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      • KCI등재SCOPUS
      • Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

        ( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

      • KCI등재후보

        등치관법이 배수관망 해석에 미치는 영향

        현인환,이상목,김영환,전경호 대한상하수도학회 2002 상하수도학회지 Vol.16 No.5

        In this study, the errors caused by improper application of equivalent pipe method on analysis of network were investigated. Especially, the errors related to selection of C-coefficients, pipe lengths, pipe diameters and flow rates were focused. To reduce errors caused by applying equivalent pipe method in network analysis, both C-coefficient of each parallel pipe and large flow rate variation in the parallel pipes between connected junctions should be considered. Results of this study are as follows. When the different C-coefficients of each parallel pipe was not considered, the application of equivalent pipe method caused 47.84% error in headloss and 24.75% error in pipe flow in model network. Also, When large flow rate variation existed in the parallel pipes between connected junctions, equivalent pipe method caused 51.61% error in headloss.

      • KCI등재후보
      • 외상에 의한 영구치의 손상과 치아 고정술의 예후에 관한 연구

        임현범,조용석,김경원 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.1

        경제 성장과 더불어 교통수단의 발달과 취미 활동에 대한 높은 관심과 함께 교통사고, 스포츠 등의 레저 활동, 폭력 등에 의하여 악안면부의 외상은 빈번하게 발생할 수 있다. 1996년 1월부터 1996년 12월까지 1년간 본과에 내원한 악안면부 외상 환자 중 상악골, 하악골, 관골 등의 악안면골 골절을 동반하지 않고 주로 치아 손상을 주소로 이에 대한 치아 고정술을 시행한 환자 43명에 대하여 의무 기록과 방사선 사진 등의 자료를 참고로 하여 영구치의 손상과 치아 고정술의 예후에 대하여 평가하여 다음과 같은 결론을 얻었기에 추후 영구치 손상 환자에 대한 치료술식과 예후 판정에 참고로 하고자 문헌 고찰과 함께 보고하는 바이다. 1. 치아 외상은 여자보다 남자에게서 더 많이 발생하였다. 2. 치아 외상을 받은 호발 연령은 10대와 20대였다 3. 치관 외상의 주된 원인은 낙상, 교통사고와 운동 순이었다. 4. 치아 외상시 가장 호발부위는 상악 전치부였다 5. 치아고정시 아치 바와 강선을 이용한 방법과 강선과 치과용 레진을 이용한 방법의 예후에는 큰 차이가 없었다. 6. 치아고정시 가장 큰 병발증은 치아 실활에 따른 신경치료, 치근 흡수, 발치였다. The injuries of the offal and maxillofacial region occrurred frequently because of the accidents, sports and violences. The authors experienced the injuries of the teeth that did not involve the bony fracture of the maxillofacial bones. We reviewed the 96 teeth of 43 patients that were fixed after replacement and/or replantation of luxated teeth during 1year(1996). We analysed and evaluated the treatment methods and the prognosis of the fixated teeth using the hospital records and radiographies. The results were as follows. 1. The occurrences of teeth injuries were more frequent in male than in female 2. The prevalent age groups were the second and third decades. 3. The major etiologies of teeth injuries were fall-down, traffic accidents and sports. 4. The prevalent teeth injured area were the upper anterior teeth area. 5. The prognosis of the teeth fixation methods between arch bar with wiring and wire with dental resin were not different significantly. 6. The major complications were the endodontic treatment due to discoloration and/or non-vitalization of teeth, root resorption and extraction of injured teeth.

