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      • KCI등재

        Antinociceptive effects of oleuropein in experimental models of neuropathic pain in male rats

        ( Huayong Chen ),( Dandan Ma ),( Huapeng Zhang ),( Yanhong Tang ),( Jun Wang ),( Renhu Li ),( Wen Wen ),( Yi Zhang ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.1

        Background: The present investigation explored the therapeutic actions of oleuropein along with the possible signaling pathway involved in attenuating neuropathic pain in chronic constriction injury (CCI) and vincristine-induced neuropathic pain in male rats. Methods: Four loose ligatures were placed around the sciatic nerve to induce CCI, and vincristine (50 μg/kg) was injected for 10 days to develop neuropathic pain. The development of cold allodynia, mechanical allodynia, and mechanical hyperalgesia was assessed using different pain-related behavioral tests. The levels of H<sub>2</sub>S, cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), orexin, and nuclear factor erythroid-2-related factor 2 (Nrf2) were measured in the sciatic nerve. Results: Treatment with oleuropein for 14 days led to significant amelioration of behavioral manifestations of neuropathic pain in two pain models. Moreover, oleuropein restored both CCI and vincristine-induced decreases in H<sub>2</sub>S, CSE, CBS, orexin, and Nrf2 levels. Co-administration of suvorexant, an orexin receptor antagonist, significantly counteracted the pain-attenuating actions of oleuropein and Nrf2 levels without modulating H<sub>2</sub>S, CSE and CBS. Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H<sub>2</sub>S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.

      • KCI등재후보

        Numerical simulation on the crack initiation and propagation of coal with combined defects

        Huayong Lv,Zhanbo Cheng,Yaqing Dong,Jing Zhang,Yujie Ma 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.79 No.2

        There is normally the occurrence of pre-existing cracks and holes in coal mass to influence its mechanical behaviours. And the crack initiation and propagation around the tip of pre-existing cracks can be observed to induce the overall failure of coal mass finally. In this study, two groups of hole with the radius of 10mm connecting one crack with length and width of 20 mm and 1 mm, respectively, were pre-existed in sample to explore the influence of crack angle (from 0 to 90°) on the unconfined compressive strength (UCS), crack initiation and propagation, and failure modes of coal mass with combined faults by using RFPA2D. The results showed that the stress-strain curves of specimen with double-hole-crack exhibit multiple stress drop compared to that of intact coal sample, especially in the post-peak stage. Moreover, UCS decreased firstly with the crack angle increasing to 30° and then increased until the crack angle reaching to 75° following by decreasing with the continuous increase of crack angle to 90°. In addition, the failure mode of double-hole-crack specimen with the crack angle of 0- 30° can be regards as the dominated tensile failure combined with shear failure, which was consist with the failure pattern of intact specimen. On the other hand, the failure mode of double-hole-crack specimen with the crack angle of 45-90° is the dominated shear failure combined with tensile failure. Meanwhile, the distribution characteristics of acoustic emission energy can be used to better reflect the deformation and failure process of coal mass with combined defects.

      • SCIESCOPUSKCI등재

        Feasibility of Tissue Engineering Small Vessel Scaffold on Vascular Transplantation

        ( Chen Huayong ),( Bai Shuling ),( Chen Yingqing ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6

        The glycoprotein with α-galactosyl-terminal is a major xenogeneic antigen for hyperacute rejection. In this study, we observed distributive features of α-galactosyl in endothelial and smooth muscle cells for small tissue engineering vessel scaffolds, and for vessels of Wistar rats and Japanese white rabbits. We also aimed to discuss the feasibility of small vessel scaffolds on xenotransplantation. We utilized 30 Wistar rat caudal arteries, non gender specific. Fifteen of caudal arteries were prepared for small acellular vessel scaffolds assigned as small vessel scaffold group, the other 15 caudal arteries were assigned as caudal artery group. We also collected eight Japanese white rabbits, non gender specific, and extracted 15 ear central arteries assigned as central artery group. We added Bandeireae Simplicifolia 1 Isolectin B4 (16 mg/L) to tissue sections for DAB staining, then we detected the positive reaction product of α-galactosyl. The expression of α-galactosyl in central artery group was mainly in membrane and nucleus of endothelial; in caudal artery group, which expressed strong positive in membrane of endothelial. However, in the vessel scaffold group, α-galactosyl expressed weakly or scarcely in the intima of the vessels. The absorbency of caudal artery group was significantly higher than that of central vessel group, and which of vessel scaffold group was significantly lower than that of caudal artery and central artery group, We could conclude xenogeneic antigenicity of endothelial membrane for caudal artery was higher than that for central artery, and we could use acellular small vessel scaffolds for xenogeneic vascular transplantation.

