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Molecular analysis of TMC1 gene in the Korean patients with nonsyndromic hearing loss
Hyo‐Kyeong Kim,Yee Hyuk Kim,사공보름,권태준,오세경,Hye‐Jin Lee,Kyu‐Yup Lee,이상흔,김언경 한국유전학회 2011 Genes & Genomics Vol.33 No.2
Hereditary nonsyndromic hearing loss (NSHL) is a highly heterogeneous disorder in humans. Mutations of the transmembrane channel‐like (TMC1) gene have been identified as the genetic cause for both autosomal recessive (DFNB7/11)and autosomal dominant (DFNA36) nonsyndromic hearing loss. To evaluate the spectrum and frequency of mutation(s)caused by TMC1 gene in the Korean population, we have performed sequencing analysis of the PCR products amplified from genomic DNA of each proband in 193 unrelated families showing 30 autosomal dominant and 163 autosomal recessive inheritance patterns. As a result, we identified eight different novel sequence variations for the first time in this study,respectively. However, none of these showed co‐segregation of phenotype in the families. Therefore, our study suggests that the TMC1 gene is not the cause of nonsyndromic hearing loss in the Korean population.
권오경,성하정,곽형일,방명주,신대희,이진영,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of New Woohwangchungsimwon (NWCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NWCH, 160 ㎎/㎏/day(low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NWCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NWCH in beagle dogs is considered to be safe.
신효식,이경주 한국 가정과 교육 학회 2003 한국가정과교육학회지 Vol.15 No.1
The purpose of this study is to investigate the cognition and experience of sexual violence and to present the influential factors of the cognition of sexual violence. The subjects were 835 high school students living in Kwangju and Chonnam. The data analysis used Mean, Standard Deviation, T-test, F-test, and Multiple Regression Analysis. The major findings is as follows; 1. There are meaningful differences in the experience of sexual violence between male and female adolescents. 2. There are meaningful differences in the cognition of sexual violence in sex, sex-role attitude, experience of obscene materials and sex education. 3. The variables which affect cognition of sexual violence is sex-role attitude, sex and experience of obscene materials that were explained about 10%.
정경효,원종식,정윤교 國立 昌原大學校 産業技術硏究所 1996 産技硏論文集 Vol.10 No.-
Inconel, super heat-resistant alloy is superior in the toughness and the creep strength. It can especially endure high temperature and corrosion. It has been, therefore, broadly used in the various fields of atomic industry, aerospace, industrial mechanics and automobile etc. But such inherent properties as high temperature strength, an affinity with tool materials and low heat-conductivity etc. of Inconel alloy 600 degrade machinability. As a result, they cause many problems in the cutting process. In this study, machinability of Inconel alloy 600 was estimated on stand points of cutting force, tool wear and welding of chip for the cutting edge. Inconel alloy 600 was cut by precision high-speed lathe and tool material was used coated tungsten carbide insert(CTCI) and ceramic insert(CI) to be done in general. Cutting force is measured by the piezo type tool dynamometer and cutting edge is observed by scanning electron microscope(SEM). As a experiment result, obtained conclusions as follows. (1) In the case of cutting Inconel alloy 600 with CTCI, value of cutting force is similar its of SM45C. In this case, however, we can not avoid the cutting trobles that is ; the large width of fluctuations for cutting force and welding of cutting chips for cutting edge because of the toughness of the material. (2) In the case of using CI, the brittleness of the tool resulted in chipping. (3) Available cutting conditions of Inconel alloy 600 for CTCI and CI were established.
