표면근전도와 적외선체열촬영을 이용한 요통의 평가

이강진,최인성,이소영,한재영,이삼규,채홍재,이성과,문재동 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3

목적 : 요통환자에서 요통의 유무와 강도를 평가하고자 표면근전도를 이용하여 근육 활동성의 차이를 검증하였고 적외선체열촬영을 이용하여 제표면 온도의 변화를 측정하였다. 방법 : 요통환자군 16명과 대조군 16명에 대하여 요부에 부착한 표면전극에서 얻은 근전도 신호와 적외선체열촬영 결과를 비교하였다. 교란요인의 영향을 배제하기 위하여 연령과 성별 그리고 비만도에 따라 정상 대조군과 요통환자군을 짝짓기하여 각각 16명씩 선정하였다. 결과 : 정적표면근전도 실시 결과 우측의 경우 중앙값이 요통환자군에서 198.1 ㎶, 정상대조군에서는 161.3 ㎶로 통계적으로 유의한 차이가 있었고(p<0.01), 좌측은 요통환자군에서 194.2 ㎶, 정상대조군에서 180.5 ㎶로 유의한 차이는 없었다. 동적표면근전도 실시 결과 재신전시와 굴곡시 근전위의 비가 우측의 경우 요통환자군에서 중앙값이 1.12였고 정상 대조군은 1.39로서 두 군간에 유의한 차이가 있었고(p=0.027), 좌측의 경우도 요통환자군에서는 1.08이었고 정상 대조군에서는 1.21로 유의한 차이가 있었다(p=0.036). 적외선체열촬영결과 ΔT가 0.5 ℃ 이상의 차이가 있을 때 이상이 있는 것으로 정하면, 요통환자군에서는 16명 모두 이상자로 판정되었고, 정상 대조군에서는 16명중 3명이 이상자로 판정되어 민감도는 100 %, 특이도는 81.3 % 였다. 표면근전도를 이용한 요통의 진단은 민감도가 78.6 %이고 특이도가 72.2 %였으며, 적외선체열촬영은 민감도가 100 %였고 특이도가 87.5 %였다. 결론 : 이러한 결과로 볼 때 표면근전도 검사법과 적외선체열촬영은 요통을 간접적으로 평가하는데 도움이 되는 검사법이며, 적외선체열촬영이 표면근전도검사법에 비하여 보다 정확한 검사법으로 판단된다. Objectives : We studied the efficacy of surface electromyography(SEMG) and digital infrared theimographic imaging (DITI) in the assessment of low back pain both(LBP) Methods : We compared electromygraphic signals from electrodes placed in the lumbar area and the digital theimographic images in 16 LBPpatients and 16 control subjects. The LBP patients and the control subjects were matched for age, gender, and body mass index(BMI) to adjust for any confounding effects Results : In the static analyses of SEMG, median value was 198.1 ㎶ for the controls on the right side, and they were 194.2 ㎶ and 180.5㎶ on left side respectively. There was a statistically significant difference between the two groups on the right side(p<0.01), but not on the left side. In the dynamic analyses of the SEMG, the median values of the extension per flexion ratio of right side were 1.12 for LBP patients and 1.39 for controls. and those on the left side were 1.08 and 1.21 respectively. There were statistically significant differences in both sodes(p<0.05). The sensitivity and specificity were 100% and 81.3% in DITI, 78.6% and 72.2% in SEMG. Conclusions : These results indicate that SEMG and DITI are useful methods for indirect assessments of LBP, and that DITI is more sensitive and specific than SEMG.

Critical role of bile acid (BA) in the cellular entry and permissiveness of Hepatitis B virus in vitro

Hong‑Jai Lee,Bo‑Young Shin,Jae‑Seung Moon,Ailyn Fadriquela,Selikem Abla Nuwormegbe,Chun‑Chang Ho,Jin‑Su Shin,Jee‑Sang Yoon,Sang‑Kyou Lee,Soo‑Ki Kim 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.3