      • Study on slope stability of waste dump with a weak layer using finite element limit analysis method

        Chong Chen,Huayong Lv,Jianjian Zhao,Zhanbo Cheng,Huaiyuan Wang,Gao Xu 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.3

        Slope stability is generally paid more attention to in slope protection works, especially for slope containing weak layers. Two indexes of safety factor and failure model are selected to perform slope stability. Moreover, the finite element limit analysis method comprehensively combines the advantage of the limit analysis method and the finite element method obtaining the upper and lower bounds of the safety factor and the failure mode under the slope stability limit state. In this study, taking a waste dump containing a weak layer as an engineering background, the finite element limit analysis method is adopted to explore the potential failure mode. Meanwhile, the sensitivity analysis of slope stability is performed on geometrical and geotechnical parameters of the waste dump. The results show that the failure mode of the waste dump slope is two wedges if the weak layer is located on the ground surface (Model A), while the slope can be observed as three wedges failure if the weak layer is below the ground surface (Model B). In addition, both failure modes are highly sensitive to the friction angle of the weak layer and the shear strength of waste disposal, and moderately sensitive to the heap height, the dip angle and cohesion of the weak layer, while the toe cutting has limited effect on the slope stability. Moreover, the sensitivity to the excavation of the ground depends on the location of the weak layer and failure mode.

      • KCI등재후보

        Wireless sensor networks for permanent health monitoring of historic buildings

        Daniele Zonta,Huayong Wu,Matteo Pozzi,Paolo Zanon,Matteo Ceriotti,Luca Mottola,Gian Pietro Picco,Amy L. Murphy,Stefan Guna,Michele Corrà 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.6

        This paper describes the application of a wireless sensor network to a 31 meter-tall medieval tower located in the city of Trento, Italy. The effort is motivated by preservation of the integrity of a set of frescoes decorating the room on the second floor, representing one of most important International Gothic artworks in Europe. The specific application demanded development of customized hardware and software. The wireless module selected as the core platform allows reliable wireless communication at low cost with a long service life. Sensors include accelerometers, deformation gauges, and thermometers. A multi-hop data collection protocol was applied in the software to improve the system flexibility and scalability. The system has been operating since September 2008, and in recent months the data loss ratio was estimated as less than 0.01%. The data acquired so far are in agreement with the prediction resulting a priori from the 3-dimensional FEM. Based on these data a Bayesian updating procedure is employed to real-time estimate the probability of abnormal condition states. This first period of operation demonstrated the stability and reliability of the system, and its ability to recognize any possible occurrence of abnormal conditions that could jeopardize the integrity of the frescos.

      • SCIESCOPUS

        Wireless sensor networks for permanent health monitoring of historic buildings

        Zonta, Daniele,Wu, Huayong,Pozzi, Matteo,Zanon, Paolo,Ceriotti, Matteo,Mottola, Luca,Picco, Gian Pietro,Murphy, Amy L.,Guna, Stefan,Corra, Michele Techno-Press 2010 Smart Structures and Systems, An International Jou Vol.6 No.5

        This paper describes the application of a wireless sensor network to a 31 meter-tall medieval tower located in the city of Trento, Italy. The effort is motivated by preservation of the integrity of a set of frescoes decorating the room on the second floor, representing one of most important International Gothic artworks in Europe. The specific application demanded development of customized hardware and software. The wireless module selected as the core platform allows reliable wireless communication at low cost with a long service life. Sensors include accelerometers, deformation gauges, and thermometers. A multi-hop data collection protocol was applied in the software to improve the system's flexibility and scalability. The system has been operating since September 2008, and in recent months the data loss ratio was estimated as less than 0.01%. The data acquired so far are in agreement with the prediction resulting a priori from the 3-dimensional FEM. Based on these data a Bayesian updating procedure is employed to real-time estimate the probability of abnormal condition states. This first period of operation demonstrated the stability and reliability of the system, and its ability to recognize any possible occurrence of abnormal conditions that could jeopardize the integrity of the frescos.

      • KCI등재

        Average Consensus Seeking of High-order Continuous-time Multi-agent Systems with Multiple Time-varying Communication Delays

        Qingjie Zhang,Yifeng Niu,Lin Wang,Lincheng Shen,Huayong Zhu 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.6

        The average consensus problem of high-order multi-agent systems with multiple time-varying communication delays is investigated in this paper. By using the idea of state decomposition, the condition for guaranteeing average consensus is converted into verifying the stability of zero equi-librium of disagreement system. Considering multiple time-varying communication delays, Lyapunov-Krasovskii approach in time-domain is employed to analyze the stability of zero equilibrium. With the help of Free-weighting Matrices (FWM) approach, the tolerant upper bounds on communication delays can be obtained through solving feasible linear matrix inequalities (LMIs). Delay-dependent stability criteria for both strongly-connected fixed and switching topologies are provided in the main results. Further, the conclusion is extended to the case of jointly-connected switching topologies. Numerical examples and simulation results are given to demonstrate the effectiveness and the benefit on reducing conservativeness of the proposed method.

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