Long-term Hepatitis B Surface Antigen Profile and Seroclearance after Severe Acute Flares of Chronic Hepatitis B

Hui Ka-Yin,Fung James,Cheung Ka-Shing,Mak Lung-Yi,Seto Wai-Kay,Yuen Man-Fung 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2

Background/Aims: Hepatitis B surface antigen (HBsAg) seroclearance remains uncommon in chronic hepatitis B (CHB) infection. During acute flares of CHB (AFOCHB), alanine aminotransferase elevation reflects a mounting immune response toward viral clearance. We hypothesized that severe AFOCHB is associated with a greater quantitative HBsAg (qHBsAg) decline and HBsAg seroclearance rate. Methods: A total of 75 patients with severe AFOCHB with alanine aminotransferase 10× the upper limit of normal were matched to a control group by age and sex in a 1:2 ratio. qHBsAg levels were measured at the time of flare and annually (for both cases and controls) until the last follow-up. Results: The median follow-up times for patients with severe AFOCHB and controls were 8.8 and 10.5 years, respectively. The cumulative rate of HBsAg seroclearance was higher in the severe AFOCHB group than in the control group (11.8% vs 5.0%, p=0.04) despite the former group having a trend of a higher baseline median qHBsAg (3,127 IU/mL vs 1,178 IU/mL, p=0.076). Compared with the control group, the severe AFOCHB group had a greater annual qHBsAg reduction (–242.4 IU/mL/yr vs –47.3 IU/mL/yr, p=0.002). Increasing age (p=0.049), lower baseline qHBsAg (p=0.002), and severe AFOCHB (p=0.014) were independently associated with HBsAg seroclearance. However, the cumulative rate of hepatocellular carcinoma was significantly higher in the severe AFOCHB group than in the control group (15.8% vs 1.9%, p<0.001). Conclusions: Severe AFOCHB was associated with a greater incidence of HBsAg seroclearance and qHBsAg decline. However, it was associated with a higher incidence of hepatocellular carcinoma.

Distinct effects of Al³⁺ doping on the structure and properties of hexagonal turbostratic birnessite: A comparison with Fe³⁺ doping

Yin, Hui,Kwon, Kideok D.,Lee, Jin-Yong,Shen, Yi,Zhao, Huaiyan,Wang, Xiaoming,Liu, Fan,Zhang, Jing,Feng, Xionghan Elsevier 2017 Geochimica et cosmochimica acta Vol.208 No.-

<P><B>Abstract</B></P> <P>Hexagonal turbostratic birnessite, one of the most reactive Mn oxide minerals, is ubiquitous throughout the ocean floor to the surface environment. During its crystallization, birnessite may coexist with Al<SUP>3+</SUP>, which is the third most abundant crustal element. However, interactions of Al<SUP>3+</SUP> with birnessite compared to the transition metal (TM) ions have rarely been explored thus far. This study examines the structure and properties of Al<SUP>3+</SUP>-doped hexagonal turbostratic birnessite to obtain insights into the interaction of metal cations with birnessite-like minerals in natural environments. For Al<SUP>3+</SUP>-incorporated birnessite, the crystal chemistry of Al<SUP>3+</SUP>, as well as alteration in the mineral structure, physicochemical properties, and reactivity toward the sorption of Pb<SUP>2+</SUP>/Zn<SUP>2+</SUP> is investigated by powder X-ray diffraction, chemical analysis, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and X-ray absorption spectroscopy. Electronic structure calculations based on density functional theory (DFT) are further combined to aid in the experimental interpretation of Al<SUP>3+</SUP> incorporation. As a comparative system, Fe<SUP>3+</SUP>-coprecipitated birnessite is also examined. Under the experimental conditions used, only a small amount of Al<SUP>3+</SUP> is incorporated into birnessite, with a final Al/(Al+Mn) molar ratio of ∼0.07, whereas Fe<SUP>3+</SUP> is incorporated into birnessite with a final Fe/(Fe+Mn) molar ratio of up to ∼0.21. Irrespective of metal type, the incorporation of a metal cation significantly alters the physicochemical properties of birnessite, such as decrease in the thickness of crystals along the <B>c</B> <SUP>∗</SUP> axis and coherent scattering domain sizes in the <B>a</B>–<B>b</B> plane and the Mn average oxidation state, increase in the specific surface area and the total amount of hydroxyl groups, in which the contents of hydroxyl groups around vacancies are decreased. The lattice parameters in the <B>a</B>–<B>b</B> plane tend to decrease in Al–incorporated birnessites but first significantly decrease and then increase in Fe-incorporated birnessites. In Fe-incorporated birnessites, ∼32–50% of the total Fe<SUP>3+</SUP> is located inside the Mn octahedral sheets (INC species). In Al–incorporated birnessites, the edge- and corner-sharing Mn–Mn distances gradually decrease. Density function theory (DFT) computation results support that the dominant species in Al–birnessite is a triple-corner-sharing complex on vacancies. The DFT geometry optimization further demonstrates that the in-plane cell size experimentally observed for these birnessites depends on not only the metal type but also its position in the mineral. The Al- or Fe-birnessites exhibit significantly increased adsorption capacities for Pb<SUP>2+</SUP> but reduced capacities for Zn<SUP>2+</SUP>. The metal incorporation effects on the chemical reactivity are discussed with the observed changes in the particle size and available vacancy sites.</P>

