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Pyo, Soon Hyoung,Lee, Jeongjin,Park, Seongjin,Kim, Kyoung Won,Shin, Yeong-Gil,Kim, Bohyung IEEE 2013 IEEE Transactions on Biomedical Engineering Vol.60 No.9
<P>Recent advances in computing hardware have enabled the application of physically based simulation techniques to various research fields for improved accuracy. In this paper, we present a novel physically based nonrigid registration method using smoothed particle hydrodynamics for hepatic metastasis volume-preserving registration between follow-up liver CT images. Our method models the liver and hepatic metastasis as a set of particles carrying their own physical properties. Based on the fact that the hepatic metastasis is stiffer than other normal cells in the liver parenchyma, the candidate regions of hepatic metastasis are modeled with particles of higher stiffness compared to the liver parenchyma. Particles placed in the liver and candidate regions of hepatic metastasis in the source image are transformed along a gradient vector flow-based force field calculated in the target image. In this transformation, the particles are physically interacted and deformed by a novel deformable particle method which is proposed to preserve the hepatic metastasis to the best. In experimental results using ten clinical datasets, our method matches the liver effectively between follow-up CT images as well as preserves the volume of hepatic metastasis almost completely, enabling the accurate assessment of the volume change of the hepatic metastasis. These results demonstrated a potential of the proposed method that it can deliver a substantial aid in measuring the size change of index lesion (i.e., hepatic metastasis) after the chemotheraphy of metastasis patients in radiation oncology.</P>
Hyoung, Un-Jun,Yang, Yun-Jung,Kwon, Su-Kyoung,Yoo, Jae-Hyoung,Myoung, Soon-Chul,Kim, Sae-Chul,Hong, Yeon-Pyo The Korean Society for Preventive Medicine 2007 예방의학회지 Vol.40 No.2
Objectives : Bisphenol A diglycidyl ether (BADGE) is the major component in commercial liquid epoxy resins, which are manufactured by co-reacting bisphenol A with epichlorohydrin. This study was performed to show the developmental effects of prenatal and postnatal exposures to BADGE in male rat offspring. Methods : Mated female rats were divided into four groups, each containing 12 rats. The dosing solutions were prepared by thoroughly mixing BADGE in corn oil at the 0, 375, 1500 and 3000 mg/kg/day concentrations. Mated females were dosed once daily by oral gavage on gestation day (GD) 6 - 20 and postnatal day (PND) 0 - 21. Pregnant female dams were observed general symptoms and body weight. Also, male pups were observed the general symptoms, body weight, developmental parameters (e.g. anogenital distance, pina detachment, incisor eruption, nipple retention, eye opening, testis descent), organ pathologic changes and hormone levels of plasma. Results : Pregnant rats treated with BADGE died at a rate of about 70% in the 1500 mg/kg/day group and all rats treated with 3000 mg/kg/day died. Body weight, for male pups treated with doses of 375 mg/kg/day, was significantly lower than in the control group at PND 42, 56, and 63 (p<0.05). Evaluation of body characteristics including; separation of auricle, eruption of incisor, separation of eyelid, nipple retention, descent of testis, and separation of the prepuce in the BADGE treated group showed no difference in comparisons with the control group. AGD and adjusted AGD (mm/kg) for general developmental items in BADGE 375 mg/kg/day treated pups tended to be longer than in controls, however, these differences were not statistically significant. Relative weights of adrenal gland, lung (p<0.05), brain, epididymis, prostate, and testis (p<0.01) were heavier than in control in measures at PND 9 weeks. There were no significant changes in comparisons of histological findings of these organs. Loss of spermatids was observed in the seminiferous tubule at PND 9 weeks, but no weight changes were observed. The plasma estrogen levels were similar in the control and treatment groups at PND 3, 6 and 9 weeks. The plasma testosterone levels in the control group tended to increase with age. However, in the BADGE 375 mg/kg/day treated male pups it did not tend to increase. Conclusions : These findings suggest that BADGE is a chemical that has developmental effects consistent with it being an endocrine disruptor.
