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Hyo-in Yun,Byung-kwon Park,Jong-hwan Lim 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.1
A highly sensitive and specific method for thedetermination of roxithromycin in broiler tissues byLC/MS was developed and validated. A dichloro-methane extract of the sample was separated on C18reversed-phase column with acetonitrile-50 mM am-monium acetate (80:20, v/v) as the mobile phase andanalyzed by LC/MS via atmospheric pressure ioni-zation/electrospray ionization interface. The limit ofdetection and limit of quantitation were 1 ng/g and 5ng/g. The method has been successfully applied todetermine for roxithromycin in various tissues ofbroilers.Residue concentrations were associated withadministered dose. At the termination of treatment,roxithromycin was found in all collected samples forboth dose groups. Liver was detected to have thehighest residual concentration of roxithromycin. Re-sidue concentrations of roxithromycin were lowerthan its LOQ in all tissues from both dose groups 10days after the treatment of roxithromycin mixed withdrinking water at a dose rate of 15 mg/L or 60 mg/Lto each broiler for 7 days.