이슬람사회의 통과의례 : 아랍 문화권을 중심으로

이희수 서울대학교 비교문화연구소 1995 비교문화연구 Vol.- No.2

Comparative double blind test에 의한 抗아메바劑 Ro7-0207(Tiberal), Metronidazole 및 Dehydroemetine의 治效成績의 比較

李午政,全鍾暉,朴弼遠,朴壽泳 대한감염학회 1974 감염 Vol.6 No.1

Introduction New and better substances are still being sought for the treatment of amoebiasis. The aim of this trial is to assess the effectiveness and tolerance of Tiberal and oral dehydroemetine in patients with oligosymptomatic (or mild) intestinal amoebiasis comparing with that of metronidazole which are known to be an active amoebicide. Selection of cases. Lately, classical symptomatic amoebiasis accompanying mucus-bloody stool and tenesmus could be seldom experienced at urban areas in this country. At here the majority of intestinal amebiasis is manifested by loose stools containing mucus, pus or blood (rare), and also by a rapid response to antibioties, but with frequent episods of recurrence caused by diet-failure or alcohol drinking. Among 187 cases of mild enterocolitis which were suspected as being mild intestinal amoebiasis clinically, authors selected amoeba-positive 60 cases and additional 7 cases which were included later in this clinical trial study. The 7 drop-outs in the original study were replaced by these additional 7 cases. The clinical trials were carried out at the St. Mary's Hospital, Catholic Medical College, Seoul, Republic of Korea. During 12 month (April 25, 1973-May 17, 1974), we treated 60 cases of so-called oligosymptomatic amoebiasis with above mentioned three amoebicides. 60 ambulatory cases suffering from mild GI troubles were admitted into the trial (liable to recurrent diarrhoeal stools including mucus, or pus with tenesmus, and also to lower abdominal discomfort of mild pain) those were suspected clinically as having intestinal amoebiasis with carriers of E. histolytica (trophozoits and/or cysts in the feces). Oligosymptomatic amoebiasis group, in this clinical trial study, consisted of 34 males and 26 females ranging from 17 to 62 years of age. All were adolescents or adults and their age distribution was shown in Table 1. Methodology on this clinical trials. We have carried out so-called the comparative double blind trials with Tiberal versus Metronidazole versus oral Dehydroemetine in symptomatic amoebiasis of mild grade. The trial drugs were given also without the knowledge of either the one who gave it or the one who got it in this comparative double blind study. Both (drug examiner) doctors and (drug examined) patients have had no knowledge of each drug. Pharmacist responded to doctor's prescription with code numbers. After the completion of the study the exact name of a drug were publically drawn from the code numbers and the purpose of double blind study was attained. In this study an arrangement for a drug administration schedule was set by as pharmacist exclusively. 60 patients were assigned to one of the three drugs by proper randomization so that 20 patients received tiberal and 20 metronidazole and 20 oral dehydroemetine. After the trial, code numbers of the drugs were identified; nos. 1, 6, 10, 14, 19, 23, 25, 27, 28, 29, 33, 34, 35, 36, 44, 45, 47, 51, 53, and 54 were tiberal; 8, 9, 11, 12, 13, 15, 16, 18, 20, 22, 32, 39, 41, 48, 49, 50, 52, 55, 56, and 57 were metronidazole, and nos. 2, 3, 4, 5, 7, 17, 21, 24, 26, 30, 31, 37, 38, 40, 42, 43, 46, 58, 59 and 60 were oral dehydroemetine. Evaluation The therapeutic effects were assessed by the clinical evolution and by stool parasitology (direct examination and concentration method) performed on day 3 and 6 on treatment, and then at the end of treatment (8-10 day) and one month after the initial treatment. This made a total 4 to 5 parasitological examination per patient, including one examination required for diagnosis prior to treatment. At the same time aspect and consistency of the stool were registered. The effect of the drugs on other protozoa found in the stools were also reported. The tolerance were assessed by clinical findings and laboratory studies made in limited cases at least before and after treatment unless otherwise stated. Blood count, BUN, Alkaline phosphatase, SGP, TECG and urinalysis were performed as laboratory controls. Authors have established following evaluation criteria for this clinical study. Radical cure: free of symptoms with no vegetative or cystic forms of E. histolytica in stool on 3 successive tests. Biological cure: no cystic forms of E. histolytica in stool on 