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Hyesu Jeon,Yujin Jin,Chang-Seon Myung,Kyung-Sun Heo 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.7
In this study, we investigated the anti-cancereffects of ginsenoside Rg2 (G-Rg2) and its underlyingsignaling pathways in breast cancer (BC) cells. G-Rg2 significantly induced cytotoxicity and reactive oxygen species(ROS) production in MCF-7 cells among various types ofBC cells including HCC1428, T47D, and BT-549. G-Rg2signifi cantly inhibited protein and mRNA expression ofcell cycle G1-S phase regulators, including p-Rb, cyclinD1, CDK4, and CDK6, whereas it enhanced the proteinand mRNA expression of cell cycle arrest and apoptoticmolecules including cleaved PARP, p21, p27, p53 and Bakthrough ROS production. These eff ects were abrogated bythe antioxidant N-acetyl-I-cysteine, or NADPH oxidaseinhibitors, such as diphenyleneiodonium chloride and apocynin. Interestingly, G-Rg2 induced mitochondrial damageby reducing the membrane potential. G-Rg2 further activatedthe ROS-sensor protein, AMPK and downstream targetsof AMPK activation, including PGC-1α, FOXO1, andIDH2, and downregulated mTOR activation and antioxidantresponse element-driven luciferase activity. Together, ourdata demonstrate that G-Rg2 mediates anti-cancer eff ectsby activating cell cycle arrest and signaling pathways relatedto mitochondrial damage-induced ROS production andapoptosis.
Dietary Assessment of Korean Non-dialysis Chronic Kidney Disease Patients with or without Diabetes
Hyesu Lee,김현숙,Tae Yeon Kim,류현진,주달래,Miyoung Jang,오국환,Curie Ahn,한성림 대한의학회 2020 Journal of Korean medical science Vol.35 No.23
Background: Dietary intervention at the early stage of chronic kidney disease (CKD) is important for preventing progression to the end-stage renal disease (ESRD). However, few studies have investigated dietary intake of CKD patients in non-dialysis stage. Therefore, we investigated the dietary intake of Korean non-dialysis CKD patients and aimed to establish baseline data for the development of dietary education and intervention strategies for CKD patients. Methods: Three hundred fifty CKD patients who visited Seoul National University Hospital outpatient clinic from February 2016 to January 2017 were recruited for this cross-sectional study. Subjects on dialysis and those who had undergone kidney transplantation were excluded. Dietary intake, demographic information, and biochemical characteristics of 256 subjects who completed three-day dietary records were analyzed. Subjects were divided into four groups based on diabetes mellitus (DM) (DM-CKD and Non-DM-CKD groups) and kidney function (Early-CKD and Late-CKD groups). Results: Total energy intake was lower in the Late-CKD group compared with the Early-CKD group. In men, carbohydrate intake was higher and protein and fat intakes tended to be lower in the Late-CKD group compared with the Early-CKD group. In women, carbohydrate intake tended to be lower in the DM-CKD group than the Non-DM-CKD group. Protein intake tended to be higher in the DM-CKD groups. Phosphorus and sodium intakes were higher in the DM-CKD groups compared with the Non-DM-CKD groups in women, and tended to be higher in the DM-CKD groups in men. Conclusion: DM and kidney function affected energy and nutrient intakes. Subjects in the Late-CKD group consumed less energy than those in the Early-CKD group. Non-DM subjects seemed to restrict protein intake starting from the Early-CKD stage than subjects with DM. Subjects in this study had low energy and high sodium intakes compared with recommended levels. Protein intake was lower in advanced CKD patients, but their intake level was still higher than the recommendation. Dietary intervention strategies for non-dialysis CKD patients need to be customized depending on the presence of DM and kidney function.