펄스 옥시미터 시스템 구현에 관한 연구

유동주,허 웅,김근이,이호재,임현수 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

In this paper, we implemented a pulse oximeter system which is measured oxygen saturation coefficient of a human blood in vivc We use the Beer-Lambert Law to measure the percentage of hemoglobin is oxygen saturation. The oximeter sensor are consisted of two LED(RED and INFRARED LED) and a single photodiode. The photodiode measures lights which transmitted through the tissue from two light source alternately, We calculated a ratio of light transmittance between two LEDs and then, it applied for the oxygen saturation coefficient calculation to formula. As a result, the oxygen saturation coefficient that measured from normal conditions men was 96.43[%]

대퇴동맥을 통한 경피적 관동맥 중재시술 환자의 천자부위 지혈을 위한 Angioseal^(�) 사용과 고식적 용수 압박법의 비교 : 전향적 연구

김용훈,권현철,김필호,안석진,유철웅,최진호,이상철,김준수,김덕경,전은석,이상훈,홍경표,박정의,서정돈 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 경피적 관동맥 중재술은 최근 양적 및 질적으로 급격한 발전을 보였지만 시술 시 천자부위의 혈관 합병증은 아직 해결해야 할 문제점이다. 저자들은 대퇴동맥을 통한 경피적 관동맥 중재술을 환자에게 천자부위 지혈을 위한 혈관폐쇄기구인 안지오실의 안전성과 유용성을 고식적인 용수 압박법과 비교 연구하고자 하였다. 방법 : 2002년 4월부터 2003년 5월 사이에 삼성서울병원 심장혈관센터에서 대퇴동맥을 통한 경피적 관동맥 중재술을 성공적으로 시행한 200명의 환자(안지오실 사용군: A군, 100명, 고식적 용수압박법 사용군 B군, 100명)를 대상으로 시술 후 주요 합병증 및 경한 합병증, 지혈 후 환자가 자리에 앉기까지의 시간, 보행개시 가능시간, 총 재원 기간과 시술 1주 후의 합병증을 전향적으로 조사하여 비교 연구하였다. 결론 : 두 군에서 연령, 성별, 기저질환, 심혈관 질환의 위험요소, 시술의 종류, 시술 중 사용한 헤파린의 양, clopidogrel의 양, ticlopidine의 양, 지혈 시 수축기와 확장기혈압, ACT (activated clotting time)는 차이가 없었다. A군이 B군에 비해 시술 후 자리에 앉기까지의 시간 (A군: 4.3±0.3시간, B군: 13.7±0.8시간, p=0.004) 및 보행개시까지의 시간(A군: 6.8±0.5시간, B군: 18.8±2.1시간, p=0.013)이 유의하게 짧았다. 시술 후 주요 합병증은 두군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 A군에서 유의하게 적었다(A군: 28명, B군: 19명, p=0.003). 반상출혈의 경우는 A군에서 유의하게 낮았지만(A군: 3명, B군: 12명, p=0.01), 혈종, 출혈의 발생은 두군간에 차이가 없었다. 총 재원기간에는 두 군간에 차이가 없었다(p=0.239). 시술 1주 후 경과관찰에서 주요합병증은 역시 두 군 모두에서 관찰되지 않았으며, 경한 합병증의 전체발생은 두 군에서 차이가 없었다(A군: 15명, B군: 13명 p=0.418), 반상출혈의 빈도는 차이가 없었지만 혈종의 발생은 A군에서 더 낮았다(A군: 2명, B군:6명, p=0.004). 두 군 모두에서 출혈은 발생하지 않았다. 결론 : 대퇴동맥을 통한 경피적 관동맥 중재술을 시행한 환자에서 안지오실의 사용은 고식적 용수 압박법에 비해 환자의 침상 안정시간을 줄여 조기 활동개시가 가능하게 하였으며 국소합병증의 위험도를 일부 낮추어, 시술에 따른 환자의 불편을 현저하게 감소시킬 수 있다고 할 수 있을 것으로 기대된다. Background : Although the number and the quality of percutaneous coronary intervention have been recently increased dramatically, the vascular complication at puncture site is still the major cause of patients' morbidity. We evaluated the safety and efficacy of newly of newly-developed collagen-based arterial closure device, Angioseal after transfemoral percuatenous coronary intervention. Methods : This study was designed as a prospective single center non-randomized comparative study. A total 200 patients undergoing transfemoral percutaneous coronary intervention were enrolled between April 2002 and May 2003. They were divided into two groups; Angioseal group (group A, n=100) and manual compression group (group B, n=100). The baseline clinical and angiographic characteristics were reviewed. The time to sit up, the time to ambulation, the duration of hospital stay, major and minor vascular puncture site complications were monitored. The patients were followed-up for 1 week after procedure by telephone. Results : The baseline clinical characteriwtics, clinical diagnosis, cardiocascular risk factors, typesof procedure, doses and numbers of anticoagulants were similar between two groups. The blood pressure and activated clotting time were also similar. The time to sit up (group A: 4.3±0.3 hours, group B: 13.7±0.8 hours, p=0.004) and the time to ambulation (group A: 6.8±0.5 hours, group B: 18.8±2.1 hours, p=0.013) were shorter in group A. No major vascular complications were noted. The incidence of hematoma and bleeding were not significantly different between two groups. The incidence of ecchymosis, however, was significantly lower in group A (group A:12%, group B: 3%, p=0.001) The duration of gospital stay was similar between groups. During 7 days of follow-up period incidence of hematoma was significantly lower in group A (p=0.004). Although the incidence of ecchymosis was not significantly different between two groups. Conclusion : The angioseal may be associated with earlier ambulation and less patients' morbidity with low incidence of local complication rate compared to manual compression after transfemoral percutaneous coronary intervention.