3 successive tests, but persistence of some intestinal disturbances. Relapse: apparent cure or improvement (with negative of 3 successive tests) followed by recurrence with vegetative amoeba on direct smear within 30 days. (re-infection may be included) Failure: the trophozoites or cystic form of E. histolytica has persisted for treatment periods, with some intestinal troubles. Methods of treatment and parasitologic examination In each group one third of the patients received 2 capsnles of 250mg. Tiberal thrice daily for 7 days, one third received 2 tablets of 250 mgmetronidazole thrice daily for 7 days, and one third received 2 tablets of 10 mgdehydroemetine thrice daily for 7 days as the only specific drug. No associated drugs were given together for symptomatic relief in all cases. The reason why fixed 7 days dose were delivered to every cases was based on convenience of stool examination and equalizing the number of days for therapy. The therapeutic drugs were delivered usually for 2 days dose (1st prescription), 3 days dose and 2 days dose (3rd prescription) successively, therefore stool examination had been done on 3rd, 6th and 8-10th day of therapy. Clinical results In oligosymptomatic amoebiasis, 20 cases each were treated with doses of 1,500mg/day of Tiberal and metronidozole for 7 days respectively, and 20 cases were treated with doses of 60mg/day of dehydroemetine for 7 days. The total doses administered were 10,5g, 10,5g, and 420mg respectively in a period of 7 days. Among tiberal group 19 cases were found to be negative after therapy whereas there was 1 with parasitological failure. The clinical effect was fast in 95% of the cases. Effective cure was achieved in 17 whereas symptoms persist in 3 patients among 20 cases. There were 1 failure and 2 late relapse. Comparing data of therapeutic results with that of metronidazole and dehydroemetine were shown in Table 2 & 3. Table 3 shows the negativity rate of trophozoits or cystic form of E. histolytica in stools according to therapeutic periods of trial drugs received. The data would indicated that 5 days dose could not be enough to eradicate the parasites even in the susceptible cases. The result data of clinical improvement and clearance of E. histolytica in patient stool among drug trial groups were shown in Table 4. The cases treated with Tiberal showed no clinical signs on average 4,9 days and negative amoeba in stool on average 4,1 days of therapeutic periods, comparing with on average 5,8 days and 4,1 days in metronidazole-treated group, and on average 6,3 days and average 4,5 days in dehydroemetine-treated group respectively. Authors put in order the therapeutic procedures and their result of failed or relapsed cases with unplanned measures in table 5. These data could be obtained after the completion of the comparative double blind study by the code numbers which were publically drawn afterwards. These therapeutic procedures had been made just incidentally, not by prior plan. 2 cases, 4 cases and 3 cases could get finally effective cure by doubling doses of 7 days course of Tiberal, metronidazole and dehydroemetine respectively. 1 failed case treated with dehydroemetine and 1 another failed case with tiberal could get effective cure by additionally receiving metronidazole and dehydroemetine respectively. 2 failed cases treated with metronidazole could be cleared of parasites by adding tiberal effectively. Adverse reactions were noticed in 20% each of the patients treated with Tiberal and also with metronidazole, and 25% of those treated with dehydroemetine. They were all transient and never severe. There was not a single case who was discontinued on therapy owing to its side-effects. No significant change of laboratory data was noticed by the administration of trial drugs. Brief summary Tiberal, metronidazole and dehydroemetine (oral) were all recognized as highly efficacious anti-amoebic drugs in this clinical studies. On account of following standpoints 1) clearance of parasites in stool 2) clinical symptomatic relieving 3) drug tolerance 4) rate of relapse and failure 5) side-effects, Tiberal could be received much more recognition than metronidazole and dehydroemetine did. P. S. Authors has experienced other 10 cases of amoebiasis among in patients (5 moderate severe intestinal amoebiasis, 4 liver abscesses and 1 lung abscess) treated with Tiberal and metronidazole with excellent therapeutic results, without any sequelae or relapse.

