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Burden of Disease Due to Outdoor Air Pollution in Korea: Based on PM<sub>10</sub>
김현진,윤석준,김형수,이건세,김은정,조민우,오인환,Kim, Hyun-Jin,Yoon, Seok-Jun,Kim, Hyeong-Su,Lee, Kun-Sei,Kim, Eun-Jung,Jo, Min-Woo,Oh, In-Hwan Korean Society of Environmental Health 2011 한국환경보건학회지 Vol.37 No.5
Purpose: This study measured the burden of disease in Korea related to outdoor air pollution using disability-adjusted life year (DALY). Materials and Methods: As a risk factor of outdoor air pollution, particulate matter with a diameter less than 10 ${\mu}m$($PM_{10}$) was used. First, $PM_{10}$-related diseases and their relative risk (RR) were selected by means of a literature review. Second, population attributable fractions were computed by using formulae including RR and population exposure to $PM_{10}$. Third, DALYs of $PM_{10}$-related diseases in Korea were estimated. Finally, the attributable burden of disease due to $PM_{10}$ was measured as the sum of the products that multiplied the DALYs of $PM_{10}$-related diseases by their population attributable fractions. Results: The disease burden of PM10 was 6.9 DALY per 1,000 persons in 2007. The attributable burden of $PM_{10}$ was 2.68 for lung cancer, 2.41 for COPD, 0.62 for ischemic heart disease, 0.61 for pneumonia, 0.55 for asthma, and 0.03 for preterm. Conclusions: This study showed the environmental burden of disease of $PM_{10}$ and burden of $PM_{10}$-related disease through objective data. It also suggested that active efforts are needed to continuously measure and reduce the burden of environmental diseases in Korea.
감모후유증(感冒後遺症)으로 기허형(氣虛型)호흡기 질환을 호소하는 환자의 한약치료에 관한 임상연구
김현진,한효정,장정아,박은영,안태한,서호석,김진원,Kim, Hyun-Jin,Han, Hyo-Jung,Jang, Jeong-A,Park, Eun-Young,An, Tae-Han,Seo, Ho-Seok,Kim, Jin-Won 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1
Objectives : In order to confirm a remedial effect and related influence of the clinic treatment by prescribing Samchuljojung-tang(蔘朮調中湯), Bojungikqi-tang(補中益氣湯) and Samso-um(蔘蘇飮) to patients who suffering from a chronic cough and rhinorrhea. Methods : 1. In a clinical observation and analysis method, we have selected the 23 patients who have visited National Oriental Medical Center, date from 2007.8.21 to 2008.7.31 and suffering from a chronic cough and rhinorrhea caused by the common cold sequelae. 2. Separated them into three types(I: cough type, II: rhinorrhea type, III: cough & rhinorrhea type). 3. Observed thoroughly the level of symptom and recorded it for each type with questionnaire survey at the beginning set 4. Prescribed Samchuljojung-tang, Bojungikqi-tang and Samso-um for type I, II, III respectively. 5. Observed the level of symptom and treatment afterwards affect, and recorded movements of intensity level for 3 types with same questionnaires. Results : 1. Type I : The survey turned out to be from 9 patients, initial level recorded 31.89 at the entry diagnosis, and next level that means changing of symptoms, recorded to 12.67 after prescribing herb medication. 2. Type II : From 11 patients, initial level was 32.82 and next level was 13.45. 3. Type III : From 3 patients, initial level was 37.67 and next one was 16.00. Conclusions : It is concluded that there is a significant remedial effect and related influence of the clinic treatment for each type of patients who suffering from a chronic cough and rhinorrhea caused by the common cold sequelae.
