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( Hye Young Jwa ),( Yoo Kyung Cho ),( Eun Kwang Choi ),( Heung Up Kim ),( Hyun Joo Song ),( Soo Young Na ),( Sun Jin Boo ),( Seung Uk Jeong ),( Bong Soo Kim ),( Byoung Wook Lee ),( Byung Cheol Song ) 대한간학회 2016 Clinical and Molecular Hepatology(대한간학회지) Vol.22 No.1
Recent studies suggest that liver cirrhosis is reversible after administering oral nucleos(t)ide analogue therapy to patients with hepatitis B virus (HBV) infection. However, few studies have addressed whether esophageal varices can regress after such therapy. We report a case of complete regression of esophageal varices during entecavir therapy in patients with HBV-related liver cirrhosis, suggesting that complications of liver cirrhosis such as esophageal varices can regress after the long-term suppression of HBV replication. (Clin Mol Hepatol 2016;22:183-187)
Jwa, Hye Jeong,Lee, Keon Su,Kim, Gu Hwan,Yoo, Han Wook,Lim, Han Hyuk The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.9
X-linked adrenoleukodystrophy (X-ALD) is a rare peroxisomal disorder, that is rapidly progressive, neurodegenerative, and recessive, and characteristically primary affects the central nervous system white matter and the adrenal cortex. X-ALD is diagnosed basaed on clinical, radiological, and serological parameters, including elevated plasma levels of very long chain fatty acids (VLCFA), such as C24:0 and C26:0, and high C24:0/C22:0 and C26:0/C22:0 ratios. These tests are complemented with genetic analyses. A 7.5-year-old boy was admitted to Department of Pediatrics, Chungnam National University Hospital with progressive weakness of the bilateral lower extremities. Brain magnetic resonance imaging confirmed clinically suspected ALD. A low dose adrenocorticotropic hormone stimulation test revealed parital adrenal insufficiency. His fasting plasma levels of VLCFA showed that his C24:0/C22:0 and C26:0/C22:0 ratios were significantly elevated to 1.609 (normal, 0-1.390) and 0.075 (normal, 0-0.023), respectively. Genomic DNA was extracted from peripheral whole blood samples collected from the patient and his family. All exons of ABCD1 gene were amplified by polymerase chain reaction (PCR) using specific primers. Amplified PCR products were sequenced using the same primer pairs according to the manufacturer's instructions. We identified a missense mutation (p.Arg163Leu) in the ABCD1 gene of the proband caused by the nucleotide change 488G>T in exon 1. His asymptomatic mother carried the same mutation. We have reported an unpublished mutation in the ABCD1 gene in a patient with X-ALD, who showed increased ratio of C24:0/C22:0 and C26:0/C22:0, despite a normal VLCFA concentrations.
( Hye Young Jwa ),( Jonghoo Lee ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: Although prior hospitalization has been considered as a risk factor for infection with PDR pathogens in patients with CAP, the evidence is limited, We aimed to elucidate the clinical impact of PH on these patients. Methods: This retrospective observational cohort study with prospectively collected data was conducted at Jeju National University Hospital between January 2012 and December 2014. Propensity scores were constructed, and the clinical outcomes were compared. We also conducted subgroup analyses. Results: A total of 704 patients were identified. Patients with PHAP had more comorbidities than those with CAP. The median CURB-65 and PSI scores were higher in patients with PHAP than in those with CAP. After matching according to propensity scores, the baseline characteristics of the PHAP group were similar to those of the CAP group. The isolation rate of PDR pathogens as well as the 30-day and total in-hospital mortality did not differ between the PHAP and propensity score-matched CAP patients. PHAP patients with prior antibiotic use or duration of PH > 10 days showed significantly higher isolation rates of PDR pathogens. Multivariate logistic regression analysis demonstrated that prior antibiotic use was associated with the isolation rate of PDR pathogens. Conclusion: PH itself might not be related with higher isolation rates of PDR pathogens or mortality in patients with CO-pneumonia. It seems reasonable that broad spectrum antibiotic therapy for PDR pathogens should be selectively applie to PHAP patients with prior antibiotic use.
