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Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyoung-Su,Kang, Dae-Gil,Lee, Ho-Sub,Jeong, Gil-Saeng,Kim, Youn-Chul Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.10
<P>Sauchinone, a biologically active lignan isolated from the roots of <I>Saururus chinensis</I> (L<SMALL>OUR</SMALL>.) B<SMALL>AILL</SMALL>. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to a reduction in COX-2-derived prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. Present study also demonstrates the effects of sauchinone in inducing heme oxygenase-1 (HO-1) expression and an increase in heme oxygenase (HO) activity in RAW264.7 macrophages. The effects of sauchinone on LPS-induced PGE<SUB>2</SUB>, NO, tumor necrosis factor-α (TNF-α) and interlukine-1β (IL-1β) production were partially reversed by the HO-1 inhibitor Tin protoporphyrin was also seen in this study. In addition, we found that treatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) reduced sauchinone-induced HO-1 expression. Sauchinone also increased ERK phosphorylation. These results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 <I>via</I> ERK pathway.</P>
사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예
배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2
Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.
A Unified Model : Arbitrage-free Term Structure Movements of Flow Risks
Thomas S. Y. Ho,Sang Bin Lee 한국재무학회 2012 한국재무학회 학술대회 Vol.2012 No.09
This paper first dichotomizes risk drivers into “stock” or “flow” attributes. Stock risk drivers are prices of tradable securities and flow risk drivers are rates represented by the stochastic movements of a term structure of securities. This paper then shows that the Black Scholes model is the relative valuation model for the stock risk drivers while the proposed unified model is for the flow risk drivers. The unified model can be described in the Ho-Lee model framework. We apply this model to five different flow risk drivers: interest rate, credit risk, liquidity risk, energy risk, and inflation risk. We then show that the unified model provides an analytical framework for securities that are subjected to several of these flow risk drivers, offering many applications. For example, the 2008 financial crisis clearly shows the importance of the use of a unified model in enterprise risk management. The crisis demonstrates that risk management should not take a silo approach to manage each flow risk driver, such as interest rate risk and credit risk. We propose an integrated approach to manage risks using the unified model.
혈액암환자에서 조혈모세포 이식 후 따르는 헤르페스 바이러스 감영 양상
이호섭,탁희상,신성훈,김양수,남성진,김혜수,박진희,정수현,김성빈,김예나 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1
배경 : 헤르페스바이러스과에는 단순포진 바이러스(HERPES SIMPLEX VIRUS, HSV), 수두대상포진 바이러스 (VARICELLA-ZOSTER VIRUS, VZV), 엡스타인-바 바이러스 (EPSTEIN-BARR VIRUS, EBV), 그리고 거대세포 바이러스 (CYTOMEGALOVIRUS, CMV) 등이 있다. 헤르페스바이러스 감염은 혈액암환자에서 조혈모세포 이식 환자에서 전파 (dissemination), 이차감염, 세균 중복 감염의 심각한 합병증을 일으킬 수 있다. 하지만 항암약물치료를 받는 림파종 환자에서 항 바이러스 약제의 사용 용량과 기간에 대한 concensus는 없다. 헤르페스바이러스 감염에 대한 발생율과 위험인자를 후향성으로 분석하였다. 방법 : 고신대학교 복음 병원에서 1995년 6월부터 2009 년 2월 사이에 새롭게 진단되어 조혈모세포 이식을 받은 전체 58명의 환자들이 후향적으로 현 연구에 등록했다. 헤르페스 바이러스 감염은 임상적 진단, 혈청학적 검사 또는 병리학적 진단에 기초하여 확진한다. 환자들의 특성은 다음과 같다: 평균 연령은 44세 (범위 19-62세)였고 남녀비는 30:28이었다. 등록된 질환은 백혈병 (n=9, 15.5%), 림프종 (n=30, 51.7%), 다발성 골수종 (n=12, 20.7%), 재생불량성 빈혈 (n=6, 10.3%) 그리고 골수이형성증후군 (n=1, 1.7%)이 포함되었다. 결과는 chi-squre test나 independent samples T test를 사용하여 분석되었다. Multivariate analysises에 대해 logistic regression test를 사용하였다. 결과 : 15명의 환자들 (25.9%)에서 조혈모세포 이식후 헤르페스 바이러스 감염이 발생하였다. 조혈모세포 이식 5년간 누적 발생율은 53.9%였다. Univariate analyses에서 헤르페스 바이러스 감염에 대한 유의한 위험 인자는 없었다. 하지만 조혈모세포 이식후 생존 기간(40.18 ± 30.14 months vs 20.06 ± 26.67 months, p=0.018)은 헤르페스 바이러스 감염의 낮은 발병율과 유의한 관련성이 있었다. 이식 편대 숙주질환 (GVHD)의 존재 (37.5% in developed GVHD vs 0% in no GVHD, p=0.200), 동종조혈 모세포 이식에서 면역억제요법의 기간 (15.98 ± 14.02 months vs 6.78 ± 3.67 months, p = 0.374)은 헤르페스 바이러스 감염에 대한 위험인자가 아니었다. 결론 : 조혈모세포 이식 후 생존 기간은 어사이클로비어 예방을 받은 혈액암 환자에서 헤르페스 바이러스 감염의 낮은 발병율과 연관성이 있는 것으로 보인다. 