http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
趙南俊,金台睍,宋昊埈,辛民敎 한국전통의학연구소 1999 한국전통의학지 Vol.9 No.1
For the purpose of developing Korean Herbalogy with the plants of Cruciferae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1. There were totaled to 23 genera and 74 species in Korea and among them medicinal plants are 13 genera, 29 species, some 39% in total but, the number of species may be added because of the similiar plants. 2. According to the oriental names which can be used for medical purpose, the medicinal plants belonging, to the Cruciferae family were classified as Herba 8,Semen 7,Radix 4,Foilum,Flos 3,Rhizoma 3,Fructus 1. Thus it was noticed that Herba was the main kind. 3. According to sum of 74 species in Cruciferae family, they were classified into Arabis genera 16, Brassica, Lepidium genera 5 each. Thus it was noticed that Arabis genera was the main kind, some 23% in total. 4. According to the number of species of the origin plants about each chinese materia medicals, they were classified into SEMEN LEPIDII 10,SEMEN SINAPIS 2. Thus the origin plants was not complexed reletively. 5. According to nature and flavour of medicinal plants, they were classified into warmth, heat; 4 each, cold, cool; 7 each, balance 14. Thus it was noticed that balance is the main in nature and flavour of medicinal plants. 6. According to the Properties and Principal curative action, they were classified into Drugs for remove toxic heat with febrifugal and detoxicant drugs, to removing evil heat and resolve dampness ,Drugs for reducing intense internal Heat Digestives and Evacuants 6 each, with promote or activate blood circulation by removing blood stasis ,to clear up heat and resolve phlegm, to remove toxic heat with febrifugal and detoxicant drugs such as 6 each, to regulate the flow of vital energy, to replenish vital essence with drugs 5 each, to dispel pathogenic factors from the exterior of the body with sudorifics pungent in flavor and warming in property, to stop diseases with drugs 3 each. Thus it wasnoticed that to promote or activite blood circuration by removing blood stasis drugs was the main kind. 7. Comparing to whole medicinal plants 89 kinds, toxic durgs include minor toxin were 8 kinds, 9% of the whole.Thus toxic durgs were rare. From this result, it was revealed that the plants for medical purpose in Liliaceae was 76% of the whole, in which Bulbus was mostly abundunt and toxic plants was so rare that it will be used for clinical treatments more easily. It is considered that many experiements and clinical approaches must be continued to use Liliaceae plants widely.
Zoon Ho Lee,김용환,이준호,이동우,Kyoung Yul Lee,Seong Youn Hwang 대한의학회 2020 Journal of Korean medical science Vol.35 No.16
Background: Patients who achieve a return of spontaneous circulation (ROSC) with prolonged cardiac arrest have been recognized to have a poor prognosis. This might lead to reluctance in the provision of post-resuscitation care. Hence, we evaluated the impact of cardiac arrest time on neurologic outcomes in out-of-hospital cardiac arrest (OHCA) patients. Methods: This cross-sectional study used a hospital-based nationwide registry of OHCAs in Korea between 2012 and 2016. All witnessed OHCA patients aged ≥ 15 years and treated with targeted temperature management were included. We collected the time from collapse to sustained ROSC, which was defined as the downtime. The primary outcome was a favorable neurological outcome at hospital discharge. A multiple logistic regression analysis was conducted to determine independent factors for primary outcome in patients with downtime > 30 minutes. Results: Overall, neurologically favorable outcome rates were 30.5% in 1,963 patients. When the downtime was stratified into categories of 0–10, 11–20, 21–30, 31–40, 41–50, 51–60, and > 60 minutes according to 10-minute intervals, neurologically favorable outcome rates were 58.2%, 52.3%, 37.3%, 24.6%, 14.1%, 17.4%, and 16.7%, respectively (P < 0.001). In patients with downtime > 30 minutes, age 51–70 years (odds ratio [OR], 5.35; 95% confidence interval [CI], 2.50–11.49), age ≤ 50 years (OR, 13.16; 95% CI, 6.06–28.57), shockable rhythm (OR, 3.92; 95% CI, 2.71–5.68), bystander resuscitation (OR, 1.80; 95% CI, 1.27–2.55), cardiac cause (OR, 3.50; 95% CI, 1.69–7.25), percutaneous coronary intervention (OR, 1.82; 95% CI, 1.18–2.81), and downtime ≤ 40 minutes (OR, 2.02; 95% CI, 1.42–2.88) were associated with favorable neurological outcomes. Conclusion: In patients with prolonged downtime, predicting favorable neurologic outcome may be multifactorial. The cutoff value for downtime is not the only determining factor to provide post-resuscitation care.