Saccharomyces cerevisiae에서 Cycloinulooligosaccharide Fructanotransferase 유전자의 표층 발현
김현진,이재형,김현철,김연희,권현주,남수완,Kim, Hyun-Jin,Lee, Jae-Hyung,Kim, Hyun-Chul,Kim, Yeon-Hee,Kwon, Hyun-Ju,Nam, Soo-Wan 한국생명과학회 2007 생명과학회지 Vol.17 No.2
Paenibacillus macerans 유래의 cycloinulooligosaccharide fructanotransferase (CFTase) 유전자(cft, 2832 bp, 103.8 kDa)를 효모 표층발현 vector인 pCTcon (GAL1 promoter)에 subcloning 하였다. 구축된 pCTECFTN (9.0 kb)를 숙주세포인 s. cerevisiae EBY100에 형질전환한 후, uracil이 결핍된 배지와 inulin 함유배지에서 선별하였다. cft 유전자는 GAL1 promoter에 의해 효모 형질전환체에서 성공적으로 발현되었다. inulin으로부터 cyclofructans (CFs)로 생산하는 효소적 능력으로부터 표층발현 유무를 확인하였다. YPDG배지에서 48시간 배양 후 분획한 균체는 5.52 unit/ l 의 활성을 보였다. CF 생산을 위한 효소의 최적 반응 조건으로 pH 8.0, 반응온도 $50^{\circ}C$, 기질농도 5%, 기질은 Jerusalem artichoke 등의 inulin과 표층 발현 CFTase 효소반응 결과, cycloinulohexaose (CF6), cycloinuloheptaose (CF7), 그리고 cycloinulooctaose (CF8)이 생성되었고, 이 중에서 CF6가 주 생성물이었다. The cycloinulooligosaccharide fructanotransferase (CFTase) gene (cft) from Paenibacillus macerans was subcloned into the surface display vector, pCTcon (GAL1 promoter). The constructed plasmid, pCTECFTN (9.0 kb) was introduced to S. cerevisiae EBY100 cell and then east transformants were selected on the synthetic defined medium lacking uracil and on the inulin containing medium. The surface display of CFTase was confirmed by immunofluorescence microscopy and its enzymatic ability to form cycloinulooligosaccharides(cyclofructans, CFs) from inulin. The total activity of the CFTase was reached about 5.52 unit/1 by cultivation of yeast transformant on YPDG medium. The optimized conditions determined were as follows; pH, 8.0; temperature, $50^{\circ}C$ ; substrate concentration, 5%; inulin source, Jerusalem artichoke. By the reaction with inulin, CFs consisting of cycloinulohexaose (CF6), cycloinuloheptaose (CF7), and cycloinulooctaose (CF8) were produced and CF6 was the major product.
김현진,정수현,정혜인,김경한,Kim, Hyeon-Jin,Jeong, Soo-Hyun,Jeong, Hye-In,Kim, Kyeong Han 대한예방한의학회 2021 대한예방한의학회지 Vol.25 No.2
Objective : This study was aimed to review randomized controlled trials (RCTs) about whether aromatherapy relieves stress. Method : We searched document about criteria to use words like 'Aroma', 'Oil' and 'Stress'. The study included 24 RCTs which were selected by total 167 studies searched in Korean Journal by searching OASIS, ScienceON, KISS, RISS. Cases that cannot be performed alone are excluded. Results : We got 24 domestic standard documents. Of the 24 studies, 14 were for students, and 6 were for patients receiving hospital treatment. Among the 7 treatments, dry-inhalation was used 13 times, and necklace-inhalation was used 9 times. Of the 24 Studies, lavender oil was used 19 times and sweet orange was used 4 times. Among the 28 types of measuring instruments used, 10 related to the autonomic nervous system and 8 STAIs and VASs were used respectively. Conclusion : It was possible to conclude that aromatherapy was effective in relieving stress. Through further research, it is necessary to study effective oil mixing methods, methods for measuring subjective stress, multimodal intervention, and effective intervention periods.
커뮤니티를 고려한 주거환경개선요소 설정 및 중요도 분석
김현진,구자훈,원제무,Kim, Hyun-Jin,Koo, Ja-Hoon,Won, Jai-Mu 한국주거학회 2009 한국주거학회 논문집 Vol.20 No.6
This study initially analyzes the meaning of Community-Based Residential Environment Improvement. A residential environment improvement factor was determined through an analysis of the function, components, Planning techniques of the community, the evaluation criteria of the residential environment, and through relative literature documenting plans for the adjustment of urban and housing environments. In terms of the methodological approach, decisions were made based on the results of an expert focus-group-interview, a goodness-of-fit test, and by using the analytic network decision-making method from which the correlation among items can be considered. Results of this analysis show that the, order of importance of factors for a community-based residential environment is as follows: interactional character, cognitive character, and locational character. Furthermore, the most important aspect for each of these factors are the neighbor-hood relationship in terms of the interactional character, common consciousness for the cognitive character and place for locational character. The results of this study can be used by linking them with questionnaire items for basic resident research when a residential environment improvement project or a plan for the adjustment of urban and housing environments is planned.