Background Lack of universal replication system for hepatitis B virus with narrow host range and organ tropism has hampered to uncover the pathogenesis of HBV. Previously, we reported the essentiality of humoral milieu and its components toward HBV and hepatitis C virus survival/viability in vitro. Of these components, the precise role of enterohepatic humoral milieu such as bile acid (BA) on HBV cultivation in vitro and in vivo is unknown. Objective We explored whether BA, specifically taurochenodeoxycholic acid (tCDCA) would directly regulate the viral DNA and surface antigen expression of HBV in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. Result We found that higher concentration of taurochenodeoxycholic acid (tCDCA) is able to preserve the genomic stability of HBV in cell-free DMEM, showing higher the surface antigenicity than taurocholic acid (tCA). In line, we found that in vitro cell culture condition (100 μmol/L of tCDCA coupled with 1 × 108 g e/mL HBV) would be optimal for HBV entry into target cells. Using this, human (HepG2, Huh7), and rodent (Hepa1c1c7, H4-II-E) hepatoma cell lines were infected by HBV, as evidenced by the presence of HBV biomarkers (HBsAg, and HBV DNA in culture supernatant, as well as HBcAg in cell). Further, cellular entry test revealed that HBV is able to infect 12 different non-hepatic cell lines regardless of species, and organ/tissue, consequently reproducing progeny as confirmed by HBV biomarkers. Last, reinfection test showed that the progenies of HBV from immortalized HepG2, and Hepa1c1c7 cells are able to enter into each or vice versa naïve HepG2, and Hepa1c1c7 cells with or without BA. Conclusion This study demonstrates that enterohepatic humoral milieu such as BA, specifically tCDCA would directly regulate HBV DNA and its surface antigen expression in vitro, consequently rendering HBV to enter into human or murine immortalized hepatocytes, and non-hepatocytes. This is the first note to render HBV permissive to human or rodent hepatic and non-hepatic cells via sole manipulation of humoral milieu, thus establishing the platform for in vitro robust replication system of HBV.

완전협업을 위한 시설채소 영농조합의 최저규모

이두희,김재홍,이광원 충남대학교 농업과학연구소 1998 농업과학연구 Vol.25 No.2

This paper is aims at identifying the minimum farm size of the greenhouse vegetable cooperatives. Farm cooperative is one of the institutional measurments for the seeking of economy of scale which could not be found in family farm. In this paper 5 cooperatives and 5 farmhouseholds which have been managed vegetable greenhouse were surveyed. The results are as follows; First, cooperatives had 29.3% less on the fixed costs, and received 43% more on prices than general vegetable farmhouseholds. This means that the cooperatives have economy of scale. Second, to establish full organized coopratives, cooperative sizes must be more than 4,582 pyung, considering the government target which will be loaned 80% goverment loan of total facility costs with no subsidy.

간질발작후 MRI 영상에서 뇌 종창을 보인 3예 보고

홍현숙,김대호,이혜경,박재성,박성진,조준희,차장규,백상현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

We report seizure induced brain swelling in three patients. MRI revealed a cortical, subcortical(3/3), and basal ganglia(2/3) high signal intensity on T2- weighted and FLAIR images. The lesion shows low signal on T1-weighted image, and enhanced after contrast administration. Follow up study after 27 days in one case revealed complete resolution of the lesion. The reversible MRI findings may be the results of a local brain swelling, breakdown of blood-brain permeability, and a defect of cerebral autoregulation during seizure activity. The transient nature of such findings have to be considered in the differential diagnosis such as reversible ischemia, migraine, inflammation and infection.