저용량의 어사이클로비어 예방은 헤르페스 바이러스 감염의 고위험군인 조혈모세포 이식을 받은 혈액암 환자에 필요하리라 생각된다. Background : Herpesviridae family includes herpes simplex virus, varicella zoster virus, Epstein-Barr virus, and cytomegalovirus, etc. Herpesviridae viral infection (HVI) can lead to serious complications including dissemination, secondary infection, bacterial superinfection in patients with hematologic malignancy following hematopoietic stem cell transplantation (HSCT). But there was no consensus on the dose and duration of antiviral agents prophylaxis in patients undergoing chemotherapy. We retrospectively analyzed the incidence and the risk factors for HVI. Method : A total of 58 patients who newly diagnosed and received HSCT with prophylaxis of acyclovir at the Kosin University Gospel Hospital, Busan, Korea between June 1995 and February 2009 were enrolled retrospectively in the current study. HVI was confirmed based on clinical diagnosis, serologic test or pathologic diagnosis. The characteristics of the patients were as follows: the median age was 44 years (range 19-62 years) with a female-to-male ratio of 30:28. The enrolled diseases included leukemia (n=9, 15.5%), lymphoma (n=30, 51.7%), multiple myeloma (n=12, 20.7%), aplastic anemia (n=6, 10.3%) and myelodysplastic syndrome (n=1, 1.7%). The results were analyzed using a chi-square test and independent samples T test. For the multivariate analysis, we used logistic regression test. Results : Fifteen patients (25.9%) developed HVI after HSCT. The cumulative incidence of HVI was 53.8% at 5 years after HSCT. In univariate analysis, there was no significant risk factor for HVI. The presence of graft-versus-host disease (GVHD) (37.5% in developed GVHD vs. 0% in no GVHD, p=0.200), duration of immunosuppressive therapy (IST) in allo-SCT (15.98 ± 14.02 months vs. 6.78 ± 3.67 months, p = 0.374) were not risk factors for HVI. Conclusion : The incidence of HVI was similar to that in historical other studies. There was no risk factor associated with development of HVI. Most of the HVI occurred within the first 24 months after transplantation. So long term use of antiviral prophylaxis may be needed to prevention of HVI after HSCT.
고호빈 호남대학교산업기술연구소 2007 산업기술연구논문집 Vol.13 No.-
이미지 테크놀러지와 소프트웨어나 하드웨어 형태의 디지털 이미지 제작 도구들을 영화 제작에 활용하는 것을 '디지털 인터미디어트'라고 한다. 원래 영화란 필름이 발명되었기 때문에 가능해진 매체이다. 지난 세기 동안 영화를 제작하는 데 있어 필름을 사용하지 않은 경우는 없었다. 필름은 영화의 동의어로 쓰일 정 도였다. 한편,지난 세기 후반 TV와 비디오라는 전자영상매체가 등장했다. 필름 영화와 전자영상매체는 한편으로는 경쟁하면서,또 다른 한편으로는 상호 보완적으로 발전했다. 여기에서 상호 보완적이었다는 것은 필름 영화가 TV와 비디오의 콘텐츠로 전환되어 보급됨으로써 전자영상매체의 발전에 큰 기여를 했다는 뜻이다. 그러나 TV와 비디오 콘텐츠가 필름 영화로 전환되는 경우는 드물었다. 가장 큰 이유는 TV와 비디오가 구현하는 영상과 음향의 질과 미학적 표현력이 필름 영화에 비해 열등했기 때문이다. 21세기,TV와 비디오의 원천 기술이 디지털 방식으로 바뀌고,HD 포맷이 개발되면서 상황이 달라지고 있다. 디지털 HD 포뱃의 영상과 음향의 질은 필름의 그것과 대등한 수준으로 평가된다. 그리고 디지털 방식의 영상 제작 공정은 대단히 경제적이고 효율적이다. 이제 영화 제작에 디지털 제작 공정을 채택하지 않을 이유가 없다. 미래의 영화는 필 름 없는 영화,디지털 영화가 될 것이다. Using digital image technology or digital image making tools in the form of software or hardware on film making is called the 'digital intermediate.' Originally, the cinema became a medium through the invention of film. During the past century it was impossible to produce the cinema using film. It even became so that the word 'film' was used as a synonym for 'cinema'. In the mean while, during the last few decades, the electronic media such as TV and video were introduced. The film media and the electronic media have been competing with each other, on the other hand, developing complementarily. What is meant here by 'complementarily' is that the distribution of the films as the contents or programs on TV and video contributed greatly to the development of the electronic media. However, not often were the contents of TV and video converted into the films. This is because the quality of image, sound, and artistic expression in TV and video were inferior to those of the films In the 21st century, as the older analog technology for TV and video changed to the digital and the HD format was developed, a new situation has been formed. The quality of image and sound of the digital HD format can now be equal to those of the film. Also, film making by the digital method is very economic and efficient. There is now no reason not to choose the digital process when making films. The cinema of the future will become a digital cinema of 'the film without film".
