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      • KCI등재

        황기桃紅湯이 Endotoxin으로 유발된 白鼠의 血栓症에 미치는 영향

        田炳薰,李鎭弘,鄭鉉雨,禹元洪,鄭遇悅 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

        연구배경 : 최근의 死亡率중에 腦血管系疾患이 차지하고 있는 比率이 대단히 높기 때문에 氣와 血의 이론적 관계인 "氣爲血之帥, 氣行則血行." 의 관점하에서 腦血管系疾患중의 하나인 血栓病을 동의학적 병리론에 의거하여 "瘀血"의 범주에 속할 것으로 사료되기 때문에 補氣之劑인 황기를 君藥으로하고 活血祛瘀之劑인 桃仁과 紅花를 加하여 실시하기로 하였다. 그리하여 본 연구가 임상에서 血栓症治療에 應用할 수 있는지를 考察하고, 작게는 東醫學 發展의 이론적 뒷받침이 되었으면 하는 바램에서 시행하였다. 방법 : 황기도홍탕이 1첩분량(318.75g)을 100ml로 減壓濃縮하여 0.2mg/kg의 endotoxin을 試料投與 1시간 후에 白鼠의 尾靜脈에 注入하고 4시간이 경과되면 urethane 痲醉下에서 心臟採血 하였다. 결과 : 血小板數와 FDP는 對照群에 비하여 增加 또는 減少되었지만 有意性은 나타내지 않았다. 그러나 prothrombin time과 fibrinogen량은 對照群에 비하여 有意性있게 短縮 또는 增加하였다. 결론 : 황기도홍탕이 endotoxin으로 誘發된 白鼠의 血栓症에 미치는 影響은 有意한 것으로 나타났다. 그렇기 때문에 黃?桃紅湯이 腦血管疾患 뿐만 아니라 瘀血性疾患에 임상적으로 응용하면 보다 높은 치료효과를 거두리라 思料된다 This study was performed to investigate the effect of Whangkidohongtang(황기도홍탕) on the intravascular coagulation induced by endotoxin in rats. The intravascular coagulation was induced by injecting endotoxin in the caudal vein of rats. And these rats were treated with extract of Whangkidohongtang(황기도홍탕)1.0ml/200g (GroupⅠ) and Whangkidohongtang(황기도홍탕) 2.0ml/200g (groupⅡ), which were administered orally. Then, the number of blood cells, platelets, concentration of prothrombin time, fibrinogen and FDP(fibrin-fibrinogen degradation products) were measured. The following results were obtained : 1. The number of platelets increased in the GroupⅡcompared with the control group, but it is not significant. 2. The prothrombin time was shortened significantly in the GroupⅡcompared with the control group. 3. The concentration of fibrinogen increased significantly in the trial group compared with the control group. 4. The degree of concentration of FDP decreased significantly in the trial group compared with the control group, but it is not significantly. According to the above results, it is considered that Whangkidohongtang(황기도홍탕) has the significant effects on thrombosis. Therefore, Whangkidohongtang(황기도홍탕) seems to be applicable to the diseases related to thrombosis.

      • 글루콘산 생산을 위한 최적 배양조건

        홍성란,이현절,정봉우,김춘영 全北大學校 1995 論文集 Vol.39 No.-

        The production of gluconic acid by Aspergillus niger KCTC 2119 was studied. The Optimal culture conditions, such as initial pH, temperature, inoculum size and medium composition were established. Maximum overall gluconic acid productivity, 0.13g/L · hr was obtained when the cultivation was carried out at 33℃ and initial pH 5.5 for 72 hrs, with medium containing 110g/L glucose, 0.5g/L (NH_4)_2SO_4, 0.2g/L KH_2PO_4, 1.0g/L MgSO_4·7H_2O, and 0.1g/L corn steep liquor. The metabolic parameters such as specific growth rate, cell and gluconic acid yields were estimated for process improvement.

      • 에어컨 냉각 팬용 브러쉬레스 DC 전동기의 역기전력 분석에 대한 연구

        조정현,김지현,정정원,황흥식,이치우 경성대학교 공학기술연구소 2012 공학기술연구지 Vol.18 No.-

        Compared to conventional dc motors having the combination of commutators and brushes, a brushless DC (BLDC) motor is one of the highly efficient motors due to its electrical commutation without a brush, and this feature allows the BLDC otor to be more suitable for an application requiring no maintenance due to mechanical wear between a commutator and a brush. Also, the BLDC motor has a few benefits over both a dc motor and an induction motor such as high dynamic response, high efficiency, logn life span, and low noise in wide speed-torque region. This paper investigates the variation of voltage induced in phase windings in a BLDC motor in several cases with respect to stack length, steel grade, and coil material. This study is numerically conducted and it is verified from the theoritical point of view by comparing the result of simulation with that of experimental measurement.

      • DSPs(TMS320C50)을 이용한 로봇 매니퓰레이터의 견실제어

        이우송,김종수,김홍래,한성현 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

        In this paper, it is presented a new scheme of adaptive-neuro control system to implement real-time control of robot manipulator. Unlike the well-established theory for the adaptive control of linear systems, there exists relatively little general theory for the adaptive control of nonlinear systems. Adaptive control technique is essential for providing a stable and robust performance for application of robot control. The proposed neuro control algorithm is one of learning a model based error back-propagation scheme using Lyapunov stability analysis method. Through simulation, the proposed adaptive-neuro control scheme is proved to be a efficient control technique for real-time control of robot system using DSPs.

      • HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

        김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

        Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

      • 강원도지역에서 발생한 발진열과 쯔쯔가무시병

        민창홍,장우현,강재승,조수익,최문기,조민기,윤창순,김윤원 대한감염학회 1988 감염 Vol.20 No.2

        In Korea, there has been an increasing concern on rickettsiosis as one of most prevailing acute febrile illness, since murine typhus and scrub typhus had not been reported for 2 decades until 1986 and thereafter a few studies were reported on these diseases. A microimmunofluorescence test was used to study antibodies to R. typhi and R. tsutsugamushi in urban and rural inhabitants students, and patiants suspected of leptospirosis or rickettsiosis from 1986 to 1987 in Kangwon-do Korea. 43% of inhabitatnts and 17% of students reacted to R. typhi. Only one inhabitant among inhabitants and students reacted to R. tsutsugamushi. Among 169 patients, 43(25%) reacted to R. typhi, 38(22%) to R. tsutsugamushi and 25(15%) to Leptospira interrogans. Sexual rate(male; female) in murine typhus was 1.7:1, that in scrub typhus was 1:2.2 and that in leptospirosis was 1.5;1. The age ditribution of patients with murine typhus was generally even over 20 years old. But 71% of patients with scrub typhus were over 40 years old. Scrub typhus was most prevailing in female over 40 years old. Murine typhus was relatively more prevailing in Choonchun city than rural area as compared with scrub typhus and leptospirosis. Most of scrub typhus occurred in rural area. Most of each disease occurred between September and November (murine typhus; 93%, scrub typhus; 95%, leptospirosis; 84%) with a peak in October. Scrub typhus considerably occurred not only October(58%) but also November(28%). All patients with scrub typhus were immediately diagnosed by antibody when they visited hospital. 53% of patients with murine typhus were diagnosed when they visited hospital within 7 days after onset of illness, and others were done by second sera obtained 8 days after. The patients in whom IgM was seronegative but antibodies of other class were seropsitive by 20 days after onset of illness, were 14% in murine typhus and 26% in scrub typhus. At least those patients were considered to be infected second. Murine typhus and scrub typhus were suggested to be endemic diseases in Kangwon-do as antibodies of inhabitants and characteristics of patients' sera were considered. By serologic finding of patients with scrub typhus in Kangwon-do, Gilliam was 59'% of etiologic strain of scrub typhus, Karp was 41q% and Kato was none. Most scrub typhus occurred in person to be related to agriculture, but murine typhus was not related to job and occurred more in small city than rural area. Rash was scarcely detected in murine typhus and scrub typhus, and eschar was in 50% of scrub typhus only. Serum transaminase elevated in many patients with scrub typhus and murine typhus. Leukocytosis and abnormal finding in chest X-ray were showed in some patients with scrub typhus but were scarcely in murine typhus.

      • 化學反應蒸着에 의한 CdS 多結晶 薄膜制作 및 그 特性硏究 (Ⅰ)

        강현식,남궁윤,최선우,홍광준,최용대 全北大學校 敎育大學院 1986 敎育論叢 Vol.6 No.-

        CdS thin film was fabricated by chemical bath deposition method and polycrystallined by the proper heat treatment. The physical properties of the amorphous and polycrystal of CdS thin film were observed and calculated by measuring the X-ray diffraction patterns, optical absorption, transmission and photoconductivity. From the present experiments, we obtained the energy band gap of the CdS polycrystal thin film to be 2.42eV and the In donor impurity level to be 0.025 eV below the conduction band : Another result was to be a_o=4.13Å and c_o=6.75Å for lattice constants of the hexagonal structure. Also, we attempted it to find the possibility of the application to photosensor. To apply cds this film to the photosensor more sufficiently, further experiments are required to accumulate data on such problems.

      • 데스크탑 밀링머신의 고속 스핀들 설계 해석

        장성현,황현영,정우영,홍정표,최영휴 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

        During a decade, there are many researches on microfactory which is the miniature, flexible, and efficient manufacturing system for the micro/meso scale machining device. Moreover many micro machine tool has developed in Japan, U.S., Europe, and Korea. Already we are developing a desktop milling machine with 380×450×450 ㎣ machine size for microfactory or BT (Bio technology) factory. In this study, we carried out the design analysis of a high speed spindle system for our desktop milling machine by using ADROS, which is our own developed S/W for dynamic design analysis of rotor systems. As the result, we obtained some analyzed dynamic characteristics of a spindle system, such as natural frequency, whirl frequency, critical speed, and harmonic response.

      • KCI등재

        담자균류의 배양에 의한 폴리페놀 함유 농산물의 전환 효과

        변광우,홍인표,정재현,최신건,이현용,이신영 한국산업식품공학회 2002 산업 식품공학 Vol.6 No.4

        The phenolics contents of eight agricultural resources(Angelica, arrow root, Injin mugwort, red-ginseng, biji, onion and brown rice) were determined. Both the solid state or submerged cultivation by four Basidiomycetes (Ganoderma lucidum, Lentinus edodes, Hericium erinaceum and Cordyceps militaris) on these substrates(or wheat bran) were examined for mycelial growth and β-glucosidase production. The good growth of G. lucidum and H. erinaceus were observed at red-ginseng and Injin mugwort, respectively. Also, the total free phenolics after solid state cultivation of 8 weeks by H. erinaceus on Injin mugwort was produced up to 3 times higher than that of no cultivation. While the bound phenolics was reduced with increasing trend of free phenolics indicating that bound phenolics was hydrolyzed by β-glucosidase of H. erinaceum. The high production of total free phenolics was also obtained through two staged submerged cultivation of G. lucidum with red-ginseng extract as medium. These results suggested that the phenolics rich agricultural resources were modified by cultivation of Basidiomycetes, indicating potential application of functional beverages due to increasing the free phenolics content.

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