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옥살酸 및 鹽酸溶液에서 Ti의 酸化還元 Polarography
金黃岩 成均館大學校 1967 論文集 Vol.12 No.-
Ti(TV)가 옥살酸水溶液 속에 있는 水銀滴下電極에서 還元될 때 TiO(C_2O_4)_2+2H +e→Ti(C_2O_4)_2^-+H_2O (1) 인 電極反應이 일어나고 이때 可逆的半波電位는 E^1/_2=E_0-0.118pH로 表示되지만 實驗式은 E_1/2=E_0-0.08pH+0.02log(H_2C_2O_4)_TO (E-1) 로 表示된다고 Pecsok는 報告하였었다. 式 (E-1)에서 (H_2C_2O_4)_TO는 옥살酸과 옥살酸?의 全濃度를 意味한다. Pecsok가 이와 같은 實驗式이 얻어지는 理由를 說明하기를 Ti(O_2C_2O_4)_2^==TiO^+++2C_2O_4^=,K_2 (2) Ti(O_2O_4)_2^-=Ti^+3+2C_2O_4^=, K_2 (3) 의 두 平衡이 일어나고 K_2의 값이 K_2의 값보다 크기 때문일 것이라고 報告하였다. Pecsok가 K_2와 K_2 값을 測定하지 못한 것은 (H_2C_2O_4)_TO이 0.2M인 한가지 濃度에서만 實驗을 하였기 때문이고 萬一濃度를 달리 하면서 E_1/2v.s pH polt를 하면 K_2와 K_2값을 同時에 求할 수 있음을 著者는 着眼하였다. Pecsok가 한 實驗을 다시해본 結果 pH가 1보다 작은 範圍內에서 (E_1/2가 (E-1)式으로 表示되는 것과 같이 pH에 對해서 直線關係가 되지 않음을 發見하였다. 이 事實을 說明할 수 있는 한가지 方法으로 平衡 (2)(3)以外에 TiO(C_2O_4)_2^=+2H^+=Ti^4++2C_2O_4^=+H_2O, K_4 (4) 인 平衡을 追加하였다. (Ⅰ) Reduction of Ti (Ⅳ)-Oxalate Complex on dropping mercury electrode has been studied as a function of oxalate concentration and of pH varied with HCI. Assuming there are equilibrium TiO(C_2O_4)^--+2H=Ti^+4+2C_2O_4^--+H_2O,K_4 in Addition to TiO(C_2O_4)_2=TiO^+++2C_2O_4^--, K_2 TiO(C_2O_4)_2^-=Ti^+3+2C_2O_4^--, K_3 in the system cathodic wave has been well explained for that pH is higher than p.5. The equilibrium constants K_2, K_3 and K_4 have been to be 2 x 10^-12, 5 x 10^-13 and 10^-11, respectively. THe reduction of Ti(Ⅳ)-oxalate system is Ti^+4+e---Ti^+3 in the concentration of hydrochloric acid, higher than 3M. (Ⅱ) Electrode reaction of Ti(Ⅳ)-Ti(Ⅲ)red-oxi. system on dropping mercury electrode (D.M.E.) has been studied, varing the HCI concentration in aq. medium. The ionic equilibrium in the concentration of about 0.2M/L, and the electrode reaction of the second wave are as follows, Ti(OH)CL^2+??TiO^+++Cl^-+H^+ TiO^+++2H+e→Ti(H_2O)^3+ The system is irreversible, and transference coefficient is 0.45. At the concentration larger than 3M/L of aq. HCI solution the ionic equilibrium and the electrode reaction of first wave at the D.M.E. as follows, Ti(OH)Cl^2++H^++Cl^-??TiCl_2^2++H_2O TiCl_2^2++e??TiCl_2^+ and the system, Ti(Ⅳ)∼Ti(Ⅲ), of the ox-red. electrode reaction is reversible.
