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좌측 전대뇌동맥 영역의 뇌경색 후 발생한 초피질성 혼합 실어증 1예
심미섭,이연수,김은희,이인숙,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
We present a case of transcortical mixed aphasia (TMA) presumably caused by left anterior cerebral artery infarction. A 53-year-old, right-handed woman suddenly developed speech disturbance and abnormal behavior. Her spontaneous speech was remarkably reduced to almost mutistic state and objective naming, comprehension, reading and writing were severely impaired. However, repetition of phonemes and sentences were fully preserved. She showed echolalia and completion phenomenon, which prompted us to make a diagnosis of TMA. Although the lesion was confined to extrasylvian area on MRI, SPECT demonstrated diminished blood flow left perisylvian cortices suggestive of functional isolation of speech area. In spite of her echolalic repetition, she couldn't repeat affective prosody, presumably, because of the left anterior corpus callosal lesion. Treatment with bromocriptine, a dopamine agonist helped her recovery of behavioral changes, namely abulia or akinetic mutism consisitent with mesial frontal syndrome.
한규량,이상배,김연희 忠州大學校 2008 한국교통대학교 논문집 Vol.43 No.-
Local self-sufficiency promotion center began to operate with the enforcement of the law for the securing of the least life of the people from October, 2000. It was made for the support of self-sufficiency of the poor who could work. As of December, 2006, 242 local self-sufficiency promotion centers are operating nationally. Their main business is to look after the patient, to repair the house, to clean, and to reuse the food. But now besides of these business, it widened its range from farming, eating out, helping mother who deliver a baby, and assisting the education of the disabled, to taking care of the old. The achievement of self-sufficiency business have inspired the will of life of the workers who took part in the self-sufficiency business and have promoted the vitality of them as components of the society by accepting their joining the social life in their community. This study has grasped the present condition of Chungbuk Association of Self-Sufficiency Promotion Center for the last 7 years and estimated its achievement and discussed the plan for the development of it.
[PB-0073] 무(Raphanus sativus L.) 품종의 표현형적 특성과 heterozygosity 간의 상관관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0071] GBS 분석을 통한 국내 무(Raphanus sativus L.) 품종의 유전적 유연관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Hui-yeon Kim 미래사회통합연구센터 2020 Journal of Conflict and Integration Vol.4 No.2
Low-skilled Cambodian workers are not concerned by “multicultural programs” in South Korea. In this context, they deal with this situation through the help of religious institutions, such as the Onnuri Presbyterian Church, by recreating a sort of ethnonational community. Labour migration permits Cambodian workers to weave different kinds of social links between them, with Koreans of the peninsula, and also with Koreans in Cambodia. This article examines the singular form of integration or exclusion of these migrant workers in South Korea, and tries to demonstrate its impact on their life upon their return home.
( Yeon Hui Jeong ),( Jin Sun Park ),( Dong Hyun Kim ),( Hee Sun Kim ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.6
In the present study, we found that the natural compound arctigenin inhibited hydrogen peroxide-induced reactive oxygen species (ROS) production in rat primary astrocytes. Since hemeoxygenase-1 (HO-1) plays a critical role as an antioxidant defense factor in the brain, we examined the effect of arctigenin on HO-1 expression in rat primary astrocytes. We found that arctigenin increased HO-1 mRNA and protein levels. Arctigenin also increases the nuclear translocation and DNA binding of Nrf2/c-Jun to the antioxidant response element (ARE) on HO-1 promoter. In addition, arctigenin increased ARE-mediated transcriptional activities in rat primary astrocytes. Further mechanistic studies revealed that arctigenin increased the phosphorylation of AKT, a downstream substrate of phosphatidylinositol 3-kinase (PI3K). Treatment of cells with a PI3K-specific inhibitor, LY294002, suppressed the HO-1 expression, Nrf2 DNA binding and ARE-mediated transcriptional activities in arctigenin-treated astrocyte cells. The results collectively suggest that PI3K/AKT signaling pathway is at least partly involved in HO-1 expression by arctigenin via modulation of Nrf2/ARE axis in rat primary astrocytes.
( Yeon-hui Jeong ),( Jin-sun Park ),( Dong-hyun Kim ),( Hee-sun Kim ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.6
Lonchocarpine is a phenylpropanoid compound isolated from Abrus precatorius that has anti-bacterial, anti-inflammatory, antiproliferative, and antiepileptic activities. In the present study, we investigated the antioxidant effects of lonchocarpine in brain glial cells and analyzed its molecular mechanisms. We found that lonchocarpine suppressed reactive oxygen species (ROS) production and cell death in hydrogen peroxide-treated primary astrocytes. In addition, lonchocarpine increased the expression of antioxidant enzymes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and manganese superoxide dismutase (MnSOD), which are all under the control of Nrf2/antioxidant response element (ARE) signaling. Further, mechanistic studies showed that lonchocarpine increases the nuclear translocation and DNA binding of Nrf2 to ARE as well as ARE-mediated transcriptional activities. Moreover, lonchocarpine increased the phosphorylation of AMP-activated protein kinase (AMPK) and three types of mitogen-activated protein kinases (MAPKs). By treating astrocytes with each signaling pathway-specific inhibitor, AMPK, c-jun N-terminal protein kinase (JNK), and p38 MAPK were identified to be involved in lonchocarpine-induced HO-1 expression and ARE-mediated transcriptional activities. Therefore, lonchocarpine may be a potential therapeutic agent for neurodegenerative diseases that are associated with oxidative stress.