遠隔制御用컴퓨터인터페이스에 관한 硏究

송철,박종백,이웅기,이강현,양원일 조선대학교 동력자원연구소 1988 動力資源硏究所誌 Vol.10 No.1

This paper deals with the computer interface for the remote control in factory automation, and the concatenated IBM PC, designed interface card, temperature sensors and displayer. As the results 1. easy to expand and maintain the objects of upgrade levels. 2. easy to measure the temperature of product lines. 3. applications can be extended by using IBM PC and its function.

위암세포주에서 Recombinant Human Interferon-r와 Adriamycin의 투여순서가 항암효과에 미치는 영향

홍원선,손영숙,김창민,강윤구,이춘택,김유철,임영혁,남현석,이진오,강태웅 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Numerous previous studies, both in vitro and in vivo, have demonstrated that the cytotoxicity can be enhanced by the combination of chemotherapeutic agent and interferons(IFNs) in various types of cancer cells. We have previously reported that combined treatment of MKN-45, human gastric adenocarcinoma cells, with adriamycin(ADM) and recombinant human interferon-r(rh-IFN-r) increased in the cytotoxicity. In this study, the effects of combination timing of rh-IFN-r and ADM on the cytotoxicity against MKN-45 were investigated using MTT assay. MKN-45 was treated with rh-IFN-r and ADM in vitro on three schedules : Treat A ; rh-IFN-r and ADM were treated simultaneously, Treat B ; rh-IFN-r was treated 24 hours after the treatment with ADM, Treat C ; rh-IFN-r was treated for 72 hours and followed by the treatment with ADM. The survival of MKN -45 was inhibited by ADM dose-dependently. 102 and 103U/ml of rh-IFN-r significantly inhibited the survival of MKN-45(% survival : 35.1 ±-1.2% and 34.4 ±1.1% in Treat A and 42.5 ± 2.1% and 45.9-±2.5% in Treat C, respectively). However no difference in the survival was observed between 102 and 103U/ml of rh-IFN-r. Combined treatment with rh-IFN-r and ADM significantly augmented the cytotoxicity at low concentrations of ADM. Combined effects of rh-IFN-r and ADM were evaluated using IC30(,ag/ml) to ADM. IC30s of MKN-45 in Treat A, B and C at 102 U/ml of rh -IFN-r _ were 0.019 -?- 0.003, 0.045 :I:0.001 and 0.054 ± 0.012, respectively, while IC30 of MKN-45 treated with ADM alone was 0.052±0.004. IC30s of MKN-45 in ADM alone group, Treat A, Treat B and Treat C at 103U/ml of rh-IFN-r were 0.047 ±0.003, 0.004 -±0.001, 0.031 ±0.004 and 0.056 0.008, respectively. These results indicate IC30s of Treat A and B were significantly lower than those of ADM alone(p<0.05) and IC30s of Treat A was significantly lower than those of Treat B(p <0.01). IC30s of Treat C, however, were not different from those of ADM alone. From these results demonstrating that cytotoxic effects were increased by the combination of rh-IFN-r and ADM in the order, Treat A > Treat B> Treat C, it can be concluded that the simultaneous administration of rh-IFN-r and ADM may be the most effective method to combine these two therapeutic modalties.

