C_(26)H_(38)N_(6)O₄Ni 의 결정 구조

김문집,홍현표 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

The structure of C_(26)H_(38)N_(6)O₄Ni has been determined by X-ray diffraction method. The crystal is Triclinic, Space group PI^_, unit cell constants, a = 31.1204(14)Å, b = 10.9622(19)Å, c=18.1212(7)Å, α=90˚, β=98.57(94)˚, γ=90˚ V=6113.05(63)ų, T=296.62K, Z=8, D_(c)=1.3608Mgm^(-3). The intensity data were collected on an Enraf-Nonius CAD4 diffractometer with graphite monochromated CuKα radiation (λ=1.54184Å). The molecular structure was solved to by Direct method and refined by full-matrix least squares to a final R=9.8733 for 2998 unique observed F_(0)>4σ(F_(0)) reflections and 343 parameters.

C_(28)H_(54)N₄O₄Ni 의 결정 구조

김문집,홍현표 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.1

The structure of C_(28)H_(54)N₄O₄Ni has been determined by X-ray diffraction methods. The crystal system is Monoclinic, space group P□, unit cell constants, a = 8.9424(4)Å, b = 10.1776(5)Å, α=62.50(1)˚, β=87.31(1)˚, γ=66.04(1)˚ V=752.71ų, T=294.9K, Z=1, D_(c)=1.3269Mgm^(-3). The intensity data were collected on an Enraf-Nonius CAD-4 Diffractometer with graphite monochromated Mo Ka radiation (λ=0.71073Å). The molecular structure was solved by direct methods and refined by full-matrix least squares to a final R=6.85% for 2321 unique observed F_(0)>4σ(F_(0)) reflections and 194 parameters.

C_(20)H_(20)N_(4)O_(2)C_(12)C_u의 결정 구조

김문접;홍현표 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.1

The structure of C_(20)H_(20)N_(4)O_(2)C_(12)C_u has been determined by X-ray diffraction methods. The crystal system is Monoclinic, space group Pa, unit cell constants, a=7.8644(9)Å, b = 18.1689 (4)Å, c = 9.0150 (5)Å, (β= 109.91(1)˚, V=1211.12 Å^3, T= 294.9K, Z= 2, D_2=1.322Mgm^(-3). The intensity data were collected on an Enraf-Nonius CAD-4 Diffractometer with graphite monochromated Cu Ka radiation (λ= 1.54184 Å). The molecular structure was solved by direct methods and refined by full-matxix least squares to a final R = 6.59% for 2498 unique observed F_0 > 4σ(F_0) reflections and 254 parameters.

C_(17)H_(18)NO 의 결정 구조

김문집;홍현표 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

The structure of C_(17)H_(18)NO has been determined by X-ray diffraction methods. The crystal system is monoclinic, space group ◁수식 삽입▷(원문을 참조하세요), unit cell constants, α= 5.6640 (50 ) Å , b= 10.7020 (50) Å , c= 11.9460(50) Å, α=105.800(5)° , β= 92.415(5)° , γ= 96.285(5)° , V= 690.61 Å^3, T= 294.9K, Z=2, D_c= 1.2134Mgm^(-3). The intensity data were collected on an Enraf-Nonius CAD-4 Diffractometer with graphite monochromated Mo Ka radiation (λ = 0.71069 Å ). The molecular structure was solved by direct methods and refined by full-matrix least squares to a final R = 3.77% for 1618 unique observed F_0>4_ σ<(F_0) reflections and 176 parameters.

