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A clinicopathological study of 51 patients with glomus tumor
( Hyeong Mok Kwon ),( Jung Eun Yim ),( Hye Ri Kim ),( Dong Hoon Shin ),( Jong Soo Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Glomus tumor is a relatively rare neoplasm that usually present in older adults. The finger is the most commonly affected site, but any anatomical site can be affected. It can be subdivided histopathologically into glomangioma, glomangiomyoma, and solid glomus tumor. There are few recent reports about clinicopathological data of glomus tumor worldwide. Objectives: The aim of this study was to examine the clinicopathological findings of glomus tumor. Methods: A total of 51 patients confirmed as glomus tumor by histologic examination at the Yeungnam University Hospital from 2001 to 2020 were reviewed retrospectively. Hospital charts were analyzed to determine the clinical manifestations, histopathological subtypes, treatment, and prognosis of glomus tumor. Results: Of the 51 patients, the ratio of males to females was 0.76:1. The mean age of patients was 42±14.9 years. The majority (64.7%) involved finger, and 8 cases (15.7%) involved arm, followed by subungual (11.8%). Histopathologically, about a half of cases were glomangioma (47.1%), 14 cases were glomangiomyoma (27.5%), followed by 13 cases of solid glomus tumor (25.5%). Total excision was chosen as primary treatment and no evidence of recurrence was presented in all cases. Conclusion: Glomus tumor favorably affected the finger and trunk. About a half of cases were glomangioma, and the rest were occupied almost equally by glomangiomyoma and solid glomus tumor. All cases were treated by total excision and had favorable prognoses.
Methotrexate-Induced Accelerated Nodulosis in a Patient with Systemic Lupus Erythematosus
( Hyeong Mok Kwon ),( Eun Hye Jeong ),( Jung Eun Yim ),( Hye Ri Kim ),( Dong Hoon Shin ),( Jong Soo Choi ),( Young Kyung Bae ) 대한피부과학회 2023 Annals of Dermatology Vol.35 No.7
Methotrexate (MTX)-induced accelerated nodulosis (MIAN) reportedly occurs in patients with rheumatic arthritis receiving MTX therapy. However, it has also been reported in patients with other autoinflammatory conditions, such as systemic lupus erythematosus (SLE). A 38-year-old woman diagnosed with SLE presented with multiple movable, firm, flesh-colored nodules on both hands that had developed 3 years ago. She was taking oral medications, specifically hydroxychloroquine, azathioprine, and MTX. Histopathological examination revealed palisaded granulomatous inflammation, surrounded by histiocytes and lymphocytes, along the dermis to the subcutaneous fat layer. Fibrinoid degeneration was observed at the center of the granulomatous inflammation, and dermal mucin deposition was not observed. The patient was diagnosed with MIAN, and therefore discontinuation of MTX was recommended. Subsequently, the lesions almost completely disappeared with no signs of recurrence. MIAN exhibits clinicopathological features similar to those of rheumatoid nodules; therefore, it can be easily misdiagnosed. Herein, we report a case of MIAN in a patient with SLE to contribute to the accurate diagnosis and appropriate management.
A clinicopathological study of 21 patients with hidradenoma
( Hyeong Mok Kwon ),( Hye Ri Kim ),( Moon Hyung You ),( Dong Hoon Shin ),( Jong Soo Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Hidradenoma is a benign adnexal tumor presents as a solitary nodule. It occurs in all areas of the body, usually in adults. Hidradenoma can be either apocrine or poroid, with variants including solid-cystic, clear cell, nodular types. There are few recent reports about clinicopathological data of hidradenoma worldwide. Objectives: The aim of this study was to examine the clinicopathological findings of hidradenoma. Methods: A total of 21 patients confirmed as hidradenoma by histologic examination at the Yeungnam University Hospital from 2000 to 2019 were retrospectively. Hospital charts were analyzed to determine the clinical manifestations, histopathological subtypes, treatment, and prognosis of hidradenoma. Results: Of the 21 patients, the ratio of males to females was 1.33:1. The mean age of patients was 44±17.7 years. The majority (29.2%) involved trunk, and 6 cases (25.0%) involved scalp. Almost all cases were apocrine hidradenoma (95.8%), except for only 1 case of poroid hidradenoma (4.2%). Among apocrine hidradenoma, the most common subtype except for the unspecified subtype was nodular hidradenoma (25.0%), followed by clear cell type (8.33%). Wide excision was chosen as primary treatment and no evidence of recurrence was presented both in all cases. Conclusion: Hidradenoma favorably affected the trunk and scalp. 20 cases were apocrine hidradenoma, and nodular subtype was the most common subtype among them. All cases were treated by wide excision and had favorable prognosis.
A clinicopathological study of 45 patients with blue nevus
( Hyeong Mok Kwon ),( Jung Eun Yim ),( Hye Ri Kim ),( Dong Hoon Shin ),( Jong Soo Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Blue nevus is a benign localized pigmented lesion generally occurs on skin. Usually blue nevus has no potential of malignant transformation, but rarely, it can occur in cellular blue nevus subtype. There are few recent reports about clinicopathological data of blue nevus worldwide. Objectives: The aim of this study was to examine the clinicopathological findings of blue nevus. Methods: A total of 45 patients confirmed as blue nevus by histologic examination at the Yeungnam University Hospital from 2010 to 2020 were reviewed retrospectively. Hospital charts were analyzed to determine the clinical manifestations, histopathological subtypes, treatment, and prognosis of blue nevus. Results: Of the 45 patients, the ratio of males to females was 1.25:1. The mean age of patients was 35±18.6 years. Among the cases, arm was the most commonly involved site (22.2%), and the next was trunk (17.8%), followed by hand (15.6%) and face (13.3%). Histopathologically, almost all cases were common blue nevus (93.3%), except for only 3 cases of cellular blue nevus which showed increased cellular number and atypia (6.7%). Wide excision was chosen as primary treatment and no evidence of recurrence was presented both in all cases. Conclusion: Blue nevus favorably affected the arm and trunk. Histopathologically, 42 cases were common blue nevus, but 3 cases were cellular blue nevus. All cases were treated by wide excision and had favorable prognoses.