Principle and Method of Breast Reduction

Hisamitsu Zaha 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11

Inhibitory Effect of Electroacupuncture on Murine Collagen Arthritis and its Possible Mechanisms

Tadashi Hisamitsu 대한약침학회 2001 Journal of pharmacopuncture Vol.4 No.1

The influence of electroacupuncture (EA), a traditional Chinese medical treatment, on type Ⅱ collagen-induced arthritis (CIA) was examined in DBA/1J mice in vivo. Mice were immunized intradermally twice at the 3-week interval with bovine type Ⅱ collagen(C Ⅱ). EA stimulation, begun on the 21 simultaneously with the second immunization, was applied at the acupoint equivalent to GV4 three times a week for 3 weeks. The results showed that EA delayed the onset, attenuated the severity of arthritis, and reduced the anti-collagen antibody level. Furthermore, we investigated the impact of EA on the productions of endogenous interleukin-1 β (IL-1 beta) and prostaglandin E2 (PGE2), and the levels of IL-1 beta mRNA in splenocytes and synovial tissues from C Ⅱ immunized mice on the 45 and cyclooxygenase-2 (COX-2) mRNA in lipopolysaccharide (LPS)-stimulated macrophages of normal mice by using reverse transcriptase-polymerase chain reaction (RT-PCR). EA stimulation significant inhibited the concentrations of splenic endogenous IL-1 beta and serum PGE2. The expression of IL-1 beta mRNA in spleen cells was obviously down-regulated and that in synovial tissues was modestly affected by EA. COX-2 mRNA was highly expressed in cultured peritoneal macrophages when stimulated with LPS. Previous treatment with EA also reduced LPS-stimulated induction of COX-2 mRNA. These data suggest that EA has an inhibitory effect on murine CIA, and the partial mechanism of its therapeutic result may be attributed to inhibiting the productions of IL-1 beta and PGE2 by suppression the IL-1 beta and COX-2 gene activations.

Influence of moxibustion on collagen-induced arthritis in mice

Tadashi Hisamitsu 대한약침학회 2000 Journal of pharmacopuncture Vol.3 No.2

The influence of moxibustion, a traditional Chinese medical treatment, on type II collagen-induced arthritis (CIA) was examined in DBA/1J mice in vivo. Mice were immunized intradermally twice at the 3-week interval with bovine type II collagen (C Il). The main incidence of arthritis started about on day 30 and lasted to day 60 after the first immunization. Moxibustion with three different regimens, was applied at the acupoint equivalent to GV 4 every other day. Moxibustion, from day 0 to day 30 after the first immunization, suppressed the onset and development of arthritis, as well as anti-collagen antibody level. Treatment with moxibustion, from the day 31 to day 60, also resulted in a significant inhibition of progression of arthritis and production of anti-C II antibody. Thirdly we examined the influence of moxibustion on the established arthritis. Moxibustion given from day 61 to day 120, significantly but mildly decreased the anti-C II antibody level in diseased mice, while the bone erosion and joint destruction were not affected. These results indicate that moxibustion could prevent the incidence and attenuates the development of murine CIA

Changes in Blood Fluidity Caused by Electroacupuncture Stimulation

Tadashi Hisamitsu,Shintaro Ishikawa 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4

In Oriental medicine, the state of blood stagnation is called “Oketsu,” meaning preceding state or symptomatic of sickness. Acupuncture stimulation is often used clinically for the treatment of “Oketsu.” The degree of “Oketsu” is indicated by tongue color and form, swelling, paroxysmal blushing, and dark circles under the eyes. The blood’s fluidity is generally thought to be a blood stagnation factor. “Oketsu” is now considered as physio- logical blood flow and is studied from the perspective of the blood’s fluidity and vascular resistance. In our preliminary research, acupuncture stimuli were very effective in treat- ing conditions associated with a decrease in the fluidity of the blood, such as “Oketsu.” In this review, we discuss recent progress in acupuncture therapy and report mechanisms of its action; we then focus on our original findings on these topics. Furthermore, we pro- pose new factors related to acupuncture stimuli, including the blood’s fluidity, and report our investigations, using the restraint stress method, on the mechanisms underlying acupuncture stimuli.