금속산화물 반도체 In_2O_3 촉매에 의한 일산화탄소의 산화반응

이성한,허권,전종호,김규홍,최재시 연세대학교 자연과학연구소 1985 學術論文集 Vol.14 No.-

순수한 In_2O_3, 환원된 In_2O_3, 그리고 NiO를 도프시킨 In_2O_3를 촉매로하여 CO의 산화반응을 433-513K 온도영역에서 실시하였다. 새로 도입된 시료상에서 산화반응은 촉매활성이 다른 두 영역을 나타내었다. 초기반응 단계에서는 Roginsky-Zcldovich 속도식에 잘 일치하며 활성화 에너지는 37.2kJ mol^-1이고, 촉매활성이 일정하게 나타나는 두번째 반응단계에서는 전반응차수가 1차이며 활성화 에너지는 27.2kJ·mol^-1로서 CO_2에 의한 억제효과를 나타내었다. CO_2trap을 사용한 결과 전반응 차수는 1.5차로서 CO에 대해 1차, O_2에 대해 0.5차의 의존성을 보였다. 결정내의 산소결함농도가 반응속도를 증가시킬 수 있는 요인으로 밝혀졌으며 CO의 흡착자리는 격자산소(O^2-_0)이고 O_2의 흡착자리는 촉매의 처리과정과 제조과정에 의해 형성된 산소공위 (V^x_o)로서 밝혀졌다. 반응속도론적 데이타와 전기전도도 데이타를 결부시켜 산화반응 메카니즘을 제안하였으며 산소공위가 반응속도에 미치는 효과및 산소공위에 O_2가 흡착하는 과정이 속도결정단계임을 설명하였다. A kinetic study of CO oxidation on pure, reduced, and NiO-doped Indium Sesquioxide systems was carried out in the temperature range of 433-513 K. Catalytic oxidation showed two step regions. First initial step of fresh sample followed the Roginsky-Zeldovich kinetics with the apparent activation energy of 37.2 kJ.mol^-1. The second step which showed a constant activity was found to be the approximate first order kinetics with the apparent activation energy of 27.2 kJ.mol^-1 and then the inhibition by produced CO_2 was observed. By use of CO_2 trap, however, the oxidation kinetics was found to be the first order with respect to CO and the one-half order to O_2. The rate determining step was considered as the adsorption process of oxygen on the surface of catalyst. The site for CO adsorption was the lattice oxygen (O_o^2-) and the site for O_2 adsorption was the oxygen vacancy formed by vacuum activation, hydrogen reduction, and NiO doping. It was believed that the oxygen vacancy was responsible for the catalytic activity for CO oxidation.

반대측 선조체에 점삼 출현이 동반된 비케톤성 고혈당성 무도증

이재규,손일홍 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

Hemichorea is usually caused by lesions in the contralateral subthalamus and/or basal ganglia. Brain MRI shows a high signal intensity on T1-weighted images and brain CT shows a hyperdense lesion in the contralateral lentiform nucleus in patients with nonketotic hyperglycemic chorea. It is not unclear that these pathophysiological mechanisms is ischemia or petechial hemorrhage. A 78 year-old woman with uncontrolled diabetic mellitus presented with sudden involuntary movement in the right limbs. Brain CT on the first HD(hospital day) revealed hyperdensity in the left lentiform nucleus and Brain MRI on the 2nd HD showed high signal intensity on Tl-weighted images in the left lentiform nucleus. After 2 month later, involuntrary movment was subsided, and the density was more decreased on follow-up brain CT. We suggest a possibility that nonketotic hyperglycemic hemichorea is associated with petechial hemorrhage in the contralateral lentiform nucleus. 편측무도증은 대부분 반대측 선조체의 문제로 발생된다. 비케톤성 고혈당 편측 무도증을 가지고 있는 환자의 뇌 단층촬영(Brain CT)에서 반대측 선조체의 고음영이 관찰되었고 뇌 자기공명영상(Brain MRI)에서는 T1 강조영상에서 고신호로 강조되었다. 하지만 고혈당과 관련된 편측 무도증의 정확한 기전은 아직도 명확하지 않으며 점상출혈이나 허혈성 변화일 것으로 추정되고 있다. 당뇨가 잘 조절되지 않는 78세 여자환자가 내원 20일전부터 발생한 우측 팔, 다리의 불수의적인 움직임을 주소로 입원하였다. 내원 초기 brain CT에서는 좌측 선조체의 고음영이 관찰되었고 Brain MRI에서는 T1 강조영상에서 고신호를 보였다. 증상 호전 보이면서 추적 관찰한 Brain MRI에서 이 병소는 T1 강조영상에서 고신호 강도가 더욱 증가하였으며, gradient echo에서는 저신호 강도가 더욱 증가하였다. 이후 증상이 더욱 호전되었고, Brian CT에서는 반대측 선조체의 고밀도 소견이 감소한 양상 관찰되어 점상 출혈 기전과 관련된 증례로 추정하여 보고하는 바이다.