全永鎬,李彬娜,林凞燮 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-
Brand asset management to build powerful brand asset is needed to have more powerful comparative advantage. In this study, critical factors of the structure of brand asset are considered. For this purpose, the relationships between the brand asset and the structure of brand asset are evaluated. And measurement of the competitive power of the specific brand at the point of clients by describing the systematic measuring methodology of the brand asset and its applications is studied. And then, the model that can be used to solve and improve the general realities and level of brand management is proposed. For this, we recognized the strategic importance of brand asset and the brand asset management with previous studies. And we improved the model that showed that the increasing of brand competitive power makes purchasing intention and the brand loyalty increase at the point of clients by pointing out the limit of previous studies. With this improved model, we investigated the brand competitive power on digital electric home appliances about images, sounds, and communications. To test this model statistically, the structural equation model that is most popular in the latest is used. By using the result of this study, companies will be able to measure of their own and the other's brand competitive power and understand the method of benchmarking and the improvements. Moreover, the government will be able to draw up the plan and the system that support to secure the brand competitive power and bring up the global brand that have international competitive power.
송호빈,서영수 明知大學校 産業技術硏究所 2000 産業技術硏究所論文集 Vol.19 No.-
This paper is execute the adapt inspection to ascertain switching device model and induction motor model. Induction motor library is modeled for the adapt inspection, and three-phase PWM inverter with induction motor load is executed to simulation using PSPICE. Speed sensorless vector control of induction motor algorithms are modeled by taking use of closed loop and TMS320C31 DSP CPU PWM related circuit and interface circuit for expedite the result, and it is proved that the output of EPLD system and SIMULINK modeling simulation are almost same.
고호빈 호남대학교 2007 학술논문집 Vol.28 No.2
The purposes of this paper is to identify six different modes of representation that function something like sub-genres of the documentary film genre itself: poetic, expository, participatory, observational, reflexive, performative. The order of representation for these six modes corresponds roughly to the chronology of their introduction. The desire to come up with different ways of representing the world contributes to the formation of each mode, as does a changing set of circumstances. New modes arise partly in response to perceived deficiencies in previous ones. but the perception of deficiency comes about partly from a sense of what it takes to represent the historical world from a particular perspective at a given moment in time. The reflexive mode is the most self-conscious and self -questioning mode of representation. Reflexive documentary films to be called fake documentaries rely on trained actors to deliver the performances we initially believe to be the self-presentation of people engaged in everyday life. Our realization of this deception, when the credits reveal the fabricated nature of the performances we witnessed, prompts us to question the authenticity of documentary in general. At its best, reflexive documentary prods the viewer to a heightened form of conscious about the relation to a documentary and what it represents, The emotional intensity and subjective expressiveness of performative documentary took shape in the 1980's. In recent work this social subjectivity is often that the underrepresented or misrepresented, of women and ethnic minorities, gays and lesbians. Performative documentary can act as a corrective to the films where 'We speak about them to us.' They proclaim, instead, that 'We speak about ourselves to you.' or 'We speak about ourselves to us.' In this formation, Filmmaker and subject are the same stock. By speaking about an ourselves that includes the filmmaker these films achieve a degree of intimacy that be quite compelling. Performative documentaries contribute to broader issues of difference, equality, and non-discrimination. They attest to a commonality of experience and to the forms of struggle necessary to overcome stereotyping, discrimination, and bigotry. The political voice of these documentaries embodies the perspectives and visions of communities that share a history of exclusion and a goal of social transformation.
고호빈 호남대학교 2007 학술논문집 Vol.28 No.2
This paper contemplates the issues of decentering in the modern cinema. The mainstream cinema for the film history is the narrative cinema. This cinema maneuvers the apparatus and codes to unify the points of view and time. Although it is minor, a series of the contemporary movies that can be named the 'acentric' films expose such a discontinuity and incoherence. The point of view and time in the acentric films is ceaselessly increased and acentred. There are several points of views and theories to interpret it. However, it is the general consensus that most of codes, system of representations, and discourses are exposed as the ideological nature. However, the assertion of the later structuralism philosopher, Gilles Deleuze, is unique and attentive. We, human beings as the living body, cannot sustain such an excessive stimulation of the images. Therefore, Deleuze argues, in order to avoid the excessive dissipation arising from the image, the circuitry of our brain is operated. The circuitry of brain that Deleuze referred to is the rationality or understanding. Following the argument of Deleuze, our function of rationality critically civilizes the image for the survival of our existence. In other words, it forms the order, coordinates and codifies. All visual codes including the perspectives, artistic codes, social and cultural regulations and systems may be understood in such a context.