조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

C_(24)H_(38)N_(4)Ni_(2)Cl_(4)0_(4) 의 결정 구조

김문집;홍현표 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

The structure of C_(24)H_(38)N_(4)Ni_(2)Cl_(4)0_(4)has been determined by X-ray diffraction method. The crystal is triclinic, space group ◁수식 삽입▷(원문을 참조하세요), unit cell constants, α=8.6020 (50) Å, b=11.0450(50)Å, c=16.5500 (50)Å, α=85.807(5)°, β=85.910 (5)°, γ= 64.487(5)°, V= 1413.89 Å^3, T=295.9K, Z=2, D_c=1.1372Mgm^(3). The intensity data were collected on an Enraf-Nonius CAD4 diffractometer with graphite monochromated MoKα radiation (λ=0.71069Å). The molecular structure was solved to by Direct method and refined by full-matrix least squares to a final R=9.87% for 2998 unique observed F_0>4σ(F_0) reflections and 343 parameters.

철도건축물의 피난동선계획에 관한 연구

임만택,김현태,정집문 朝鮮大學校 建設技術硏究所 2004 建設技術硏究 Vol.24 No.2

The importance of the railway station is focused in this study, since it plays role of the traffic center in the region. This study is aimed to plan the escape flow in the railway station in order to maintain the safety and promote conveniency for passengers and loadings. The investigation of the escape flow is conducted for the most highly used platform and waiting room. Then, this study provides information in designing the railway station in terms of the case situation and types of railway building. Finally, this study gives useful information for determining the requirements for planning the escape flow in the railway buildings.

