Association between C16orf47 Gene and Serum Liver Enzyme Levels in the Korean Population

Hyo?Jun Ahn,Yong?Bin Eom 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3

Serum liver enzyme levels are widely used in the clinical diagnosis of liver diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for type 2 diabetes, cardiovascular disease. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum liver enzyme levels in American population. We aimed to confirm whether the genetic variation of C16orf47 (chromosome 16 open reading frame 47) gene also influence the serum liver enzyme levels in Korean population. We genotyped variants in or near C16orf47 in a population?based sample including 994 unrelated Korean adult. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in C16orf47 gene with serum liver enzyme levels. By examining genotype data of a total of 944 subjects in 5 hospital health promotion center, we discovered the C16orf47 gene polymorphisms are associated with serum liver enzyme levels. The common and highest significant polymorphism was rs7203412 (β=3.68, P=3.66E?06) with glutamic oxaloacetic transferase (GOT) and rs7203412 (β=6.2, P=7.06E?05) with glutamic pyruvate transaminase (GPT) in all group. Furthermore, the SNP rs7203412 was consistently associated with GOT (β=6.41, P=6.78E?08) and GPT (β=11.53, P=2.81E?06) in men group. Consequently, we found statistically significant SNP in C16orf47 gene that are associated with serum levels of GOT and GPT. In addition, these results suggest that the individuals with the minor alleles of the SNP in the C16orf47 gene may be more elevated serum liver enzyme levels in the Korean population.

기초운동기술 프로그램 참여가 유아의 자기효능감과 사회적 능력에 미치는 효과

전선혜(Jun, Sun-Hye),백효현(Baeck, Hyo-Hyun) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.5

The purpose of this study was to examine the effects of participation in basic motor skill programs on children’s self-efficacy and social competence. Jun’s physical education program for children was conducted in 46 children in experimental group, and a childhood education institute’s own program was conducted in 48 children in control group. Also, to compare scores of self-efficacy and social competence of each group before and after the programs, the independent sample t-test and analysis of covariance (ANCOVA) were performed, and the following results were obtained. First, the basic motor skill program for children had effects on self-efficacy and its sub-domains including physical, cognitive, social and emotional domains. Second, the basic motor skill program for children showed effectiveness in improving children’s social competence and its sub-factors including social activity, stability, cooperativeness, autonomy, adaptability, and leadership. The children in experimental group, particularly, generally exhibited higher degree of improvement in self-efficacy and social competence than those in control group. Hence, it was found that the basic motor skill program could facilitate children’s self-efficacy and social competence more effectively than the child education institute’s own physical education program did. These results implied that it is necessary to improve conditions of education for dissemination of systemic children’s physical activity programs and invigoration and change the way of dealing with these programs.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

수강 등록 데이터의 빈출 패턴을 이용한 학업 진척도 및 상태 분석을 위한 시퀀스 데이터 마이닝

정효남·전성희·황준 서울여자대학교 컴퓨터과학연구소 2014 정보기술논문지 Vol.12 No.-

안드로이드 기반 소셜 네트워크 서비스를 지원하는 '슈게더' 설계 및 구현

정효남,손예진,황준 서울여자대학교 컴퓨터과학연구소 2011 정보기술논문지 Vol.9 No.-

최근 페이스북, 트위터 그리고 카카오톡과 같은 SNS (Social Network Service)는 많으 사람들에게 인기를 얻고 있다. 사용자들은 SNS를 통해 자신의 일상을 다른 사람들에게 가시화하고, 오프라인에서 서로 모르는 사람과 친구 관계를 맺으며 서로의 생각이나 정보 등을 실시간으로 공유한다. 또한 SNS을 통해 연구 설문조사가 이루어지기도 하고, 기업은 마케팅, PR활동 그리고 고객 관리까지 SNS을 이용하고 있다. 본 논문에서는 SNS가 가진 장단점을 면밀히 분석하여 구글의 개방형 모바일 플랫폼인 안드로이드기반의 소셜 네트워크 애플리케이션, '슈게더'를 제작하였다. '슈게더'애플리케이션을 이용해 서울여대 학생들은 모르고 지냈던 사람들과의 관계 형성을 할 수 있으며, 교내에서 본인의 관심사를 타인과 함께 나눌 수 있는 효과를 기대할 수 있다.

