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Effects of Herbal Extracts Used in Oriental Medicines on Heme Oxygenase-1 Expression
Jeong, Gil-Saeng,Oh, Seung-Hwan,Kang, Dae-Gill,Lee, Ho-Sub,Kim, Youn-Chul The Physiological Society of Korean Medicine and T 2006 동의생리병리학회지 Vol.20 No.5
Effects of twenty-three aqueous herbal extracts used in oriental medicines on heme oxygenase (HO)-1 expression were estimated in a mouse hippocampal cell line, HT22. HO-1 is one of the cytoprotective enzymes activated various stimuli, and Western blot analysis was used for evaluated HO-1 expression. Six aqueous extracts such as Rhei Rhizoma, Paeoniae Radix, Uncariae Ramulus et Uncus, Theae Folium, Prunellae Spica, and Coptidis Rhizoma significantly increased HO-1 expression in HT22 cells at the concentration of 300 ${\mu}$g/ml. In Addition, four aqueous extracts including Eucommiae Cortex, Moutan Cortex Radicis, Ginseng Radix Rubra, and Scutellariae Radix moderately increased HO-1 expression. These results would be usefulfor the isolation and identification of their neuroprotective principles.
Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyoung-Su,Kang, Dae-Gil,Lee, Ho-Sub,Jeong, Gil-Saeng,Kim, Youn-Chul Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.10
<P>Sauchinone, a biologically active lignan isolated from the roots of <I>Saururus chinensis</I> (L<SMALL>OUR</SMALL>.) B<SMALL>AILL</SMALL>. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to a reduction in COX-2-derived prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. Present study also demonstrates the effects of sauchinone in inducing heme oxygenase-1 (HO-1) expression and an increase in heme oxygenase (HO) activity in RAW264.7 macrophages. The effects of sauchinone on LPS-induced PGE<SUB>2</SUB>, NO, tumor necrosis factor-α (TNF-α) and interlukine-1β (IL-1β) production were partially reversed by the HO-1 inhibitor Tin protoporphyrin was also seen in this study. In addition, we found that treatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) reduced sauchinone-induced HO-1 expression. Sauchinone also increased ERK phosphorylation. These results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 <I>via</I> ERK pathway.</P>
110 m 허들경기의 제 1허들에 대한 우수선수와 비우수선수의 운동역학적 요인 비교
길호종 ( Ho Jong Gil ),윤석훈 ( Suk Hoon Yoon ) 한국운동역학회 2013 한국운동역학회지 Vol.23 No.1
본 연구는 남자 110 m 허들경기의 제 1허들의 허들링 기술에 대한 중요성을 인지하고 최근 1년간 국내 허들경기 입상경력이 있는 14초 대의 우수선수 5명(SG)과 입상 경력이 없으며 출전 경험이 적은 15초대 비우수 선수 5명(LSG)을 대상으로 출발로부터 제 1 허들링이 완료되는 순간까지를 운동역학적으로 분석하였다. 이러한 목적을 수행하기 위하여 선수들의 허들링시 시간요인, 거리요인, 각도 요인, 각속도 요인, 그리고 지면반력 요인을 분석하였다. 본 연구결과 두 그룹 사이에 각 국면별에서는 소요시간의 차이가 나타나지 않았으나, 전체 허들링 시간에서는 통계적으로 유의하게 SG가 LSG에 비하여 빠른 결과를 나타내었다( p<.05). 이러한 결과는 Yoon(1999)의 연구에서 SG가 LSG에 비해 빠른 소요시간을 보인다는 연구와 유사한 결과를 나타내고 있으며, 스타트 후 15 m에서 발생하는 균형성, 리듬, 운동량이 기록에 가장 크게 영향을 미친다는 연구(Goss, 1991)를 뒷받침 해주고 있다. 또한 각 국면별 그룹간의 통계적인 시간 차이는 보이지 않으나, 전체 허들링 시간의 통계적인 차이를 보인 결과는 본 연구의 실험대상자의 수에 기인한다고 보인다. 