Brunner’s Gland Hyperplasia: Treatment of Severe Diffuse Nodular Hyperplasia Mimicking a Malignancy on Pancreatic-Duodenal Area

Woong Chul Lee,Hyeon Woong Yang,Yun Jung Lee,Sung Hee Jung,Gi Young Choi,Hoon Go,Anna Kim,Sang Woo Cha 대한의학회 2008 Journal of Korean medical science Vol.23 No.3

Brunner’s gland hyperplasia is a benign tumor of the duodenum and it is rarely associated with clinical symptoms. We report on a 64-yr-old man with Brunner’s gland hyperplasia who had undergone a duodenocephalo-pancreatectomy. The reason is that he presented upper gastrointestinal obstructive symptoms and the esophagogastroduodenoscopic finding revealed the lesion to be an infiltrating type mass on the second portion of the duodenum with luminal narrowing. An abdominal computed tomography showed a 2.5 cm-sized mass in the duodenal second portion with a suspicious pancreatic invasion and 7 mm-sized lymph node around the duodenum. Duodenocephalopancreatectomy was successfully performed. Histological examination revealed a Brunner’s gland hyperplasia. The final diagnosis was the coexistence of Brunner’s gland hyperplasia and pancreatic heterotopia with a pancreatic head invasion. The literature on Brunner’s gland hyperplasia is reviewed.

The Quality Improvement of Emulsion-type Pork Sausages Formulated by Substituting Pork Back fat with Rice Bran Oil

Hyeon-Woong Yum,Jin-Kyu Seo,Jin-Yeon Jeong,Gap-Don Kim,M. Shafiur Rahman,Han-Sul Yang 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.1

The effects of pork back fat (PBF) substitution with various concentrations of rice bran oil (RBO) (50%, 45%, 40% and 35%) on the physicochemical characteristics and sensory attributes of emulsion-type pork sausages were studied. The modified pork sausages were compared with control sausages produced using PBF only. The sausages with RBO had significantly lower (p<0.05) moisture content than the control sausages. Sausages made from PBF substituted with 40% RBO showed the lowest cooking loss. Substitution of PBF with RBO had no significant effect on the emulsion stability of pork sausages. All sausages with RBO showed significantly lower (p<0.05) hardness values than control sausages. Sausages with RBO also had significantly higher values (p<0.05) of unsaturated fatty acid and polyunsaturated to saturated fatty acid contents than the controls. RBO substitution had no effect on the flavor intensity of sausages, but it improved the tenderness and produced a softer texture.

Niclosamide improves the anti-proliferative effect of gemcitabine on pancreatic cancer by inducing the ubiquitination of Β-catenin in wnt/β-catenin signaling

Hyeon Woong KANG,Daeun LEE,Myeong Jin KIM,So Yi KIM,YunSun LEE,Jung Min LEE,Hyung Sun KIM,Hyo Jung KIM,Joon Seong PARK 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B

( Hyeon Woong Yang ),( Byung Seok Lee ),( Tae Hee Lee ),( Heon Young Lee ),( Kwan Woo Nam ),( Young Woo Kang ),( Hee Bok Chae ),( Seok Hyun Kim ),( Seok Bae Kim ),( Hyang Ie Lee ),( An Na Kim ),( Il H 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.4