Diversity of Bovine Rumen Methanogens In Vitro in the Presence of Condensed Tannins, as Determined by Sequence Analysis of 16S rRNA Gene Library

Hui Yin Tan,Chin Chin Sieo,Chin Mei Lee,Norhani Abdullah,Juan Boo Liang,Yin Wan Ho 한국미생물학회 2011 The journal of microbiology Vol.49 No.3

Molecular diversity of rumen archaeal populations from bovine rumen fluid incubated with or without condensed tannins was investigated using 16S rRNA gene libraries. The predominant order of rumen archaea in the 16S rRNA gene libraries of the control and condensed tannins treatment was found to belong to a novel group of rumen archaea that is distantly related to the order Thermoplasmatales, with 59.5% (15phylotypes) and 81.43% (21 phylotypes) of the total clones from the control and treatment clone libraries,respectively. The 16S rRNA gene library of the control was found to have higher proportions of methanogens from the orders Methanomicrobiales (32%) and Methanobacteriales (8.5%) as compared to those found in the condensed tannins treatment clone library in both orders (16.88% and 1.68% respectively). The phylotype distributed in the order Methanosarcinales was only found in the control clone library. The study indicated that condensed tannins could alter the diversity of bovine rumen methanogens.

The Comparison of Quality of Life Between Day-hospital and Home Care Schizophrenic Patients

Hui-Yin Lin,Ya-Fen Lee,Hsiu-Yueh Wu 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Synthesis of Co₃O₄ nanowires on nickel foam by a novel microwave-assisted template-free method

Hui, K.S.,Hui, K.N.,Yin, C.L.,Hong, X. North-Holland 2013 Materials letters Vol.97 No.-

Spinel cobalt oxide (Co<SUB>3</SUB>O<SUB>4</SUB>) nanowires grown on Ni foam are successfully synthesized using a novel microwave-assisted template-free method. The effect of reaction temperature, concentration of reactants, and reaction time on the morphology and crystalline structures of the prepared nanowires is studied. The present work has demonstrated that uniform Co<SUB>3</SUB>O<SUB>4</SUB> nanowires with diameters of 500-580nm and lengths of 6-8μm can be synthesized under proper reaction condition. Moreover, the proposed microwave-assisted template-free method can significantly reduce reaction time, increase reaction efficiency, and provide better control over the geometry of the nanostructures.

Synthesis of Co3O4 nanowire arrays supported on Ni foam for removal of volatile organic compounds.

Hui, K N,Yin, Cui-Lei,Hui, K S,Lee, J Y,Li, M,Lee, S K,Tsui, K L,Chao, C Y H,Kwong, C W American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.4

<P>Crystalline Co3O4 nanowire arrays freely supported on Ni foam are successfully synthesized using a template-free method. The effects of reaction time, concentration of reactants, and temperature on the morphology of the nanowires are studied. The results indicate that uniform Co3O4 nanowires could be synthesized at 90 degrees C, and a transformation of the samples' morphology from nanoparticles to nanowires to microrods is observed by controlling the concentration of the reactants. The well-ordered nanowires synthesized under the selected reaction conditions are composed of spinel Co3O4 with diameters of 500-580 nm and lengths of 6-8 microm. These nanowires show good catalytic activity for the ozone catalytic oxidation of toluene.</P>

The Compile Purport of Yi Li Jing Zhuan Tong Jie and the Status in Zhu Xi’s Thought and Learning

