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이화영 ( Lee¸ Hwayoung ) 한국수학교육학회 2021 初等 數學敎育 Vol.24 No.2
본 연구는 소수 나눗셈에서의 ‘몫’과 ‘나머지’ 용어 사용의 문제점을 인식하고 이를 개선하기 위한 방안을 탐색하였다. 지금까지의 선행 연구와 현행 교과서를 분석한 결과, ‘몫’, ‘나머지’ 용어 사용에 대해 연구자마다 상이한 견해를 주장한 근원에 나눗셈 알고리즘에서의 q, r값과 계산 결과의 해석에 따른 결과 값과 남는 양을 동일하게 보는 데에 원인이 있음을 밝히고, 소수 나눗셈의 ‘몫’과 ‘나머지’ 취급에 대한 일관된 관점과 교과서 개선 방안을 제안하였다. 즉, 나눗셈 알고리즘 b=α×q+r에 의한 소수 나눗셈의 결과인 q, r을 ‘몫’, ‘나머지’로 보고, 문제 맥락에 따라 q와 같거나 작은 양을 최종적인 ‘결과 값’으로, 결과 값을 취하고 난 잔여량을 ‘남는 양’으로 지칭할 것을 제안하였다. 또한, 몫을 반올림하여 나타낸 근삿값을 ‘몫’으로 지칭하지 않을 것을 제안하였다. In this study I recognized the problems with the use of the terms 'quotient' and 'reminder' in the division of decimal and explored ways to improve them. The prior studies and current textbooks critically analyzed because each researcher has different views on the use of the terms 'quotient' and 'reminder' because of the same view of the values in the division calculation. As a result of this study, I proposed to view the result 'q' and 'r' of division of decimals by division algorithms b=α×q+r as 'quotient' and 'reminder', and the amount equal to or smaller to q the problem context as a final 'result value' and the residual value as ‘remained value’. It was also proposed that the approximate value represented by rounding the quotient should not be referred to as 'quotient'.
Hwayoung Park,안강모,박명희,Sang Il Lee 대한천식알레르기학회 2012 Allergy, Asthma & Immunology Research Vol.4 No.3
Purpose: We investigated whether particular HLA-DRB1 polymorphisms contribute to egg allergy development in Korean children with atopic dermatitis (AD). Methods: HLA-DRB1 alleles were determined by PCR-sequence-specific oligonucleotide (SSO) and PCR-single-strand conformation polymorphism (SSCP) methods in 185 patients with AD and 109 normal control (NC) subjects. AD patients were divided into two groups: 1) AD with egg allergy, consisting of 96 patients with egg allergies as determined by egg-specific immunoglobulin E (IgE) reactivity; and 2) AD without egg allergy,consisting of 89 patients without egg allergies. HLA-DRB1 alleles were classified into functional groups (A, De, Dr, E, Q, R, a). HLA-DRB1 phenotype and functional group frequencies in the AD, AD with egg allergy, and AD without egg allergy groups were compared with those in the NC group. Results: The frequency of DRB1*08:02 was decreased in the AD with egg allergy group compared with the AD without egg allergy group (2.1%vs. 10.1%, P=0.021), and DRB1*15:01 was increased in the AD with egg allergy group compared with the AD without egg allergy group (22.9% vs. 11.2%, P=0.036). However, significance was lost after Bonferroni correction. HLA-DRB1*11:01 had a significantly higher frequency in AD patients compared with NCs (12.4% vs. 1.8%, corrected P=0.048) and was regarded as a susceptibility factor associated with AD. DRB1*08:03 was decreased in AD patients compared with NCs (10.8% vs. 19.3%, P=0.043). HLA-DRB1 functional group ‘a’, which includes DRB1*15:01, seemed to be associated with the development of egg allergy in AD (P=0.033), but this result was not significant after Bonferroni correction. Conclusions: HLADRB1polymorphism is not associated with egg allergy, but HLA-DRB1*11:01 is associated with AD in Korean children.