Clinical Usefulness of Corticotropin Releasing Hormone Testing in Subclinical Cushing’s Syndrome for Predicting Cortisol Replacement after Adrenalectomy

Masahiro Inoue,Hisamitsu Ide,Koji Kurihara,Tatsuro Koseki,Jingsong Yu,Toshiyuki China,Keisuke Saito,Shuji Isotani,Satoru Muto,Shigeo Horie 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.6

Purpose: The purpose of this study was to investigate the clinical and hormonal features of patients with incidentally discovered adrenal adenomas in relation to corticotropin releasing hormone (CRH) testing and the clinical outcome of adrenalectomy. Materials and Methods: Twenty-three consecutive patients with incidentally detected adrenal adenomas were included in this retrospective study. All the patients underwent abdominal computed tomography scans and hormonal assays, including assessment of circadian rhythms of plasma cortisol and corticotropin (adrenocorticotropic hormone, ACTH), a corticotropin stimulation test, and low-dose and high-dose dexamethasone tests. The patients were reevaluated at regular intervals (6, 12, and 24 months) for a median period of 24 months. Subclinical Cushing’s syndrome (SCS) was diagnosed in patients with subtle hypercortisolism who did not present clinical signs of Cushing’s syndrome. Results: We calculated the responsive index (peak value of ACTH in CRH test/baseline value of ACTH in CRH test). Of 23 patients, 6 had Cushing’s syndrome, 8 had SCS, and 9 had a non-functioning tumor. All patients underwent laparoscopic adrenalectomy. Several patients (5 of 6 with Cushing’s syndrome and 2 of 8 with SCS) required cortisol replacement therapy after surgery. The remaining patients required no hormonal replacement after surgery. Those who required hormone replacement had a responsive index of less than 1.2. Those who did not need hormone replacement therapy had a responsive index of more than 2.0. Conclusions: In our limited experience, the responsive index of the CRH test might be a valuable tool for predicting the need for cortisol replacement after surgery in patients with SCS. Purpose: The purpose of this study was to investigate the clinical and hormonal features of patients with incidentally discovered adrenal adenomas in relation to corticotropin releasing hormone (CRH) testing and the clinical outcome of adrenalectomy. Materials and Methods: Twenty-three consecutive patients with incidentally detected adrenal adenomas were included in this retrospective study. All the patients underwent abdominal computed tomography scans and hormonal assays, including assessment of circadian rhythms of plasma cortisol and corticotropin (adrenocorticotropic hormone, ACTH), a corticotropin stimulation test, and low-dose and high-dose dexamethasone tests. The patients were reevaluated at regular intervals (6, 12, and 24 months) for a median period of 24 months. Subclinical Cushing’s syndrome (SCS) was diagnosed in patients with subtle hypercortisolism who did not present clinical signs of Cushing’s syndrome. Results: We calculated the responsive index (peak value of ACTH in CRH test/baseline value of ACTH in CRH test). Of 23 patients, 6 had Cushing’s syndrome, 8 had SCS, and 9 had a non-functioning tumor. All patients underwent laparoscopic adrenalectomy. Several patients (5 of 6 with Cushing’s syndrome and 2 of 8 with SCS) required cortisol replacement therapy after surgery. The remaining patients required no hormonal replacement after surgery. Those who required hormone replacement had a responsive index of less than 1.2. Those who did not need hormone replacement therapy had a responsive index of more than 2.0. Conclusions: In our limited experience, the responsive index of the CRH test might be a valuable tool for predicting the need for cortisol replacement after surgery in patients with SCS.

