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Wu Shih-Ching,Hsu Hsueh-Chuan,Liu Mei-Yi,Ho Wen-Fu 한국세라믹학회 2021 한국세라믹학회지 Vol.58 No.1
Hydroxyapatite (HA) has been vigorously studied for orthopedic and dental applications due to its excellent bioactivity, osteoconductivity, and osteoinductivity. This study aims to present a simple room-temperature aqueous precipitation method for obtaining carbonated HA nanoparticles of high purity from biowaste chicken eggshells. Biowaste chicken eggshells were used for preparing HA through aqueous precipitation method. Moreover, mulberry leaf extract was used as a template to regulate the morphology, size, and crystallinity of HA. All produced nanocrystalline HA powders exhibited rod-like particle agglomerates of a size below 100 nm. The HA particles synthesized with the mulberry leaf extract showed higher crystallinity and slightly decreased crystallite sizes compared to the samples prepared without adding the extract. Carbonate peaks observed for the specimens closely matched those of A- and B-type carbonates, which can contribute to the low crystallinity. Notably, the HA synthesized from the eggshell powders contains several important trace elements such as Mg and Sr, which are benefi cial to the overall biological performance as biomaterials. The morphology, size, structure, and composition of the obtained HA products are similar to those of natural bones, and consequently, the products show potential as a material for biomedical applications.
Ka‑Kin Wong,Hsueh‑Chuan Hsu,Shih‑Ching Wu,Wen‑Fu Ho 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.10
In this study, novel nonequiatomic Ti-rich Ti-Zr-Nb-Mo medium-entropy alloys (Ti-MEAs) with a metastable body-centeredcubic structure were designed using Mo equivalent theory ([Mo]eq) for biomedical applications. The Ti65-Zr20-Nb14-Mo1(at%; Ti65-M1) and Ti65-Zr18-Nb16-Mo1 (at%; Ti65-M2) exhibited high yield strength of 1188 and 1118 MPa, respectively. Notably, the moduli of Ti65-M1 and Ti65-M2 were as low as 67.4 and 61 GPa, respectively, which were considerably lowerthan those of commercial biomedical alloys and several biomedical HEAs/MEAs. Transmission electron microscopy imagesindicated that Ti65-M2 reached a metastable state, resulting in a low elastic modulus. Furthermore, the yield-strength-to-elastic-modulus ratios (× 1000) of Ti65-M1 and Ti65-M2 were as high as 17.6 and 18.3, respectively, which were approximatelythree times greater than that of a commercial Ti-6Al-4V ELI implant. This study applied metastable theory for developingtwo metastable Ti-MEAs with low elastic moduli.
Hydroxyapatite prepared from eggshell and mulberry leaf extract by precipitation method
Wu, Shih-Ching,Hsu, Hsueh-Chuan,Hsu, Shih-Kuang,Liu, Mei-Yi,Ho, Wen-Fu Techno-Press 2019 Biomaterials and Biomechanics in Bioengineering Vol.4 No.1
Eggshell is a waste material after the usage of egg. In this work, biowaste chicken eggshells were used for preparing carbonated hydroxyapatite (HA) nanoparticles of high purity through aqueous precipitation method at room temperature. The eggshell-derived HA will be a cost-effective bioceramics for biomedical applications and an effective material-recycling technology. Additionally, mulberry leaf extract was used as a template to regulate the morphology, size and crystallinity of HA, and the effects of pH value were also examined. Characterization of the samples was performed by X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Scanning electron microscopy (SEM) was used to determine the size, shape and morphology of HA. The results indicate that only one phase of HA were synthesized in the both absence and presence of mulberry leaf extract at pH of 7 and above, while DCPD or DCPA/DCPD phase was observed at pH 4 condition. The crystallite sizes of the HA samples obviously decreased when adding mulberry leaf extract as a template, while they decreased gradually as the solution pH levels increased. With increasing pH level from 7 to 14, the rod-like HA nanoparticles gradually changed to spherical shape at pH 14. Note that, the obtained product is Mg and Sr containing A- and B-type carbonate HA at alkaline pH and it can be a potential material for biomedical applications.
Behc¸et의 患者의 單球細胞에서 溫淸飮의 cytokine 分泌抑制 효과
임홍진,황충연,강학천,김남권,권일호 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.4
Behc¸ets disease is a systemic inflammatory disorder. The etiology and pathogenesis of Behc¸ets disease has yet been fully elucidated but might involve immune dysfunction. Cytokines involved in the regulation of inflammatory reactions and immune responses may play a role in the pathogenesis of Behc¸ets disease (BD). Onchungeum is an Oriental herbal medication, which has been successfully used in Korea for the treatment of BD. This report describes modulation effects of Onchungeum on cytokine production from phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) of Behc¸ets patients by ELISA. Onchungeum significantly inhibited the production of pro-inflammatory cytokines, TNF-α and IL-1β, compared to absence of Onchungeum (by 52.3 1.4% inhibition for TNF-α and 113.5 3.3% for IL-1β, p < 0.001). Onchungeum also inhibited the production of IFN-γ, immunoregulatory Th1 cytokine, by 89.4 0.8% (p < 0.001). The inhibitory effects of Onchungeum on cytokine production showed dose-dependent manner, and the pre-treatment of 1㎎/㎖ Onchungeum had better effects than immunosuppressive drug for treatment of BD, cyclosporin A. Our results suggest that Onchungeum treatment for Behc¸ets disease patients may have pharmacologic activities and abilities of regulation of immune and inflammatory responses by cytokine modulation.