비만 및 과체중 성인에서 주관적 비만 인식과 신체계측에 의한 비만과의 일치도

정휘수 ( Hwee Soo Jeong ) 한국보건정보통계학회 (구 한국보건통계학회) 2009 보건정보통계학회지 Vol.34 No.2

Objective: Weight control in obese people have been affected by self perception of body image more than body mass index. We conducted this study to identify the agreement and associating factors between self-perceived obesity and obesity classified by body measure in obese and overweighted adults. Methods: The data were collected from 293 subjects who visited health examination center of a university hospital located in Gyeong-ju between July 7th, 2008 and Oct 31th, 2008 and had body mass index(BMI) ≥23kg/m2 by self questionnaire. Results: One hundred and ninety three(65.9%) participants had the agreement between self perception and measurement of obesity classified body mass index, but the agreement was lower for abdominal obesity with 134(45.7%) participants agreeing. Factors related to disagreement of self perception as obese and obesity classified by body measure were sex, age, family history of obesity. Conclusion: Considerable disagreement was identified between self perception as obese and obesity classified by body measure in obese and overweight adults. We should check disagreement before recommending weight control in these people.

입원환자 영양지원에 대한 일개대학병원 의료진의 태도 및 관련 요인

정휘수 ( Hwee Soo Jeong ),등건훈 ( Chen Hsuen Teong ),최유정 ( You Jung Choi ),김우정 ( Woo Jeng Kim ),이아란 ( Ah Ran Lee ) 한국정맥경장영양학회 2014 한국정맥경장영양학회지 Vol.6 No.1

Purpose: Knowledge of nutritional support and attitudes of medical staff both affect patient care. We identified attitudes regarding nutritional support among medical staff as well as changes in attitudes when a nutritional support team is present. Methods: Data were collected from 172 medical staff members who served at a university hospital located in Gyeongju by self-administered questionnaire from June 12∼August 30, 2013. The questionnaire inquired about importance of nutritional support, self-confidence about nutritional support, consideration of nutritional support for patient care, consideration of nutritional support when a nutritional support team is present, and nutritional knowledge training during the past year. Results: A total of 169 subjects (98.3%) thought that nutritional support is important for patient care. Only 19 subjects (11.0%) were highly self-confident about nutritional support. In total, 147 subjects (85.5%) considered nutritional support for some or all patients, whereas 169 (98.3%) considered nutritional support for patient care when a nutritional support team is present. Thirty-eight subjects (22.1%) received nutritional knowledge training during the past year. High self-confidence for nutritional support was related to nutritional knowledge training and service part. Positive changes regarding nutritional support when a nutritional support team is present were associated with nutritional knowledge training and high self-confidence for nutritional support. Conclusion: No differences in nutritional support attitudes for patient care were observed among the medical staff. Nutritional knowledge training and service part affected self-confidence of nutritional support and induced positive changes in attitudes for nutritional support.

아토바스타틴의 새로운 약물 적응증 탐색을 위한 비정형 데이터 분석

정휘수 ( Hwee-soo Jeong ),강길원 ( Gil-won Kang ),최웅 ( Woong Choi ),박종혁 ( Jong-hyock Park ),신광수 ( Kwang-soo Shin ),서영성 ( Young-sung Suh ) 한국보건정보통계학회(구 한국보건통계학회) 2018 한국보건정보통계학회지 Vol.43 No.4

Objectives: In recent years, there has been an increased need for a way to extract desired information from multiple medical literatures at once. This study was conducted to confirm the usefulness of unstructured data analysis using previously published medical literatures to search for new indications. Methods: The new indications were searched through text mining, network analysis, and topic modeling analysis using 5,057 articles of atorvastatin, a treatment for hyperlipidemia, from 1990 to 2017. Results: The extracted keywords was 273. In the frequency of text mining and network analysis, the existing indications of atorvastatin were extracted in top level. The novel indications by Term Frequency-Inverse Document Frequency (TF-IDF) were atrial fibrillation, heart failure, breast cancer, rheumatoid arthritis, combined hyperlipidemia, arrhythmias, multiple sclerosis, non-alcoholic fatty liver disease, contrast-induced acute kidney injury and prostate cancer. Conclusions: Unstructured data analysis for discovering new indications from massive medical literature is expected to be used in drug repositioning industries.