H.264/AVC 비디오 코덱을 위한 효율적인 자료 재사용 디블록킹 필터 알고리즘
이형표(Hyoung Pyo Lee),이용석(Yong Surk Lee) 대한전자공학회 2007 電子工學會論文誌-CI (Computer and Information) Vol.44 No.6
H.264/AVC 표준은 복호된 영상의 블록간 경계면에서 발생하는 왜곡 및 불연속성을 보정하기 위하여 디블록킹 필터를 사용하여 더 나은 품질을 제공하였다. 하지만 이 과정에서 수많은 메모리 참조연산이 불가피하였으며, 이로 인해 전체 복호기의 처리 시간을 지연시키는 결과를 초래하였다. 본 논문에서는 이러한 디블록킹 필터의 처리 속도를 높이기 위한 자료 재사용 알고리즘을 제안한다. 자료 재사용을 위하여, 새로운 필터링 순서를 제안하여 메모리 참조를 감소시키고 디블록킹 필터의 처리 속도를 높인다. 제안된 알고리즘을 모델링하여 ARM ADS1.2에서 컴파일하고 ARM966E-S프로세서 시스템을 Armulator를 이용하여 시뮬레이션 하였다. 실험 결과, H.264/AVC 표준보다 매크로블록 당 실행 사이클, 메모리 참조 사이클에서 각각 58.45%, 57.93%의 성능 향상을 보였다. H.264/AVC provides better quality than other algorithms by using a deblocking filter to remove blocking distortion on block boundary of the decoded picture. However, this filtering process includes lots of memory accesses, which cause delay of overall decoding time. In this paper, we propose a data-reuse algorithm to speed up the process for the deblocking filter. To reuse the data, a new filtering order is suggested. By using this order, we reduce the memory access and accelerate the deblocking filter. The modeling of proposed algorithm is compiled under ARM ADS1.2 and simulated with Armulator. The results of the experiment compared with H.264/AVC standard are achieved on average 58.45% and 57.93% performance improvements at execution cycles and memory access cycles, respectively.
FMH Impact test 용 머리모형의 환경인자 변화에 따른 가속도 거동 및 Low Level Corridor에 대한 연구
표형순(Hyoung-soon Pyo),임종수(Jong-soo Lim),이재우(Jae-woo Lee) 한국자동차공학회 2009 한국자동차공학회 학술대회 및 전시회 Vol.2009 No.11
For better understanding the characteristic of FMH headform itself, the behavior of peak resultant acceleration was investigated when the temperature, the common environmental factor, was changed. Also the amount of influence on HIC value was estimated due to the variation of acceleration from the FMH headform. And the current Peak Resultant Acceleration value that is one of the head drop test corridors, specified on US safety regulation Part 572 Subpart L, is too high to satisfy the requirement HIC(d) 1000, so we suggested low level peak resultant acceleration corridor considering current level of peak resultant acceleration.
