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Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2
Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.
전신마취유도 중 발생한 심방세동과 회복중 발생한 발작성 상심실성 빈맥
방윤식,신동욱,이태규,박정현,길현주,이종연 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2
A healthy 35-year-old man who was scheduled for closed reduction of nasal bone fracture developed atrial fibrillation during induction of general anesthesia after intravenous glycopyrrolate injection. During emergence of general anesthesia, atrial fibrillation was suddenly changed to paroxysmal supraventricular tachycardia with 200 beat per minute and lasted for about 10 seconds. Because blood pressure was stable, esmolol was used to reduce ventricular response. At recovery room, ventricular response reduction about 55 beat per minute was observed after intravenous injection of verapamil 5 mg. Thereafter, the rhythm was returned to normal sinus rhythm with bradycardia.
NiTi scissors-bite corrector의 와이어 굵기에 따른 3차원적 치아 이동 양상
전현주,박선형,정상혁,전윤식 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.1
Objective: The purpose of this study was to compare the difference in three dimensional tooth movement using three different wire sizes (0.018 × 0.025-in, 0.016 × 0.022-in, 0.016-in) on a NiTi scissors-bite corrector. Methods: Computed tomography (CT) images of the experimental model before and after tooth movement were taken and reconstructed into three dimensional models for superimposition. The direction and the amount of tooth movement were measured and analyzed statistically. Results: The lingual and intrusive movements of the crown of the maxillary second molar were increased as the size of the NiTi wire increased. The roots of the maxillary second molars moved buccally except for the 0.016-in group. The intrusive movement of the roots of the maxillary second molars was increased as the size of the NiTi wire increased. Due to the use of orthodontic mini-implants, anchorage loss was under 0.2 mm on average. Conclusions: The 0.018 × 0.025-in NiTi wire was most effective in lingual and intrusive movement of the maxillary second molar which was in scissors-bite position. Indirect skeletal anchorage with a single orthodontic mini-implant was rigid enough to prevent anchorage loss. 본 연구에서는 NiTi scissors-bite corrector를 세 가지 서로 다른 굵기 0.018" × 0.025", 0.016" × 0.022", 0.016" 의 NiTi 와이어로 제작하였을 때 각각의 치아 이동 양상을 치아 이동 시뮬레이션 장치인 Calorific machine을 이용하여 3차원적으로 분석하고자 하였다. 가위교합에 이환된 상악 제2대구치 모형을 제작하고 제2소구치와 제1대구치 사이에 교정용 미니 임플랜트(orthodontic mini-implant)를 식립하여 제1대구치에 간접골성고정원을 설계하였다. 세 가지 굵기의 NiTi scissors-bite corrector를 부착하여 실험하였다. 치아의 이동 전후에 실험 모형은 computed tomography (CT)로 촬영하고 3차원 데이터로 변환하여 중첩하였다. 치아 이동 방향과 이동량을 계측하여, NiTi scissors-bite corrector 와이어 굵기에 따른 치아 이동 양상에 관한 통계적 유의성을 검정한 결과, 제2대구치 치관의 설측 이동량은 0.018" × 0.025"군(2.65 mm)이 가장 많았으며, 0.016"군(1.96 mm)과 통계적으로 유의한 차이를 보였다(p < 0.05). 제2대구치 치관의 압하량은 0.018" × 0.025"군(2.35 mm), 0.016" × 0.022"군(1.18 mm), 0.016"군(1.00 mm)으로 0.018" × 0.025"군이 나머지 두 군과 유의한 차이를 보였고 (p < 0.05), 치근의 압하량은 0.018" × 0.025"군(4.19 mm), 0.016" × 0.022"군(3.29 mm), 0.016"군(2.24 mm)으로 세 군 간 모두 통계적 유의차를 보였다 (p < 0.05). 치아의 이동 양상을 관찰한 결과, 0.016"군에서는 제2대구치 치근의 협측 이동이 나타나지 않았다. 간접골성고정원으로 사용된 제1대구치의 고정원 소실은 0.2 mm 이하로 나타났다. 이상의 결과를 토대로 0.018" × 0.025" NiTi 와이어로 제작한 NiTi scissors-bite corrector를 교정용 미니 임플랜트를 이용한 간접골성고정원과 함께 이용하였을때, 최소한의 고정원의 소실과 함께 가장 큰 상악 제2대구치의 설측 이동 및 압하가 일어났다고 할 수 있다.
