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이상호,장의성,정승은,신송우,강호영 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
Objective: Currently, normal data of cervical disc height and depth of Korean adults are not available. The objective of this study is to compile a Korean normative database of the disc height and depth of the cervical spine, valid for healthy Korean adults. Methods: All the volunteers were attached a coin on the anterior midline of the neck. From the lateral X-ray films of the cervical spine, anterior and middle disc height and anteroposterior disc depth from C2-3 to C6-7 were measured. The magnification of radiographic films as compared with real measurement of the coin was taken into consideration. Analysis of data was done by use of independent sample t-test, Pearson's correlation, and one-way analysis of variance(ANOVA). Results; A normal database for the dimensions of cervical discs was compiled from 42 lateral views of healthy Korean adults. There were 20 males(mean age, 29,6 years; mean height, 174.3 cm) and 22 females(mean age, 27,4 years; mean height, 161.2 cm). The means of anterior height, middle height and anteroposterlor depth of cervical disc space were 4.09mm, 5,82mm, and 16,86mm for men and 3,40 mm, 5.30 mm, and 14.86 mm for women, respectively, The height of C4-5 disc space was highest at the middle disc space from C2-3 to C6-7. Conclusion: This study will contribute to the clinical diagnosis, treatment and development of instruments of cervical disc diseases for Korean patients with cervical disc diseases.
한국인 및 중국 한족 정신분열병 환자의 5-HT2A 수용체 유전자 -1438A/G 다형성
이장호,이광철,이승부,오용인,최영근,조아랑,정주호,장환일 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1
Objectives : The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population. Methods : A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Resthction Fragment Length Polymorphism (RFLP). Results : There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G Poly-morphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. Conclusion : These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.
Sheng-Min Wang,Jung-Bum Kim,Jeong Kyu Sakong,Ho-Suk Suh,Kang Seob Oh,Jong-Min Woo,Sang-Woo Yoo,Sang Min Lee,Sang-Yeol Lee,Se-Won Lim,Seong Jin Cho,Ik-Seung Chee,Jeong-Ho Chae,Jin Pyo Hong,Kyoung-Uk Le 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.2
Objective: This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders. Methods: Inclusion criteria were as follows: age >20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant, and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale (CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep). Results: Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted. After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep scores ( p <0.001). There were no differences in mean changes in CGI-S, CGI-anxiety and CGI-sleep among the three benzodia-zepine groups. The incidence of side effects was significantly lower in the clonazepam group than with the other benzodiazepines. The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were 26.7% (n=20), 48.4% (n=31), and 43.9% (n=18), respectively. Conclusion: The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders. Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study.
Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients
Jin, Sheng-Yu,Park, Hyun-Ho,Li, Guang-Zhe,Lee, Hee Jae,Hong, Mee-Suk,Park, Hae-Jeong,Park, Hun-Kuk,Seo, Jung-Chul,Yim, Sung-Vin,Chung, Joo-Ho,Lee, Mu-Hyoung KYUNG HEE UNIVERSITY MEDICAL CENTER 2005 고황의학상 수상논문집 Vol.Vol.21-22 No.-
Association of estrogen receptor 1 intron 1 C/T polymorphism in Korean vitiligo patients
Jin, Sheng-Yu,Park, Hyun-Ho,Li, Guang-Zhe,Lee, Hee Jae,Hong, Mee-Suk,Park, Hae-Jeong,Park, Hun-Kuk,Seo, Jung-Chul,Yim, Sung-Vin,Chung, Joo-Ho,Lee, Mu-Hyoung KYUNG HEE UNIVERSITY MEDICAL CENTER 2005 고황의학상 수상논문집 Vol.21-22 No.-
Background: Vitiligo is a common disease characterized by cutaneous white maculae due to loss of melanocytes. It is a polygenic disease, however, the exact pathogenesis of vitiligo is not yet known. The estrogen receptor (ESR) 1 gene was selected as a candidate gene because some researchers treated vitiligo successfully with the steroid-thyroid hormone mixture containing estrogen. Furthermore ESR was expressed in the melanocytes which have an important role in the pigmentation. The polymorphisms of ESR1 gene in vitiligo patients was not reported yet. Objective: To determine whether polymorphisms of ESR1 gene were associated with susceptibility to vitiligo patients in Korean population. Methods: We conducted case-control association study of vitiligo patients (120) and healthy controls (254). Genotypes of ESR1 gene (intron 1 C/T, exon 4 C/G, and exon 8 A/G) were determined by polymerase chain reaction followed by restriction enzyme digestion. Results: Intron 1 T/C allele frequency was significantly different between patients and controls (P=0.034). Intron 1 T/C genotype distribution (P=0.021) and allele frequency (P = 0.013) were different between female vitiligo patients and female controls. Intron 1 T/C allele frequency showed significantly difference between generalized type of vitiligo patients and controls (P=0.044). Genotype distributions and allele frequencies of exon 4 C/G and exon 8 A/G polymorphisms were not different between patients and controls. Conclusion: The present study suggests that ESR1 may be a possible risk factor for female or generalized type of vitiligo patients.