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson’s Disease
Hung-Li Wang,Chin-Song Lu,Tu-Hsueh Yeh,Yu-Ming Shen,Yi-Hsin Weng,Ying-Zu Huang,Rou-Shayn Chen,Yu-Chuan Liu,Yi-Chuan Cheng,Hsiu-Chen Chang,Ying-Ling Chen,Yu-Jie Chen,Yan-Wei Lin,Chia Chen Hsu,Huang-Li 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.4
Background and Purpose It is essential to develop a reliable predictive serum biomarker for Parkinson’s disease (PD). Te accumulation of alpha-synuclein (αSyn) and up-regulated expression of Rab35 participate in the etiology of PD. Te purpose of this investigation was to determine whether the combined assessment of serum αSyn and Rab35 is a useful predictive biomarker for PD. Methods Serum levels of αSyn or Rab35 were determined in serum samples from 59 sporadic PD patients, 19 progressive supranuclear palsy (PSP) patients, 20 multiple system atrophy (MSA) patients, and 60 normal controls (NC). Receiver operating characteristics (ROC) curves were calculated to determine the diagnostic accuracy of αSyn or/and Rab35 in discriminating PD patients from NC or atypical parkinsonian patients. Results The levels of αSyn and Rab35 were increased in PD patients. The serum level of Rab35 was positively correlated with that of αSyn in PD patients. Compared to analyzing αSyn or Rab35 alone, the combined analysis of αSyn and Rab35 produced a larger area under the ROC curve and performed better in discriminating PD patients from NC, MSA patients, or PSP patients. When age was dichotomized at 55, 60, 65, or 70 years, the combined assessment of αSyn and Rab35 for classifying PD was better in the group below the cutof age than in the group above the cutof age. Conclusions Combined assessment of serum αSyn and Rab35 is a better biomarker for discriminating PD patients from NC or atypical parkinsonian patients, and is a useful predictive biomarker for younger sporadic PD patients.
In vivo와 In vitro 평가모델을 利用한 韓藥抽出物의 毛髮成長 및 促進에 미치는 實驗的 硏究
강학천,이수형,김남권,임홍진,황충연,Chiang, Hsueh-Chuan,Lee, Soo-Hyeong,Kim, Nam-Kwen,Lim, Hong-Jin,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2
To screen the effective materials for hair loss treatment, several natural extracts were tested using in vivo and in vitro test models. Firstly, all test materials were applicated onto the back skin of C57BL/6 mouse and then hair growth promoting effect was measured using hair growth index. As a result, Prunus mume, black bean, Brassica campestris subsp. black sesame and Rubi Fructus showed potent hair growth promoting effect, ranking as 1.5-2.0 of hair growth index. However, there were no plant extracts, which have remarkable potential of growth promotion of human hair dermal papilla cells cultured in vitro. In the experiments of 5${\alpha}$-reductase type Ⅱ inhibition assay, Prunus mume, Eriobotryae Folium showed effective potential to inhibit the activity of 5${\alpha}$-reductase type Ⅱ. To investigate the possible involvement of the effect of several plant extracts on the gene expression of growth factors in human hair dermal papilla cells, RT - PCR analyses were performed. However, there were no plant extracts, which have profound effect on the gene expression of several growth factors such as IGF-I, KGF, HGF and VEGF in the dermal papilla cells. Another tests for inhibition of microbial such as P. acne were also carried out to find whether these plant extracts have anti -microbial activities. Rubi Fructus showed anti -microbial effects on Propionibacterium acnes, which is believed as a pathogen of acne. Together, these results showed several plant extracts can be used for hair growth promotion.
Robin Jung-Cheng Chen,Hsin-Chih Lin,Yi-Lung Hsueh,Chuan-Chung Hsieh 서울대학교 교육연구소 2020 Asia Pacific Education Review Vol.21 No.4
This study aims to explore relationship between teacher self-efficacy and teacher teaching practice in junior high schools at Taiwan. TALIS (2018) survey database is adopted, and 3106 teachers were analyzed in this research. Through literature review and exploratory factor analysis (EFA), the research model is assumed to include two constructs (classroom management efficacy and instruction efficacy) in teacher self-efficacy, and three constructs (clarity of instruction practice, cognitive activation practice, and classroom management practice) in teacher teaching practice. Through the analysis of Structural Equation Modeling (SEM), the main findings are as follows. (1) For clarity of instruction practice, instruction efficacy has more positive influences than classroom management efficacy. (2) For classroom management practice, classroom management efficacy as more positive influences than instruction efficacy. (3) For cognitive activation practice, instruction efficacy has positive influences but classroom management efficacy has negative influences.