올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

고정식 교정 환자에서 전동치솔 효과에 관한 연구

박창헌,이기헌,황현식,홍석진 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.4

Patients with fixed orthodontic appliances frequently have increased levels of plaque accumulation leading to the possibility of gingivitis or enamel decalcification. Although many methods may be helpful in reducing dental plaque formation, optimal mechanical removal of plaque is tile most important factor during orthodontic treatment. The porpose of this study was to evaluate the efficacy of'an electric toothbrush, with a specially designed orthodontic brush head. compared with a manual toothbrush in controlling plaque and gingivitis for patients with fixed orthodontic appliances. Oral hygiene status was measured in thirty four patients, using a plaquc index, a gingival index and a bleeding index. before and four weeks after attachment of fixed orthodontic appliances. Patients were randomly divided into two groups, the electric and the manual toothbrush groups. Oral hygiene instruction was given according to the type of toothbrush used. The Braun Oral-B D9511 with Braun Oral-B Ortho OD 15-1 brush head was used as the electric toothbrush while the Butler G.U. M 124 was given as the manual toothbrush. After 4 weeks and 8 weeks, oral hygiene status was measured again. Through the comparison berween the electric and the manual toothbrush grpups. following results were obtained. 1. All oral hygiene indices showed increasing tendency after 4weeks of fixed orthodontic appliances. 2. All indices presented decreasing tendency four and eight weeks after oral hygiene instruction. 3. In case of gingival index and bleeding index. decreasing tendency did not show a statistically significant difference between the electric and the manual toothbrush groups. 4. The decreasing tendency of plaque index presented statistically significant difference between the two groups. showing that the electric toothbrush was more effective in terms of oral hygiene. These findings suggest that an electric toothbrush is useful to the orthodontic patients with fixed appliances.

고유량 고효율 혈액투석막 재사용의 임상경험

조현경,김승정,임병국,정혁준,최영일,마경애,신규태,김흥수,김도헌 대한신장학회 2001 대한신장학회잡지 Vol.20 No.3

고정식 교정 환자에서 전동치솔 효과에 관한 연구

박창헌,황현식,이기헌,홍석진 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.4

고정식 교정장치를 부착한 경우 장치주위의 치태 축적 가능성이 증가되고 이로 인해 치은염, 법랑질 탈회 등의 부작용이 초래 될 수 있는 바 치태 제거를 위한 효과적인 치솔질이 필요하다. 본 연구는 교정환자에서 일반적으로 사용되고 있는 치솔에 비하여 전동치솔이 구강위생에 도움이 되는지 알아보기 위하여 시행되었다. 고정식 장치에 의한 교정치료 예정인 환자 34명을 본 연구의 대상으로 하여 고정식 교정장치 부착 전에 치태지수, 치은염지수, 치은출혈지수를 측정하였다. 장치 부착 4주 후에 각 지수를 측정한 다음, 연구대상을 치솔의 종류에 따라 전동치솔군과 수동치솔군으로 임의 구분하여 수동치솔 또는 전동치솔을 사용하도록 구강위생교육을 각각 시행하였다. 이때 전동치솔의 경우 본체는 Braun Oral-B D9511을 브러쉬 헤드는 Braun Oral-B Ortho OD 15-1을 사용하게 하였으며, 수동치솔의 경우는 Butler G.U.M 124를 사용하게 하였다. 구강위생교육 4주 및 8주 후에 각 지수를 측정한 다음 시간 경과에 따른 전동치솔군과 수동치솔군의 구강위생 상태를 비교 분석하여 다음과 같은 결과를 얻었다. 1. 고정식 교정장치 부착 4주 후 치태지수, 치은염지수, 치은출혈지수 모두 증가 양상을 나타내었다. 2. 구강위생교육 후 치태지수, 치은염지수, 치은출혈지수 모두 감소 양상을 나타내었다. 3. 치은염지수, 치은출혈지수의 경우 감소양상이 수동치솔과 전동치솔군 간의 유의한 차이를 보이지 않았다. 4. 치태지수의 경우 수동치솔에 비해 전동치솔군에서 감소효과가 유의하게 크게 나타났다. 이상의 연구 결과는 고정식 교정장치로 치료받는 환자에서 전동치솔이 구강위생에 도움이 됨을 시사하였다. Patients with fixed orthodontic appliances frequently have increased levels of plaque accumulation leading to the possibility of gingivitis or enamel decalcification. Although many methods may be helpful in reducing dental plaque formation, the optimal mechanical removal of plaque is the most important factor during orthodontic treatment. The purpose of this study was to evaluate the efficacy of an electric toothbrush (with a specially designed orthodontic brush head) compared to a manual toothbrush in controlling plaque and gingivitis for patients with fixed orthodontic appliances. Oral hygiene status was measured in thirty-four patients using a plaque index, a gingival index and a bleeding index, before and four weeks after the attachment of fixed orthodontic appliances. Patients were randomly divided into two groups: electric and manual toothbrush groups. Oral hygiene instruction was given according to the type of toothbrush used. The Braun Oral-B D9511 with Braun Oral-B Ortho OD 15-1 brush head was used as the electric toothbrush while the Butler G.U.M. 124 was given as the manual toothbrush. After four and eight weeks, oral hygiene status was measured again. Through a comparison between the electric and the manual toothbrush groups, the following results were obtained. 1. All oral hygiene indices showed an increasing tendency after four weeks of fixed orthodontic appliance. 2. All indices presented a decreasing tendency four and eight weeks after oral hygiene instruction. 3. In case of the gingival index and bleeding index, the decreasing tendency did not show a statistically significant difference between the electric and the manual toothbrush groups. 4. The decreasing tendency of plaque index presented a statistically significant difference between the two groups, showing that the electric toothbrush was more effective in terms of oral hygiene. These findings suggest that an electric toothbrush is useful to orthodontic patients with fixed appliances.

