p= .02), compared with the scores of typical antipsy-chotic treatment group. Conclusion : Olanzapine was more effective than typical antipsychotics in reducing the severity of psychopathology and in improving some subareas of social functionings in patients with schizophrenia. The benefits of olanzapine on social functioning, although modest, may be important factor considering their accumulative effects for long-term treatment.

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