Correlation coefficient Between gingival crevicular fluid and oral malodor
hoh, Woo-Jin Jwa, Su-Kyung An Hye-Won Cho, Ja-Won 대한임상예방치과학회 2009 International Journal of Clinical Preventive Denti Vol.5 No.1
Objectives: The correlation coefficient between each component of oral malodor and amount of gingival crevicular fluid which is known as related with gingivitis, was estimated in order to apply the oral malodor control clinically. Methods: 90 adults (Male=50, Female=40) were participated who visited at Seoul Ho Dental Clinic or the department of Preventive Dentistry in Dankook Dental Hospital. Oral examination, halitosis check, and gingival crevicular fluid at maxillary right first molar and central incisor portions were measured. Results: In the Oralchroma measurement, the average value of 37.52±84.26ppb in the Hydrogen Sulfide, 19.64±41.50ppb in Methyl Mercaptan value, and 29.77±60.57ppb in Dimethyl Sulfide was investigated. In the other hand, the rest of average measurement values were investigated with 41.31±12.09 BBV in BB checker, 29.59±31.87ppm in Attain. The average value of gingival index was calculated 0.85±0.30 and 1.69±0.92 in CPITN, otherwise GCF was estimated 52.77±15.60. Due to the correlation test results, GCF value had a correlationship with r=0.221(p<0.05) of Methyl Mercaptan, r=0.285(p<0.05) with the BB checker value, r=0.458(p<0.05) for the ATTAIN value, r=0.634(p<0.05) for Gingival index and r=0.404(p<0.05) with in the CPITN. It revealed that more gases of Hydrogen Sulfide, BBV, and Ammonia were measured in moderate periodontitis group than in mild periodontitis group(p<0.05), otherwise only Ammonia was checked more in CPITN 2 or 3 group than in CPITN 0 or 1 group(p<0.05). Conclusion: Volatile sulfur compound, BB checker value and ammonia elements increase in accordance to the periodontal health. And this finding supports that using GCF level to determine the periodontal disease patient have more valuable classification in halitosis towards the periodontal disease patient.
Hye Jeong Gil,Yangmin X. Kim,Jwa-Kyung Sung,Eun Sung Jung,Digar Singh,Yejin Lee,Deogbae Lee,Choong Hwan Lee,Seulbi Lee 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.2
Appropriate adjustment of various microclimatic and nutrient conditions can improve crop productivity under greenhousecultivation. Here, we performed non-targeted profi ling to investigate metabolite variation in tomato fruits following diff erentsupplementary LED lighting (SL) (red: R; blue: B; and a combination of red and blue light: RB, for 1 h/day and 6 h/dayper condition) and mineral nutrient supply (N, K, Mg). The diff erent SL treatments aff ected metabolite variation in tomatofruits more signifi cantly than mineral nutrients. Importantly, regulating the SL period induced a more distinct metabolitecomposition in tomato fruits than that induced by varying the SL sources. Tomato fruits cultivated under RB for 6 h/dayhad a relatively higher content of sugar derivatives, especially sucrose, thus infl uencing the gustatory characteristics of thefruit. In contrast, fruit from tomatoes cultivated under RB for 1 h/day showed a distinctive increase in the abundance ofamino acids, organic acids, and several secondary metabolites, adding to its nutritional quality. Intriguingly, the diff erentmineral supplements elicited discriminant metabolic variation in tomato fruits cultivated under reduced levels of mineralsupply; however, the eff ects were insignifi cant under enhanced levels of mineral supply. Specifi cally, reduced level in nitrogensupply resulted in a lower abundance of amino acids, whereas reduced level in potassium supply increased metabolitelevels including amino acids, sugars, and fatty acids in tomato fruits. In the present study, we employed a non-targetedmetabolomics approach to unravel the eff ects of microclimatic parameters and mineral nutrients on fruit quality parametersof tomato plants, by which regulating the period of SL and reducing the potassium concentration were suggested to improvediff erent nutritional qualities.