Seo, Jae Ho,Lim, Jung Chae,Lee, Duck-Yeon,Kim, Kyung Seok,Piszczek, Grzegorz,Nam, Hyung Wook,Kim, Yu Sam,Ahn, Taeho,Yun, Chul-Ho,Kim, Kanghwa,Chock, P Boon,Chae, Ho Zoon American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.20
<P>Peroxiredoxins (Prxs) are a group of peroxidases containing a cysteine thiol at their catalytic site. During peroxidase catalysis, the catalytic cysteine, referred to as the peroxidatic cysteine (C(P)), cycles between thiol (C(P)-SH) and disulfide (-S-S-) states via a sulfenic (C(P)-SOH) intermediate. Hyperoxidation of the C(P) thiol to its sulfinic (C(P)-SO(2)H) derivative has been shown to be reversible, but its sulfonic (C(P)-SO(3)H) derivative is irreversible. Our comparative study of hyperoxidation and regeneration of Prx I and Prx II in HeLa cells revealed that Prx II is more susceptible than Prx I to hyperoxidation and that the majority of the hyperoxidized Prx II formation is reversible. However, the hyperoxidized Prx I showed much less reversibility because of the formation of its irreversible sulfonic derivative, as verified with C(P)-SO(3)H-specific antiserum. In an attempt to identify the multiple hyperoxidized spots of the Prx I on two-dimensional PAGE analysis, an N-acetylated Prx I was identified as part of the total Prx I using anti-acetylated Lys antibody. Using peptidyl-Asp metalloendopeptidase (EC 3.4.24.33) peptide fingerprints, we found that N(alpha)-terminal acetylation (N(alpha)-Ac) occurred exclusively on Prx II after demethionylation. N(alpha)-Ac of Prx II blocks Prx II from irreversible hyperoxidation without altering its affinity for hydrogen peroxide. A comparative study of non-N(alpha)-acetylated and N(alpha)-terminal acetylated Prx II revealed that N(alpha)-Ac of Prx II induces a significant shift in the circular dichroism spectrum and elevation of T(m) from 59.6 to 70.9 degrees C. These findings suggest that the structural maintenance of Prx II by N(alpha)-Ac may be responsible for preventing its hyperoxidation to form C(P)-SO(3)H.</P>
Stoichiometric Effects. Correlation of the Rates of Solvolysis of Isopropenyl Chloroformate
Zoon Ha Ryu,Young Ho Lee,Yunghee Oh 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.11
Solvolysis rates of isopropenyl chloroformate (3) in water, D2O, CH3OD and in aqueous methanol, ethanol, 2,2,2-trifluoroethanol (TFE), acetone, 1,4-dioxane as well as TFE-ethanol at 10 oC are reported. Additional kinetic data for pure water, pure ethanol and 80%(w/w) 2,2,2-trifuoroethanol (T)-water (W) at various temperatures are also reported. These rates show the phenomena of maximum rates in specific solvents (30% (v/v) methanol-water and 20% (v/v) ethanol-water) and, variations in relative rates are small in aqueous alcohols. The kinetic data are analyzed in terms of GW correlations, steric effects, kinetic solvent isotope effects (KSIE), and a third order model based on general base catalysis (GBC). Solvolyses based on predominately stoichiometric solvation effect relative to medium solvation are proceeding in 3 and the results are remarkably similar to those for p-nitrobenzoyl chloride (4) in mechanism and reactivity.
Young Zoon Kim,김대용,Heon Yoo,Hee Seok Yang,Sang Hoon Shin,Eun Kyung Hong,Kwan Ho Cho,Seung Hoon Lee 대한암학회 2007 Cancer Research and Treatment Vol.39 No.1
Purpose: Although radiation-induced necrosis (RIN) is not a tumor in itself, the lesion progressively enlarges with mass effects and diffuse peritumoral edema in a way that resembles neoplasm. To identify the RIN that mimics progression of brain metastasis, we performed surgical resections of symptomatic RIN lesions. Meterials and Methods: From June 2003 to December 2005, 7 patients received stereotactic-guided radiotherapy (SRT) for metastatic brain tumor, and they later underwent craniotomy and tumor resection due to the progressive mass effects and the peritumoral edema that caused focal neurological deficit. On MR imaging, a ring-like enhanced single lesion with massive peritumoral edema could not be distinguished from progression of brain metastasis. Results: Four patients had non-small cell lung cancer, 2 patients had colorectal cancer and 1 patient had renal cell carcinoma. The mean tumor volume was 8.7 ml (range: 3.0~20.7 ml). The prescribed dose of SRT was 30 Gy with 4 fractions for one patient, 18 Gy for two patients and 20 Gy for the other four patients. The four patients who received SRT with a dose of 20 Gy had RIN with or without microscopic residual tumor cells.Conclusions: Early detection of recurrent disease after radiotherapy and identifying radiation-induced tissue damage are important for delivering adequate treatment. Therefore, specific diagnostic tools that can distinguish RIN from progression of metastatic brain tumor need to be developed. (Cancer Res Treat. 2007;39:16-21) Purpose: Although radiation-induced necrosis (RIN) is not a tumor in itself, the lesion progressively enlarges with mass effects and diffuse peritumoral edema in a way that resembles neoplasm. To identify the RIN that mimics progression of brain metastasis, we performed surgical resections of symptomatic RIN lesions.Meterials and Methods: From June 2003 to December 2005, 7 patients received stereotactic-guided radiotherapy (SRT) for metastatic brain tumor, and they later underwent craniotomy and tumor resection due to the progressive mass effects and the peritumoral edema that caused focal neurological deficit. On MR imaging, a ring-like enhanced single lesion with massive peritumoral edema could not be distinguished from progression of brain metastasis.Results: Four patients had non-small cell lung cancer, 2 patients had colorectal cancer and 1 patient had renal cell carcinoma. The mean tumor volume was 8.7 ml (range: 3.0~20.7 ml). The prescribed dose of SRT was 30 Gy with 4 fractions for one patient, 18 Gy for two patients and 20 Gy for the other four patients. The four patients who received SRT with a dose of 20 Gy had RIN with or without microscopic residual tumor cells.Conclusions: Early detection of recurrent disease after radiotherapy and identifying radiation-induced tissue damage are important for delivering adequate treatment. Therefore, specific diagnostic tools that can distinguish RIN from progression of metastatic brain tumor need to be developed. (Cancer Res Treat. 2007;39:16-21)