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Solar urticaria in Korean patients
( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.
Hong‑Jai Lee,Bo‑Young Shin,Jae‑Seung Moon,Ailyn Fadriquela,Selikem Abla Nuwormegbe,Chun‑Chang Ho,Jin‑Su Shin,Jee‑Sang Yoon,Sang‑Kyou Lee,Soo‑Ki Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3
Background Lack of universal replication system for hepatitis B virus with narrow host range and organ tropism has hampered to uncover the pathogenesis of HBV. Previously, we reported the essentiality of humoral milieu and its components toward HBV and hepatitis C virus survival/viability in vitro. Of these components, the precise role of enterohepatic humoral milieu such as bile acid (BA) on HBV cultivation in vitro and in vivo is unknown. Objective We explored whether BA, specifically taurochenodeoxycholic acid (tCDCA) would directly regulate the viral DNA and surface antigen expression of HBV in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. Result We found that higher concentration of taurochenodeoxycholic acid (tCDCA) is able to preserve the genomic stability of HBV in cell-free DMEM, showing higher the surface antigenicity than taurocholic acid (tCA). In line, we found that in vitro cell culture condition (100 μmol/L of tCDCA coupled with 1 × 108 g e/mL HBV) would be optimal for HBV entry into target cells. Using this, human (HepG2, Huh7), and rodent (Hepa1c1c7, H4-II-E) hepatoma cell lines were infected by HBV, as evidenced by the presence of HBV biomarkers (HBsAg, and HBV DNA in culture supernatant, as well as HBcAg in cell). Further, cellular entry test revealed that HBV is able to infect 12 different non-hepatic cell lines regardless of species, and organ/tissue, consequently reproducing progeny as confirmed by HBV biomarkers. Last, reinfection test showed that the progenies of HBV from immortalized HepG2, and Hepa1c1c7 cells are able to enter into each or vice versa naïve HepG2, and Hepa1c1c7 cells with or without BA. Conclusion This study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.
한국 고등학교 학생들의 환경문제 및 환경교육에 대한 인식 연구
홍수미,성효현 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-
The purpose of this study is to develop guiding priciples of the environment education in high school geography courses through the search for the consciousness of the matter of environment and environment education on the part of high school students. The method of questionaire is taken up for the inquiry. The subjects of this inquiry include 260 students in Seoul,the metropolice, 150 students in an industrial city, Incheon, 60 in a small and medium sized city, Choon-chun, and 60 in a farming community. The investigation into the consciousness of environment iclude the degree of environmental interest, the degree of virtual contamination in the inhabited regions, general knowledge of environment, and the policy of environment. The investigation into the environment education comprises general environment education, environment education in geography class, teaching methods in environment education, and thepractice of environment education and the preservation of environment. The guides at which should be aimed in environment education in every situations and geography class are as follows. At first, the environment education should be done, with the awarness of respective regional aspects; the awarness of virtual degree of contamination and the cause of environmental pollution vary in every situation. Secondly, despite of high awarness of the degree of interest in the matter of environment and environment education, the degree of awarness of term, representing the amount of environmental pollution, and of the government's policy toward environment is somewhat low. The majority become aware of the necessity of environment preservation and the environment-related information chiefly by mean of mass media, so the reinforcement of environment education toward these area is required through formal environmental education. Thirdly, the students emphasize on active participation in theactivities, in which are at the formation of the pleasant environment. In view of their inactive participation in environment preservation at home and in and out their campuses after school, the greatest emphasis should be put on the practical aspects of life with ecological understanidng of relationship between human and environment for the purpose of practice of environment education in every day life. Fourth, the current curriculum should be shifted from the emphasis on individual phenomenon and individual cases to those of multiple phenomena and materials dealing with common environmental issues. The field of study in class should be emphasized not only their own inhabitation areas but also other areas, which will help enhance the abilites to think in a comprehensive way and to make their decisions in a reasonable way. Finally, the use of multimedia including photographs, maps, tables, and statistic data, is required in environment education in geographic class, in addition to these, the use of a variety of audio-visual aids and a variety of new teaching method are recommended.
