A Message of Congratulation on Behalf of the International Commission on Mathematical Instruction

( Hyman Bass ),( Bernard R. Hodgson ) 한국수학교육학회 2003 수학교육연구 Vol.7 No.2

국제수학교육위원회(ICMI)로부터의 축하 메시지

( Hyman Bass ),( Bernard R. Hodgson ) 한국수학교육학회 2003 수학교육 Vol.42 No.2

Why Recognize? Explaining Victorian Britain’s Decision to Recognize the Sovereignty of Imperial Japan

Jacques E. C. Hymans 한국국제정치학회 2014 The Korean Journal of International Studies Vol.12 No.-

The question of why leading states recognize other states’ sovereignty hasattracted increasing attention in the IR literature. I analyze the important historicalcase of the sovereign recognition of Japan by the West in the 1890sand in particular by Great Britain, the most important Western power at thattime. I argue that Britain’s decision to fully recognize the sovereignty ofImperial Japan is best explained by a theoretical synthesis of English Schooland rationalist approaches. Britain’s recognition decision was driven by acombination of genuine respect for legal propriety and its perceived materialself-interest. In other words, Britain recognized Japan upon realizing that itwould do well by doing good.

Assessing North Korean Nuclear Intentions and Capacities: A New Approach

Jacques E. C. Hymans 동아시아연구원 2008 Journal of East Asian Studies Vol.8 No.2

This article develops a novel assessment of the nuclear program of the Democratic People's Republic of Korea. Using a theory-driven approach rooted in comparative foreign policy analysis, the article undermines two common assumptions about the DPRK nuclear threat: first, that the North Korean leadership's nuclear intentions are a measured response to the external environment and, second, that the DPRK has developed enough technical capacity to go nuclear whenever it pleases. In place of these assumptions, the article puts forth the general theoretical hypotheses that (1) the decision to go nuclear is rarely if ever based on typical cost-benefit analysis, and instead reflects deep-seated national identity conceptions, and (2) the capacity to go nuclear depends not only on raw levels of industrialization and nuclear technology, but also on the state's organizational acumen. Applied to the case of the DPRK, these hypotheses suggest that it has long been strongly committed to the goal of acquiring an operational nuclear deterrent, but also that it has been finding it very difficult to successfully implement that wish. The article also demonstrates that these hypotheses are supported by the meager evidence available on this case.

International Patterns in National Identity Content: The Case of Japanese Banknote Iconography

Jacques E. C. Hymans 동아시아연구원 2005 Journal of East Asian Studies Vol.5 No.2

The present article suggests that expressions of Japanese identity may be more malleable and receptive to international influences than is usually thought. Through a study of the evolution of images printed on Japanese banknotes and of the political processes behind that evolution, the article shows Japanese state elites consciously following international models of identity content. In particular, it describes the shifts in Japanese banknote iconography in the early 1980s and again in the early 2000s as the product of a drive for conformity with the iconographic norms of European currencies. The state has been the main protagonist in this story, but for a full accounting of the magnitude and pace of iconographic change on the yen it is necessary to unpack the “black box” of the state.

핵무장을 강행할 것인가 말 것인가-비교 관점에서 본 남북한의 핵 무장결정-

자크 하이만스(Jacques E.C. Hymans),김승영,헤닝 리이키(Henning Riecke) 사회과학원 2000 계간 사상 Vol.45 No.-

Model for Prioritizing Best Management Practice Implementation: Sediment Load Reduction

Jang, Taeil,Vellidis, George,Hyman, Jeffrey B.,Brooks, Erin,Kurkalova, Lyubov A.,Boll, Jan,Cho, Jaepil Springer-Verlag 2013 Environmental management Vol.51 No.1