제2형 당뇨병 동물모델인 OLETF 쥐에서 장기간 라미프릴 투여가 내당능 및 췌도 베타세포에 미치는 효과

고승현,윤건호,김명미,안유배,송기호,유순집,손현식,차봉연,이광우,손호영,강성구 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:최근 소개된 HOPE(Heart Outcomes Prevention Evaluation)study의 결과에 의하면, 심혈관질환이나 이에 대한 위험인자가 1가지 이상인 9,541명을 대상으로 안지오텐신 전환효소 억제제의 일종인 라미프릴을 투여하여 사망율과 뇌졸증, 심부전, 당뇨병 합병증이 개선되었을 뿐 아니라 다른 항고혈압제에 비해 새롭게 당뇨병으로 진단되는 환자가 줄었음을 보고한바 있다. 이에 저자들은 라미프릴(ramipril)을 제2형 당뇨병 동물모델에 장기간 투여함으로써 당뇨병을 예방하거나 고혈당 상태 또는 인슐린 감수성을 개선시킬수 있는지를 알아보고자 하였다. 방법:생후 24주된 체중 400∼450g의 OLETF와 LETO 쥐를 대상으로 6개월간 라미프릴 경구투여 하였고 혈압, 24시간 단백뇨 및 인슐린 내성검사를 시행하였다. 6개월 이후로는 8주간 투여군과 대조군의 체중을 비슷하게 맞추어 내당능 상태를 평가하였고 이후 다시 8주간 고농도 포도당을 투여하였다. 경구당부하검사를 시행한 후 희생시켜 조직표본을 만들어 guinea pig anti­human insulin 항체로 염색후 DAB로 발색하여 point count 법으로 베타세포를 정량하였고, 면역염색으로 췌도의 변화와 섬유화의 정도를 관찰하였다. 결과:라미프릴을 6개월간 투여하였을 때 OLETF 쥐에서 1)체중 증가가 적었으며 2)경구 당부하검사시 포도당하 면적은 의미있게 감소하였고 3)인슐린 내성검사상 Kitt가 증가되는 경향을 보였으며 4)수축기, 이완기 혈압과 24시간 단백뇨양이 의미있게 감소하였고 5)체중을 맞추면 내당능 상태가 비슷해졌다가 고농도 포도당 주입시 다시 포도당하 면적이 대조군에서 더 증가되었다. 라미프릴 투여군에서 췌도변형 및 파괴와 탈과립, 췌도내 섬유화가 감소하였다. 결론:본 실험에서는 인슐린 비의존성 당뇨병 동물 모델인 OLETF 쥐에서 당뇨병 발생 이전 단계부터 장기간 라미프릴을 투여할 경우 체중증가가 적었고, 투여군과 대조군의 체중을 맞추었을 때는 내당능상태의 차이가 없아가 고혈당 투여시 다시 투여군과 대조군에서 의미있는 차이를 보였다. 라미프릴 투여가 베타세포의 기능면에서 이로운 효과를 보일 것으로 생각되었다. 따라서 비만한 환자에서 안지오텐신 전환효소 억제제의 장기투여는 단백뇨 감소, 혈압강하 효과 이외에 체중증가의 억제 및 당뇨병 발생을 억제할 가능성을 시사한다. Background : In a Heart Outcomes Prevention Evaluation HOPE study, ramipril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, significantly reduced the death rates the number of myocardial infarctions, strokes, heart failure as well as the risk of complications related to diabetes and of diabetes itself. However, it is known that ACE inhibitors improve glucose tolerance or insulin sensitivity or reduce the incidence of diabetes. Methods : 24 week-old OLETF (Otsuka Long Evans Tokushima Fatty) rats weighing 400 ~ 450 g were used in this study. 4 groups of rats were examined in parallel for 40 weeks. The OLETF rats were randomized for treatment with an aqueous solution of ramipril (5 mg/Kg) daily [OL (RMP), n=10)] and with saline [OL (CON), n=10)]. The LETO rats were also randomized in the same was as the OLETF rats (LT(RMP), n=10, LT (CON), n=10). The blood glucose level, body weight, systolic and diastolic blood pressure was assessed every month. At 3 and 6 months, the 24hrs urinary protein concentration was measured, and as insulin tolerance test and oral glucose tolerance test were conducted in all experimental groups. After 6 months, the body·weight was matched for 2 months in each corresponding group. Subsequently, a 15% sucrose loading was done for 2 months. After the glucose tolerance test, the pancreas was excised and immuno histochemical staining was conducted for insulin to quantify the beta cell mass by a point-counting method. In addition, the islet morphology was evaluated in the pancreas. Results : Ramipril treatment for a period of 6 months improved the 2hr blood glucose level, the area under the glucose curve in the oral glucose tolerance test, insulin sensitivity in addition to lowering significantly systolic and diastolic blood pressure and 24hrs urinary protein level significantly in OLETF rats. Of note, a lower weight gain was observed in both the ramipril-treated animals at 6 months. After weight matching, the AUC g and 2hr blood glucose level values were similar between the corresponding groups, but a 15% sucrose loading worsened the AUC g value. Histologically, the islets were less disorganized and the extent of fibrosis was lower in the ramipril-treated OLETF rats in the trichrome stain. Conclusion : Long-term treatment of ramipril, a long acting angiotensin-converting enzyme inhibitor may be useful for suppressing weight gain and proteinuria in addition to having a protective effect on the islet to harmful stimuli such as hyperglycemia (J Kor Diabetes Asso 25:469~482, 2001).

시상부위에 발생한 단일성 뇌농양 : 증례 보고 및 문헌고찰 Report of Two Cases and Review of the Literature

곽호신,김동규,이상형,정희원,이현구,김현집,한대희 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12

The authors present two cases of solitary thalamic abscess which were intially diagnosed as malignant thalamic glioma. After treatment with steroids and osmotic agents, the patients' clinical conditions improved after two to three days. However, sudden deterioration of consciousness level developed and the CT scan showed acute hydrocephalus with increment of thalamic low-density lesions. We performed extraventricular drainage and obtained CSF containing numerous inflammatory cells. This suggested the possibility that the lesion was a pyogenic abscess. which progressed to ventriculitis, rather than a malignant glioma. Stereotactic aspiration of the lesion confirmed thalamic abscess. These findings and review of previous reports of thalamic abscess suggested that early diagnosis and stereotactic drainage of the thalamic abscess is of primary importance.