교합 및 심리적 요소와 측두하악관절내장증 발현과의 관계
홍수민,김재형,김병국 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.3
Background : The aim of this study was to investigate the relationship between temporomandibular dlsorder and occlusion, emotional factor. Through this study, it attempted to provide proper recognition of diagnosis and therapy of temporomandibular disorder. Methods: A total of 154 subjects with permanent dentition were included in this study. Internal derangement without reduction(n=82) were selected as experimental group and symptom-free subjects(n=72) were included as control group by means of clinical examination, radiographic examination and questionnaire. Investigation of morphological occlusion in each group and SCL-90-R questionnaire was performed to compare both groups Results: It was found that internal derangement without reduction was more prevalent in the individuals who have some occlusal features of open bite and deep bite. In SCL-90-R analysis, it had been observed significant relation between 5 indices(SOM,0-C. DEP, ANX, PAR) and internal derangement. And DEP. ANX,0-C were more prevalent to female than male in experimental group. Conclusion : There was significant correlation between some occlusal variables(open bite. deep bite) and internal derangement of TMJ. Some emotional factor(DEP. ANX,0-C. PAR) was found to be related to internal derangement. Female seemed to be affected by emotional factors more than male as well.
홍수민;박경식;박일권;손형래;구호석;고행일 인제대학교 2011 仁濟醫學 Vol.32 No.-
Hepatitis A is a mild, self-limiting disease of the liver, critical complications of which, such as acute kidney injury, are rare. Two cases of patients with acute hepatitis A who had an acute renal failure complication are reported herein. The first case is that of a 30-year-old man who showed up at the author’s hospital complaining of fever and myalgia. His laboratory tests upon his admission showed 9,520 lU/L of aspartate transaminase, 5,600 lU/L of alanine transaminase, 31.9 mg/dL of blood urea nitrogen, and 5.5 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. Upon his admission, supportive treatment was started, which included fluid therapy. The laboratory tests on the next day showed 53 mg/dL of blood urea nitrogen, 9.9 mg/dL of creatinine, and lower urine output per day. Renal replacement therapy was performed only once. A renal biopsy was performed and the result was Acute Tubular Necrosis (ATN). The patient recovered from acute renal failure without sequela. In the second case, a 35-year-old man complained of fever and abdominal pain. His laboratory tests upon his admission showed 8,570 lU/L of aspartate transaminase, 4,510 lU/L of alanine transaminase, 16 mg/dL of blood urea nitrogen, and 1.19 mg/dL of creatinine, and he was positive for the Anti-HAV IgM antibody. He experienced acute renal failure and recovered after two-time renal replacement therapy. The result of the renal biopsy was Acute Tubular Necrosis and C1q nephropathy.
진행성 폐 종양 환자에서 종양 내 OK-432 주입술의 효과
정수현,김성빈,박진희,탁희상,옥철호,장태원,정만홍,천봉권 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2
Background: Intratumoral injection of OK-432 produced significant antitumor effects. There are reports that OK-432 was injected directly into tumor tissue on gastrointestinal tracts and HCC tissue, producing decrease in serum alpha-fetoprotein level. We adopted this technique for treating locally advanced lung cancer. The object of this study is to evaluate the local therapeutic efficacy, side effects of injection for treating symptomatic mass. Methods: Twenty lung cancer patients (13 males and 7 females) underwent sonography guided OK-432 injection. We analyzed relationships between response of OK-432 and response of skin test, histology and age. Pain that patients feel was evaluated by VAS (Visual Analog scale). Results: A significant decrease of tumor size was observed. The mean pre-injection diameter of the lesions was 54.7±11.3mm, PR rate were 15.0% (3/20) and minimal change (50%<tumor size decreased.) patients were 35.0% (7/20). The VAS score before injecting OK-432 into the lesion was 5±3, this was decreased to 2.5±1.5 (p=0.04). Object response was significantly correlated with skin response, adenocarcinoma, and age. Conclusion: A significant decrease of tumor size and pain was observed. So OK-432 is a valuable treatment option for patients with symptomatic lesion from advanced lung cancer who are not amenable to further therapy.
