A Neurofeedback Protocol for Executive Function to Reduce Depression and Rumination: A Controlled Study

Sheng-Hsiang Yu,Chao-Yuan Tseng,Wei-Lun Lin 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.3

Objective: Rumination is a maladaptive emotional-regulation strategy that is strongly associated with depression. Impaired executive function can lead to difficulties in disengaging from rumination, thus exacerbating depression. In this study, we inspect an electroencephalograph neurofeedback protocol that enhance the target peak alpha frequency (PAF) activation in the prefrontal region. We examine the protocol’s effects on depression and rumination. Methods: We randomly assigned 30 dysphoric participants into either the neurofeedback training group or the control group. We then evaluated their depression, rumination, and executive function at pre- and posttraining so as to examine the effects of the neurofeedback. Results: The results show that this neurofeedback protocol can specifically enhance participants’ target PAF. The participants’ executive function performances significantly improved after undergoing 20 neurofeedback sessions. Compared with those in the control group, those in the neurofeedback group had significantly fewer depressive symptoms and significantly reduced rumination. Moreover, as target PAF and executive function improved, depression and rumination both declined. Conclusion: Our data are in line with those of previous studies that indicated a relationship between upper-band alpha activity and executive function. This PAF neurofeedback can effectively enhance participants’ executive function, which can reduce rumination and ameliorate depression. This neurofeedback training is based on basic cognitive neuroscience, so it sheds light on depression’s pathological factors and etiology

Enhancement of the Polar Coercive Force for Annealed Co/Ir(111) Ultrathin Films

Wen-Yuan Chan,Du-Cheng Tsai,Wei-Hsiang Chen,Cheng-Hsun-Tony Chang,Jyh-Shen Tsay 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

The alloy formation and the magnetic properties of Co/Ir(111) ultrathin films have been investigated. As the temperature is increased above 400 K, interdiffusion of Co and the Ir substrate occurs. Due to a compositional change in the surface layers, the polar coercive force is greatly enhanced. At temperatures above 600 K, magnetic hysteresis appears only in the polar configuration. Thisshows that the easy axis of the magnetization of Co/Ir(111) may be stabilized in the direction ofthe surface normal by thermal-annealing treatments. From systematic investigations of Co/Ir(111)ultrathin films thinner than 4 monolayers, a magnetic phase diagram has been established. Accordingto the compositional changes and related magnetic properties, the phase diagram can beseparated into three regions. In region I at temperatures below 400 K, Co films are ferromagnetic. In region II where atomic interdiffusion occurs in the surface layers, an enhanced polar coerciveforce is observed. The phase transition from phase I to II is related to the interdiffusion betweenthe Co overlayer and the iridium substrate. In region III for low coverage or at high temperatures,a nonferromagnetic behavior is observed. The phase transition from phase II to III is mainly dueto the reduced atomic percent of cobalt in the Co-Ir alloy and to the lowered Curie temperaturecaused by a reduction in the thickness of the magnetic layers.

Exchange Coupling in FePt/Os/FePt Trilayers

Shih-Yuan Chen,Yeong-Der Yao,Yung-Hsiang Teng,Chin-Chung Yu 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Does the Fit of Managerial Ability with Firm Strategy Matters on Firm Performance

CHENG, Teng Yuan,LI, Yue-Qi,LIN, Yu-En,CHIH, Hsiang-Hsuan Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.4

The study aims to answer why the previous studies find the positive or insignificant effect of the CEO's abilities on firm performance. Using 34,285 CEO-firm-year panel data from the U.S. publicly traded firms drawn from the BoardEx and EXECUXOMP database during from 1992 to 2014, the results show that the fit of the CEO's generality or specialist ability with firm strategy matters on firm performance and risk. This study computes a discrete STRATEGY composite measure to construct firm strategy types, such as Prospect or Defend and use CEOs' résumés to construct an index of general skills that are transferable across firms and industries. The results find that generalist CEOs are more suitable for prospectors than specialist CEOs. Firm performance is much better when specialist CEOs work for Defenders. Although the firm performance is better too for the generalist CEOs who fit for the Prospect strategy, the firm's risk is up too. The result suggests that firms need to consider their chosen business strategy to recruit and select CEOs Our findings provide direct evidence that the match between CEO's ability and the firm's strategy is crucial to firm performance and risk.