Cervical Spondylotic Myelopathy : Postoperative Results and Prognostic Factors

Kim, Hyun Jib,Chung, Chun-Kee 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.6

목 적 : Cervical Spondylotic Myelopathy(CSM)의 치료에 대하여는 많은 논란이 있다. 이의 예후에는 연령, 수술전 증세정도, 증상지속기간등이 관계한다고 알려져 있다. 본 연구는 영향력이 있다고 알려진 예후 인자들의 영향력을 조사하여 치료의 지침을 삼고자 하였다. 대상 및 방법 : 최근 10년간 본 교실에서 수술하였던 CSM증례중 검토가 가능하였던 56례를 대상으로 하였다. 남녀비는 남자가 53례, 여자가 3례였다. 연령분포는 22세에서 74세로 평균 50.8세였다. 전방경유법을 25례, 후방경유법을 33례에서 시행하였다. 2례에서는 전방 및 후방경유법을 같이 시행하였다. 척수증의 정도는 Nurick Grade를 사용하였다. 수술전 Nurick Grade의 분포는 2.75±0.16(mean±standard error)였다. 추적 관찰기간은 13.8±2.1개월이었다. 전 증례들을 대상으로 연령, 수술전 증세정도 및 증상지속기간의 예후영향력을, 87년도 이후의 증례에서는 자기공명영상상 T2WI에서 보이는 고신호강도의 예후영향력을 검토하였다. 결 과 : 마지막 추적검사상의 Nurick Grade는 2.125±0.14로 수술전과 비교하면 0.63±0.12의 호전을 관찰할 수 있었다. 전방경유법의 경우 0.52±0.14, 후방경유법의 경우 0.73±0.18의 호전이 관찰되었으나 통계적으로 의미가 없었다(P=0.82). 합병증으로는 전방경유법에서 식도루가 1례, 이식골편의 골절 또는 흡수가 2례에서 관찰되었다. 후방경유법의 경우 경추의 굴곡변화가 6례에서 관찰되었다. 예후인자의 분석에서 마지막 추적검사상의 Nurick Grade와 수술전후의 호전에 미치는 영향력은 수술전 증세정도만이 의의 가 있었다(P=0.000). 기타 연령, 증상지속기간 및 T2WI상의 고신호강도는 의미있는 영향력을 보이지 못했다. 결 론 : 적절한 적응증을 적용한다면 전방 경유법이나 후방경유법이나 예후에 차이는 없다고 판단된다. 수술전 증세정도가 마지막 추적검사상의 Nurick Grade에 영향을 미치는 유일한 수술전 예후인자였다. There a* many factors affecting surgical results of cervical spondylotic myelopathy. Age, duration of symptom, neurologic status, and direction of surgical approach are said to have prognostic implications. Also a high signal intensity on T2 weighted magnetic resonance imaging (HSI on T2WI) is insisted as a poor prognostic factor. We analyzed these factors in 56 patients treated over a 10-year period retrospectively. Statistical analysis was done using chi square, Mantel-Haenszel, Cochran-Mantel-Haenszel, Wilcoxon, and logistic procedure. We preferred anterior decompression when compressive lesions existed ventrally. H o w e r posterior decompression was performed in a 4 or more level stenosis Age ranged from 22 to 74 yeadmean : 50.8). 25 patients underwent the anterior procedure, 33 patients the posterior procedure, and 2 both procedures. Neurologic status was graded both preoperatively and at follow-up using the Nurick grading system from 1 to 5. The preoperative Nurick grade was 2.75f 0.16(meank SE.) Mean follow-up period was 13.8 months(SE 0.14). The follow-up Nurick grade was 2125f 0.14, and these was noted an improvement of 0.63f0.12. The amount of improvement was equivalent between the anterior and the posterior approaches(0.52 vs. 0.73 respectively, p=0.67). There was no mortality. Uni- and multivariant analysis demonstrated that age, duration of symtom and HSI on T2WI had no si@icant effect on either follow-up Nurick grade or amount of improvement but the preoperative Nurick grade had a significant effect(p<O.W). Comparable results can be obtained with either approaches if chosen properly. Only the preoperative Nurick grade has the prognostic value.