Formation and photoluminescence of Y2O3-H3BO3:Eu3+ powders by mechanical alloying
Hyun-Sic Gong,김현구 한국물리학회 2013 Current Applied Physics Vol.13 No.3
Y2O3eH3BO3:Eu3+powders were synthesized by the mechanical alloying (MA) method, and their structural and photoluminescent characteristics were investigated by X-ray diffractometry (XRD), scanning electron microscopy (SEM), thermogravimetric/differential thermal analysis (TG/DTA), and luminescence spectrophotometer. The crystallite size of the powder mixture milling for 30 minutes (min) by the WillaimsoneHall method was approximately 58.8 nm with strain of 0.00141; overall, the internal strain increased with the milling time (tm). The morphology of the powder mixture with tm, as observed by SEM, divided into three different stages: agglomeration (0 < tm ≤ 30 min), disintegration (30min < tm ≤ 120 min), and homogenization (120min < tm ≤ 300 min). The transition temperature and the weight reduction rate of the sample powders were 645.58 ℃ and 2.851%, respectively. Furthermore, the photoluminescence of the powder mixture excited to 240 nm by a zenon discharge lamp (20 kW) was detected near 592 nm(5Do→7F1), 613 nm, 628 (5Do→7F2), and 650 nm (5Do→7F3).
( Hyun-sic Jang ),( Bo-an Jang ) 대한지질공학회 2018 지질공학 Vol.28 No.3
The strain and acoustic emission (AE) signals of Pocheon granite were measured during uniaxial compression tests to investigate microcrack formation and damage. Crack closure, initiation, and damage stresses of each sample were determined through an analysis of the crack volumetric strain and stiffness. The samples experienced four damage stages according to stress levels: stage 1 = crack closure stage; stage 2 = elastic stage; stage 3 = crack initiation stage; stage 4 = crack damage stage. At least 75% of all AE signals occurred in stages 3 and 4, and different AE parameters were detected in the four stress stages. Rise time, count, energy, and duration clearly showed a tendency to gradually increase with the damage stress stage. In particular, the rise time, energy, and duration increased by at least 95% in stage 4 as compared with stage 1. However, the maximum amplitude showed a smaller increase, and the average frequency decreased slightly at higher stages. These results indicate that as the degree of rock damage increases, the crack size grows larger. The crack types corresponding to the AE signals were determined using the relationship between RA (Rise time / Amplitude) values and average frequencies. Tension cracking was dominant in all stress stages. Shear cracking was rare in stages 1 and 2, but increased in stages 3 and 4. These results are consistent with previous studies that reported cracking begins after samples have already been damaged. Our study shows that the state of rock damage can be investigated solely through an analysis of AE parameters when rocks are under compressive stress. As such, this methodology is suitable for understanding and monitoring the stress state of bedrock.
Recurrent Psychosis after Phentermine Administration in a Young Female: A Case Report
Hyun-Sic Jo,Sheng Min Wang,Jung-Jin Kim 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1
Phentermine is a sympathomimetic amine, like amphetamine, which is one of the most often prescribed drugs for weight loss. Although exact mechanism of phentermine causing psychosis is still not clear, numerous reports already showed that phentermine can induce psychosis. Psychotic symptoms are generally resolved once the medications are stopped. In contrast, we present a case of a 25-years-old Asian female patient who developed psychotic symptoms repeatedly after phentermine administrations. This case suggests that phentermine can cause psychotic episodes repeatedly, resulting in chronic occupational and social impairment. Therefore, a precautious measure such as government regulations for physicians prescribing and an education for patients taking phentermine are urgently needed.