Hwayoung Lee,Minyoung Lee,Hyung-Ki Kim,Young Ock Kim,Jun-Tack Kwon,Hak-Jae Kim 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.6
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead acetate (0.2%) in drinking water during pregnancy and lactation causes behavioral impairment and affects the expression of proteins associated with neurodevelopment. Lead exposure altered several parameters in rat offspring compared with those unexposed in open-field, social interaction, and pre-pulse inhibition tests. These parameters were restored to normal levels after clozapine treatment. Western blot and immunohistochemical analyses of the hippocampus revealed that several neurodevelopmental proteins were downregulated in lead-exposed rats. The expression was normalized after clozapine treatment (5 mg/kg/day, postnatal day 35–56). These findings demonstrate that downregulation of several proteins in leadexposed rats affected subsequent behavioral changes. Our results suggest that lead exposure in early life may induce psychiatric disorders and treatment with antipsychotics such as clozapine may reduce their incidence.
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
Hwayoung Lee,Jiyun Im,Hansol Won,Wooyoung Nam,Young Ock Kim,Sang Won Lee,Sanghyun Lee,Ik-Hyun Cho,Hyung-Ki Kim,Jun-Tack Kwon,Hak-Jae Kim 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM symptoms, we constructed a FM animal model induced by restraint stress with intermittent cold stress. All mice underwent nociceptive assays using electronic von Frey anesthesiometer and Hargreaves equipment. To assess the relationship between tianeptine and expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element-binding protein (CREB), and phosphorylated cAMP response element-binding protein (p-CREB), western blotting and immunohistochemistry analyses were performed. In behavioral analysis, nociception tests showed that pain threshold was significantly decreased in the FM group compared to that in the control group. Western blot and immunohistochemical analyses of medial prefrontal cortex (mPFC) and hippocampus showed downregulation of BDNF and p-CREB proteins in the FM group compared to the control group. However, tianeptine recovered these changes in behavioral tests and protein level. Therefore, this FM animal model might be useful for investigating mechanisms linking BDNF-CREB pathway and pain. Our results suggest that tianeptine might potentially have therapeutic efficacy for FM.
Influence of Amylose Content on Cooking Time and Textural Properties of White Salted Noodles
Hwayoung Heo,Byung-Kee Baik,Chon-Sik Kang,추병길,박철수 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2
White salted noodles were prepared from reconstituted flours of various amylose content to determine the effects of amylose content on noodle dough properties and texture of noodles cooked for optimum cooking time. With decrease of amylose content from 26.5 to 3.0%,optimum water absorption of noodle dough increased from 39 to 49% and cooking time of noodles decreased from 16to 7 min. Hardness of cooked noodles prepared from reconstituted flour consistently decreased with increase in proportion of waxy starch. Noodles less than 12.4% amylose content exhibited higher springiness and cohesiveness than noodles greater than 17.1% amylose content. Cohesiveness and springiness of noodles prepared with partial waxy starches, of which amylose content ranged from 16.6 to 22.7%, were comparable to those of noodles prepared from <12.4% amylose content. Amylose content of starch was significantly correlated with hardness, springiness, and cohesiveness of cooked noodles prepared from reconstituted flours.
HwaYoung Lee,ChaeKeun Oh,ByungJoo Ham,HunSoo Chang,JongWoo Paik,EunSoo Won,SangWoo Hahn,SeHoon Shim,YoungJoon Kwon,HeeYeon Jung,MinSoo Lee 대한신경정신의학회 2013 PSYCHIATRY INVESTIGATION Vol.10 No.2
Objective-Activation of one or more serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of serotonergic antidepressants. The serotonin 2C (5HT 2C) receptor is known to be associated with antidepressant action and weight gain. We sought to determine whether the 5-HTR 2C receptor -759C/T polymorphism was associated with weight gain and treatment response to mirtazapine in major depressive disorder (MDD) patients. Methods-The 5-HT 2C receptor -759C/T polymorphism was analyzed in 323 MDD patients. All patients were evaluated using the 21-item Hamilton Depression Rating Scale at the beginning of the study and at 1, 2, 4, and 8 weeks of mirtazapine treatment. Results-There was no significant difference in the 5-HT 2C receptor -759C/T genotype distribution between responder and non-responder groups. The 5-HT 2C receptor -759C/T polymorphism was not associated with weight change over time after mirtazapine administration. Conclusion-The 5-HT 2C receptor -759C/T polymorphism does not appear to be a predictor of treatment response to mirtazapine. This polymorphism was not associated with weight change after 8 weeks of mirtazapine treatment. Further investigation on other polymorphisms of the 5-HT 2C gene is required to determine whether the 5-HT 2C gene influences treatment response and weight change after mirtazapine administration in patients with major depressive disorder.