      • KCI등재

        응급환자 의료정보의 공유 현황과 개선방안

        오세현,이부수,김병철,김원,임경수 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

        Background: To manage the EMS(emergency medical services) system effectively, departments, such as fire stations, emergency information centers, hospitals, and The Ministry of Health and Welfare, should exchange information that they own and/or gather during patient care and/or transportation. Medical records and information are very important for continuing the patient's care and for deciding on a treatment plan, but medical information is not exchanged fully in spite of its importance. Method: We analyzed the transfer medical reports that were written by medical doctors who transferred emergency patients to our hospital. The contents and the accuracy of the transfer medical records were analyzed and graded into 4 groups. Group A was fully described and was equipped with diagnosis, laboratory data, X-ray fi1ms; group B had a diagnosis and full laboratory data; group C had a diagnosis, but only partial laboratory data; and group D had only a diagnosis. Results: Among 38,214 patients who visited our hospital from Jan. 2001 to Jun. 2001, 7,031 cases were transferred from other hospitals with transfer medical records. According to the accuracy and important contents of the transfer records, Group A occupied 1.9%, group B 5.2%, group C 32.5%, and group D, with only a diagnosis,60.4%. In the case of our hospital, we delivered all emergency medical information by written paper(transfer note), E-mail, and web-based information system(caber-AMC) to the doctors concerned with managing the patient. However, 93% of the medical records of patients transferred from other hospital contained insufficient information to adequately care for the emergency patients. In addition, most of the transferred patients had been transorted without prior information about transportation. Conclusion: Within the near future, a medical information center equipped with a computerized system should be operated to exchange medical data. As most general hospitals are operating the OCS(order communication system), EMR(electronic medical record), telemedicine, and PACS(picture-archiving communication system), medical information can be exchanged freely in real time if a code standard and HL7(Health Level 7) can be established.

      • 췌장의 점액성 낭선암 1예

        송현주,김도영,정혜경,남승현,문일환,구혜수 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.2

        Nowadays increasing use of abdominal ultrasound in routine check-up may increase the detection rate asymtomatic cystic lesions of pancreas. Even through the majority of the cystic lesions of pancreas is pseudocyst, about 10-15% of those lesions are caused by pancreatic cystic tumor. In the pancreatic cystic tumor, especially, mucinous cystic tumor should be exicised due to its malignant potential, while the pancreatic pseudocyst or serous cystic tumon can be observed for a period or treated medically. Several clinical, radiological, biochemical and pathologic guidelines have been developed in order to distinguish among them. Among pancreatic cystic tumors, mucinous cystic adenocarcinoma is very rare and accounts for only 1% of all pancreatic neoplasms. Unlike extremely poor prognosis of pancreatic adenocarcinoma, mucinous cystic adenocarcinoma has an indolent course and shows a good prognosis after its curative resection. Recently we experienced a 69-year-old woman who had a mucinous cystic adenocarcinoma of the pancreas. We report this case with a review of literature.

      • 지능형 원격 네트워크 온실

        문병현,송주열,이현성,손경규,엄태환,김정우,김아름 대구대학교 정보통신연구소 2004 情報通信硏究 Vol.3 No.2

        The system designed in this paper, can mark the interior state of greenhouse using sensors of temperature, humidity and illumination on greenhouse interior by greenhouse system for farm village area's agriculture automation. And, the real time monitor is possible real time monitoring by camera. Also, system that can supply water using spring cooler system and humidifier. The proposed system can sustain a designed environment of the greenhouse through rentilation fan, fluorescent light and roof door control. TCP/IP is used for the remote control of state the sensors in the client program. 본 논문에서 설계된 시스템은 농촌 지역의 농업 자동화를 위한 온실 시스템으로 온실 내부에 온도, 습도, 조도 센서를 이용한 온실 내부의 상태를 표시할 수 있으며 카메라를 이용하여 실시간 관측이 가능하다. 또한 본 시스템은 지붕 개폐, 스프링 쿨러와 가습기를 이용한 수분 공급, 환풍기, 형광등 등을 통하여 온실 내부의 환경을 유지시킬 수 있다. 모든 센서를 이용한 상태와 온실 제어를 TCP/IP를 이용한 클라이언트 프로그램에서 원격으로 관리할 수 있다.

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