심병용,Guk Jin Lee,Hyunho Kim,Sung Shim Cho,Hyung Soon Park,Ho Jung An,In Sook Woo,Jae Ho Byun,Ji Hyung Hong,Yoon Ho Ko,Der Sheng Sun,Hye Sung Won,Jong Youl Jin,Ji Chan Park,In-Ho Kim,Sang Young Roh 대한위암학회 2023 Journal of gastric cancer Vol.23 No.2
Purpose: Oxaliplatin, a component of the capecitabine plus oxaliplatin (XELOX) regimen, has a more favorable toxicity profile than cisplatin in patients with advanced gastric cancer (GC). However, oxaliplatin can induce sensory neuropathy and cumulative, dose-related toxicities. Thus, the capecitabine maintenance regimen may achieve the maximum treatment effect while reducing the cumulative neurotoxicity of oxaliplatin. This study aimed to compare the survival of patients with advanced GC between capecitabine maintenance and observation after 1st line XELOX chemotherapy. Materials and Methods: Sixty-three patients treated with six cycles of XELOX for advanced GC in six hospitals of the Catholic University of Korea were randomized 1:1 to receive capecitabine maintenance or observation. The primary endpoint was progression-free survival (PFS), analyzed using a two-sided log-rank test stratified at a 5% significance level. Results: Between 2015 and 2020, 32 and 31 patients were randomized into the maintenance and observation groups, respectively. After randomization, the median number of capecitabine maintenance cycles was 6. The PFS was significantly higher in the maintenance group than the observation group (6.3 vs. 4.1 months, P=0.010). Overall survival was not significantly different between the 2 groups (18.2 vs. 16.5 months, P=0.624). Toxicities, such as hand-foot syndrome, were reported in some maintenance group patients. Maintenance treatment was a significant factor associated with PFS in multivariate analysis (hazard ratio, 0.472; 95% confidence interval, 0.250–0.890; P=0.020). Conclusions: After 6 cycles of XELOX chemotherapy, capecitabine maintenance significantly prolonged PFS compared with observation, and toxicity was manageable. Maintenance treatment was a significant prognostic factor associated with PFS.
Clozapine Induces Apoptosis in HIT-T15 Pancreatic β-Cell Lines
Sheng Yu Jin(김성우),Joo-Ho Chung(정주호),Cheol-Woo Guak(곽철우),Mi-Kyoung Kim(김미경),Jong-Woo Kim(김종우) 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2
목적 : Clozapine의 드문 부작용으로 췌장염이나 고혈당증 등이 보고되고 있지만 아직까지 정확한 기전은 밝혀지지 않고 있다. 본 연구는 이러한 부작용과 관련하여 clozapine이 췌장 조직에 직접적인 세포 독성을 일으킬 것이라는 가설 하에, clozapine이 HIT-T15 췌장 β-세포주에서 세포 사멸 과정인 apoptosis를 유도하는지를 알아보고자 하였다. 방법 : 먼저 MTT assay로 HIT-T15 췌장 β-세포주에서 clozapine의 세포 독성을 알아보고 형태학적 변화를 관찰하였으며 이러한 세포 독성의 형태로 apoptosis가 일어나는지를 DAPI staining TUNEL assay, caspase-3 assay 등의 방법을 사용하여 알아 보았다. 결과 : Clozapine이 HIT-T15 췌장 β-세포주에서 농도와 시간 의존 양상으로 세포 독성을 일으키고, 형태학적 관찰, DAPI staining, TUNEL assay 결과에서 apoptosis의 특징적인 소견을 나타내었다. 그리고 clozapine 처치 시 caspase-3의 활성이 유의하게 증가되어, caspase-3에 의해 매개되어 apoptosis가 유도된다는 것을 알 수 있었다. 결론 : 본 연구결과로 볼 때, HIT-T15 췌장 β-세포주에서 clozapine에 의해 유도되는 apoptosis가 clozapine 에 의해 발생되는 췌장염이나 고혈당증 같은 부작용의 병태생리학적 기전에 관여할 가능성이 있을 것으로 생각한다.
Achieving One Billion Key-Value Requests per Second on a Single Server
Sheng Li,Hyeontaek Lim,Lee, Victor W.,Jung Ho Ahn,Kalia, Anuj,Kaminsky, Michael,Andersen, David G.,Seongil O,Sukhan Lee,Dubey, Pradeep IEEE 2016 IEEE micro Vol.36 No.3
<P>Distributed in-memory key-value stores (KVSs) have become a critical data-serving layer in cloud computing and big data infrastructure. Unfortunately, KVSs have demonstrated a gap between achieved and available performance, QoS, and energy efficiency on commodity platforms. Two research thrusts have focused on improving key-value performance: hardware-centric research has started to explore specialized platforms for KVSs, and software-centric research revisited the KVS application to address fundamental software bottlenecks. Unlike prior research focusing on hardware or software in isolation, the authors aimed to full-stack (software through hardware) architect high-performance and efficient KVS platforms. Their full-system characterization identifies the critical hardware/software ingredients for high-performance KVS systems and suggests optimizations to achieve record-setting performance and energy efficiency: 120~167 million requests per second (RPS) on a single commodity server. They propose a future many-core platform and via detailed simulations demonstrate the capability of achieving a billion RPS with a single server platform.</P>