VIEKIRA PAK associated drug-induced interstitial lung disease: Case series with systematic review of literature

Yu Jun Wong,Si Yuan Chew,John Chen Hsiang,Prem Harichander Thurairajah,Rahul Kumar,Eng Kiong Teo,Roshni Sadashiv Gokhale,Imran Bin Mohamed Noor,Jessica Tan 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.2

Composite components damage tracking and dynamic structural behaviour with AI algorithm

Z.Y. Chen,Sheng-Hsiang Peng,Yahui Meng,Ruei-Yuan Wang,Qiuli Fu,Timothy Chen 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.2

This study discusses a hypothetical method for tracking the propagation damage of Carbon Reinforced Fiber Plastic (CRFP) components underneath vibration fatigue. The High Cycle Fatigue (HCF) behavior of composite materials was generally not as severe as this of admixture alloys. Each fissure initiation in metal alloys may quickly lead to the opposite. The HCF behavior of composite materials is usually an extended state of continuous degradation between resin and fibers. The increase is that any layer-to-layer contact conditions during delamination opening will cause a dynamic complex response, which may be non-linear and dependent on temperature. Usually resulted from major deformations, it could be properly surveyed by a non-contact investigation system. Here, this article discusses the scanning laser application of that vibrometer to track the propagation damage of CRFP components underneath fatigue vibration loading. Thus, the study purpose is to demonstrate that the investigation method can implement systematically a series of hypothetical means and dynamic characteristics. The application of the relaxation method based on numerical simulation in the Artificial Intelligence (AI) Evolved Bat (EB) strategy to reduce the dynamic response is proved by numerical simulation. Thermal imaging cameras are also measurement parts of the chain and provide information in qualitative about the temperature location of the evolution and hot spots of damage.

Stochastic intelligent GA controller design for active TMD shear building

Z.Y. Chen,Sheng-Hsiang Peng,Ruei-Yuan Wang,Yahui Meng,Qiuli Fu,Timothy Chen 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.81 No.1

The problem of optimal stochastic GA control of the system with uncertain parameters and unsure noise covariates is studied. First, without knowing the explicit form of the dynamic system, the open-loop determinism problem with path optimization is solved. Next, Gaussian linear quadratic controllers (LQG) are designed for linear systems that depend on the nominal path. A robust genetic neural network (NN) fuzzy controller is synthesized, which consists of a Kalman filter and an optimal controller to assure the asymptotic stability of the discrete control system. A simulation is performed to prove the suitability and performance of the recommended algorithm. The results indicated that the recommended method is a feasible method to improve the performance of active tuned mass damper (ATMD) shear buildings under random earthquake disturbances.

Organic Thin-Film-Transistor Arrays for Active-Matrix Display on Flexible Substrate

Cheng-Chung Lee,Hsiang-Yuan Cheng,Jia-Chong Ho,Tarng-Shiang Hu 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.I

Differently from a traditional inorganic transistor, the organic thin-film transistor can be fabricated at low temperature, so we can choose a light, thin, and cheap plastic substrate to replace glass substrate. Here, an organic thin-film transistor (OTFT) has been formed on plastic substrate. An active-matrix back plate with 64 × 128 pixels has been fabricated to drive a TNLCD. We achieved a field-effect mobility of 0.03 cm2/V·s and on/off current ratio of about 105 for the pentacene OTFT on plastic substrate. Besides vacuum deposition, these properties offer potential methods to fabricate OTFT on flat panel displays, such as spin coating, ink-jet printing, and even a roll-to-roll process.