강경아,류점숙,신효식 한국 가정과 교육 학회 1998 한국가정과교육학회지 Vol.10 No.2
This study investigated the relationship between parental abuse and maladjustment perceived by school student. The subjects were 448 middle school students in Kwangju. The main results of this were as follows ; 1. There were found significant differences according to background variables in parental abuse and maladjustment. Physicalabuse was found significantly different according to gender of the child and unreasonable rearing behavior of the parents, but emotional abuse was found significantly different according to job of the father and unreasonable rearing behavior of the parents. And, neglect was found significantly different according to educational level of the father and unreasonable rearing behavior of the parents. Social withdrawal was found significantly different according to gender of the child, family income and unreasonable rearing behavior of the parents, but hyperactivity was found significantly different according to gender of the child and unreasonable rearing behavior of the parents. Agression and reteat were found significantly different according to gender of the child and unreasonable rearing behavior of the parents. Obsesive-compulsion was found significantly different according to unreasonable rearing behavior of the parents. 2. There were significantly positive correlation between parental abuse and maladjustment. 3. The finding of multiple regression analysis demonstrated that neglect, physical abuse, family income, gender of child were found to be important variables in predicting social with drawal. Neglect, unreasonable rearing behavior of the parents, physical abuse, gender of child were found to be important variables in predicting hyperactivity. Neglect, emotional abuse, and unreasonable rearing behavior of the parents were found to be important variables in predicting aggression. Gender of the child, emotional abuse, and unreasonable rearing behavior of the parents were found to be important variables in predicting retreat. And, unreasonable rearing behavior of the parents, neglect, and physical abuse were found to be important variables in predicting obsessive-compulsion.
와인관광의 개념에 관한 고찰 : 프랑스 보르도 지역의 와인관광사례를 중심으로 Wine tourism in Bordeaux region
최인섭,손효경 한국관광정보학회 2002 觀光情報硏究 Vol.- No.10
Wind tourism comes out as one of tour forms in the area of Europe, old continent, and America and Oceania, new one where wine is being produced. Wine tourism is encouraged as people realize the worth of comfortable life, the symbol of wine, want to enjoy the nature leaving the city where they live and to feel the new wine with a great pleasure, and most of all people's curiosity about wine makes wine tourism amplified its potential demands. Now that the national consumption over wine is increasing as culture of drinking alcoholic beverage is changing from hard liquor to soft one, new trend of alcoholic beverage is expected to come out. As a good example of national wine tourism there is D company's wine tourism which is a tour to sightsee the winery brew wine and its area. Facing the cases of wine tour increasing chiefly in the area producing wine, new touristic product can be suggested for the purpose of wine tour targeting the mania. which national tourist business companies should take account of. As our continuous subject wine tourism leave us some of things we have to consider as follows: R&D on cultural touristic product for the foreign tourist introducing Korean traditional food accorded with its traditional alcoholic beverage, and on tourist route of Korean traditional alcoholic beverage.
탈수 칼륨 및 칼슘-제올라이트 A 구조에서 큰바구니의 8-고리에 존재하는 양이온 1가 및 2가와 골격산화물 이온에 대한 화학 특성
손만식,박경원,백우현,김효기 국립경상대학교 공과대학 부설 첨단소재연구소 1992 尖端素材 Vol.2 No.-
Starting with the structural unit of 8-ring in supercage for dehydrated ?? and Ca-zeolite A, we studied chemical characterization and electronic structure and properties of monovalent ?? and divalent ?? cations with framework oxide ions of the above materials by semiempirical molecular orbital theory. On 8-ring in the supercage for dehydrated Tl and Ca-zeolite A, framework oxide ions are strongly bonded by chemical bonding. This results show structure stability of structural skeleton for z대lite A. When ?? or ?? cations are incorporated in 8-ring, framework oxide ions with ?? cation are bonded by chemical antibonding while framework oxide ions with ?? cation are weakly bonded by chemical antibonding. Charge transfer in ?? with framework oxide ions is moved ?? to 8-ring. Then, net charge of O atoms in 8-ring including ?? cation are increased. But, net charge of O atoms in 8-ring including ?? cation are decreased. With these results, we here indicate that ?? ion are located in the 8-ring and ?? ion are not located in the 8-ring. These results are supported by the recent X-ray experimental study by Kim et al..
성하정,권오경,방명주,곽형일,이진영,신대희,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Single and 4 weeks oral administration of New wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs (3 males and 3 females) in acute experiments were administered orally with sinlge dose of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of NSCH, 160 ㎎/㎏/day (low dosage group), 400 ㎎/㎏/day (middle dosage group), 1,000 ㎎/㎏/day (high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korea Food and Drug Administration (1996. 4. 16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ per oral for both male and females. In animals administered with NSCH, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign, urinalysis, eye examination, hematology, serum chemistry, organ weight and other fingings. No histological lesions were observed in both control and treatment groups. Above data strongly suggset that NSCH in beagle dogs is considered to be safe.