Background/Aims: Clevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naive patients with CHB living in Daejeon and Chungcheong Province, South Korea. Methods: One hundred five adults with CHB were administered 30 mg of clevudine per day for an average of 51 weeks. We evaluated viral markers and liver biochemistry retrospectively every 3 months. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B virus (HBV) DNA before the treatment were 184 ± 188 IU/L, 150 ± 138 IU/L, and 7.1 ± 1.2 log copies/mL, respectively. Undetectable rates (< 60 IU/mL) of DNA were 36.2%, 68.9%, 83.6%, 76.2%, and 75.8% at 12, 24, 36, 48, and 60 weeks, respectively. Seroconversion rates were 9.1%, 13.6%, 24.6%, 26.5%, and 26.1% and ALT normalization rates were 64.5%, 78.1%, 87.9%, 90.0% at 12, 24, 36, and 48 weeks, respectively. Six patients (5.7%) had a viral breakthrough. Conclusions: Clevudine is a useful drug in the initial treatment of patients with CHB, with a potent antiviral effect and low incidence of viral breakthrough. (Korean J Intern Med 2010;25:372-376)

Fitz-Hugh-Curtis 증후군의 임상양상 : 25예의 분석

양현웅 ( Hyeon Woong Yang ),정성희 ( Sung Hee Jung ),한현영 ( Hyun Young Han ),김안나 ( An Na Kim ),이윤정 ( Yun Jung Lee ),차상우 ( Sang Woo Cha ),고훈 ( Hun Go ),최기영 ( Gi Young Choi ),조성훈 ( Soung Hoon Cho ),임신형 ( Sin H 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.2

파키스탄의 격동과 파란

이웅현(Woong-Hyeon Lee) 충남대학교 사회과학연구소 2015 사회과학연구 Vol.26 No.1

미국의 대테러 전쟁의 선포(2001년)와 함께 등장한 파키스탄의 부정적 이미지는, 정치적으로 불안정한 파키스탄의 핵무기 통제능력에 대한 회의 그리고 아프가니스탄의 반군 즉 탈레반과 파키스탄 정부의 어두운 관계에 관한 의혹에서 비롯되었다. 1954년 이래 냉전의 종결 시까지 파키스탄은 미국의 대소련 봉쇄의 변방기지로서의 역할을 수행해 왔지만, 미국의 대테러 전쟁의 시기에 이르러 ‘믿을 수 없는 친구’로 전락했다. 그 이유는 무엇일까? 본고에서는 파키스탄의 핵무장과 이슬람 극단주의세력 특히 파키스탄 탈레반 등장의 역사적 연원을 최근 기밀 해제된 미국 정부 문서, 관련 인물의 회고록 그리고 기존 연구를 토대로 추적한다. 파키스탄에 대한 불신과 부정적 이미지의 연원이 된 ‘파키스탄의 핵무장 의혹’ 그리고 ‘탈레반과의 유착관계’를 검토한다. 이를 통해 파키스탄과 미국의 동맹관계가 어떻게 변화되어 왔는지, 이것이 정상적이지 않은 ‘동맹’현상인지 분석한다. 국가 간 관계는 여하한 경우에도 전면적이거나 대칭적일 수 없다. 국가 간의 윤리와 인간 사이의 윤리를 혼동해서도 안 된다. 1947년 건국 이래 파키스탄의 민간정부나 군부정권 모두 ‘친구’의 활용에 관한 한 현실주의적 사고를 해 왔다. 이는 지정학적 위치와 ‘동맹’에 대한 가장 정상적인 인식에서 비롯하는 자연스런 현상이다. 파키스탄의 격동과 파란은 동맹‘이론’이 아니라 역사적 ‘경험’과 지정학으로만 설명될 수 있다. The negative images of Pakistan are mainly originated from the skepticism toward politically unstable Pakistan’s nuclear control capability and suspicion about the shadowy relation between Pakistan and the Afghan insurgency. Though since 1954 through the end of the Cold War, as a peripheral military base Pakistan had taken part in the containment policy toward the Soviet Union, up to the era of the War on Terror it was degraded into ‘an unreliable ally.’ How has ‘an ally of allies’ become a suspicious friend? This article follows the historical traces of Pakistan’s nuclear armament policy and the advent of Pakistani extremists with the recent declassified primary sources of American government’s documents, autobiographies of concerned persons, and the related studies precedent. It analyzed the historical vicissitudes and the characteristics of Pakistani-USA alliance. Is it an abnormal one? Since its independence in 1947, the Pakistani governments, whether civilian or military, have been thinking realistically at least on the utility of alliance. This is a natural attitude of state with the conscience of geopolitics and its own turbulent history. Pakistan’s drift into chaos and turbulence would be explained not by any general theory of alliance but by peering into its historical experience and its geopolitics.