金黃岩 成均館大學校 1962 論文集 Vol.7 No.-
Solution to the diffusion layer for the first reaction at a droping mercury electrode is presented. Equations are derived for polarographic currents for the reactions at the droping mercury electrod. A factor which is aplicabie to the droping mercury electrod is derived, when we use the equations of hte polarographic currents for the reactions at a plane electrode, and the rate constants of the backward reactions are negligible small, polarographic currents from a combination of diffusions and reactions are obtained at the droping mercury electrode with special approximation. Rate constant for reaction of ferrous ion with hydrogen peroxide is determined at the droping mercury electrode using the data of KOLTHOFF and PARRY for the kinetic current of ferric ion in the presence of hydrogen peroxide is good. Ratios of diffusion layer at the droping mercury electrode to the diffusion laver at the plane electrode are discussed and show that when the rate constants of the backward reactions for the first order reactions are larger then 1/0.05 sec^-1 and drop time about 3 sec., we cane use the equations of polarographic currents at the plane electrode to the droping mercury electrode. And, on the other hand, solution of the diffuison problem applicable to steady state reduction at the ideal streaming mercury electrode are presented, with special atention being given to the influence of stream contraction caused by the gravity. To eliminate the convection occuring in the layer between the streaming mercurry and electrolytic solusion. A new method have been invented, in this case the solution being tested was streamed with same velocity of the streaming mercury. Experiment have been made in order to compare the experimental value with the theoretical value and the experimental diffusion current was approached more to the theoretical value than the value obtained by earlier form of the streaming mercury electrode used by Heyrovsky.
Kim, Yong Jin,Kim, Do Young,Seo, Jung Woong,Lee, Song Am,Hwang, Jae Joon,Kim, Hee Joung,Lee, Kye Young The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.74 No.1
We present a case of congenital cystic adenomatoid malformation (CCAM) in a 25-year-old male who was presented with chronic cough. Chest radiography revealed an abnormal mass-like shadow in the right lower pulmonary zone. A contrast enhanced computed tomography showed an 11 cm solid, cystic mixed mass on the right lower lobe. A right lower lobectomy was performed by video-assisted thoracoscopic surgery without complications. The gross specimen showed a massive cavitation with multiloculated cysts of varying size, consistent with CCAM, along with noticeable granulomatous inflammation. Non-tuberculosis mycobacteria were isolated from a bronchial wash specimen, and the resected tissue homogenates were positive for Mycobacterium avium-intracellulare complex by polymerase chain reaction.
( In Ae Kim ),( Hee Joung Kim ),( Jae Young Hur ),( Wan Seop Kim ),( Song Am Lee ),( Jae Jun Hwang ),( Kye Young Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Despite surgical resection, stage I pulmonary adenocarcinoma has a recurrence rate of 18.4%-25%. Predictable marker for recurrence in early resected-lung adenocarcinoma is not clear. Targeted next-generation sequencing (NGS) is rarely used to identify recurrence-related genes. We aimed to identify genetic alterations that can predict recurrence by comparing molecular profiles of group with recurrence and those of group without recurrence through targeted NGS. Methods: Tissues from 201 patients who had complete resection of stage I lung adenocarcinoma (median follow-up: 49 months), were analyzed by targeted NGS with the 170 cancer related genes. The recurrence-free survival (RFS) according to the number and kinds of gene alteration were estimated using the Kaplan-Meier method. The independent biomarkers related with recurrence were identified by Cox proportional hazard regression analysis. Results: Recurrence was not associated with the number of the pathogenic mutations (p=0.13). CTNNB1 mutation and fusion genes were negative predictive factor for recurrence in multivariate analysis.(p<0.001) EGFR mutation was good predictive factor, (p<0.001) but the patients with CTNNB1/EGFR co-mutation had shorter RFS significantly than the patients with pure EGFR mutation(p=0.003). Conclusions: The CTNNB1 mutation and fusion genes were predictive factors for recurrence in early lung adenocarcinoma. Larger datasets are required to validate these findings. Targeted NGS can provide valuable information to predict the recurrence and to select the patients with high risk of recurrence to treat adjuvant chemotherapy in even stage I lung adenocarcinoma
Yong Jin Kim,Do Young Kim,Jung Woong Seo,Song Am Lee,Jae Joon Hwang,Hee Joung Kim,Kye Young Lee 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.74 No.1
We present a case of congenital cystic adenomatoid malformation (CCAM) in a 25-year-old male who was presented with chronic cough. Chest radiography revealed an abnormal mass-like shadow in the right lower pulmonary zone. A contrast enhanced computed tomography showed an 11 cm solid, cystic mixed mass on the right lower lobe. A right lower lobectomy was performed by video-assisted thoracoscopic surgery without complications. The gross specimen showed a massive cavitation with multiloculated cysts of varying size, consistent with CCAM, along with noticeable granulomatous inflammation. Non-tuberculosis mycobacteria were isolated from a bronchial wash specimen, and the resected tissue homogenates were positive for Mycobacterium avium-intracellulare complex by polymerase chain reaction.
