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Comparative Genomic Hybridization 기법을 이용한 한국인 원발성 간세포암에서의 염색체 변화에 대한 연구
박훤겸,정풍만,이광수,조율희 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
Comparative genomic hybridization(CGH) technique is one of the screening tests for DNA sequence copy number changes(losses, deletions, gains, amplifications) in tumor genomes. DNA changes in 23 hepatocellular carcinomas(HCC) associated with hepatitis B virus(HBV) were analyzed by CGH technique. Eighteen of the 23 cases showed genetic alterations. The remaining 5 cases showed no detectagble aberration. The losses of chromosome regions 17p(74%), 4q (57%), 16p (52%), 16q (48%), 8p (43%) and 13q (43%) were detected in the order of decreasing frequency. In cases of multiple losses of chromosomes, a combination of 17p,16p,16q,4q, and 8p losses was found in 5 cases (30%). On the other hand, chromosomal gains occurred on 1q (65%), 8q (52%), 20p (48%) and 20q (43%) in the order of decreasing frequency. And the simultaneous genomic gains of these 4 chromosomes were found in 9 cases (40%). Moreover, the combination of 5 genomic losses (17p, 16p, 16q, 4q, & 8p) and 4 genomic gains (1q, 8q, 20p, & 20q) was observed in 4 case s(23%). The pattern of chromosomal gains and losses in HCC with hepatitis B in Korean patients is very complex and involves virtually every site in the genome. This indicated a high genomic instability. This could possibly be explained either as the result of random chromosomal changes during early development of tumor, or as the highly variable and random pattern of integration of HBV in the HCC. The hepatocarcinogenesis may be the result of cumulative effocts rather than those orders of occurrence of those genomic changes. The sites of cellular DNA at which HBV integrates frequently undergo rearrangements, resulting in translocations, inverted duplications, deletions, and possibly recombinational events. But, CGH only detects changes of chromosomal copy number but could not identify translocations, inversions, and other aberrations of chromosome. The chromosomal analysis of HCC with HBV in Korean patients by CGH technique confirms the presence of complex and sporadic, but nonrandom genetic changes in the chromosome. In the future, more detailed oncogenic study could be carried out on the chromosomes which showed abnormal aberrations through this study.
혈소판 감소증 환자에서 대마비와 전신 상태의 급격한 악화 : 급성 대동맥 혈전증 A Case Report of Acute Aortic Thrombosis 증례 보고
이홍기,박훤겸,백홍규,남영수,김영선,김용수 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2
Acute aortic occlusion is rare but poses a high mortality and morbidity. Prompt diagnosis and treatment is essential. Typical presentation is rest pain with bilateral absent femoral pulse. When the non-typical symptoms predominate such as paraplegia, acute abdomen or sudden-onset hypertension, diagnosis may be difficult. We experienced a case of acute aortic thrombosis who suddenly developed paraplegia and rapidly deteriorated within several hours. When the paraplegia developed, he was under treatment with heparin and urokinase, was thrombocytopenic, and the femoral arteries were pulsatile. Spinal cord compression due to bleeding complication had to be ruled out. Duplex sonography and lumbar CT scan were not diagnostic. Aortic thrombosis was diagnosed by abdominal CT scan. This case illustrates the need for high suspicion of acute aortic occlusion presenting with paraplegia especially in patients with associated atherosclerotic disease.
