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한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계
여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.
스위스 볼 운동이 남성 노인의 근력 및 균형능력에 미치는 영향
성혜련,양점홍,강문선 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.1
Maintaing a high level of balance and mobility is essential to aging successfully. Balance can be defined as the ability of controling the body's center of mass with respect to the base of support when the body is stationary or moving. The purpose of this study is to investigate the effects of Swiss ball exercise on muscular strength and balance in male elderly.......
Hye‑Won Choi,Sang‑Yong Park,최효상 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.4
We research team has proposed a current-limiting superconducting DC circuit breaker that combines a High-temperature superconducting wire (HTS) with a DC circuit breaker, and secured its operation performance in our previous study via simulation. In this paper, we designed and produced an actual current-limiting superconducting DC circuit breaker, as well as analyzed its current limiting and breaking performance. In addition, the operation characteristics at diferent lengths of the HTS with increasing voltage were analyzed. The operation reliability of the proposed DC circuit breaker was demonstrated by a simulation system that was built similar to the actual system.
경주마 생체시료에서의 난드로론과 대사체의 검출 및 정량
김성진,조성희 중앙대학교 기초과학연구소 2000 基礎科學硏究所 論文集 Vol.14 No.-
In veterinary practice, anabolic steroid the nandrolone have been widely used in androgen therapy and illegal treatment. So current study was undertaken to quantify the steroids (nandrolone and its major metabolite estranediol) after administration and develope the screening method for the detection of anabolic steroid residues in equine body fluids. In the equine plasma, after extracted by disposable C18 Sep-pak cartridge with elution solvent, the organic layer was evaporated to dryness. The residue was subjected to LC/MS/MS analysis. After LC/MS/MS analysis, liquid chromatographic retention time data and mass spectral data were used for the detection and identification of nandrolone. The good quality control and recovery range were obtained for the present method. In the urine, after enzyme hydrolysis, the urine was extracted by disposable C18 Sep-pak cartridge and diethyl ether. After the ether layer was evaporated to dryness, the residue was subjected to derivatization prodedure and GC/MS analysis. After GC/MS analysis, both gas chromatographic retention time and mass spectral data were used for the detection and identification of estranediol. Also good quality-control data and recovery range were obtained for the present method. Using these methods, the concentrations of nandrolone and estranediol were determined in equine plasma and urine. Excretion profile of nandrolone presents the rapid increase up to maximum values at Days 4 after dosing and the slow regression in plasma and estrandiol major urinary metabolite of nandrone also presents increase up to maximum values at Days 5 after dosing and slow regression in urine.
2-O-α-D-Glucopyranosyl L-Ascorbic acid 생산을 위한 Cyclodextrin glucanotransferase의 고정화
성경혜,김성구,장경립,전홍기 부산대학교 김치연구소 2003 김치의 과학과 기술 Vol.9 No.-
AA를 AA-2G로 전환하는 CGTase를 고정화하여 AA-2G 대량 생산의 가능성을 고찰한 결과, CNBr-sepharose 4B가 가장 효과적인 담체로 판명되었고, CGTase의 고정화 최적 조건과 고정화 CGTase에 의한 AA-2G 생산의 최적조건 및 재사용성을 검토하였다. 최적 고정화 조건은 효소량 24,000 units/g resin으로 9시간 반응하여 약 18,000 units/g resin의 최고 고정화율을 얻을 수 있으며, pH 5.0(50 mM sodium citrate buffer)용액에 12% AA-Na와 8% soluble starch를 기질로 하여 800 units/ml의 고정화 CGTase를 첨가한 후 37℃에서 100 rpm으로 교반하면서 25시간 반응하여 약 18 mM의 AA-2G 최고량을 얻을 수 있었다. 또한 0.015 mM의 CaCl₂를 첨가하여 고정화 CGTase의 재사용성을 관찰한 결과, 5회까지 50% 이상의 AA-2G 생산율로서 그 가능성을 입증할 수 있었다. 그리고 효소의 재사용성이란 측면에서, 본 고정화의 다른 한 방법인 ultrafiltration(한외 여과)에 의해서는 Millipore사의 YM10 membrane을 이용하여 먼저 단백질량과 효소 활성 변화를 측정하여 그 가능성을 확보할 수 있었으며, 기질 20 ml을 사용하여 AA-2G를 생성시킨 후, 한외여과에 의해 효소만을 회수하여 연속 반응해 본 결과 8회까지 50% 의 생성률을 유지하였다. 따라서 한외 여과는 CNBr-sepharose 4B와 함께 효율적인 고정화의 한 방법으로 판명되었으며, 앞으로 이들 고정화 효소를 이용한 연속 반응 시스템의 구축이 뒤따라야 할 것이다. Cyclodextrin glucanotransferase (CGTase) from Paenibacillus sp. JB-13 was immobilized on various carriers by several immobilization methods such as ionic binding, covalent linkage and ultrafiltration to improve the process performance. The ultrafiltration and covalent linkage with CNBr-activated sepharose 4B were found as the best method for immobilization of CGTase. The ability of was as follows: contact time 6 hrs at 37℃, pH6.0, 100rpm and enzyme loading 24,000 units/g resin. The optimum conditions for production of 2-O-α-D-Glucopyranosyl L-Ascorbic acid by immobilized CGTase turned out to be: pH 5.0, temperature 37℃. 20% substrate solution containing 8%(w/v) of soluble starch and 12%(w/v) of L-ascorbic acid sodium salt, 100 rpm, for 25 hrs and with 800 units of immobilized CGTase/ml substrate solution. More over the CGTase activity could be stably maintained for 8 times of repetitive reactions after removing products by ultrafiltration through YM 10 membrane.