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      • SCOPUSSCIEKCI등재

        Deep Brain Stimulation of the Subthalamic and Pedunculopontine Nucleus in a Patient with Parkinson's Disease

        Liu, Huan-Guang,Zhang, Kai,Yang, An-Chao,Zhang, Jian-Guo The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.4

        Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN-DBS using motor and gait subscores. The PPN-DBS provided modest improvements in the gait disorder and freezing episodes, while the STN-DBS failed to improve the dominant problems. This special case suggests that PPN-DBS may have a unique role in ameliorating the locomotor symptoms and has the potential to provide improvement in FOG.

      • SCIESCOPUSKCI등재

        Blooms of the woloszynskioid dinoflagellate Tovellia diexiensis sp. nov. (Dinophyceae) in Baishihai Lake at the eastern edge of Tibetan Plateau

        Zhang, Qi,Zhu, Huan,Hu, Zhengyu,Liu, Guoxiang The Korean Society of Phycology 2016 ALGAE Vol.31 No.3

        Freshwater red tides due to dinoflagellates have caused spectacular and regular “summer reddening” in recent years in Baishihai Lake, a temperate, meromictic, meso- or oligotrophic, high-altitude, landslide-dammed, deep lake located at the eastern edge of Tibetan Plateau in China. Based on morphological and molecular analyses, the causative organism has been identified as a new woloszynskioid dinoflagellate, Tovellia diexiensis Q. Zhang et G. X. Liu sp. nov. The vegetative cells are 20-32 μm long and 16-24 μm wide. They have a hemispherical episome and a broadly rounded hyposome with a short characteristic antapical spine. Usually cells are bright red due to the presence of numerous red-pigmented bodies, which often masked the yellowish green discoid chloroplasts. The amphiesma of motile cells comprise mainly quadrilateral, pentagonal or hexagonal thin plates, arranged in 4-5 latitudinal series on the episome, 1 in the cingulum and 4 on the hyposome. Molecular phylogenies based on small subunit ribosomal DNA and large subunit ribosomal DNA (LSU) indicate T. diexiensis from Baishihai Lake to belong to the family Tovelliaceae, which was monophyletic in our LSU phylogenies. During the bloom-forming period in 2005, cell density of T. diexiensis reached 9.15 × 10<sup>5</sup> cells L<sup>−1</sup>. Astaxanthin and its diester were found to be the major pigments in T. diexiensis, resulting in a characteristic blood-red color of the water in Baishihai Lake.

      • Study on High Resistance Distance Relay in Directly Earth System

        Liu, Huan-Zhang,Li, Ying-Hong The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.4

        The coverage of transition resistance and the avoidance of load impedance is in essence a contradiction for distance protection. It's evident from the impedance plane that the requirement to avoid the load impedance results in that the action space of the distance relay is greatly limited, which accordingly reduces the ability of the relays to cover the transition resistance. In fact, there are some limitations to analyze the distance relays in the impedance plane. It would be better in the voltage plane. The three elements of distance relay in the voltage plane are the polarization voltage, operation voltage and operation characteristic, of which the polarization voltage is most important. The relay could ideally select pre-fault voltage as polarization voltage, while it practically employs the positive voltage. The difference between the two kinds of polarization voltage is negligible in the state of low impedance ground fault, while significant in the state of high impedance ground fault. Thus, this paper uses the memory and the non-fault phase parameters to gain the pre-fault voltage, that is, the new polarization voltage, and puts forward a new self-adaptive high impedance ground distance relay.

      • KCI등재
      • KCI등재

        One-step preparation of MnO2 nanozyme by PS-CDs for antibacterial, inhibition of S. aureus biofilm growth and colorimetric assay of tiopronin

        Huan Liu,Dan Zhao,Changpeng Zhang,Minghao Li,Shijie Zhang,Xincai Xiao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

        The novel nanozyme has been used in the detection field as biosensor, but has also been employed in newfields like antibacterial and inhibiting of biofilm growth applications. This paper reports the rapid preparationof the nanozyme PS-CDs-MnO2 with oxidase activity by using PS-CDs as reducing agent to reduceKMnO4. The mechanisms of positive electrical property of PS-CDs-MnO2 and the single linear oxygen(1O2) have promised the broad-spectrum antibacterial ability and high efficiency in eliminating bacteria,with 48 h long-term antibacterial effect. The minimum inhibitory concentration (MIC) againstStaphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and Pseudomonasaeruginosa (P. aeruginosa) at 7.50 lg/mL, 60 lg/mL, 15 lg/mL and 60 lg/mL, respectively. The preparedPS-CDs-MnO2 could effectively inhibit the formation of S. aureus biofilm at the concentration of 10 lg/mL. The visually sensitive and selective sensing platform based on PS-CDs-MnO2-TMB was established, andrealized the colorimetric detection of tiopronin (TPN) with a detection range at 285.71 nM–14.28 lMand detection limit at 6.30 nM. This research provides a good theoretical and practical basis for the preparationof oxidase nanozyme and its application in detection, antibacterial and inhibition of biofilm formationfields.