박훤겸,정유교,이광수 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.1
A clinical evaluation and follow up for the results on 15 patients(16 cases) with liver metastatic tumor from colorectal cancer who were performed hepatic resection at the Department of General Surgery, Hanyang University Hospital from March, 1987 to December, 1994, have been analyzed. The results were follows; 1) The primary lesion was colon in 6 patients, rectum in 9 patients and almost all advanced stage as 1 case was Dukes' B2 and others Dukes' C2. 2) The liver metastases was found synchronously in 8 cases, metachronously in 8 cases, and all synchronous cases were resected synchronously. 3) The location of liver metastases was single metastases in 6 cases, multiple metastases in 10 cases and unilober metastases in 9 cases, bilobar metastases in 7 cases. 4) In operative findings, no evidence of porta hepatis invasion and tumor was well encapsulated in 10 cases. 5) In operative method, major hepatic resection was done in 8 cases and in 4 of 8 cases have no evidence of recurrence during 4-57 months. 6) In adjuvant therapy, systemic chemotherapy was done in 6 cases, combination of systemic and hepatic-arterial chemotherapy in 5 cases, radiation therapy in 1 case. And 1 of 5 patients after combination therapy has no evidence of recurrence during 55 months. 7) The mean survival period was 23 months and the survival rate was 0.41 during 57 months with Kaplan-Meier equation. The results of this study demonstrate that almost all metastatic hepatoma was not combined with liver cirrhosis and had normal liver function, major hepatic resection was appliable and adjuvant therapy indicated as remmnant liver functions were normal. In diagnosis and treatment of metastatic hepatoma, aggressive attitude is needed.
김학겸(Hak Kyum Kim),박진우(Jin Woo Park),이진훤(Jin Hwon Lee) 한국증권학회 2014 한국증권학회지 Vol.43 No.1
본 논문에서는 한국거래소(KRX)에 의한 투자주의 환기종목 지정의 정보효과를 분석하고 투자자유형별 매매패턴을 살펴봄으로써 투자주의 환기종목 지정 제도가 투자자 보호에 어떤 역할을 수행하고 있는지 평가하고자 한다. 분석결과는 다음과 같이 요약된다. 첫째, 투자주의 환기종목 지정 후 이틀 동안의 누적초과수익률이 -13.66%에 달해 투자주의 환기종목 지정이 상당한 정보 효과를 보이며 해당 기업의 주가에 매우 부정적인 영향을 미치고 있다. 둘째, 기관 및 외국인 투자자는 지정 이전에 순매도를 통해 투자주의 환기종목 지정에 따른 손실을 회피하고 있는 반면에 개인투자자는 지속적인 순매수로 인해 불리한 투자결과를 초래하고 있다. 셋째, 투자주의 환기종목 지정 이후에도 개인투자자의 순매수는 지속되는데, 특히 상장폐지로 이어지는 기업에 대한 순매수 강도가 더욱 크게 나타나 손실 규모가 커지고 있다. 넷째, 수익성이 낮고 부채비율이 높으며 불투명한 재무정보를 가진 기업일수록 투자주의 환기종목 지정 이후 상장폐지로 이어지는 확률이 높은 것으로 나타나고 있고, 투자주의 환기종목 지정 이전 1년 동안 개인투자자의 순매수 비율이 높은 기업이 지정 이후에 상장폐지 확률이 높다는 것을 보여 줌으로써 개인투자자의 정보열위로 인한 비합리적인 매매행태를 확인시켜 주고 있다. 결론적으로 투자주의 환기종목 지정제도는 개인투자자의 정보열위를 해소하고 비합리적인 매매행태를 개선하는데 기여하지 못하여 실질적인 투자자 보호를 위해서는 제도적으로 개선해야 할 여지가 많은 것으로 판단된다. This paper examines the information effect of investment alert issues by the Korea Exchange (KRX) and the trading patterns of investors classified by individual, institutional, and foreign investors. The results are summarized as follows. First, the cumulative abnormal return (CAR) is -13.66% over two days after investment alert issues, indicating that it is a highly negative event in the market. Second, prior to investment alert issue both institutional and foreign investors are net sellers whereas individual investors bear the brunt of loss as a net buyer of the stock. Third, the net purchases of individual investors continue even after investment alert issue. This phenomenon is more evident for the to-be-delisted firms, engendering substantial loss to individual investors. Fourth, the firms with higher debt ratio, more discretionary accruals and lower profitability are more likely to face delisting after investment alert issue. In addition, the net purchase ratio of individual investors is a predictor of delisting after investment alert issue. In conclusion, investment alert issue by the KRX does not seem to contribute to resolve the information asymmetry between investors and protect the retail individual investors.