즉, 본 연구의 결과에서는 제시되지 않았으나 통계적인 검증값인 t 값은 구간별로 -1.119∼-1.912의 범위에 있었고 p 값도 .6∼.8 사이의 결과를 나타내고 있어 보다 많은 연구대상자를 확보하였다면 구간별로 통계적인 차이를 발견할 수 있었을 것으로 생각된다. 또한 <Figure 4>에서 제시된바와 같이 SG는 허들링 기술의 시작(P1)보다는 마무리단계(P3)에서 LSG와 더 큰 시간 차이를 보였다. 이러한 패턴은 SG와 LSG를 구분 할 수 있는 좋은 근거라고 할 수 있다. 즉 <Table 1>에서 제시된 것처럼 SG가 LSG에 비하여 높은 COM 위치를 가지고 있음에도 불구하고 짧은 구간시간(P3)을 보여주고 있다는 점은 SG가 P3에서 큰 전진 낙하 속도를 생성하고 이러한 결과는 다음번 허들을 넘기 위한 빠른 3보 4스텝의 만드는 도움을 주고 있다는 방증이라 할 수 있다. 두 번째, 제 1허들을 넘는 과정에서 나타나는 보폭과 신체중심의 위치의 경우 보폭에서 SG가 약 10 cm 짧게, 신체중심의 최대 높이에서 SG가 LSG보다 약 5 cm가량 높게 나타나면서 소요시간이 빨랐다는 것은, 동작의 변화가 SG가 매우 빠르다는 것을 나타내고 있다. 그러나 허들을 넘기 위한 최적의 신체중심의 최대 높이가 120 cm라는 (Park, 1996) 연구 결과와는 현저한 차이가 나타나면서 효과적인 허들링을 구사하기 위해선 좀 더 낮은 자세로 신체중심을 유지해야 한다는 것을 알 수 있었다. 이것은 훈련상황에서 의도적으로 낮게 유지하여 지속해야 한다는 점을 시사해주고 있다. 세 번째, 착지구간의 전경각도에서 SG와 LSG가 유의한 차이를 보이면서 SG가 상대적으로 작은 각도를 유지하며 허들링을 구사하는 것을 볼 수 있었다. 이 결과는 Lee(2008)의 연구에서 보고된 우수선수일수록 도약과 착지구 간에서 낮은 자세로 유지하며 넘는 기술적 차이가 존재한다는 것을 뒷바침 해주고 있다. 한편, 허들링구간인 공중에서는 LSG가 SG에 비해 상체 전경각도의 각속도가 높게 나타나면서 유의한 차이를 보였다. 이것은 LSG가 상하의 움직임에 큰 변화를 시도하는 것으로 보여지며, 이는 Goss(1991)가 주장한 신체중심의 상하 이동을 최소화해야 한다는 연구결과에 비효과적 동작을 취하고 있다는 것을 나타낸다. 이 결과에 따르면 효과적인 허들링을 구사하기 위해선 전경각의 크기보다 신체중심에 대해 최소한의 변화를 주는 전경각 속도의 변화훈련을 적극 도입해야 할 것으로 추측된다. 본 연구는 제 1허들을 기술력 차이를 규명하기 위한 방법으로 운동학적 분석과 함께 직접적으로 신체중심의 제동력과 추진력에 영향을 주는 3차원 지면반력을 분석하여 비교하였다. 이 결과에 따르면 LSG의 경우 신체중심의 높이에 직접적으로 영향을 미치는 최대 수직반력에서 SG보다 약 1.4 N/Bw 높은 수치를 기록하면서 통계적으로 유의한 차이가 나타났다. 또한 통계적인 유의차이가 나타나지 않았으나, 지면 반력의 제동력을 나타내는 전-후 지면반력에서 SG가 약 0.5 N/Bw의 힘으로 제동이 발생하는 것을 알 수 있다. 이를 통해 SG가 LSG에 비해 도약구간에서 수평속도를 잃지 않고 이동 한다는 것을 짐작할 수 있다. 110 m 허들경기의 제 1허들에 대한 운동역학적 기술차 이를 분석한 결과를 종합해 보면, 제 1허들을 넘기 위한 도약구간부터 착지 순간까지 전반적으로 우수 선수가 비 우수선수에 비해 동작의 변화를 최소화 한다는 것을 관찰할 수 있었으며, 특히 허들을 넘기 위한 수평속도에 영향을 미치는 지면반력에서 우수선수가 추진력을 감소시키지 않으며 넘는 것으로 나타났다. 따라서 제 1허들의 성공적인 수행을 위해서는 무엇보다도 허들 도입구간에서 추진력을 발생시키는 발구름과 동시에 최소의 동작 변화를 실시하는 훈련이 필요할 것으로 판단된다. The purpose of this study was to provide a fundamental information for enhancing 110m hurdlers` performance through conducting comparative biomechanical analysis between Skilled Group(SG) and Less- Skilled Group(LSG) those who are not in the first section of 110m hurdles. To persue the purpose of this study, total of 10 hurdlers participated. Then they were divided into two groups; SG: five hurdlers who have won awards with 14-second range at 2010 national track and field event, and LSG: five hudlers who did not win any awards with 15-second range. Three-dimensional motion analysis with 12 infrared cameras(Oqus 300, Qualisys) and 1 force plate(Type 9286AA, Kistler) was performed. From this study following conclusions were obtained. 1) For the overall runtime, SG revealed faster elapsed time than that of LSG. 2) At E4, LSG showed greater trunk angle than that of SG. 3) At E3 LSG revealed higher angular velocities than that of SG. 4) No significant differences was found for AP GRF between groups but LSG showed greater VGRF than that of SG.
길정수,강상엽,권호열 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-