Targeted NGS Application to Evaluate Recurrent Impact in Resected EGFR-mutated Lung Adenocarcinoma
( In Ae Kim ),( Kye Young Lee ),( Jae Young Hur ),( Hee Jung Kim ),( Jung Hoon Park ),( Song Am Lee ),( Jae Joon Hwang ),( Wan Seop Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Targeted next-generation sequencing (NGS) is widely applied in personalized therapy of advanced lung adenocarcinoma patients to identify driver oncogenes, but it also can be applied to resected early stage patients. We investigated mutation profile of resected EGFR-mutated lung adenocarcinoma to evaluate prognostic and recurrent impact using targeted NGS analysis. Methods Tissues from 131 patients who had complete resection of stage I to IIIA EGFR mutated lung adenocarcinoma (median follow-up: 50.1 months) were analyzed by targeted NGS with 207 cancer-related genes. Recurrence-free survival (RFS) according to genetic alterations was estimated using the Kaplan-Meier Method and Cox proportional regression analysis. Results The relapses rate was 25.2% (33/131). 5-year RFS of stage IA, IB, II and IIIA was 82%, 75%, 35% and 0% (p<0.001). RFS was proportionally decreased according to the number of accompanying co-mutations. (p=0.025). Among co-mutations, the CTNNB1 mutation was associated with short RFS in a multivariate analysis (hazard ratio [HR]: 5.4, 95% confidence interval: 2.1- 14.4; p=0.001). TP53 was also associated with short RFS in stage IB-IIIA. (p=0.01) RFS of exon 19 deletion was shorter than RFS of L858R in stage IB-IIIA tumors (p=0.008). Of exon 19 deletion subtypes, pL747_P753delinS (6/56, 8.9%) had shorter RFS than the most frequent pE746_A750del (39/56, 69.6%) (p=0.004). Conclusions Targeted NGS analysis reveals that the number of concomitant mutations, CTNNB1 co-mutation, and the subtype of exon 19 deletion especially, pL747_P753delinS, were negative prognostic factors for recurrence and can be used as a novel platform to predict prognosis and recurrence in resected EGFR-mutation lung adenocarcinoma patients.
Safety of Train Passengers in a Tunnel
Kim, Dong-Jin,Moon, Dae-Seop,Moon, Seong-Am,Hwang, Young-Ha The Korean Society for Railway 2007 한국철도학회논문집 Vol.10 No.1
Along with the opening of the high speed railroad in 2004, the number of long tunnels constructed is increasing and will be continued. In this respect, the fro inside the tunnels is a main cause of drastic damages to both facilities and lives of passengers on board, especially more severe consequences are expected if the fire occurs on a train in urban area. Even though, the threat to human lives due to the increasing number of tong tunnels and increasing train operation times inside such tunnels is getting bigger, the studies to measure safety of the tunnel and to enhance the safety of passengers have not been carried out enough in Korea. Therefore, in this paper, we will use the probabilistic method to predict the average number of deaths of passengers in case of fire on a train iii tunnel, and show the potential risk to passengers which can be a guide for safer design of tunnels to be constructed.