      • KCI등재

        What Are the Differences in Psychological Outcomes Between People Who Posted COVID-19-Related Content on Social Media and Those Who Did Not?

        Shu Zhang,Yanwen Zhang,Dini Xue,Huan Zhang,Miao Chao,Tour Liu 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1

        Objective During the lockdown of cities and home quarantine, media became the only way for people to conveniently get coronavirus disease-2019 (COVID-19)-related information. And media engagement was closely related to psychological outcomes. But fewer researchers took COVID-19-related posting behaviors into consideration. Therefore, the present study aimed at examining the differences in psychological outcomes between people who posted COVID-19-related content on social media and those who did not. Methods The present study included 917 participants (304 males, 613 females) who had answered the questionnaires of media engagement, positive affect, negative affect, depression, anxiety, stress, satisfaction with life, death anxiety, and meaning in life. Results Results of t-tests showed that the Post group had lower levels of negative affect, anxiety, stress, and death anxiety than the Not Post (Npost) group. Network comparison tests indicated that the Npost group’s network and the Post group’s network differed in global strength, two edge-weights, and node centrality indices. Conclusion The results indicated that more attention should be paid to people who did not post any COVID-19-related content, especially when they have higher levels of stress and depression to prevent comorbidities. And for people who posted content, more attention should be paid when they have a higher level of negative affect.

      • KCI등재

        Blooms of the woloszynskioid dinoflagellate Tovellia diexiensis sp. nov. (Dinophyceae) in Baishihai Lake at the eastern edge of Tibetan Plateau

        Qi Zhang,Huan Zhu,Zhengyu Hu,Guoxiang Liu 한국조류학회I 2016 ALGAE Vol.31 No.3

        Freshwater red tides due to dinoflagellates have caused spectacular and regular “summer reddening” in recent years in Baishihai Lake, a temperate, meromictic, meso- or oligotrophic, high-altitude, landslide-dammed, deep lake located at the eastern edge of Tibetan Plateau in China. Based on morphological and molecular analyses, the causative organism has been identified as a new woloszynskioid dinoflagellate, Tovellia diexiensis Q. Zhang et G. X. Liu sp. nov. The vegetative cells are 20–32 μm long and 16–24 μm wide. They have a hemispherical episome and a broadly rounded hyposome with a short characteristic antapical spine. Usually cells are bright red due to the presence of numerous red-pigmented bodies, which often masked the yellowish green discoid chloroplasts. The amphiesma of motile cells comprise mainly quadrilateral, pentagonal or hexagonal thin plates, arranged in 4–5 latitudinal series on the episome, 1 in the cingulum and 4 on the hyposome. Molecular phylogenies based on small subunit ribosomal DNA and large subunit ribosomal DNA (LSU) indicate T. diexiensis from Baishihai Lake to belong to the family Tovelliaceae, which was monophyletic in our LSU phylogenies. During the bloom-forming period in 2005, cell density of T. diexiensis reached 9.15 × 105 cells L−1. Astaxanthin and its diester were found to be the major pigments in T. diexiensis, resulting in a characteristic blood-red color of the water in Baishihai Lake.

      • KCI등재

        Binary Structured Polypropylene/Polyethylene Glycol Micronanofibrous Membranes with Enhanced Water and Air Permeability

        Heng Zhang,Qi Zhen,Jing-Qiang Cui,Huan-Wei Sun,Rang-Tong Liu,Yi-Feng Zhang,Yong Liu 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1

        As a stable chemical material, polypropylene (PP) micro-nanofibrous membranes are widely used in medical andhealth care. However, PP fibrous membranes with single nano scale diameter are conducive to high packing density, whichresults in large flow resistance across the membrane. Therefore, to improve the material’s water and air permeability,polyethylene glycol (PEG), an incompatible polymer with PP, was introduced by blending in a modified method using a meltblowing process. This proposed approach allows large 10 μm diameter fibers to be entangled with fine 300 nm diameterfibers to produce highly porous binary structured fibrous membranes with small pore size. Because of its binary structure, theair permeability in the material reached 569.56 mm/s and the water vertical velocity was 70.15 mm/s. Additionally, the threedimensionalnumerical calculations suggested that the high porosity and binary structure were key to enhancing waterpermeability in the fibrous membranes. These binary structured micro-nanofibrous membranes are expected to be used forfiltration, separation, health care, oil/water separation, medical wound dressings, and other applications.