With the rapid development of communication technology and widespread uses of internet service, we showed on interest in information security. This environment was required protection of personal information and keeeping of data transmission secure. In this paper, we will enhance safty of RSA and the high speed processing of DES with the system. This chatting program is based on JAVA
강태호,정길상 동국대학교 관광산업연구소 2000 관광·호텔경영연구 Vol.2 No.1
This is the basic study for service the traditional military arts site in Gyeongju. We've compared Golgulsa(骨堀寺) in Korea with Shaolinsi(少林寺) in China. Shaolinsi is located at Songshan(嵩山), which is one of the five sacred mountains in China. Therefore, it has plenty of cultural properties, which has much values as various resources for sightseeing such as beautiful scenery, miliary arts, history, and religion. Golgulsa has very similar cultural and historical background with Shaolinsi. And its peculiar practicing form Sunmudo(禪武道) interested in by many foreign lover of military arts. The transportational and geographical condition of Golgulsa is better than that of Shaolinsi. They can be so easily connected with the traffic network such as airplane, road, railroad that they can be utilized as resources of sightseeing. Therefore, if we develop the Taekwondo(跆拳道) park area connected with Sunmudo, which is our traditional and Buddhist military arts, as the articles of tourist. It will be much contributed on the development of Gyeongju tourist.
송호달,정길채 용인대학교 산업경영연구소 1998 산업경영논총 Vol.4 No.-
Environmental expenditures are a major issue facing Korean corporations with increasing concern for environmental information by business enterprises has been the subject of substantial research for the past several decades. Surveys in a number of studies show and increasing trend of disclosing such information statements. there has been an increase of empirical studies on reporting practices in recent years(Ingram and Frazier, 1980; Wiseman, 1982; Freedman and Jaggi, 1996) These studies provide insights into the number of companies disclosing environmental information. Korea economy has accelerated the expansion and globalization of business enterprises in recent years. Many cases of river pollution caused by effluents discharged by some Korea firms have caused even greater concern about the environmental damages. The purpose of this study is to investigate the nature of the first environmental disclosure by Korean listing corporations in terms of quantity of the investment and expenditures. This study provides the empirical evidence in Korea regarding the environmental investment and expenditure disclosure in corporate financial statements. And this study suggests managerial implications about the treatments of environmental expenditure. The sample firms comprised all of the 660 companies that disclosed some amount of environmental information in the supplementary footnotes of 1997 audited interim financial statements in accordance with GAAP.
