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위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구
노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.
위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동
이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.
신현무, 이상화 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1
Surfactant washing process being operated in ex-situ mode could be appropriate one of the most effective remediation alternatives for NAPLs(non-aqueous phase liquids) in soil. The adsorption of sufactants has been concern of the reduction of expenditure and the increase of efficiency. Through the result of estimating the extent of adsorption of surfactants to soils, notion sufactants showed higher adsorption to soils than anion surfactants. From the results of evaluating which model could explain the surfactant adsorption to soils, it was determined that anionic surfactants were described well with Langmuir adsorption isotherm model, while nonionic surfactants were with Freundlich model.
현무성 江南大學校産學技術硏究所 2004 산학기술연구소논문집 Vol.- No.17
이 연구는 사회화 주관자가 스키 참여자의 여가 태도에 영향을 미칠 것이라는 전제 하에 스키 참여자의 개인적 특성 및 사회화 주관자가 스키 참여자의 여가태도에 어떠한 영향을 미치는가를 규명하는데 그 목적이 있다. 따라서 이 연구는 2003년/2004년 스키 시즌 동안 강원도에 위치한 스키장에 내장한 방문객 332명을 대상으로 하여 스키 참여자의 개인적 특성 및 사회화 주관자가 여가태도에 어떠한 영향을 미치는가를 알아보기 위하여 빈도분석과 중다회귀분석을 사용하여 분석하였다. 그 결과 첫째, 스키 참여자의 개인적 특성 변인 중 연령과 아버지의 직업이 다른 변인에 비해 여가태도에 유의한 영향을 미친 것으로 나타났다. 둘째, 사회화 주관자 중 아버지, 친구, 유명선수의 영향과 아버지, 어머니, 형제자매, 친구, 선ㆍ후배, 스키강사의 스키에 대한 생각, 친구의 권유 등이 다른 변인에 비해 스키 참여자의 여가태도에 유의한 영향을 미치는 것으로 나타났다.
현무성 師範大學 體育硏究所 1998 서울大學校 體育硏究所論集 Vol.19 No.2
Historically, scientific approaches to human motion have been based on accumulated scientific knowledge base of that period. Since the era of Aristoteles, scientists have been interested in the movement principles and analysis of human motion. Specifically, the 20th century noticed rapid development of mechanical approaches to human motion. Since 1950s, scientific interests in and needs for biomechanics are increasing as systematic principles drawn from the results of sport sciences are successfully adopted for performance enhancement. Thus, it is timely task to examine the origin of scientific bases of human motion and how the knowledge has been developed at various historical stages. This paper reviewed historical development of biomechanics of human motion, focusing on the works of major scholars from ancient times to the 19th century. From ancient times to the 19th century, research questions and answers regarding human motion have been around philosophical perspectives on human motion, movement principles, analytic techniques of specific human motion. The review of the historical development of biomechanics leads to the extension of our understanding of contemporary biomechanical approaches to human motion.
현무성 師範大學 體育硏究所 1991 서울大學校 體育硏究所論集 Vol.12 No.2
The purpose of this study was to analyze the gait of amputee compared with the normals and quantify the deviation, so that the effect of prothesis could be verified. The subjects were 12 prothesis-using amputee for experimental group, and 3 normals for control group. 3-D analysis was used for experiment process to analyze Uneven Heel Rise, Lateral Trunk Bending, Wide Walking Base, Circumduction, Swing Phase Whips, Velocity of C.G., stride length and group reaction when walking. The results were as follows; 1. Degree of lateral Trunk Bending was appeared more widely in BK.& A.K. group than in control group; 1∼2。 in control group, 3。 in A.K. group, 7。 in A.K. group, 14。 in R.A.K. group. 2. The velocity of vertical trunk movement was not appeared significantly between Control & B.K. group but velocity of A.K. group was appeared almost 2 times faster. 3. The Unevens Heel Rise was appeared lower in B.K.& A.K. group than in control group. 4. Circumduction of feet was more serious(5。) in B.K. group than in control & A.K. group. 5. In all groups the tendency of Foot Abduction was generally but in R.A.K. group Foot Adduction could be observed. 6. Stride length was longer in B.K.& A.K. group than in control group because of the Body-Balancing problem. 7. Wide walking Base was appeared 3㎝ longer in B.K. group than in group 8㎝ longer in A.K. group than in control group.
스키 턴 동작의 운동학적 분석 : Parallel Turn을 중심으로
현무성 師範大學 體育硏究所 1999 서울大學校 體育硏究所論集 Vol.20 No.1
The purpose of this study was to investigate the kinematical variables such as ankle angulation, shoulder-hip-knee angulation, body leaning degree, height of c.o.g.(center of gravity) that are presumed to influence the parallel turn. In order to meet the purpose of the study, the researcher himself analysed the aforementioned variables with four experienced skiers and beginners resepectively. The primary findings from these analysis follow. First, experienced skiers' ankle angulation degree appeared higher than their counterparts in parallel turn's up movement performance. Contray to this, novice's ankle angulation degree showed higher in down movement. Second, experienced skiers' shoulder-hip-knee angulation degree appeared less than their counterparts in parallel turn's up movement performance. Third, experienced skiers' shoulder-hip-knee leaning degree appeared less than their counterparts in parallel turn's up movement performance. Fourth. experienced skier's c.o.g. difference appeared higher than their counterparts in parallel turn's up-down movement performance. Within its limitations and findings, this study concluded that the ideal parallel turn movement is keeping lower hip joint angulation smaller and maintaining shoulder-hip-knee angulation smaller along with maximizing the height difference in c.o.g..