Improved Urothelial Cell Proliferation, Cytoskeleton and Barrier Function Protein Expression in the Patients With Interstitial Cystitis/Bladder Pain Syndrome After Intravesical Platelet-Rich Plasma Injection

Jia-Fong Jhang,Yuan-Hong Jiang,Yung-Hsiang Hsu,Han-Chen Ho,Lori A Birder,Teng-Yi Lin,Hann-Chorng Kuo 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.S1

Purpose: To investigate urothelial cell proliferation, cytoskeleton, inflammation, and barrier function protein expressions in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) after intravesical platelet-rich plasma (PRP) injections Methods: A total of 19 patients with IC/BPS underwent 4 monthly intravesical PRP injections. Bladder biopsies were taken at the first and fourth PRP treatment. The bladder specimens were analyzed using the Western blot and immunochemical staining for progenitor cell markers for sonic hedgehog (Shh), CD34, and cytoskeleton proteins cytokeratin 5 (CK5), CK14, CK20; barrier function markers for zonula occludens-1 (ZO-1), E-cadherin, and intercellular adhesive molecule-1, tryptase and transforming growth factor-β (TGF-β). Global response assessment (GRA) was used to evaluate treatment outcomes. Results: The mean age of patients was 55.6 years. After PRP injections, the functional bladder capacity and maximum flow rate increased, and the visual analogue scale (VAS) of pain, interstitial cystitis (IC) symptom index, IC problem index, O’Leary-Sant symptom score, and GRA improved in all patients. Urothelium Shh, CK5, ZO-1, E-cadherin, and TGF-β expressions increased significantly after repeated PRP injections. By subgrouping, according to PRP treatment outcomes, significant increases in Shh, E-cadherin, and ZO-1 expressions were noted only in patients with GRA ≥1 or improved VAS, but not in patients with GRA=0 and no improvement in VAS. Conclusions: The level of urothelial barrier function protein and cell proliferation protein expression in the patients with IC/ BPS was increased after repeat intravesical PRP injections. Intravesical repeat PRP injections may have potential to improve urothelial health and result in symptoms improvement in the patients with IC/BPS.

Fe3+-binding transferrin nanovesicles encapsulating sorafenib induce ferroptosis in hepatocellular carcinoma

Youmei Xiao,Zhanxue Xu,Yuan Cheng,Rufan Huang,Yuan Xie,Hsiang‑i Tsai,Hualian Zha,Lifang Xi,Kai Wang,Xiaoli Cheng,Yanfeng Gao,Changhua Zhang,Fang Cheng,Hongbo Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibiting the Solute Carrier family 7 member 11 (SLC7A11), with inadequate ferroptosis notably contributing to SOR resistance in tumor cells. Methods To further verify the biological targets associated with ferroptosis in HCC, an analysis of the Cancer Genome Atlas (TCGA) database was performed to find a significant co-upregulation of SLC7A11 and transferrin receptor (TFRC), Herein, cell membrane-derived transferrin nanovesicles (TF NVs) coupled with Fe3+ and encapsulated SOR (SOR@TF-Fe3+ NVs) were established to synergistically promote ferroptosis, which promoted the iron transport metabolism by TFRC/TF-Fe3+ and enhanced SOR efficacy by inhibiting the SLC7A11. Results In vivo and in vitro experiments revealed that SOR@TF-Fe3+ NVs predominantly accumulate in the liver, and specifically targeted HCC cells overexpressing TFRC. Various tests demonstrated SOR@TF-Fe3+ NVs accelerated Fe3+ absorption and transformation in HCC cells. Importantly, SOR@TF-Fe3+ NVs were more effective in promoting the accumulation of lipid peroxides (LPO), inhibiting tumor proliferation, and prolonging survival rates in HCC mouse model than SOR and TF- Fe3+ NVs alone. Conclusions The present work provides a promising therapeutic strategy for the targeted treatment of HCC.