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Hongming Wu,Dinghong Xu,Ying Zhou,Chengtao Gao,Jianbing Guo,Weidi He,Yong He,Shuhao Qin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.9
Natural fibers reinforced composites (NFCs) have renewable and low cost advantages. In this paper, the tung oilanhydride (TOA) modified polypropylene (PP)/hemp fiber composites have been prepared by a melt-blended process. Thereaction between the tung oil anhydride and the as-treated hemp fiber make the TOA molecules to accumulate on the surfaceof hemp fiber and to form a TOA layer on the surface of hemp fibers, which is confirmed by the FT-IR and SEM analyses. The TOA layer improves the compatibility between PP matrix and hemp fibers. The elongation at break (EB) and impactstrength of the PP/hemp fiber/TOA composites are twice more than the PP/hemp fiber composites. Thermal analysis showsthe Toneset and Tmax of the composites increasing that reflects the thermal stability of the composites improved. The crystallineproperty reveals that the Tc moves to high temperature with the TOA or hemp fiber added in the blends. The DMA andrheology properties analysis indicate that the TOA layer improved molecular mobility of the composites and show a shearthinning effect.
Hongming Lv 대한수의학회 2023 Journal of Veterinary Science Vol.24 No.1
Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4°C) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.
( Hongming Song ),( Dengfeng Li ),( Tianqi Wu ),( Dan Xie ),( Kaiyao Hua ),( Jiashu Hu ),( Xiaochong Deng ),( Changle Ji ),( Yijun Deng ),( Lin Fang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.11
Aberrant expression of microRNAs (miRNAs) plays important roles in carcinogenesis and tumor progression. However, the expression and biological role of miR-301b in triple-negative breast cancer (TNBC) remains unclear. Here we aimed to evaluate the roles and mechanisms of miR-301b in TNBC cells. miR-301b expression was assessed in TNBC specimens and cell lines by quantitative Real-Time PCR (qRT-PCR). TNBC cells were transfected with miR-301b mimics, inhibitors or Cylindromatosis (CYLD) small interfering RNA (siRNA) using Lipofectamine 2000. The functional roles of miR-301b were determined by cell proliferation, colony formation, and apoptosis assays. Western blots and qRT-PCR were used to measure the expression of mRNAs and proteins in the cells. We found that miR-301b was upregulated in TNBC specimens and cell lines. Overexpression of miR-301b promoted cell proliferation in TNBC cells, while inhibited the apoptosis induced by 5-FU. CYLD was downregulated by miR-301b at both mRNA and protein levels in TNBC cells. Dual-luciferase report assay confirmed that miR-301b downregulated CYLD by direct interaction with the 3’-untranslated region(3’-UTR) of CYLD mRNA. NF-κB activation was mechanistically associated with miR-301b-mediated downregulation of CYLD. However, inhibition of miR-301b reversed all the effects of miR-301b. In conclusion, miR-301b plays an oncogenic role in TNBC possibly by downregulating CYLD and subsequently activating NF-κB p65, and this may provide a novel therapeutic approach for TNBC. [BMB Reports 2018; 51(11): 602-607]
VGLL4 interacts with STAT3 to function as a tumor suppressor in triple-negative breast cancer
Hongming Song,Qifeng Luo,Xiaochong Deng,Changle Ji,Dengfeng Li,Amik Munankarmy,Wei Jian,Junyong Zhao,Lin Fang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Triple-negative breast cancer (TNBC) is an aggressive malignancy with a poor prognosis, and there are no effective molecular-targeted drugs for TNBC patients in clinical practice. The JAK-STAT pathway is implicated in tumorigenesis and the progression of various cancers. In this study, the results demonstrated that VGLL4 is expressed at low levels in both TNBC specimens and cell lines and that VGLL4 expression is negatively correlated with Ki67 expression and tumor size in TNBC patients. VGLL4 knockdown can promote the growth of TNBC cells, while VGLL4 overexpression significantly suppresses the growth of TNBC cells in vitro. More importantly, VGLL4 significantly inhibits tumor progression in a nude mouse model. In addition, VGLL4 is a direct target of miR-454, and the upregulation of miR-454 decreases VGLL4 expression and promotes the cell growth of TNBC cells. Furthermore, we also demonstrated that VGLL4 interacts with STAT3, the core component of the JAK-STAT pathway, leading to the inactivation of STAT3 and the inhibition of STAT3 downstream transcription. Collectively, these findings indicate that VGLL4 expression is negatively associated with poor prognosis in TNBC patients. High expression of miR-454 may be one of the causes of the downregulation of VGLL4 in TNBC, and VGLL4 acts as a tumor suppressor in TNBC by interacting with STAT3 and subsequently suppresses the STAT3 signaling axis, providing potential biomarkers and therapeutic approaches for this fatal disease.
Hongming Li,Yumei Qiu,Mengdie Xie,Changsheng Ouyang,Xiaoyun Ding,Hao Zhang,Wei Dong,Yinhua Xiong,Xilan Tang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.1
This study aimed to observe the protective effect of momordicine I, a triterpenoid compound extracted from momordica charantia L., on isoproterenol (ISO)-induced hypertrophy in rat H9c2 cardiomyocytes and investigate its potential mechanism. Treatment with 10 μM ISO induced cardiomyocyte hypertrophy as evidenced by increased cell surface area and protein content as well as pronounced upregulation of fetal genes including atrial natriuretic peptide, β-myosin heavy chain, and α-skeletal actin; however, those responses were markedly attenuated by treatment with 12.5 μg/ml momordicine I. Transcriptome experiment results showed that there were 381 and 447 differentially expressed genes expressed in comparisons of model/control and momordicine I intervention/model, respectively. GO enrichment analysis suggested that the anti-cardiomyocyte hypertrophic effect of momordicine I may be mainly associated with the regulation of metabolic processes. Based on our transcriptome experiment results as well as literature reports, we selected glycerophospholipid metabolizing enzymes group VI phospholipase A2 (PLA2G6) and diacylglycerol kinase ζ (DGK-ζ) as targets to further explore the potential mechanism through which momordicine I inhibited ISO-induced cardiomyocyte hypertrophy. Our results demonstrated that momordicine I inhibited ISO-induced upregulations of mRNA levels and protein expressions of PLA2G6 and DGK-ζ. Collectively, momordicine I alleviated ISO-induced cardiomyocyte hypertrophy, which may be related to its inhibition of the expression of glycerophospholipid metabolizing enzymes PLA2G6 and DGK-ζ.
