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Hyperresponsiveness to Boiled Egg Yolk in Early Life Leads to Prolonged Egg Allergy
Satoshi Horino,Hiroshi Kitazawa,Taiki Satou,Katsushi Miura 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.3
Hen's egg is the most common allergen in IgE-mediated food allergy among children in Japan. Although the majority of patients with egg allergy can eat heated egg yolk safely because of its low allergenicity, severely allergic patients show an immediate-type reaction to heated egg yolk. We hypothesized that patients with hyperresponsiveness to boiled egg yolk may have difficulty in acquiring tolerance to egg. The purpose of this study was to examine the prognosis of patients with hyperresponsiveness to boiled egg yolk. Data from 121 patients with egg allergy who underwent oral food challenge (OFC) with boiled egg yolk between January 2012 and December 2013 were analyzed retrospectively. The proportion of patients who could consume heated whole egg 3 years after OFC was 15.4% in the OFC-positive group and 75.8% in the OFC-negative group. Hyperresponsiveness to boiled egg yolk in early life might lead to prolonged egg allergy in children. This finding might aid in the selection of an appropriate population requiring practical immunotherapy.
Sadao Horino,Midori Mori,Naoyuki Kubota,Shunsuke Gennai,Kazutaka Kogi 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
Conditions relating to universal design of the historic tourist areas around the JR Kita-Kamakura Station were studied in order to develop a barrier-free road map for wheelchair visitors. On the average, about 18,000 passengers were utilizing the station per day. Access conditions of the station facilities including means of using the platforms and toilets were examined in cooperation with wheelchair passengers. Access conditions of shops along a 1.8 km-long main streets leading to the station were examined in terms of road-floor height differences, and entrance and aisle widths, road signs and toilets. For the station, the need was suggested for providing a lift for reaching the platform and a multi-purpose toilet. Of 70 shops along the street, only 23% had the road-floor height difference of 2cm or less, 31% that of 3-6cm and 46% that of 7cm or more. The entrance width of 90cm or more was cleared by 41% and the aisle width of 90cm or more by 44% of the shops. Thus, 36% of the shops were evaluated to be accessible for wheelchair users. There were few multi-purpose toilets available along the street and an insufficient number of road signs for tourist routes. It was suggested that the rate of wheelchair-accessible shops would increase substantially by eliminating road-floor differences and that there was an urgent need for improving the accessibility for wheelchair visitors in terms of the station facilities, road signs and toilets. On the basis of these results, a road map describing barrier-free conditions for wheelchair visitors was designed and published. It was found useful together with barrier-free maps previously offered for other tourist routes of the city.
Mori Mori,Sadao Horino,Yuji Inomata,Hiroki Sasayama,Yuko Hirota 대한인간공학회 2007 대한인간공학회 학술대회논문집 Vol.- No.-
In Japan, Quarter-million crossing collisions at intersections accounted for one-fourth of the total accidents in 2005. Three-fourths of collisions took place at urban intersections, more than half of them occurred at uncontrolled intersections. Risks of crossing collisions depend on the quality of visual environment at intersection. This study aimed to assess the legibility and effectiveness of 23 traffic convex mirrors installed at 10 urban intersections, after the road management authority inspected and repaired. The legibility of mirror was assessed by means of the photographs of each mirror taken from the drivers’ viewpoint at a legal stop line, entering from the lower priority direction. “Three ergonomics requirements” suggested by the authors were used as the criteria of legibility assessment; (1) Position of road lane, (2) Blind area and (3) Road surface markings. Combining these 3 criteria, the comprehensive assessment of mirror was indicated in 2-grade scale, such as “Good” or “Poor”, namely so dangerous to be improved. A field assessment revealed that 11 among 23 mirrors were still improperly installed. However, simulation analysis showed that 7 among 11 poor mirrors could be improved by adjusting the angle of mirror plate or displacing mirror plate/poles. In conclusion, the present official guideline in regard with installing mirror should be revised to add newly “three ergonomics requirements” for preventive safety. Application of these new guidelines in practice, a typical low-cost and low technology-oriented improvement to reduce crossing collisions, was highly recommended.
전병선(Byeong-Seon Jeon),양재원(Jai-Won Yang),박채규(Chae-Kyu Park),고성룡(Sung-Ryong Ko),掘野俊郞(Toshiro Horino),손종록(Jong-Rok Son),박원종(Won-Jong Park) 한국식품영양과학회 1993 한국식품영양과학회지 Vol.22 No.5
인삼의 재배년근별, 국내산지별 및 국가별 무기물의 분포를 조사하기 위하여 시험한 결과 Mn은 2년근에 비하여 5년근에서 4배 가까운 증가추세를 나타내었다. 재배산지별로 볼 때 P은 각 지역별로 큰 차이를 나타내지 않았다. 한편 각국 인삼별로는 중국 전칠삼에서 N의 함량이 적게 나타났으며 P은 한국산 정상흥삼에서 높게 나타났다. Mineral compositions in various ginseng, which was grown in different region, different age, were analyzed by atomic absorption spectrophotometer. Mn^(++) content in ginseng of five years old was four times higher than that of two years old, suggesting that the amount of Mn^(++) would be increased as they are cultivated. The content of phosphate in the various ginseng did not show much difference, whereas that of Ca^(++), Mn^(++) did. Korean red ginseng revealed much higher in Mn^(++) content than that of others investigated. When the amount of N was compared, San Chi, Chinese ginseng was significantly lowered. Korean red ginseng of 100g contains highest phosphate ion of 328.3㎎.