케틀벨 운동과 초음파 치료가 20대 성인의 체질량지수, 체지방률에 미치는 영향
김현진,김명훈,Kim, Hyun-Jin,Kim, Myung-Hoon 대한물리치료과학회 2018 대한물리치료과학회지 Vol.25 No.2
Background: This study was to examine the influence of BMI and PBF of adults in 20's through the Kettlebell exercise and ultrasound for 4 weeks. Methods: 24 adults men and women, whose BMI is over 23, was divided into 3 groups, group I (control group), group II (Kettlebell exercise group), group III (ultrasound treatment and Kettlebell exercise group). The ultrasound treatment was done before exercise for 15 minutes 3 times a week for 4 weeks, and exercise worked out with Kettlebell exercise during 15 minutes and were stretched for 10 minutes before and after exercise. Results: For 4 weeks of Kettlebell exercise and ultrasound, there was a statistically meaningful difference between group I and group III (p<.05). For 4 weeks, there was no statistically meaningful difference of BMI and PBF between group II and group. I Conclusion: A complex application of Kettlebell exercise and ultrasound treatment was thought to effective decreasing for BMI and PBF.
김현진,정수현,이준호,김대용,양갑식,Hyeon Jin Kim,Soo Hyun Jeong,JunHo Lee,Dae Yong Kim,Gabsik Yang 대한융합한의학회 2022 대한융합한의학회지 Vol.4 No.1
Objectives: Inflammasomes are molecular platforms that are generated inside cytoplasmic compartments. The objective is to mediate immunological responses of the host to cell damage and infection. Caspase-1 is triggered by inflammasome to generate interleukin-1𝛽 (IL-1𝛽), an inflammatory cytokine, and pyroptosis, an inflammatory form of apoptosis. Methods: In the past two decades, scientists have uncovered several inflammasomes. The most research has been conducted on NLRP3 inflamamsomes, whose activity can be stimulated by a variety of induction factors. However, the unregulated activation of NLRP3 inflammasomes is also a role in the etiology of several human disorders. Previous research has demonstrated that NLRP3 inflammasomes have a significant role in the innate and acquired immune systems, as well as in the prevalence of joint illnesses such rheumatoid arthritis. Conclusion: Within the scope of this review, we will present a brief overview of the biological features of NLRP3 inflamamsomes as well as a description of the underlying mechanisms governing activation and regulation. In particular, we explore the function of inflammasomes in the development of rheumatoid arthritis as well as the promise of recently identified medicines that target inflamasomes.
김현진,Kim, Hyun-Jin 한국기록학회 2006 기록학연구 Vol.0 No.14
이 글은 독일 기록관리 이론의 역사를 평가론 중심으로 개괄한다. 18세기 이전 독일의 기록관리의 목표는 법률적, 정치적 지식을 조직하는 것이었다. 따라서 기록 소유자의 법률적 권리보전을 위해 특별히 중요한 증명서나, 정치적으로 중요한 문서들만 선별, 관리되었다. 19세기에, 구체제의 붕괴로 보호해야 할 특권이 없어지면서 기록관리의 목적은 연구기능을 지향하게 되었다. 다양한 기관에서 생산되어 집적된 기록들을 조직하기 위해 출처주의가 확립되었고, 학문적인 필요에 부합하는 내용지향적인 평가방식이 선호되었다. 1차 대전은 현대 기록학 이론 형성의 결정적인 계기가 된다. 전쟁수행 중 생산된 방대한 양의 기록을 처리해야 하는 당면 과제가 종전 이후의 민주화 분위기와 결합하여 출처 지향적 평가론이 형성된다. 기록의 가치는 생산기관의 업무와 활동을 증거하는 능력에 따라 평가되는 것이다. 나찌 시대를 지나 온 전후 독일의 반(反)관료제적인 분위기 속에서 출처 지향적 평가론 대신 내용지향적인 평가방식이 다시 등장한다. 봄스로 대표되는 이 이론은 20세기 후반 다큐멘테이션 전략 이론의 토대가 된다. In diesem Aufsatz wird die Geschichte der Bewertungsdiskussion in Deutschland vorgestellt. Bis zum 18. Jh. war das Ziel der Archivarbeit die Systematisierung der rechtlichen und politischen Kenntnissen. Der juristisch geschulte Archivar hob Unterlagen in der Regel aus $Gr{\ddot{u}}nden$ der Rechtssicherheit auf. Vernichtet wurde, was schon seit $l{\ddot{a}}ngerem$ im Archiv lag. Nach dem Zusammenfall des alten Regimes haben die Archivare keine mehr mit dem Recht des Herrschers zu tun. Und die Archive wurden zu $Lagerst{\ddot{a}}tten$ der Geschichte und Forschung. $F{\ddot{u}}r$ den Ordnung der Archivgut, die aus den verschiedener Dienststellen stammten, wurde das Provenienzprinzip gebildet. Die Archivare richtete sich auf das inhaltsorientierten Bewertungsverfahren, das