H.264/AVC 표준의 디블록킹 필터를 가속하기 위한 ASIP 설계
이형표(Hyoung Pyo Lee),이용석(Yong Surk Lee) 대한전자공학회 2008 電子工學會論文誌-CI (Computer and Information) Vol.45 No.3
복호된 영상의 블록 경계에서 발생하는 왜곡을 보정하기 위해 사용된 H.264/AVC 표준의 디블록킹 필터는 개선된 품질의 영상을 제공하지만, 이에 사용되는 복잡한 필터링 연산은 복호기의 처리 시간을 지연시키는 주된 요인이 되고 있다. 본 논문에서는 이러한 필터링 연산을 더 빠르게 수행할 수 있는 명령어를 제안하고 ASIP을 구성하여 디블록킹 필터를 가속하였다. LISA를 이용하여 MIPS 기반의 기준 프로세서를 설계하고 디블록킹 필터 모델을 시뮬레이션하여 제안하는 명령어 적용에 따른 실행 사이클의 성능 향상을 비교하였으며, 설계된 기준 프로세서를 CoWare의 Processor Designer를 통해 HDL을 생성하고 Synopsys의 Design Compiler를 이용하여 TSMC 0.25㎛ 공정으로 합성하고 제안하는 명령어를 추가할 경우에 대해 면적 및 동작 지연시간 등을 비교하였다. 합성 결과, 제안하는 명령어 셋을 적용함에 따라 면적 및 동작 지연시간에서 각각 7.5%와 3.2%의 증가를 보였으며, 이로 인해 실행 사이클 면에서는 평균 18.18%의 성능 향상을 보였다. Though a deblocking filter of H.264/AVC provides enhanced image quality by removing blocking artifact on block boundary, the complex filtering operation on this process is a dominant factor of the whole decoding time. In this paper, we designed an ASIP to accelerate deblocking filter operation with the proposed instruction set. We designed a processor based on a MIPS structure with LISA, simulated a deblocking filter model, and compared the execution time on the proposed instruction set. In addition, we generated HDL model of the processor through CoWare's Processor Designer and synthesized with TSMC 0.25㎛ CMOS cell library by Synopsys Design Compiler. As the result of the synthesis, the area and delay time increased 7.5% and 3.2%, respectively. However, due to the proposed instruction set, total execution performance is improved by 18.18% on average.
Hyoung Woo Chang,Yang Hyun Cho,Suhyun Cho,Kiick Sung,Pyo Won Park 대한중환자의학회 2015 Acute and Critical Care Vol.30 No.4
We report a case of successful heart transplantation after 67 days of support with venoarterial extracorporeal membrane oxygenation (ECMO) in a patient who underwent surgery for type A aortic dissection and myocardial infarction complicated by irreversible myocardial damage and a deep sternal wound infection. During ECMO support, left heart vent and distal limb perfusion were performed. Mediastinitis was treated with mediastinal washout and irrigation. Multiple complications from peripheral ECMO were successfully managed.
Pyo, Chul-Woo,Chung, Seo-Young,Hur, Seong-Suk,Kim, Hyoung-Jae,Choi, Jee-Yeoun,Kim, Yang-Kyum,Yoo, Ha-Jung,Choi, Hee-Baeg,Kim, Tai-Gyu The Korean Association of Immunobiologists 2003 Immune Network Vol.3 No.2
Background: As all HLA class II genes, the DQ genes show their polymorphic variation mainly in the second exon, which encodes the first extracellular domain of the molecule. PCR-SSOP (Polymerase chain reaction-Sequence specific oligonucleotide probe) techniques were frequently used for HLA-DQA1 and DQB1 typing but certain alleles, $DQA1^*0101/0104/0105$, $^*302/0303$, $*0501/0505$ and $DQB1^*0201/^*0202$ which differ from each other in segment other than exon 2, could not be unequivocally assigned. Methods: To overcome this problem, we applied additional PCR-SSP (PCR-Sequence specific primer) method to analyze DQA1 exons 1, 3 and 4 and DQB1 exon 3. And we investigated the distributions and haplotypes of HLA-DRB1, DQA1 and DQB1 alleles in 406 unrelated Korean healthy individuals. Results: Using this method the indistinguishable alleles of DQA1 and DQB1 in PCR-SSOP were typed definitively. We also found several important associations between DQA1 and DQB1 alleles in the Korean population; $DQA1^*0101-DQB1^*0501$, $DQA1^*0104-DQB1^*0502$ or $-^*0503$, $DQA1^*0105-DQB1^*0501$, $DQA1^*0302-DQB1^*0303$, $DQA1^*0303-DQB1^*0401$ or $-^*0402$, $DQA1^*0501-DQB1^*0201$, $DQA1^*0505-DQB1^*0301$, and $DQA1^*0201-DQB1^*0202$. The haplotypes of DRB1-DQA1-DQB1 associated with $DQA1^*01$, $^*03$, $^*05$, and $DQB1^*02$ subtypes were investigated. Several haplotypes associated with these alleles were observed in the Korean population. Conclusion: Our results can be helpful to find potential unrelated donors for bone marrow registries and study the HLA-associated disease and anthropology at high-resolution allelic level.