<P>Understanding the best way to allocate limited resources is a constant challenge for water quality improvement efforts. The synoptic approach is a tool for geographic prioritization of these efforts. It uses a benefit-cost framework to calculate indices for functional criteria in subunits (watersheds, counties) of a region and then rank the subunits. The synoptic approach was specifically designed to incorporate best professional judgment in cases where information and resources are limited. To date, the synoptic approach has been applied primarily to local or regional wetland restoration prioritization projects. The goal of this work was to develop a synoptic model for prioritizing watersheds within which suites of agricultural best management practices (BMPs) can be implemented to reduce sediment load at the watershed outlets. The model ranks candidate watersheds within an ecoregion or river basin so that BMP implementation within the highest ranked watersheds will result in the most sediment load reduction per conservation dollar invested. The model can be applied anywhere and at many scales provided that the selected suite of BMPs is appropriate for the evaluation area’s biophysical and climatic conditions. The model was specifically developed as a tool for prioritizing BMP implementation efforts in ecoregions containing watersheds associated with the USDA-NRCS conservation effects assessment project (CEAP). This paper presents the testing of the model in the little river experimental watershed (LREW) which is located near Tifton, Georgia, USA and is the CEAP watershed representing the southeastern coastal plain. The application of the model to the LREW demonstrated that the model represents the physical drivers of erosion and sediment loading well. The application also showed that the model is quite responsive to social and economic drivers and is, therefore, best applied at a scale large enough to ensure differences in social and economic drivers across the candidate watersheds. The prioritization model will be used for planning purposes. Its results are visualized as maps which enable resource managers to identify watersheds within which BMP implementation would result in the most water quality improvement per conservation dollar invested.</P>

β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease

Fukumoto, Hiroaki,Cheung, Bonnie S.,Hyman, Bradley T.,Irizarry, Michael C. 한림대학교 환경·생명과학연구소 2003 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.5

Context : Amyloid plaques, a major pathological feature of Alzheimer disease(AD), are composed of an internal fragment of amyloid precursor protein (APP): the 4-kd amyloid-β protein(Aβ). The metabolic processing of APP that results in Aβ formation requires 2 enzymatic cleavage events, а γ-secretase cleavage dependent on presenilin, and a β-secretase cleavage by the aspartyl protease β-site APP-cleaving enzyme(BACE). Objective : To test the hypothesis that BACE protein and activity are increased in regions of the brain that develop amyloid plaques in AD. Methods : We developed an antibody capture system to measure BACE protein level and BACE-specific β-secretase activity in frontal, temporal, and cerebellar brain homogenates from 61 brains with AD and 33 control branis. Results : In the brains with AD, BACE activity and protein were significantly increased (p<.001). Enzymatic activity increased by 63% in the temporal neocortex (P=.007) and 13% in the frontal neocortex (P=.003) in brains with AD, but not in the cerebellar cortex. Activity in the temporal neocortex increased with the duration of AD(P=.008) but did not correlate with enzyme-linked immunosorbent assay measures of insoluble Aβ in brains with AD. Protein level was increased by 14% in the frontal cortex of brains with AD (P=.004), with a trend toward a 15% increase in BACE protein in the temporal cortex (P=.07) and no difference in the cerebellar cortex. Immunohistochemical analysis demonstrated that BACE immunoreactivity in the brain was predominantly neuronal and was found in tangle-bearing neurons in AD. Conclusions : The BACE protein and activity levels are increased in brain regions affected by amyloid deposition and remain increased despite significant neuronal and synaptic loss in AD.