기저세포 상피암이 동반된 파종상 수장족저 한공각화증

정휘정(Hwee Jeong Cheong),한영수(Young Soo Han),김석민(Seog Min Kim),오칠환(Chil Hwan Oh),김수남(Soo Nam Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.4

Porokeratosis may be due to an abnormal clone of cells, predisposing affected individusls to development of malignant neoplssm over involved area. A 58-year old female is prsented with basal cell epithelioma associated with PPPD, exhibiting the classical histopathologic criteria of the disease. Total excision for basal cell epithelioma and oral administration of etretinate for the treatment of porokeratosis plantaris, palmaris et disseminata and for the prevention of cancer developrnent resulted in good response.

방사성핵종의 지하이동 연구

Hun Hwee Park,Kyong Won Han,Nak June Sung,Chul Soo Kim Korean Nuclear Society 1984 Nuclear Engineering and Technology Vol.16 No.2

방사성폐기물 처분과 관련하여 산청, 온양 그리고 무안에서 채취한 국산점토에 대한 Cs-137 및 Sr-90의 흡착특성과 이들 핵종의 점토층이동에 대하여 고찰하였다. 흡착분배계수(Ksorp)를 회분식 흡착실험으로 결정한 결과 Cs-137의 경우 8,000-17,000ml/g 그리고 Sr-90의 경우 10,000-15,000m1/gr 범위의 값이었다. 이때 액상의 초기농도는 0.l$\mu$Ci/ml이었다. 산청과 온양의 점토는 흡착성능이 우수하였으나 무안의 점토는 현저하게 낮았다. 이것은 무안점토에 다량 존재하는 석영성분때문인 것으로 생각되었다. 이상의 흡착특성을 Freundlich형의 형태로 다음과 같이 표시할 수 있었다. $C_{R}$=18.0 $C_{A}$$^{0.74}$ : Cs-137, $C_{R}$=0.84 $C_{A}$$^{0.45}$ : Sr-90. 이 관계식을 BOX모델에 적용하여 점토층내에서의 핵종이동을 모사한 결과 국산점토가 처분장의 충진제로서 효과적임을 확인하였다.하였다.하였다. With regard to the radioactive waste disposal, adsorption properties and migration rates have been evaluated for Cs-137 and Sr-90 with the domestic clay sampled from Cnyang, Sanchong and Mooan. Sorption coefficients (Ksorp) were determined by batch experiments. The measured values of Ksorp were ranged from 8000 to 17,000 ml/gr for Cs-137 of 0.1$\mu$Ci/ml, and from 10,000 to 15,000m1/gr for Sr-90 of 0.l$\mu$Ci/ml. Remarkably, Mooan clay showed lower values of Ksorp than those of the others. This could be explained by the poor soprtion capacity of the quartz found only in the Mooan clay. For the quantitative analysis, sorption isotherm equations of Freundlich type were made with the obtained values of Ksorp. $C_{R}$=18.0 $C_{A}$$^{0.74}$ : Cs-137, $C_{R}$=0.84 $C_{A}$$^{0.45}$ : Sr-90. By introducing the BOX model combined with the above relationships, simulation of underground nuclide movement was carried out. The results showed that the domestic clays could be the effective backfill material for repositories.itories.ies.

Adductor canal block versus intra-articular steroid and lidocaine injection for knee osteoarthritis: a randomized controlled study

( Lee Hwee Ming ),( Chan Soo Chin ),( Chung Tze Yang ),( Anwar Suhaimi ) 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.2