( Yin Hui ) 성균관대학교 유교문화연구소 2012 儒敎文化硏究(中文版) Vol.0 No.17

《儀禮經傳通解》對宋以后的《儀禮》學硏究影響深遠, 引來的聚訟也紛纭。實際上, 朱熹編撰《儀禮經傳通解》, 有着學術和政治的雙層考慮。就《儀禮經傳通解》表現出的特点而言, 它是朱熹試圖溝通經傳、實現禮文與性理統一的編著, 幷非考證禮文、評議禮義的專著。它幷非强調要人踐履古禮, 而是重在讓學者識禮。同時, ?還是朱熹向往聖人之道, 融義理與禮樂爲一爐, 力求經史結合的經世致用之作, 其最終的編撰目的在于能使禮治之工夫和義理适得其所, 達到安邦定國的大治境界。《儀禮經傳通解》是朱熹畢生禮學探索的總結與展現, 也是朱熹應對永嘉、永康學術挑戰的反省與綜合之作。《儀禮經傳通解》篇章如家禮、鄕禮、學禮、邦國、王朝禮的設立均與朱熹的學術思想以及參與的政治生活有着密切的聯系, 是朱熹禮學思想乃至自身學術思想的總結。同時, 《儀禮經傳通解》吸收了浙學重史重經制的精華, 成爲朱熹完善自身學術的重要著作。 Zhu Xi composed Yi Li Jing Zhuan Tong Jie out of both academic and politic reasons. From the characteristics of Yi Li Jing Zhuan Tong Jie, one may find that it is not a book on examining rituals or discussing rituals; it does not intend to make people practise the ancient rituals, but make people understand rituals; the goal of Yi Li Jing Zhuan Tong Jie lies in bringing peace and stability to the country via properly placing the cultivation and its meaning. Yi Li Jing Zhuan Tong Jie was Zhu Xi’s life-long conclusion and demonstration about the ritual study, and it was also his perception of the challenging criticism from Yong-jia school and Yong-kang school. [Article in Chinese]

Game Theory Analysis on the Innovation of Quality Development mechanism for Service-based Enterprise

Yin Hui,Wang Chenming 한국유통과학회 2013 한국유통과학회 학술대회 논문집 Vol.2013 No.-

Based on the reasonable and indefinite space, this paper mainly does research on the multi-player game between service-based enterprise with the government, the service industry and the clients for the innovation of quality development mechanism severally. According to the game theory analysis with the help of the behavior strategies which are different but influence each other, it is concluded that which parts of the innovating quality development mechanism for service-based enterprise should be strengthened and the suggestions about promoting this mechanism are put forward.

N6-Methyladenosine modification (m6 A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats

Yin Ronghuan,Yin Ronglan,Bai Man,Fan Yixing,Wang Zeying,Zhu Yubo,Zhang Qi,Hui Taiyu,Shen Jincheng,Feng Siyu,Bai Wenlin 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.4

Objective: The objective of this study was to investigate the effects of N6-Methyladenosine modification-circRNA-zinc finger protein 638 (m6A-circRNA-ZNF638) on the induced activation of secondary hair follicle (SHF) stem cells with its potential mechanisms in cashmere goats. Methods: The m6A modification of ZNF638 was analyzed using methylation immunoprecipitation with real-time quantitative polymerase chain reaction technique in SHF stem cells. The effects of circRNA-ZNF638 on the induced activation of SHF stem cells in m6A dependence were evaluated through the overexpression of circRNA-ZNF638/its m6Adeficient mutants in circRNA-ZNF638 knockdown SHF stem cells. The competitive binding of miR-361-5p to circRNA-ZNF638/Wnt5a 3′- untranslated region was analyzed through Dual-luciferase reporter assay. Results: The m6A-circRNA-ZNF638 had significantly higher transcription at anagen SHF bulge of cashmere goats compared with that at telogen, as well as it positively regulated the induced activation of SHF-stem cells in cashmere goats. Mechanismly, m6A-circRNA-ZNF638 sponged miR-361-5p to heighten the transcriptional expression of Wnt5a gene in SHFstem cells. We further demonstrated that the internal m6A modification within circRNAZNF638 is required for mediating the miR-361-5p/Wnt5a pathway to regulate the induced activation of SHF stem cells through an introducing of m6A-deficient mutant of circRNAZNF638. Conclusion: The circRNA-ZNF638 contributes the proper induced activation of SHF-stem cells in cashmere goats in m6A-dependent manner through miR-361-5p/Wnt5a axis.

Electroreduction of H2O2 by Co3O4 and NiCo2O4 nanowires and beta-Ni(OH)2 nanoplates grown on Ni foam.

Hui, K N,Yin, Cui-Lei,Hui, K S,Lee, J Y,Cao, Dianxue,Wang, Guiling American Scientific Publishers 2012 Journal of nanoscience and nanotechnology Vol.12 No.4

<P>Nanowires (Co3O4 and NiCo2O4) and nanoplates (beta-Ni(OH)2) grown on Ni foam are successfully prepared by a template-free method and used as cathode electrodes for the electroreduction of H2O2, in an alkaline medium. Catalytic performance is investigated via cyclic voltammetry and chronoamperometry. The Co3O4 and NiCo2O4 nanowire electrodes exhibit much better catalytic activity, stability, and mass transfer properties for H2O2 electroreduction than pressed Co3O4 and NiCo2O4 nanoparticle/carbon/PTFE electrodes. A current density of 101.8 mA cm(-2) and 122.7 mA cm(-2) are respectively achieved on Co3O4 and NiCo2O4 nanowire electrodes at -0.4 V in 0.4 mol/L H2O2, and 3.0 mol/L NaOH solution at room temperature.</P>