Recombinant canstatin inhibits angiopoietin‐1‐induced angiogenesis and lymphangiogenesis

Hwang‐,Bo, Jeon,Yoo, Ki Hyun,Park, Jong‐,Hwa,Jeong, Han‐,Sin,Chung, In Sik Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.2

<P><B>Abstract</B></P><P>We describe the effect of recombinant canstatin, the NC1 domain of the α2 chain of Type IV collagen, on suppression of angiogenesis and lymphangiogenesis both <I>in vitro</I> and <I>in vivo</I>. Recombinant canstatin produced from stably transformed <I>Drosophila</I> S2 cells reduced the expression of angiopoietin‐1 in hypoxia mimetic agent, CoCl<SUB>2</SUB>‐treated CT‐26 cells. Recombinant canstatin inhibited proliferation, tube formation and migration of human angiopoietin‐1 (rhAngpt‐1)‐treated human umbilical vein endothelial cells (HUVEC) and lymphatic endothelial cells (LEC). Recombinant canstatin suppressed the expression of Tie‐2 and vascular endothelial growth factor‐3 (VEGFR‐3) transcripts in rhAngpt‐1‐treated HUVEC and LEC, respectively. The inhibitory effect of recombinant canstatin on tumor growth was also investigated using a heterotopic CT‐26 colon carcinoma animal (BALB/c mice) model. Recombinant canstatin reduced the final volume and weight of tumors, and blood and lymphatic vessel densities of tumors, which were evaluated by CD‐31 and LYVE‐1 immunostaining. Immunohistochemical analysis showed that recombinant canstatin dramatically reduced the expression of angiopoietin‐1 in CT‐26 colon carcinoma‐induced tumor, but not the expression of VEGF‐C. Tie‐2 and VEGFR‐3 expressions were also reduced in recombinant canstatin‐treated tumors. These results indicate that recombinant canstatin has anti‐tumoral activities against CT‐26 colon carcinoma cells. Recombinant canstatin reduces the expression of angiopoietin‐1 in hypoxia‐induced CT‐26 cells and inhibits the angiogenic and lymphangiogenic signaling induced by angiopoietin‐1. Recombinant canstatin probably inhibits angiogenesis and lymphangiogenesis <I>via</I> suppression of the integrin‐dependent FAK signaling induced by angiopoietin‐1/Tie‐2 and/or VEGFR‐3.</P>

Tough-Movement

黃保根 대구대학교 인문과학연구소 1982 人文科學硏究 Vol.1 No.-

Tough-Movement, as a transformational rule, clearly exists in English. It applies to limited construction which have as predicates adjectives like hard, tough, easy, difficult, etc. and nouns including breeze, cinch, snap and a number of more obscene expressions. The operation of it is that this rule extracts a nonsubject NP out of an extraposed complement and moves it into the position of the higher clause. Three different hypotheses are proposed for deriving sentences like "Tony is difficult for me to persuade." The Phrase Structure Hypothesis is inadequate as a linguistic theory because it fails to capture the linguistic intuition of a native speaker, and violates the principle of economy. The Coreferential NP Deletion Hypothesis also fails to explain the difference in meaning of the surface structure derived from the same underlying one. Its inadequacy is proved by the fact that the subject NP of the higher clause does not exist within the underlying structure but is derived from the application of a transformational rule. The raising Hypothesis turus out to be the best as a linguistic theory, since it not only captures the linguistic intuition of a native speaker but also explains the problems the former two can not. Tough-Movement is subject to many restrictions, selectional and syntactic. This rule operates within the domain of Postal's Cross-over Constraints and Ross's Pied Piping Convention.

펄스정전응력법을 이용한 고분자 재료에서 공간전하분표 측정에 대한 이론적 고찰

황보승 호남대학교 산업기술연구소 1998 산업기술연구논문집 Vol.6 No.-

본 논문에서는 최근 국 ·내외적으로 활발하게 연구되고 있는 고체 고분자 재료 내의 공간전하 측정법과 관련하여, 공간전하의 비파괴 측정법 중의 하나인 펄스정전응력법(PEA 법)에 대한 이론적 고찰을 수행하였다. 또한, 두꺼운 압전소자를 이용해서 PEA 법의 공간분해능을 향상시킬 수 있는 새로운 방법을 제안하였다. In this paper, we have evaluated theoretically the PEA method which is one of the most popular methods for the nondestructive measurement of space charge distribution in polymers. On the basis of this theoretical evaluation, we also suggest a new measuring method that uses a thick piexo-material for improving the space resolution of PEA method.

공주지역사회 체육의 진흥방안

황보연 공주교육대학교 초등연구원 1974 公州敎大論叢 Vol.11 No.-

.