Background: This study aimed to assess the efficacy of the adductor canal block (ACB) in comparison to intra-articular steroid-lidocaine injection (IASLI) to control chronic knee osteoarthritis (KOA) pain. Methods: A randomized, single-blinded trial in an outpatient rehabilitation clinic recruiting chronic KOA with pain ≥ 6 months over one year. Following randomization, subjects received either a single ACB or IASLI under ultrasound guidance. Numerical rating scale (NRS) scores for pain, and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were recorded at baseline, 1 hour, 1 month, and 3 months post-injection. Results: Sixty-six knees were recruited; 2 were lost to follow-up. Age was normally distributed (P = 0.463), with more female subjects in both arms (P = 0.564). NRS scores improved significantly for both arms at 1 hour, with better pain scores for the IASLI arm (P = 0.416) at 1st month and ACB arm at 3rd month (P = 0.077) with larger effect size (Cohen’s d = 1.085). Lower limb function improved significantly in the IASLI arm at 1 month; the ACB subjects showed greater functional improvement at 3 months (Cohen’s d = 0.3, P = 0.346). Quality of life (QoL) improvement mirrored the functional scores whereby the IASLI group fared better at the 1st month (P = 0.071) but at the 3rd month the ACB group scored better (Cohen’s d = 0.08, P = 0.710). Conclusions: ACB provides longer lasting analgesia which improves function and QoL in chronic KOA patients up to 3 months without any significant side effects.

Semicircular Lipoatrophy

정휘정(Hwee Jeong Cheong),노주영(Joo Young Roh),오칠환(Chil Hwan Oh),김수남(Soo Nam Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3

A 21-year-old female is presented with semicircular lipoatrophy, which had developed since birth with annular depressed strophic lesion of the left thigh. Biopsy specimen from the depressed area of left thigh showed no abnormal pathologic findings. But X-ray and CT scan of the lower extremity revealed remarkably reduced fat layer of the left thigh, compared to the right side. (Kor J Dsrmatol 28(3): 358 361, 1990)

건강검진 수검자에서 발견된 단순 신낭종과 관련된 요인

정휘수,박기흠,이동욱 동국대학교 의학연구소 2009 東國醫學 Vol.16 No.1

Simple renal cyst is one of renal neoplasm detected incidentally in abdominal ultrasonography (USG). we carried out this study to detect prevalence of simple renal cyst and identify factors relation of simple renal cyst as hypertension. We collected age, sex, body mass index, systolic blood pressure, diastolic blood pressure, serum glucose, serum creatinine, proteinuria, hematuria, report of abdominal USG among 1,762 subjects who had health screening at Dongguk university Gyeongju hospital from Mar 2004 to Jan 2005. Prevalence of simple renal cyst was 3.2% (n=55) and high in subjects who was over 50 years-old (6.3%, p<.0001). Factor related to simple renal cyst was only age. As increasing oneyear old, risk of simple renal cyst increased 1.058 (95% confidence interval 1.029~1.089)times. Other factors as sex, systolic blood pressure, diastolic blood pressure, hypertension, diabetes, serum creatinine, body mass index, obesity, smoke, serum glucose, proteinuria, hematuria were not significantly related to simple renal cyst. Simple renal cyst is commonly detected in health screening of older subjects but is not relation of hypertension and renal function. 단순신낭종은 복부 초음파검사를통해 우연히 발견되는신종물중 하나이다. 저자들은 단순신낭종의 유병률을 확인하고, 고혈압을 비롯한 단순 신낭종 소견과 관련된 요인을 확인하기 위해 본 연구를 수행하였다. 2004년 3월부터 2005년 1월까지 동국대학교 경주병원에서 건강검진을 받았던 1,762명을 대상으로 연령, 성별, 체질량 지수,수축기, 이완기 혈압, 헐당, 크테아티닌, 단백뇨,혈뇨,복부 초음파 검사 결과지를 확인하였다. 단순 신낭종 유병률은 3.2%(55명)였고 50세 이상에서 유의하게 유병률이 증가하였다(6.3%, p<.0001). 단순 신낭종 유무와 유의한 관련성을 보인 요인은 연령만 확인할 수 있었는데, 연령이 한 살씩 증가할수록 신낭종 위험은 1.058배 (95% 신뢰구간 1.029~1.089)높아졌다. 기타 성별,수축기 혈압,이완기 혈압, 고혈압 병력,당뇨 병력, 혈중 크레아티닌 농도,체질량 지수, 비만, 흡연,혈당, 단백뇨, 혈뇨는 단순 신낭종 유무와 유의한 관련성을 보이지 않았다. 단순 신낭종은 연령 증가에 따라 건강 검진에서 비교적 흔히 확인할 수 있지만 혈압과 신장 기능과의 관련성은 없었다.