The Mount Sinai Hospital Institute for critical care medicine response to the COVID-19 pandemic

Jennifer Wang,Evan Leibner,Jaime B. Hyman,Sanam Ahmed,Joshua Hamburger,Jean Hsieh,Neha Dangayach,Pranai Tandon,Umesh Gidwani,Andrew Leibowitz,Roopa Kohli-Seth,Mount Sinai Anesthesiology and Critical C 대한중환자의학회 2021 Acute and Critical Care Vol.36 No.3

Background: The coronavirus disease 2019 (COVID-19) pandemic resulted in a surge of critically ill patients. This was especially true in New York City. We present a roadmap for hospitals and healthcare systems to prepare for a Pandemic. Methods: This was a retrospective review of how Mount Sinai Hospital (MSH) was able to rapidly prepare to handle the pandemic. MSH, the largest academic hospital within the Mount Sinai Health System, rapidly expanded the intensive care unit (ICU) bed capacity, including creating new ICU beds, expanded the workforce, and created guidelines. Results: MSH a 1,139-bed quaternary care academic referral hospital with 104 ICU beds expanded to 1,453 beds (27.5% increase) with 235 ICU beds (126% increase) during the pandemic peak in the first week of April 2020. From March to June 2020, with follow-up through October 2020, MSH admitted 2,591 COVID-19-positive patients, 614 to ICUs. Most admitted patients received noninvasive support including a non-rebreather mask, high flow nasal cannula, and noninvasive positive pressure ventilation. Among ICU patients, 68.4% (n=420) received mechanical ventilation; among the admitted ICU patients, 42.8% (n=263) died, and 47.8% (n=294) were discharged alive. Conclusions: Flexible bed management initiatives; teamwork across multiple disciplines; and development and implementation of guidelines were critical accommodating the surge of critically ill patients. Non-ICU services and staff were deployed to augment the critical care work force and open new critical care units. This approach to rapidly expand bed availability and staffing across the system helped provide the best care for the patients and saved lives.

Factors associated with anti-tumor necrosis factor effectiveness to prevent postoperative recurrence in Crohn’s disease

Anthony Buisson,Lisa Cannon,Konstantin Umanskiy,Roger D. Hurst,Neil H. Hyman,Atsushi Sakuraba,Joel Pekow,Sushila Dalal,Russell D. Cohen,Bruno Pereira,David T. Rubin 대한장연구학회 2022 Intestinal Research Vol.20 No.3

Background/Aims: We assessed the effectiveness of anti-TNF agents and its associated factors to prevent endoscopic and clinical postoperative recurrence (POR) in Crohn’s disease (CD). Methods: From a prospectively-maintained database, we retrieved 316 CD patients who underwent intestinal resection (2011–2017). Endoscopic (Rutgeerts index ≥ i2 at 6 months) and clinical (recurrence of symptoms leading to hospitalization or therapeutic escalation) POR were assessed. Results: In 117 anti-TNF-naïve patients, anti-TNF therapy was more effective than immunosuppressive agents (odds ratio [OR], 8.8; 95% confidence interval [CI], 1.8–43.9; <i>P</i>= 0.008) and no medication/5-aminosalicylates (OR, 5.2; 95% CI, 1.0–27.9; <i>P</i>= 0.05) to prevent endoscopic POR. In 199 patients exposed to anti-TNF prior to the surgery, combination with anti-TNF and immunosuppressive agents was more effective than anti-TNF monotherapy (OR, 2.32; 95% CI, 1.02–5.31; <i>P</i>= 0.046) to prevent endoscopic POR. Primary failure to anti-TNF agent prior to surgery was predictive of anti-TNF failure to prevent endoscopic POR (OR, 2.41; 95% CI, 1.10–5.32; <i>P</i>= 0.03). When endoscopic POR despite anti-TNF prophylactic medication (n = 55), optimizing anti-TNF and adding an immunosuppressive drug was the most effective option to prevent clinical POR (hazard ratio, 7.38; 95% CI, 1.54–35.30; <i>P</i>= 0.012). Anti-TNF therapy was the best option to prevent clinical POR (hazard ratio, 3.10; 95% CI, 1.09–8.83; <i>P</i>= 0.034) in patients with endoscopic POR who did not receive any biologic to prevent endoscopic POR (n = 55). Conclusions: Anti-TNF was the most effective medication to prevent endoscopic and clinical POR. Combination with anti-TNF and immunosuppressive agents should be considered in patients previously exposed to anti-TNF.