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Purpose: To evaluate the relationship between levels of total testosterone and totalprostate-specific antigen (PSA) in healthy men with PSA<4 ng/mL. Materials and Methods: The study comprised 179 men with a mean age of 59.19±12years who visited Osmaniye State Hospital, Osmaniye, Turkey, between January 2006and January 2007 for a routine checkup. The patients were divided into two subgroups:patients with PSA<2.5 mg/ml (group I, n=160 patients) and patients with PSA of 2.5to 4 ng/mL (group II, n=19 patients). The relationship between PSA and testosteronelevels was investigated in both groups and in patients aged <60 years. The mean testosteronelevel was calculated for patients aged <50 years and was compared with themean value of patients aged ≥50 years. Results: In all patients, the mean values for serum PSA and total testosterone were1.27±0.88 ng/mL and 404.04±158.86 ng/mL, respectively. No correlation was detectedbetween serum PSA and testosterone levels in either subgroup (group I, r=0.072,p=0.363; group II, r=0.031, p=0.900) or in patients aged <60 years (r=0.032, p=0.72). The mean values of testosterone in patients aged ≥50 years and in patients aged <50years were 417.01±163.35 and 344.16±120.21 ng/dL, respectively (p=0.02). Conclusions: No impact of testosterone was found on the PSA level in healthy men withPSA <4 ng/mL. Therefore, a high serum testosterone level may not mandate adjustmentof PSA values. This serum sex hormone showed a significant increment after theage of 50 years. Further studies including a larger number of patients should be carriedout to confirm these findings.
Metastatic malignant melanoma of the prostate is extremely rare in clinical practice,and only one case has been reported in the English literature in the past 30 years. We report a case of malignant melanoma that metastasized to the prostate and review the current literature. A 50-year-old man with a history of malignant melanoma metastasis to the left axilla, which was excised 3 years ago, presented with lower urinary tract symptoms and gross hematuria. He underwent cystoscopy and transurethral resection of the prostate. The pathological examination showed metastatic malignant melanoma of the prostate gland. The patient died 6 months after the transurethral resection.
Purpose: Ischemic priapism, a compartment syndrome, requires urgent treatment in order to nourish the corpora cavernosa. As the first step, aspiration of blood and irrigation of the cavernosal bodies is performed to prevent fibrotic activity and secure erectile capability. During aspiration, there are risks of cardiovascular side effects of adrenergic agonists. We aimed to evaluate a transient distal penile corporoglanular shunt technique in place of aspiration and irrigation techniques for treatment of early ischemic priapism. Materials and Methods: A transient distal penile shunt was applied to 15 patients with early ischemic priapism between January 2011 and May 2012. Priapism duration, history,causes, pain, and any prior management of priapism were assessed in all patients. A complete blood count and penile Doppler ultrasonography were performed, which showed attenuated blood flow in the cavernosal artery. A sterile closed system blood collection set, which has two needles and tubing, was used for the transient distal penile shunt. Results: Ten of 15 patients with early ischemic priapism were successfully treated with this transient shunt technique. No additional procedures were needed after the resolution of rigidity in the 10 successfully treated patients. Conclusions: The transient nature of this technique is an advantage over aspiration and irrigation in the treatment of early ischemic priapism. Our results indicate that the technique can be offered for patients with an ischemic priapism episode of no more than 7 hours.