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Effect of Korean Red Ginseng in chronic liver disease
Park, Tae Young,Hong, Meegun,Sung, Hotaik,Kim, Sangyeol,Suk, Ki Tae The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4
Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of Korean Red Ginseng on chronic liver disease, a condition encompassing nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, and hepatocellular carcinoma, as supported by experimental evaluation and clinical investigation.
Effect of Korean Red Ginseng in chronic liver disease
Tae Young Park,Meegun Hong,Hotaik Sung,Sangyeol Kim,Ki Tae Suk 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4
Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of Korean Red Ginseng on chronic liver disease, a condition encompassing nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, and hepatocellular carcinoma, as supported by experimental evaluation and clinical investigation.
Chang Seok Bang,So Hyung Hong,Ki Tae Suk,Jin Bong Kim,Sang Hak Han,Hotaik Sung,Eun Ji Kim,Myoung Jo Kim,Moon Young Kim,Soon Koo Baik,Dong Joon Kim 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.3
Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group (0.37±0.06 ng/ mL, 0.39±0.12 ng/mL, and 0.33±0.07 ng/mL, respectively, vs. 0.88± 0.31 ng/mL; p < 0.05). Interleukin- 1b levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-a level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.
Transarterial chemoembolization in Barcelona Clinic Liver Cancer Stage 0/A hepatocellular carcinoma.
Kim, Heung Cheol,Suk, Ki Tae,Kim, Dong Joon,Yoon, Jai Hoon,Kim, Yeon Soo,Baik, Gwang Ho,Kim, Jin Bong,Kim, Chang Hoon,Sung, Hotaik,Choi, Jong Young,Han, Kwang Hyub,Park, Seung Ha WJG Press 2014 WORLD JOURNAL OF GASTROENTEROLOGY Vol.20 No.3
<P>To evaluate the clinical characteristics of patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 and A hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE).</P>
Effect of Korean Red Ginseng on metabolic syndrome
Sang Jun Yoon,Seul Ki Kim,Na Young Lee,Ye Rin Choi,Hyeong Seob Kim,Haripriya Gupta,Gi Soo Youn,Hotaik Sung,Min Jea Shin,Ki Tae Suk 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.3
Metabolic syndrome (MS) refers to a clustering of at least three of the following medical conditions: high blood pressure, abdominal obesity, hyperglycemia, low high-density lipoprotein level, and high serum triglycerides. MS is related to a wide range of diseases which includes obesity, diabetes, insulin resistance, cardiovascular disease, dyslipidemia, or non-alcoholic fatty liver disease. There remains an ongoing need for improved treatment strategies for MS. The most important risk factors are dietary pattern, genetics, old age, lack of exercise, disrupted biology, medication usage, and excessive alcohol consumption, but pathophysiology of MS has not been completely identified. Korean Red Ginseng (KRG) refers to steamed/dried ginseng, traditionally associated with beneficial effects such as anti-inflammation, anti-fatigue, anti-obesity, anti-oxidant, and anti-cancer effects. KRG has been often used in traditional medicine to treat multiple metabolic conditions. This paper summarizes the effects of KRG in MS and related diseases such as obesity, cardiovascular disease, insulin resistance, diabetes, dyslipidemia, or non-alcoholic fatty liver disease based on experimental research and clinical studies.