STRUCTURAL DESIGN PROCESS OF TRANSDISCURSIVE AUTEUR
Henry Hongming Kim 한국디자인학회 2015 한국디자인학회 학술발표대회 논문집 Vol.2015 No.10
The aim of this paper is theorizing the structural process of design, designification based on strong philosophies about the true value and role of design and designers in 21C. The proposed system is not a proclamation of a singular truth, but rather an analysis and convergence of multiple discourses. As designers, we must consider our role in this process more critically; we must broaden our scope of knowledge, and develop a clear theoretical understanding of what it means to communicate and how it needs to be done.
Zhang Hongming,Liu Chengcheng,Zhang Shiwei,Wang Youhua,Lei Gang,Zhu Jianguo 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.6
This paper proposes an axial–radial flux hybrid excitation permanent magnet eddy current coupling (HE-PMEC), where the ferrite magnet is employed for producing the radial flux and the DC excitation current is adopted for producing the axial flux. Moreover, a shielding layer is developed to regulate the radial magnetic field. Its magnetic field distribution, electromagnetic performance, and temperature distribution are calculated based on the 3D finite element method (FEM). By adjusting the applied DC excitation current density and the insertion depth of the shielding layer, the variable current starting process, the variable current braking process, and the speed regulation characteristic of the proposed HE-PMEC are obtained. It can be seen that the starting process, braking process, and speed regulation ability of the HE-PMEC have been enhanced greatly. Furthermore, the copper ring shape of the HE-PMEC is optimized by using the proposed improved multilevel optimization method. It can be seen that the performance of the HE-PMEC can be improved by using the new optimized copper ring shape. Lastly, compared with the conventional PMECs, the proposed HE-PMEC has shown its superior electromagnetic performance.
Novel assessment method of heavy metal pollution in surface water
Yingran Liu,Hongming Yu,Yu Sun,Juan Chen 대한환경공학회 2017 Environmental Engineering Research Vol.22 No.1
The primary purpose of this research is to understand those elements that define heavy metals contamination and to propose a novel assessment method based on principal component analysis (PCA) in the Yangping River region of Lingbao City, China. This paper makes detailed calculations regarding such factors the single-factor assessment (Pi) and Nemerow’s multi-factor index (PN) of heavy metals found in the surface water of the Yangping River. The maximum values of Pi (Cd) and Pi (Pb) were determined to be 892.000 and 113.800 respectively. The maximum value of PN was calculated to be 639.836. The results of Pearson’s correlation analysis, hierarchical cluster analysis, and PCA indicated heavy metal groupings as follows: Cu, Pb, Zn and As, Hg, Cd. The PCA-based pollution index (Pαn) of samplings was subsequently calculated. The relative coefficient square was valued at 0.996 between Pαn and PN, which indicated that Pαn is able to serve as a new heavy metal pollution index; not only this index able to eliminate the influence of the maximum value of Pi, but further, this index contains the principal component elements needed to evaluate heavy metal pollution levels.
Shaoyu Li,Hongming Huang,Li-Chuan Tsai 한국재무학회 2012 한국재무학회 학술대회 Vol.2012 No.09
The main purpose of this paper is to derive the analytic valuation formulae of xed range accrual notes (FiRAN) and oating range accrual notes (FlRAN) in the context of an a¢ ne term-structure model incorporating stochastic long-run mean, stochastic volatility and jumps according to the empirical ndings of An- dersen et al.(2004). We propose a quasi-analytic pricing and hedging solutions for range accrual notes and these solutions are demonstrated in sensitivity analysis. Our numerical results show all these three factors signi cantly a¤ect the values and hedging strategies of range accural notes, and the factor of stochastic mean plays the most important role in either valuation or hedging.
Lei Zhang,Hongming Xu,Chunsheng Pu,Guangyu Yuan,Guangyao Leng,Chunlei Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
In order to increase the economic efficiency of conformance control in the time of low oil price, a gelant should be injected into the specified location (positioning conformance control) to improve the swept volume in the maximum extent in the heterogeneous oil reservoir. For this purpose, an in-situ crosslinking polymer gelant (it is consisting of modified starch, acrylamide, N, N'- methylene diacrylamide, and potassium persulfate) is taken as the object of study by CT scan. Based on the dynamic and visible images of fluids distribution in the porous media, the gelant can be used to achieve the positioning conformance control because it can almost maintain a whole slug during transportation in porous media. According to the relationship of transportation distance and injection volume of the gelant in porous media, the gelant can be displaced to the specified location in porous media. In addition, the characteristics of water flooding of heterogeneous porous media before and after positioning conformance control are studied by CT scan, which can investigate the function of positioning conformance control and the extent of improving the swept volume in the heterogeneous reservoirs. The experimental results in this paper can provide theoretical guidance for the practical application of positioning conformance control in the heterogeneous oil reservoirs.