佛語의 强勢後置傾向 硏究

皇甫淳 慶北大學校 1983 論文集 Vol.35 No.-

고대영어의 수동구조

黃保根 대구대학교 인문과학연구소 1986 人文科學硏究 Vol.4 No.-

A structural description of passive constructions in Old English is the primary purpose of this paper. In other words, it can fairy be said to be the preliminary stage for further studies on syntactic changes in English, since diachrony must be studied on the basis of patterned synchronic data. The structural description of passives in Old English, unlike that in Modern English, is not an easy task. Major obstacles are: passives in OE have few corresponding actives, and the analysis performed only on literature-written language-not on spoken one. However, the following can be classified, as the three major patterns of OE passive constructions, by the analysis of them in Anglo-Saxon Chronicles, Alfred’s Pastoral Care, and several primary OE texts available: 1. NP hatan NP beon/wesan NP 2. NP{ weorpan }+PP (Prep) {AP} (Prep+NP) beon/wesan 3. NP weorpan +PP NP (Prep +NP) Except for the Tppe 1, the passive auxiliaries used in OE are beon, wesan and weorpan, and their semantic functions are different in the early OE period. Later they came to be used interchangibly as the original meaning of weorpan disappeared. The identification of the semantic functions of prepositions in agentive adjuncts is grueling. The reason is the agentive adjuncts can be viewed as ‘principle agents’, ‘medium’, ‘means’, ‘cause’, ‘reason’, or ‘instrumentality’according to modern interpretation. The preposition used before agent NPs in Oe are : at, by/be, fram/from, mid, of, purh, etc.

경제적 형광등 교체를 위한 표시장치 개발에 대한 연구

황보승 호남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.7 No.-

본 논문에서는 현재까지 광원의 주류를 이루고 있는 형광등에 의한 불필요한 전력소모를 억제하고 전기요금을 절약하기 위한 최적의 형광등 교체주기 표시에 대한 연구를 수행하였다. 이를 위하여 본 연구에서는 시간경과에 따른 형광등 노화에 의한 소모전력의 증가와 그에 따른 경제성을 분석하였으며, 이를 바탕으로 최적의 교환시기가 되면 자동으로 적색 LED가 소등(또는 점등)되는 장치를 설계 및 개발하였다. 또한 P-spice를 통한 회로 해석과 실험을 통하여 개발된 장치의 정상적인 동작을 확인하였다. In this paper, in order to restrict the power consumption and save electric charges due to the fluorescent lamp which is still main lighting source, we have carried out the studies on the indicating the optimal replacement time of it. For these purposes, we have evaluated the increment of power consumption of the fluorescent lamp and its economical efficiency due to degradation according to elapsed time. On the basis of the evaluation, we have designed and developed the system that turned off(or on) the red LED at the optimal replacement time. We also verified correct operations of the developed system through the circuit simulation by P-spice and experiments.

푸쉬코 메카니즘 언어학 : 원리,방법,적용에 관한 시론 le principe, la me'thode et des applications

황보순 慶北大學校 語學硏究所 1989 語文硏究 Vol.14 No.-

인터넷 기반의 전자공간을 활용한 과학기술혁신 모델

황보열,김소용 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

인터넷 사용자의 폭발적인 증가와 함께 이를 기반으로 한 전자공간은 새로운 혁신을 지향하고 있다. 본 연구에서는 과학기술 혁신을 위한 전자공간 활용에 초점을 두고 국가 혁신의 새로운 모델을 도출하는 것을 목표로 하였다. 과거에는 혁신을 위한 과학기술 정보의 유통모델은 선형적인 특징을 갖고 있지만 새로운 모델은 한 곳으로 모이는 수렴(Convergence) 모델로 요약될 수 있다. 즉 새로운 과학기술 혁신 모델에서는 과학기술 정보의 공급자와 수요자가 함께 전자공간에 모여 공급과 수요가 동시에 발생하는 것이 특징이다. 결국 공급자인 동시에 수요자이고 수요자인 동시에 공급자이다. 본 연구에서는 새로운 모델을 구체화시키기 위해 정보기술을 적용한 과학기술 혁신을 위한 수요공급 아키텍쳐를 제시함과 동시에 전자공간 활용을 위한 주요 과제를 도출하였다.

펄스정전응력법에 의한 XLPE에서 DC 과전에 의한 공간전하의 교류전압에서의 거동관찰

황보승 호남대학교 2000 호남대학교 학술논문집 Vol.21 No.2

In this paper, in order to evaluate quantitavely the formation mechanism of space charge by DC application and the behavior of pre-formed space charge at AC volatge in XLPE, We have modified the PEA method to measure simultaneously discharging (or leakage) current and space charge distribution under DC and AC. By using this system, we have analyzed the effects of pre-formed space charge accumulated by DC stress on AC in XLPE (560 ㎛) when there is no air gap between electrode and XLPE. Form the experimental, it was found that, DC conduction current decrease because of the effects of potential barrier at interface and most of pre-formed space charges still remained when AC voltage was applied up to 8kV. Thus the field distortion and localization due to pre-formed space charge is very important under AC voltage and may cause a critical damage on the AC insulating characteristics of insulator, especially in AC long-term service.