공급사슬관리의 전략적 과제에 관한 탐색적 연구

안병훈,이승규,정희돈,안현수 한국경영과학회 1997 經營 科學 Vol.14 No.1

This study addresses strategic issues related to the question of "how can a supply chain become more competitive?" We examine several cases of manufacturing supply chains. Results show that each constituent firm is required to maintain different manufacturing capabilities and to play different roles by its position (up/mid/down-stream) in a chain. Furthermore, there are patterns of required capabilities by the positions in a chain. These findings imply that the "position in a chain" should be treated as one of the strategic factors when discussing the buyer-seller relationship. It is also shown that different action programs are required for building different manufacturing capabilities of individual firms in a supply chain. Additionally, we argue that some programs need to be done simultaneously, by all the members of the chain, while some need to be carried out by only a small group or an individual firm. Finally, we propose a direction for a theoretical framework for analyzing supply chain structures and strategies.

소아 중등도 두뇌손상환자에 대한 임상적 고찰

송시헌,고현송 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

The authors review the records of 88 pediatric head injured patients whose initial Glasgow coma scale (GCS) scores ranged from 9 to 12 and who were treated at Chungnam National University Hospital over a recent 4-year period. These results are compared with reports from other centers and severely brain injured groups. The results were as follows : 1. The peak age group was between 6 and 8 years and were predominantly males (2.7 : 1 ratio). 2. The most common cause of head injury was as a pedestrian in a motor vehicle accident (72.7% ). 3. The number of patients with abnormalities on cranial computerized tomography (CT) and magnetic resonnance imaging (MRI) was 71 (80.7%) and the most common lesion was brain contusion (20/88). 4. The number of patients with intracranial hematoma was twenty-three (26%). 5. Twelve patients (13.6%) received cranial operation (four for hematoma removal and eight for repair and elevation of depressed fractures). 6. Eighty-three patients (94.3%) showed a good recovery, one patient (1.1%) died and four patients (4.5%) showed moderate or severe disability. 7. There was no relationship between age and intracranial lesions or GCS score and also there was no relationship between skull fracture and intracranial lesions or GCS score.

라틴아메리카 문화연구의 쟁점과 동향

김현균,이성훈 서울大學校 스페인中南美硏究所 2007 이베로아메리카硏究 Vol.18 No.-

Este trabajo tiene por objeto revisar algunas conceptualizaciones pole´micas y diversos debates trascendentales que han atravesado los llamados estudios culturales latinoamericanos. Durante las últimas de´cadas ha habido una acalorada discusio´n en torno a este campo de estudio en casi todas sus instancias: desde sus caracteri´sticas y objetivos hasta sus ori´genes y perspectivas futuras. A lo largo de este proceso los estudios culturales latinoamericanos se han ido convirtiendo en un verdadero paradigma alternativo, cada vez más adecuado a la diversidad y complejidad de la nueva realidad latinoamericana. Como resultado de nuestra revisio´n se pondri´a en evidencia que este campo de estudio no representa únicamente una ruptura epistemolo´gica, en lo que se refiere a una visio´n transnacional y transdisciplinaria de los estudios de Ame´rica Latina, sino una continuidad de la propia tradicio´n cri´tica latinoamericana.

흉수부에 발생한 희돌기 교세포종(Oligodendroglioma) 1예 : 증례보고 Case Report

고현송,송시헌,김관태,김성호,김윤 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.5

Primary oligodendroglioma of the spinal cord is a very rare tumor. On searching through the literature from 1931. we could find only about 46 cases, and tumor is almost absent in Korea on the review of the literature. The authors present a case of 8-year-old female patient with the symptoms of paraparesis, urination difficulty. diffuse back pain and hypesthesia in both lower extremities. Spine MRI revealed the mass at the level of T(3)-T-(12), with combined nature of cystic and solid portion. Decompressive laminectomy and partial mass removal was performed, and then adjunctive radiotherapy and chemotherapy was done. The patient was improved after operation with radiotherapy and chemotherapy. so he walks alone and has no voiding difficulty at present (postoperative about 20months),

이차원 LMS 알고리즘의 Systolic Array 구현

박완수,최훈,홍기섭,박봉수,배현덕 충북대학교 컴퓨터 정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.1

적응알고리듬의 VLSI 구현에 있어서 파이프라이닝이나 시스토릭과 같은 구조적 설계기법을 이용하여 알고리듬을 변환하는 것은 효과적이다. 알고리듬 변환은 z-변환 영역에서 연산의 규칙성과 반복성을 찾아 이루어 진다. 본 논문에서는 이차원 필터와 계수갱신 시스템을 시스토릭 구조로 설계하여 LMS의 확장 형태인 TDLMS을 STDLMS로 변환한다. 변화된 STDLMS를 이용 이차원 ALE를 Altera사의 Max-PlusII 상에서 구현하여 시뮬레이션을 통해 성능을 평가한다. 시뮬레이션 결과 salt-pepper 잡음과 가우시안 잡음에 오염된 화상을 ALE가 개선할 수 있음을 보였다. In VLSI realization of adaptive algorithm. it is necessary and efficient that the algorithm is transformed to structural one suitably using architectural design techniques such as pipelining or systolic array. These transform method use regular and recursive of operation of the algorithm on z-transform domain. In this paper, the TDLMS which is a extended version of LMS is transformed to STDLMS which has systolic array architecture in two dimensional filter and coefficients update system. The transformed STDLMS is applied for realization of two dimensional ALE. And the ALE performances are evaluated by Max-PlusII of Altera Co.. The simulation results show that the ALE enhances image data which were corrupted by salt-pepper noise and Gaussian noise.

한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).