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Oxidative Stress for the Stroke
Hyangkyu Lee,Younghwa Kim 한국생활환경학회 2014 한국생활환경학회지 Vol.21 No.4
The aim of this study is to provide fundamental knowledge for the mechanism of oxidative stress in stroke. The collection of literatures in this study was performed through a biomedical database, Pubmed, Korean research information service system, Riss4U, a science and technical database, ScienceDirect and Internet. This study investigated the known mechanisms of oxidative stress in stroke through published literature reviews. Stroke is associated with the production of reactive oxygen species (ROS) after ischemia-reperfusion in prehospital emergency system, and the use of many antioxidants is being considered in order to reduce the pathological damage caused by ROS. To enhance the quality of prehospital practice, the emergency medical technicians need to understand the accurate mechanism of oxidative stress, identify the risk factors affecting the process of ROS production, and monitor the cellular balance in oxidation-reduction. Providing effective prehospital care reducing oxidative stress will reduce cerebral damage and improve the status of health. Very few studies related to molecular mechanisms on the development of CVA were conducted in health care service field including nursing, therefore, it is important to encourage and continue related researches in the fields.
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Understanding of Antioxidants Mechanism in Clinical Nursing Practice
Hyangkyu Lee,Younghwa Kim 한국생활환경학회 2013 한국생활환경학회지 Vol.20 No.6
The aim of this study is to provide fundamental knowledge for the efficient use of antioxidants in nursing intervention by identifying cellular damage by Reactive Oxygen Species (ROS), antioxidant defense mechanism, and a broad range of antioxidant use. This study investigated the known mechanisms and clinical applications of antioxidants through published literature reviews. The state of nursing research using antioxidants between the period 1966 and 2011 was reviewed using analysis criteria. The collection of literatures in this study was performed through a biomedical database, Pubmed, Korean research information service system, Riss4U, a science and technical database, ScienceDirect and Internet. Acute and chronic diseases are associated with the production of ROS in the human body, and the use of many antioxidants is being considered in order to reduce the pathological damage caused by ROS. Providing effective nursing intervention reducing oxidative stress will prevent various diseases and improve the status of health. To enhance the quality of clinical nursing practice, nurses need to understand the accurate mechanism of antioxidants, identify the risk factors affecting the process of ROS production, and monitor the cellular balance in oxidation-reduction.
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Caregiving Distress and Inflammatory Response among Family Caregivers of Cancer Patients
Yoonjoo Kim,Hyangkyu Lee,Heejung Kim,Sangyeon Suh,Hyun-Ki Park 한국간호과학회 2018 한국간호과학회 학술대회 Vol.2018 No.1
Purpose: Caregivers of cancer patients suffer from a wide range of problems, including fatigue, care burden, burnout and depression. Researches on cancer caregivers have demonstrated that the caregiving distress is related not only to mental but also to physical health such as dysregulation of inflammatory function. This study aimed to investigate the relationship between caregiving distress and serum IL-6 and TNF-α, which are implicated in immune function of caregivers of cancer patients. Methods: Total 63 family caregivers of cancer patients participated in this study. Caregiving distress (fatigue, caring burden, burnout, and depression) was measured by using structured self-report questionnaires. Two inflammatory cytokines, IL-6 and TNF-α levels were obtained using a high-sensitivity enzyme-linked immunosorbent assay (ELISA). Data were analyzed using descriptive statistics, t-test, ANOVA, Spearman correlation coefficient analysis, and Hierarchical multiple regression analyses. Results: There was a significant correlation between fatigue, caring burden, burnout, depression. Caregiving distress was associated with the increased serum IL-6 and TNF-α levels. Gender, experience in radiotherapy, length of caregiving, and fatigue are associating factors for the levels of cytokines. Conclusions: Caregiving distress is a negative experience that affects mental health and inflammatory response to family caregivers. It is necessary to develop practical nursing intervention that supports caregivers and manages caregiving distress.