쇄석 골재의 광물학적 및 화학적 특성과 알칼리-실리카 반응성

전쌍순,박현재,이효민,진치섭 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-

본 연구에서는 쇄석 골재의 광물학적 및 화학적 특징과 알칼리-실리카 반응에 대한 골재의 유해 가능성을 연구하였다. 이를 위하여 알칼리-실리카 반응을 유발하는 광물들의 포함여부 및 이에 따라 잠재적으로 조기 열화현상을 유발할 수 있는 암석을 유형별(화성암, 변성암, 퇴적암 및 탄산염암)로 골재를 수집하였다. 암종 별로 선별하여 수집한 골재 내의 알칼리 반응성 유해 물질 존재 여부 확인 X선 회절분석(XRD)과 편광현미경에 의한 광물학적 방법을 사용하였다. 알칼리-실리카 반응성 유무해 판단을 ASTM C 227의 Mortar-Bar 시험방법에 의해 평가 분석하였고, 주 화학성분은 X선 형광분석기(XRF)로 실시하였다. In Korea, due to the shortcomings of natural aggregates and increasing needs of crushed stones, it is necessary to examine the alkali-silica reaction of the crushed stones. The purpose of this study is to analyze petrographic, chemical properties and alkali-silica reaction of crushed stones. This study was performed to investigate the alkali-silica reaction of crushed stones using chemical analysis, physical properties, XRD, XRF and mortar-bar method. As a result, most of test aggregates didn't show any reaction, but many test aggregates have common deleterious mineral. Therefore, there exists the possibility of chemical reaction in petrographic point of view.

환경교육을 위한 웹 기반 프로젝트 학습 시스템의 설계 및 구현

전우천,정효숙,김동용,엄종진,정성모,최수경 서울교육대학교 2001 한국초등교육 Vol.12 No.2

The use of the Web (World Wide Web) has been changing roles of traditional education style. Especially, the Web can overcome time and space limitations in the traditional schools. Teachers and students are now using the Web to access vast amounts of information and resources on cyber space. Also, the learning via the Web enables both synchronous and asynchronous communication. Despite of many benefits of the Web, it may weaken students motivation due to lack of face-to-face communication. In this paper, we provide a learning model called Web Project Learning, which is based on the contructivism, to provide motivation and collaborative learning for students in the Web environment. The model is based on the Project-Based Learning model and is revised for use in the Web. The model can also encourage the participation of parents as well as students, and be applied to any subject. We implement our model and show that the model can be used for environmental education as an instance.

