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全泰玉,全彦燦,朴興植 동아대학교 공과대학 부설 한국자원개발연구소 1984 硏究報告 Vol.8 No.2
For the study, thermoplastic rigid polyvinyl chloride, which has been widely used for the parts of machine, has been applied as high polymetric materials and has been investigated into relationship between circumferential surface and steel sphere in order to clear the characteristics of the softened surface layer with frictional velocity, contact load and feed. The results obtained are as follows. 1. In constant frictional velocity, as the contact load was increased by degree the coefficients of friction was slowly decreased and it has inclination of increasing by softness on the surface layer according as the contact load was increased. 2. In constant contact load, as the frictional velocity was increased by 63m/min the coefficients of friction was slowly decreased, and in more than, the coefficients of friction was rapidly decreased by a lubricating effect of the frictional surface layer. 3. The fusional trace on the harden polyvinyl chloride was appeared by the frictional force with it according as the frictional velocity and the contact load were become high, especially appeared the deep ones with softening on the frictional surface. 4. Under condition of feeding, the coefficients of friction of a new surface was high in higher than 503m/min of the frictional velocity, but low in lower than the value comparing with repeated friction.
Nedumaran, Balachandar,Hong, Sungpyo,Xie, Yuan-Bin,Kim, Yong-Hoon,Seo, Woo-Young,Lee, Min-Woo,Lee, Chul Ho,Koo, Seung-Hoi,Choi, Hueng-Sik American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.40
<P>DAX-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital critical region on X chromosome, gene 1) is an atypical member of the nuclear receptor family and acts as a corepressor of a number of nuclear receptors. HNF4alpha (hepatocyte nuclear factor 4alpha) is a liver-enriched transcription factor that controls the expression of a variety of genes involved in cholesterol, fatty acid, and glucose metabolism. Here we show that DAX-1 inhibits transcriptional activity of HNF4alpha and modulates hepatic gluconeogenic gene expression. Hepatic DAX-1 expression is increased by insulin and SIK1 (salt-inducible kinase 1), whereas it is decreased in high fat diet-fed and diabetic mice. Coimmunoprecipitation assay from mouse liver samples depicts that endogenous DAX-1 interacts with HNF4alpha in vivo. In vivo chromatin immunoprecipitation assay affirms that the recruitment of DAX-1 on the phosphoenolpyruvate carboxykinase (PEPCK) gene promoter is inversely correlated with the recruitment of PGC-1alpha and HNF4alpha under fasting and refeeding, showing that DAX-1 could compete with the coactivator PGC-1alpha for binding to HNF4alpha. Adenovirus-mediated expression of DAX-1 decreased both HNF4alpha- and forskolin-mediated gluconeogenic gene expressions. In addition, knockdown of DAX-1 partially reverses the insulin-mediated inhibition of gluconeogenic gene expression in primary hepatocytes. Finally, DAX-1 inhibits PEPCK and glucose-6-phosphatase gene expression and significantly lowers fasting blood glucose level in high fat diet-fed mice, suggesting that DAX-1 can modulate hepatic gluconeogenesis in vivo. Overall, this study demonstrates that DAX-1 acts as a corepressor of HNF4alpha to negatively regulate hepatic gluconeogenic gene expression in liver.</P>
Yun-Yong Park,Hueng-Sik Choi,Ju-Seog Lee 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.5
Nuclear receptors (NRs) play pivotal roles in cell growth, proliferation, differentiation and homeostasis. Recent progress demonstrates that NR is tightly linked to human disease such as cancer, diabetes and obesity. Here we explore NR expression profiles in human tissue using systematic approaches. NR gene profiles reveal that individual NR has its own gene expression signature depending on tissue type. Of many organs, NRs expression is enriched in liver. Expression of many NRs was significantly changed in liver cancer. Notably, NR0B2/SHP expression level was significantly decreased in human liver cancer but not in normal liver. In addition, expression of SHP is well associated with good prognosis. SHP gene network analysis based on microarray data in liver cancer shows that SHP regulates cell proliferation and metabolism related gene sets. Our systematic approaches suggest that loss of SHP expression in liver might be key genetic events during hepatocarcinogenesis.