대약진 운동기 중국의 토지운영체계에 관한 연구

이종수,김재홍 충남대학교 농업과학연구소 2004 농업과학연구 Vol.31 No.2

This study is aimed at identifying China's land operating system in the great leap periods. the findings are as follows. For one thing, though the landownership in China was basically performed in public, a portion of private management was allowed. The more this kind of private management allowed, the more the life standard of farmers enhanced. For another thing, the conversion from agricultural cooperatives to people's commune happened swiftly, and the problems according to the conversion arose instantly, which made the operation system changed partially. The last, but not the least, even in the point of the rapid communistic movement, private management was locally accepted in the name of three seif and one private management. Besides, as we can recognize from the case study of Daichai village, the operation of a large working group and a small working group was done in political context.

방울토마토 경영성과에 영향을 미치는 요인분석

李光遠,金再洪 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2

In this study, certain factors influencing cherry tomato were estimated using system equations. In addition, the amount of influence to income from each factor was estimated from both direct and indirect effects. Based on OLS(Ordinary Least Squares) estimation, path analysis and factor analysis were employed to overcome multicollinearity problems. Data used in this study is interviewed cross sectional data of 65 cherry tomato producing farm in Chungnam-do area. Average age of the producers is 46.5. Average year of the production is 8 years. Average farm size, productivity, and income are 1.123 pyong, 7,439kg/10a, 8,112,000won/ 10a, respectively. The business performance of the sample farms were above average, in terms of the diagnosis by「 Standard Business Diagnosis for Cherry tomato」. To identify the factors influencing productivity, 15, 19, and 25 independent variables were selected for the dependent variables of yield, price (quality), and business cost, respectively. Finally, yield, quality, and business cost variables were set as independent variables to explain income as dependent variable. As a result of main factor analysis, 10, 12, 15, and 16 factors were identified as main factors for yield, quality, business cost, and income, respectively.

Burkitt림프종 환아의 증례 보고

홍현진,최병재,이제호,윤정훈,손흥규 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

Burkitt 림프종은 중앙아프리카 지역의 어린이 악골에서 흔하게 나타는 악성 종양으로 림프조직으로부터 발생되며 매우 빠른 성장 양상을 보인다. 임상적으로는 7∼8세 아동에 주로 호발하며 악골에 발생하는 경우 안면부 종장이 나타날 수 있으며 유지의 비정상적 동요 및 구치부 조기 맹출등이 나타날 수 있다. 방사선 소견으로는 경계가 불규칙한 방사선투과성 병소로 나타나며 조직학적으로는 종양세포들 사이에 대식세포가 분포되어 "starry-sky" appearance치 특징적인 양상이 관찰된다. 본 증례는 좌측 안면부 종창을 동반한 유구치의 심한 동요도를 주소로 내원한 3세 남환아에서 임상 및 방사선 검사와 조직학적 검사를 통해 Burkitt 림프종으로 진단하였고 항암 화학요법에 의해 치료중이며 양호한 치료 결과론 얻고 있다. Burkitt's lymphoma is a malignant tumor that commonly occurs in the jaws of children of Central Africa. It originates from the lymphatic tissue. and it shows rapid growth Clinically. It is commonly found in children between age of 3 and 8. When it is found in the jaw, facial swelling, mobility of deciduous teeth. and early eruption of posterior teeth can also be found. Upon radiographic examination, radiolucent lesions with irregular border can be observed Histologically, macrophage can be seen among tumor ce11s, and this special pattern is called "starry-sky" appearance. In this case, 3 year-old male patient came to our hospital with left facial swelling and severe mobility of deciduous molars. He was diagnosed as Burkitt's lymphoma based on clinical, radiographic, and histologlc examination. He is being treated with chemotherapy and progress seems promising.

승모판 성형술 이후 발생한 좌심실 유출로 협착과 승모판의 수축기 전방 운동

이석기,유재근,서홍주 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Left ventricular outflow tract obstruction and systolic anterior motion of the mitral valve after myxomatous mitral valve repair is due to excess tissue of mitral valve among numerous other factors. A patient who had myxomatous mitral valve and acute mitral regurgitation due to chordae rupture was admitted for mitral valve repair. The hospital course of the patient was not significantly different compared to other patients. On the 40th postoperative day, the patient experienced syncope and came to ER. The patient showed severe left venthcular outflow tract obstruction and systolic anterior motion of mitral valve. The patient was treated medically and was discharged with normal echo findings. We report this case with brief review of related literatures.