市販 衣類製品의 消費者 問題에 關한 實證的 硏究 : centering around outer wear outerwear를 中心으로

전효순,차옥선 漢陽大學校 韓國生活科學硏究所 1985 韓國 生活 科學 硏究 Vol.- No.3

Clothing goods are one of the most important necessaries that are consumed in large quantities with various kinds and uses, while they several problems. First, consulter have difficulties in choice since a number of synthetic fibers appear. Second, it is very difficult to presuppose the changes in quality in the process of consumption. Third, it is difficult to estimate the goods because they are not only utility goods but also fashionable goods. And the last, it is hard to see where the responsibility for quality lies owing to the complexity of manufacturing process and distribution structure. The aim of this study is to analyze the problems not in the place of producer or dealer of clothing goods but in the place of consumer, and to propose their remedied. This study is based on the findings of questionnaires drawn up on the basis of references and the 439 claims related to the clothings which were submitted to three comsumer's complaint centers. The concrete aims of this study areas follows: (1) to define consumer's problems by looking into documentary records and to research the necessity of consumerism. (2) to analyze consumer's thoughts by questioning housewives and making a survey of their attitudes toward the use and the choice of clothing goods in the market. (3) to study the claims submitted to consumer's complaint centers and to compare them with the conditions of latent dissatisfaction on the questionnaires, in order to examine the problems about the quality of clothing goods in the market and the actual conditions of dealings. PROCEDURE The research was carried out from july 10 to july 15, 1983 on 600 housewives. They were randomly selected from parents of students of 5 primary schools in Seoul. The questionnaire designed by the researcher consists of 25 questions. The questions were made on the model of face-validity tests of professors, and seven of the questions were prestested. The statistical methods used are frequency, percentile and χ3 test. FINDINGS AND CONCLUSIONS A survey upon consumer's attitude toward clothing goods revealed that the younger housewives took more interest than the older ones in making complaints against the prior clothings, but the older ones had more experiences in making complaints. On the whole, however, consumer's attitude toward clothing goods seems to be in a lower level. The frequency of checking the garment label of clothing goods was comparatively high and tended to increase in proportion to the education and income level of the participants. The degree of perception on the safety of clothing goods is generally low and also tends to increase in proportion to the education and income level of the participants. The research on the actural conditions of consumer's complaints against clothing goods revealed the following facts. Among the claims submitted to consumer's complaint center, those against poor quality ranked first, and those against laundry, service, label, price and safety came after in order. But on the questionnaire, price problem took the firstplace. The lack of strength and the unsound sewing was the main concern of the complaints against poor quality, the fading color and the contraction against laundry, the refusal of exchange against service, the faulty indication of care and no indication against travel, and the difference of price among the shops against price. From the result of the above study, I propose several devices as follows: (1) For the more reasonable use and choice of clothings, we need consumer education based upon tile end-use of clothing goods. (2) Producers should concentrate their efforts on the management for consumer by taking good care of consumer's complaints aginst poor clothings. (3) The authorities concerned should give the administrative consideration for the protection from consumer's damage of clothing goods by suoolement of the regulations related to the quality control over clothings, the safety and the improvement in destribution structure.

의사소통, 가족, 정치 : 가족에 대한 표상과 의사소통의 관계 The Representation of Korean Family and its Relationship to Communication

전효관 연세대학교 사회발전연구소 2001 사회발전연구 Vol.- No.7

Ciprofloxacin의 돼지 호흡기 감염증 및 설사증에 대한 치료효과

전무형,김지영,채미경,서상희,김명철,박창식,김태용,윤효인 충남대학교 수의과대학 동물의과학연구소 2003 動物醫科學硏究誌 Vol.11 No.-

To evaluate the clinical efficacy of ciprofloxacin (CFX) on treatment of the pigs with respiratory diseases or diarrhea, CFX at various dosages were administered intramuscularly to the diseased pigs selected from the pig farms located in Chungnam province. One hundreds and fourteen heads of pigs with respiratory diseases were divided into five groups and CFX at 0.25, 0.5, 1.0 ( = 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were found 31.8%, 73.9%, 91.3% and 92.0%, respectively, being higher than that of the untreated control group (19.0%). The mortality of the treated groups were 0%, that is lower than that of the control (9.5%). Seven kinds of bacteria were isolated from the respiratory organs of 86 pigs, and 34 (39.5%) of 86 pigs showed the complicated infection. In analyzing by the pigs infected with a single pathogen as P. multocida, A. pleuropneumonia, Staphylclcoccus spp. or Mycoplasma spp., the recovery rates were 0∼66.6% at 0.25 dose. 66.6∼100% at 0.5 dose and 100% in all of 4 pathogens at 1.0 to 2.0 doses. At 0.25 dosage the pigs infected with A. pleuropneumonia showed the lowest recovery rate. One hundreds and twenty two heads of pigs with diarrhea were divided into five groups and CFX at 0.25, 0.5, 1.0 ( = 2.5mg CFX/Kg B.W.) and 2.0 doses were administered i.m. for 5 days. The recovery rates were 29.1%, 40.0%, 80.0% and 88.0%, respectively. The mortality of the treated groups were 0-8.3%, being much lower than that of the control. Four kinds of bacteria were isolated from the fecal specimens of 94 pigs, and 84 (89.0%) of 94 pigs showed the complicated infection.