협동 미술활동이 유아의 사회·정서적 발달에 미치는 영향
홍순옥,정수금 부산유아교육학회 2003 유아교육논총 Vol.12 No.-
본 연구는 유아교육현장의 여러 활동 중에서 유아의 사회·정서적 발달과 관계가 깊은 협동 활동의 중요성과 필요성을 이해하며 협동활동으로서의 가치와 활용도가 높다고 보여지는 미술활동이 사회·정서적 발달에 긍정적인 효과가 있는지를 검증하는 것을 목적으로 한다. 이에 부산광역시 소재 H유치원 유아 68명을 대상으로 실험집단과 비교집단으로 나누어 실험연구를 하였으며 그림책을 활용하여 13회의 협동미술활동을 실험집단에게 실시하였다. 그 겨로가 협동 미술활동이 유아의 사회·정서적 발달에 긍정적인 영향을 미친다는 것이 검증되었다. 즉 사회·정서적 발달의 하위요인인 교사에 대한 비 의존성, 내적 통제, 또래와의 상호작용, 유치원에서의 안정감, 성취동기, 호기심의 6개 하위 요인에 있어 협동미술활동이 긍정적인 영향을 미쳤다. The purpose of this study was to investigate the effects of cooperative art activities young children’s social and emotional development. Subjects of this study were 68 five-year-old kindergarten children(36 boys and 32 girls) attends the kindergartens in Busan. Their everage age was 5 years and 11 months. Two instruments used in this study were the Thirteen Cooperative Art Activities Programs and the Mun’s (1987) Rating Scale for Young Children’s Social·Emotional Development, a revised version of Korean Institute for Research in the Behavioral Sciences’s (1978) Scale. Experimental and control groups’ scores of social and emotional development scale were obtained from the collected data, and then the scores were analyzed with t-test to confirm research questions. Results of this study were as follows: First, there were significant positive affect of experimental group children’s social-emotional development according to cooperative art activities experience. Second, there were significant positive affect of experimental group children’s independence on teacher(internal control, interaction with peers, sense of security in kindergarten, achievement motive, curiosity) according to cooperative art activities experience.
홍성관,오수일 江原大學校附設體育科學硏究所 2004 江原大學校附設體育科學硏究所論文集 Vol.- No.27
This research has an goal to offer useful materials for beginner Judo players who are middle&high school students and coaches. Furthermore, it has an prupose to analyze using technique during matches which men Judo players who are high school students and I present research question like this. I established with research question that first, difference of each weight players who use technique, second, difference of using technique about players who won a prize, players who didn't win a prize. I would like to notice this researfh's investigative subject that the 3rd Tamragi Judo contest, the 32nd national Judo league of springtime, YMCA Judo contest etc. In addition, I made an object participated 294 players who are high school students for 2003∼2004 season. I also analyzed contest recorded paper which Korea Judo association, research assistant practiced video tape and I made an check paper by myself. I used χ^(2)verification for statical method, I made notice level is α=.05. I made an conclusion with research method & procedure like this. First, it showed an order Ashi-waza, Te-waza, Koshi-waza, Renraku-waza, which total tried 811 times technique in all weight. Second, it showed an order Daki-age, Seoinage, Harai-goshi, Uchi-mata in detail technique otherwise most few used technique was Yoko-guruma. Third, it showed the difference of each weight which showed an order Ashi-waza, Te-waza in -55kg, -66kg, - 77kg, Ashi-waza, Koshi-waza in -90kg, -100kg,+100kg. So it means the difference of using technique between light weight player and heavy weight player. Fourth, it showed the difference of technique of players who won a prize that showed an order Renraku-waza, Daki-age, Uchi-mata, Seoinage, Osaekomi-waza.
수학교과 수준별 교수-학습 자료에서 MathML과 XSLT의 활용
홍은표,이수현 한국수학교육학회 2003 수학교육 Vol.42 No.5
In this paper, we propose an authoring methodology of differentiated instruction-learning materials in mathematics course using MathML and XSLT, and give utilizing suggestions of these materials as differentiated textbook and individual learning. Incorporation MathML into instruction-learning materials, there are many advantages such that view of the materials in web browser is improved since mathematical expressions are compatible with text, and an expression can be modified in more convenient way since the expression is represented in text format not an image. In authoring of differentiated materials, the author provides one document for various levels of materials is generated from the document via XSLT transformation. This enables author-driven progress control rather than student-driven which does in previous approaches, since students don't need to select components of the material.