die wissenschaftlichen $Bed{\ddot{u}}rfnisse$ befriedigte. Der Anlass der Bildung der modernen Archivtheorie war der ersten Weltkrieg. Das Problem, wie man die Massenakten, die $W{\ddot{a}}hrend$ dieses Krieges entstanden, behandeln sollten, $f{\ddot{u}}hrte$ unter dem $Einflu{\ss}$ der Demokratie zur Bildung der Provenienz-orientierte Bewertungsdiskussion. Aufbau, Zielsetzung und Verfahren der aktenbildenden Stelle bildeten den Ausgang der Bewertung. Im Klima ${\ddot{o}}ffentlicher$ $B{\ddot{u}}rokratieablehnung$ der 50er und 60er Jahren wurde die inhaltsorientierte Auswahl wieder die vorherrschende Methodenvorgabe. Diese Theorie, die Booms vertritt, $f{\ddot{u}}hrt$ zu der Theorie der dokumentation strategy von Ende 20. Jh.
김현진,이현주,임기환,Hyun-Jin Kim,M,D,Hyun-Joo Lee,M,D,Key-Hwan Lim,M,D 대한안과학회 2008 대한안과학회지 Vol.49 No.5
Purpose: To investigate the clinical characteristics and disability rates of patients seeking expert consultation for legal reasons because of ophthalmologic symptoms. Methods: We analyzed the gender, age, reason for consultation, and result of consultation, among other factors, by retrospectively examining the medical files of 89 patients from January 1999 to December 2004. Results: Out of 89 patients, men constituted 76.4% and patients in their forties constituted 23.0%. The most common reason for consultation was a traffic accident (64.0%), followed by a medical lawsuit (11.2%). Forty-nine patients (55.1%) were diagnosed with a disability, while 30 patients (33.7%) were not. Diagnostic decisions for the other 10 patients (11.2%) were deferred. Optic atrophy was the most frequent cause for deteriorating visual acuity in patients, accounting for 19 cases, and diplopia caused by orbital wall fracture was also prevalent (9 patients). Among the resulting types of damage, brain damage was the most frequent, while the percentage of patients with an impairment in the visual system was approximately 29.0% among the patients diagnosed with a disability. Conclusions: Our results will be helpful in elucidating the clinical characteristics of patients referred to the ophthalmic clinic for consultation because of legal concerns.
내경계막 제거술 후 광간섭단층촬영에서 나타난 황반부 형태의 변형에 대한 분석
김현진,이정희,Hyun-Jin Kim,Jeong-Hee Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.2
`Purpose: To analyse the postoperative anatomical changes of maculae using optical coherent tomography after internal limiting membrane peeling during vitrectomy. Methods: A retrospective review of 22 patients (22 eyes) who underwent vitrectomy with internal limiting membrane peeling was performed. Age, sex, fundus findings, BCVA, operation methods, complications, and postoperative OCT findings were recorded. Results: Of 22 eyes, 12 eyes had epiretinal membranes, 5 eyes had macular holes, and 5 eyes had diffuse diabetic macular edemas. Eighteen of 22 eyes underwent internal limiting membrane peeling using ICG, with 1 eye treated with triamcinolone and 3 eyes treated with nothing. The postoperative improvement of BCVA was statistically significant in epiretinal membrane and diffuse macular edema patients (p<0.05), but insignificant in macular hole patients (p>0.05). Postoperative OCT findings of 17 eyes showed that they had returned to normal shape and thickness. However, among the 18 eyes that underwent ICG dye-assisted ILM, 3 eyes showed irregular macular thinning and 1 eye showed macular cystic changes. One eye treated with triamcinolone presented with a recurrent cytoid macular edema. No postoperative complications or recurrences were reported by epiretinal membrane patients. Conclusions: Changes to macular shape did not significantly affect the final BCVA after internal limiting membrane peeling, but they can cause changes to the microstructure of maculae. Therefore, caution during surgery and close follow-up are necessary.`