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Wonhee Baek,Hyangkyu Lee 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Background: Since there is a high incidence of delirium after spinal surgery and the prognosis is poor, it is important to predict and detect delirium early by identifying risk factors for delirium before surgery. In addition, since delirium symptoms are episodic and are common in the elderly, the rate of diagnosis by the medical staff is low. Therefore, it is necessary to search for biomarkers that are helpful in the prediction and diagnosis of delirium. Based on Jeffrey and Stacie"s (2013) model of the potential relationships among anesthesia, surgery, and the ultimate development of long-term cognitive impairment, this study aimed to investigate the risk factors affecting postoperative delirium in older adults who have undergone spine surgery, identify the association between postoperative delirium and cognitive decline, and discover the biological markers. Methods: Data collection was carried out from October 23, 2019 to May 20, 2020 on 100 patients over 70 years of age who underwent spinal surgery at S city Y hospital. Urine exosomes were analyzed for tau, UCH-L1, NFL, and GFAP using a single molecule array (Simoa). The collected data were analyzed using the R program (Version 4.0.0). Results: There were differences between delirious and non-delirious participants with regard to their past history of psychiatric illness and use of benzodiazepines (p=.005 and p=.026, respectively). There was a difference in the ratios of preoperative WBC and total protein between delirious and non-delirious participants (p=.013, p=.013, respectively). There was a difference in the ratios of CRP and eosinophil count on the day of operation between delirious and non-delirious participants (p=.05 and p=.013, respectively). Tau and UCH-L1 concentrations were found to be high in the severely delirious participants (p=.002 and p=.001, respectively). The MMSE scores upon discharge (p<.012) and the differences between the preoperative and postoperative MMSE scores (p<.009) were significantly different between delirious and non-delirious participants. Conclusion: Based on these results, medical staff will be able to accurately investigate risk factors before surgery, classify high-risk patients, and predict and detect delirium early. In addition, since delirious participants are at risk for cognitive decline, follow-up and preventive interventions for cognitive dysfunction will be required, depending on the patient. In addition, exosome analysis of the urine of patients showed that there was a high degree of brain injury in delirious patients after surgery.
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Cho Young-Eun,Lee Hyangkyu,Kim Hyungsuk,Yun Sijung,Cashion Ann 한국기초간호학회 2020 Journal of korean biological nursing science Vol.22 No.2
Purpose: Weight gain after kidney transplantation is a critical factor that can lead to poor outcomes with cardiovascular complications. Many studies have been conducted to identify predictive markers of future weight changes at the time of transplant. Recently, circulating exosomes and its contents including miRNAs and proteins have attracted attention as potential biomarkers. In this pilot study, we investigated exosomal proteins and weight change after kidney transplant. Methods: Recipients (n=10) were classified into two groups; weight gainers (n=5, 9.7±4.4kg) and weight losers (n=5, -6.4±1.8kg) based on their weight changes at 12-months posttransplant. Based on the exosomal protein profiles obtained by the LC-MS/MS, differentially expressed proteins were identified between the groups. Results: Concentration and the mean size of exosomes significantly increased at 12-months compared to the baseline (p=.009) in the total group. Eleven exosomal proteins were found at the baseline as differentially expressed between the two groups. In the weight gain group, complement proteins including HV169, C3, C4B, and C4A, were significantly upregulated. Conclusion: Our pilot study suggests that exosomal complementary proteins are associated with weight gain after kidney transplantation. Further studies are needed to clarify the role of these exosomal proteins in the underlying mechanisms of weight changes in kidney transplant recipients.
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남선영(Nam, Sun Young),이향규(Lee, Hyangkyu),김수(Kim, Sue),이령아(Lee, Ryung-Ah) 대한종양간호학회 2018 Asian Oncology Nursing Vol.18 No.1
Purpose: The purpose of this study was to describe factors affecting body image and sexual life for colorectal cancer patients with stoma. Methods: A cross-sectional descriptive correlational study was applied to 102 ostomates from June to November in 2015 using self-report questionnaires: the Body image scale (BIS), and the Derogatis interview for sexual functioning self report (DISF-SR). Results: The influencing factors for body image were ‘need for preoperative sexual education and sexual counseling’ (β=-.29, p=.003), and clinical stage II of colorectal cancer (β=-.26, p=.006). The influencing factor for sexual life was educational level (college education or higher) (β=.21, p=.02). Conclusion: The results of this study showed that colorectal cancer patients with stoma had a negative body image. The sexual counseling and education for ostomates should be approached by considering gender characteristics.
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