      • KCI등재

        Chlorophyll Fluorescence Characteristics and Rapid Light Response Curves of Alpine Rhododendron

        Yuan-Huan Liu,Fang-Li Liu,Bo Long,Xiong-Li Zhou,Xue Zhang,Yue Zhang,Wen-Li Wang,Shi-Kang Shen 한국원예학회 2019 원예과학기술지 Vol.37 No.4

        The aim of this study was to determine the photosynthetic adaptability of Rhododendron species toalpine environments. The chlorophyll fluorescence parameters and rapid light response curves ofeight Rhododendron species were determined under field conditions across elevation gradients (atelevations of 2,950, 3,560, 3,660, 3,770, and 4,030 m) in the Jiaozi Mountain National NaturalReserve, Yunnan Province, southwestern China. The effect of different elevations, species, and theirinteractions significantly affected most of the chlorophyll fluorescence and rapid light response curveparameters. The variable to maximum fluorescence ratio (Fv/Fm) ranged from 0.78 to 0.81 at the fiveelevation gradients. This result indicated that the studied species were well grown and adapted to thecurrent environment. The correlation analysis indicated that the elevation was positively significantlycorrelated with the photochemical efficiency of photosystem II, electron transport rate, maximumelectron transport rate, light saturation coefficient (Ek), and chlorophyll relative content (SPAD: leafchlorophyll content index) and was negatively significantly correlated with photochemicalquenching, nonphotochemical quenching, and linear initial slope values. Although no significantrelationship was observed between the elevations and Fv/Fm, the apparent difference in Fv/Fm both atelevation gradients and elevation × species levels indicated that the Rhododendron speciesdemonstrated species-specific adaptation to the environment at different elevations. Our resultsprovided evidence that Rhododendron species exhibit variations in photosynthetic activities in analpine environment at different elevations. These differences may improve the understanding of thephysiological adaptation variations of Rhododendron species across elevation gradients in associationwith climate change in the mountains of southwestern China.

      • KCI등재

        Feasibility of a Clinical-Radiomics Model to Predict the Outcomes of Acute Ischemic Stroke

        Zhou Yiran,Wu Di,Yan Su,Xie Yan,Zhang Shun,Lv Wenzhi,Qin Yuanyuan,Liu Yufei,Liu Chengxia,Lu Jun,Li Jia,Zhu Hongquan,Liu Weiyin Vivian,Liu Huan,Zhang Guiling,Zhu Wenzhen 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.8

        Objective: To develop a model incorporating radiomic features and clinical factors to accurately predict acute ischemic stroke (AIS) outcomes. Materials and Methods: Data from 522 AIS patients (382 male [73.2%]; mean age ± standard deviation, 58.9 ± 11.5 years) were randomly divided into the training (n = 311) and validation cohorts (n = 211). According to the modified Rankin Scale (mRS) at 6 months after hospital discharge, prognosis was dichotomized into good (mRS ≤ 2) and poor (mRS > 2); 1310 radiomics features were extracted from diffusion-weighted imaging and apparent diffusion coefficient maps. The minimum redundancy maximum relevance algorithm and the least absolute shrinkage and selection operator logistic regression method were implemented to select the features and establish a radiomics model. Univariable and multivariable logistic regression analyses were performed to identify the clinical factors and construct a clinical model. Ultimately, a multivariable logistic regression analysis incorporating independent clinical factors and radiomics score was implemented to establish the final combined prediction model using a backward step-down selection procedure, and a clinical-radiomics nomogram was developed. The models were evaluated using calibration, receiver operating characteristic (ROC), and decision curve analyses. Results: Age, sex, stroke history, diabetes, baseline mRS, baseline National Institutes of Health Stroke Scale score, and radiomics score were independent predictors of AIS outcomes. The area under the ROC curve of the clinical-radiomics model was 0.868 (95% confidence interval, 0.825–0.910) in the training cohort and 0.890 (0.844–0.936) in the validation cohort, which was significantly larger than that of the clinical or radiomics models. The clinical radiomics nomogram was well calibrated (p > 0.05). The decision curve analysis indicated its clinical usefulness. Conclusion: The clinical-radiomics model outperformed individual clinical or radiomics models and achieved satisfactory performance in predicting AIS outcome

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