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Clinicopathological Characteristics of Alpha-Fetoprotein- Producing Gastric Cancer
Huan Chun,권성준 대한위암학회 2011 Journal of gastric cancer Vol.11 No.1
Purpose: Ձ-fetoprotein (AFP)-producing gastric cancer is a rare tumor with high rates of liver metastasis and a poor prognosis. Many studies have been performed but there have been no comprehensive investigations of the clinicopathological and prognosis. Materials and Methods: Six hundred ninety four patients with gastric cancer who underwent a curative gastric resection in Hanyang University Hospital from February 2001 to December 2008 were evaluated retrospectively after excluding active or chronic hepatits, liver cirrhosis and preoperative distant metastasis. Among them, thirty five patients had an elevated serum level of AFP (>7 ng/ml) preoperatively. The clinicopathological features of AFP-producing gastric cancer were analyzed. Results: There was poorer differentiation, a higher incidence of lymph node metastasis, more marked lymphatic and vascular invasion in the AFP-positive group than in the AFP-negative group. The 5-year survival rate of the AFP-positive group was significantly poorer than that in the AFP-negative group (66% vs. 80%, P=0.002). A significantly higher incidence of liver metastasis was observed in the AFP-positive group than in the AFP-negative group (14.3% vs. 3.6%, P=0.002) with a shorter median time period from the operation to the metachronous liver metastasis (3.7 months vs. 14.1 months, P=0.043). Multivariate survival analysis revealed the depth of invasion, degree of lymph node metastasis and AFP-positivity to be the independent prognostic factors. Conclusions: AFP-producing gastric cancers have an aggressive behavior with a high metastatic potential to the liver. In addition, their clinicopathological features are quite different from the more common AFP-negative gastric cancer.
Zijian Song,Huanchun Cai,Qingyang Liu,Linhua Jiang,Hongqiang Chu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-
In this study, an ultrasound-assisted enzymatic extraction (UEE) method was proposed to augment theanti-corrosion performance of the green inhibitor extracted from waste Platanus acerifolia leaves. Chemical compositions and anticorrosive properties of UEE extract were characterized via multiple technologies. The adsorption film on the steel surface was characterized via X-ray photoelectron spectroscopy(XPS). The surface information of corroded steel was also analyzed. Results showed that, compared withthe ultrasound-assisted alkali extraction (UAE), UEE increased the utilization rate of raw plant materialsby 22%39%. After optimized via response surface methodology, the maximum yield of UEE extract couldreach 27.081 mg/g. Electrochemical results showed, compared with 3% UAE extract, the inhibition efficiencyof 3% UEE extract after 72 h in 0.5 M NaCl was increased by 22% while the extraction time wassaved by 90%. Microscopic observations also proved that UEE extract can effectively mitigate the corrosiondegree where the roughness of steel surface decreased by 63.67%. XPS results revealed that a carbonaceousprotecting layer was formed on steel surfaces. The inhibition mechanism analysis suggestedthat flavonoids and their derivatives were apt to adsorb on the steel surface via chelation and surfacephysical adsorption, which could block the pathway of chloride attack.
Ti, Wenxin,Wu, Huanchun,Xue, Fei,Zhang, Guodong,Peng, Qunjia,Fang, Kewei,Wang, Xitao Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.8
The effect of thermal aging at 475 ℃ and 750 ℃ of Z3CN20.09M cast duplex stainless steel (CDSS) on microstructure, mechanical and intergranular corrosion properties were investigated by transmission electron microscope (TEM), nano indenter, scanning electron microscope (SEM) and corrosion fatigue test system. The result indicated that the spinodal decomposition and G precipitated were occurred after aged at 475 ℃, as well as sigma precipitated at 750 ℃. The microstructure degeneration of ferrite was saturated after aged for 2000h and 200 h at 475 ℃ and 750 ℃ respectively. The mechanical properties, intergranular corrosion resistance and corrosion fatigue lives were continuing deteriorated with increasing the aging time at both temperatures. The difference of the degeneration mechanisms of Z3CN20.09M CDSS aged at 475 ℃ and 750 ℃ was analyzed.
In silico identification of potential drug targets in swine pathogen Haemophilus parasuis
Zhuofei Xu,Lifang Ma,Huanchun Chen,Rui Zhou 한국유전학회 2012 Genes & Genomics Vol.34 No.2
Gram-negative bacterium Haemophilus parasuis has recently become one of the most important etiological agents causing serious systemic disease (Glässer’s disease) in pigs. Antibiotic therapy has played a crucial role in the treatment of this disease. Antibiotic resistance observed from the clinical isolates of this pathogen urges us to discover novel drug targets for antimicrobial agents. In this study, we used a combined strategy including exploration of the gene essentiality and comparison of metabolic pathways to infer drug targets of H. parasuis. We identified 931 gene products essential for bacterial growth according to the DEG database. One hundred and ninety-nine enzyme-coding genes were found in the genome of H. parasuis but were absent in that of the swine host. Lastly,we determined 117 enzymes exhibiting essentiality and specificity to H. parasuis as a candidate set of drug targets. Comparison of metabolic pathways between the pathogen and host showed that 25 targeting enzymes belonged to nine unique pathways of the pathogen. The profile of promising targets identified in our study will provide a useful basis for developing more effective antibiotics against the severe swine disease caused by H. parasuis.
Xiabing Chen,Zhuofei Xu,Lu Li,Huanchun Chen,Rui Zhou 한국미생물학회 2012 The journal of microbiology Vol.50 No.6
Actinobacillus pleuropneumoniae is an important swine respiratory pathogen causing great economic losses worldwide. Identification of conserved surface antigenic proteins is helpful for developing effective vaccines. In this study, a genome-wide strategy combined with bioinformatic and experimental approaches, was applied to discover and characterize surface-associated immunogenic proteins of A. pleuropneumoniae. Thirty nine genes encoding outer membrane proteins (OMPs) and lipoproteins were identified by comparative genomics and gene expression profiling as beinghighly conserved and stably transcribed in the different serotypes of A. pleuropneumoniae reference strains. Twelve of these conserved proteins were successfully expressed in Escherichia coli and their immunogenicity was estimated by homologous challenge in the mouse model, and then three of these proteins (APJL_0126, HbpA and OmpW) were further tested in the natural host (swine) by homologous and heterologous challenges. The results showed that these proteins could induce high titers of antibodies, but vaccination with each protein individually elicited low protective immunity against A. pleuropneumoniae. This study gives novel insights into immunogenicity of the conserved OMPs and lipoproteins of A. pleuropneumoniae. Although none of the surface proteins characterized in this study could individually induce effective protective immunity against A. pleuropneumoniae, they are potential candidates for subunit vaccines in combination with Apx toxins.