Oyster-Zeolite 흡착탑을 이용한 하수의 유기물질과 질소제거
정병길,정유진,박성현,최호은,성낙창 東亞大學校 建設技術硏究所 2005 硏究論文集 Vol.29 No.1
The objective of this study is to investigated the removal possibility of organic matter and nitrogen contained final effluent of sewage treatment plant using oyster-zeolite adsorption column with waste oyster shell and natural zeolite. The raw water was collected the final effluent of Janglim sewage treatment plant in Busan city. The organic matter and T-N removal efficiency ranged from 2~60% and 38~97%, respectively. In conclusion, oyster-zeolite adsorption column could organic matter and nitrogen removal of final effluent of sewage treatment plant and its economical efficiency is enough because of using recycled waste oyster shell and a cheap natural zeolite.
Distributed Object Oriented Software System에 관한 연구
오길호 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-
The DOWS(Distributed Object Web System)[1] is a WWW support system. It guarantees integrity of resource references and transparency of migration. It also makes software maintenance much easier. To retain integrity of references, migration and modification of resource are prohibited during resource referencing time. Therefore it is almost impossible to move a resource from one location to another if the resource is frequently referenced. Intentional suspension of resource referencing activity is required to move the resource and this reduces system performance. To solve this problem, a dynamic resource migration method is proposed in this paper. The proposed method makes it possible to reduce delay of resource migration and increase the system performance.
분산된 자동 생산 시스템 소프트웨어를 위한 온라인 테스팅 방법
오길호 國立金烏工科大學校附設生産技術硏究所 1995 産業技術開發硏究 Vol.11 No.-
Some of the software systems for the distributed manufacturing systems are required to have on-line expansion and on-line modification capabilities. An on-line testability is also naturally required in such type of systems. In this paper an on-line testing method for the distributed automatic manufacturing system software is presented. The scope of testing modules can be optionally limited by this method. Unnecessary communication overhead and processor overhead can be much more reduced than by other method with a broadcasting mechanism.
신건호,김길생 단국대학교 1998 論文集 Vol.33 No.-
To increase effectiveness of management, Korean corporations recently perform actively many innovations including reengineering within in structure. Big Deal among business, and M&A. In order to success the managerial innovations, first of all, recognition innovations for management and labour should be spread over whole company, and action innovation is needed to operate them by drawing out a management principle and sectional tasks to practice based on recognition innovations. Indeed, system innovations would by done through the managerial innovations which meet with the surrounding and real condition of corporation. The result of managerial innovations, however, may depend on the type of corporative culture. To investigate a corporative culture that will be advantageous for the managerial innovations, therefore, this thesis study on the managemental innovation of each type of corporate culture. The results are as follows: First, resonable culture was more others among Korean corporation. Second, there was no significant difference statistically in the difference between participations and supports of top management and members of types corporative culture. Third, as for the results of examination on the difference between results of managemental innovation of each type of corporative culture, there were significant differences statistically according to the reduction of operational process, increasement of working willingness, intention of separation, quality reform and increasement of customer’s satisfaction. That is, a corporation with progressive culture tends to reduce sharply its operational process sand increase working willingness of structure members, and shows high degree of quality reform and increasement of customer’s satisfaction. Fourth, the more innovative and adventurous a corporative culture is, the highter the participations and supports of top management shows, and the more humanistic and familiar it is, the high the participations and supports of its members show. Beside, the more innovative, adventurous, humanistic and familiar it is, the highter the result of managemental innovation and the reduction of separation from the corporations, a corporation that has a flexible, outward and progressive culture will be more active in performing managemental innovation and be expected to yield better results.