Cosmetic Evaluation Methods Adapted to Asian Patients after Breast- Conserving Surgery and Examination of the Necessarily Elements for Cosmetic Evaluation

Yuki Nohara,Noriko Hanamura,Hisamitsu Zaha,Hiroko Kimura,Yumi Kashikura,Takashi Nakamura,Aya Noro,Nao Imai,Mai Shibusawa,Tomoko Ogawa 한국유방암학회 2015 Journal of breast cancer Vol.18 No.1

Purpose: Although various strategies have been reported, thereare no defined criteria for cosmetic evaluation methods afterbreast-conserving surgery (BCS). Since Asians tend to havesmaller breasts, indistinct inframammary folds, and conspicuousscars, differences in the cosmetic results are expected. So weexamined two subjective methods and one objective method todetermine the differences, and elements necessary for a cosmeticevaluation after BCS. Methods: Frontal photographs of 190Japanese were evaluated using the Harris scale (Harris) and theevaluation method proposed by the Japanese Breast Cancer SocietySawai group (Sawai group) as the subjective methods, andthe Breast Cancer Conservation Treatment cosmetic results(BCCT.core) as the objective method, respectively. In order to examinethe necessary elements for developing a new ideal method,100 out of 190 were selected and assessed separately by sixraters using both the Harris and modified Sawai group methodsin the observer assessment. The correlation between the twomethods was examined using the Spearman rank-correlation coefficient. Results: The results of the BCCT.core and the other twomethods were clearly different. In the observer assessment, theconsensuses of the six raters were evaluated as follows: 27, 27,26, and 20 cases were evaluated as “excellent,” “good,” “fair,”and “poor,” respectively. For the Spearman rank-correlation coefficient,values higher than 0.7 indicated a strong correlation, asseen by the values of 0.909 for the breast shape and 0.345 forthe scar. The breast shape accounted for the most significantpart of the evaluation, and the scar had very little correlation. Conclusion:In this study, we recognized a clear difference betweenthe subjective and objective evaluation methods, and identifiedthe necessary elements for cosmetic evaluation. We would like tocontinue developing an ideal cosmetic evaluation that is similar tosubjective one and is independent from raters.

Ku-band satellite signal propagation experiments and MVL experiments using satellite network in Asian pacific region under Post-PARTNERS project

Igarashii, Kiyoshi,Minakoshi, Hisamitsu,Watari, Shinichi,Ojima, Takeyuki,Hemmakorn, Narong,Sang-In, Akachai,Sastrokusmo, Utoro,Hassan, Syed Syed Idris,Reyes, Rosula,Maitava, Kevin,Sasaki, Makoto,Minod 통신위성우주산업연구회 2001 Joint Conference on Satellite Communications Vol.2001 No.-

Under the Post-PARTNERS (Pan-pacific Regional Telecommunication Network Experiment and Research by Satellite) project we have established Ku band satellite communication network system in Asian pacific region, including Thailand, Indonesia, Malaysia, Philippine, and Fiji in 2000. Results of second year Ku-band beacon signal measurement are presented. One of the* results indicate that the rain attenuation in Malaysia is much higher than that obtained using the ITU rain attenuation prediction model. In order to promote a basic science and remote education a trial experiment of MVL (Multimedia Virtual Laboratory) experiments is explained by using a network connected between satellite communication network and ground high speed network.

가변속 펌프시스템의 최고 성에너지방법 - [유량제어에 의한 약 25%의 성에너지 실현]

관원 구광,Sugawara Hisamitsu 대한기계설비건설협회 1999 기계설비 Vol.103 No.-

Influence of moxibustion on collagen-induced arthritis in mice

Fang, Jian-Qiao,Aoki, Eri,Seto, Akira,Yu, Ying,Kasahara, Takako,Hisamitsu, Tadashi KOREAN PHARMACOPUNCTURE INSTITUTE 2000 Journal of pharmacopuncture Vol.3 No.2

The influence of moxibustion, a traditional Chinese medical treatment, on type II collagen-induced arthritis (CIA) was examined in DBA/1J mice in vivo. Mice were immunized intradermally twice at the 3-week interval with bovine type II collagen (C Il). The main incidence of arthritis started about on day 30 and lasted to day 60 after the first immunization. Moxibustion with three different regimens, was applied at the acupoint equivalent to GV 4 every other day. Moxibustion, from day 0 to day 30 after the first immunization, suppressed the onset and development of arthritis, as well as anti-collagen antibody level. Treatment with moxibustion, from the day 31 to day 60, also resulted in a significant inhibition of progression of arthritis and production of anti-C II antibody. Thirdly we examined the influence of moxibustion on the established arthritis. Moxibustion given from day 61 to day 120, significantly but mildly decreased the anti-C II antibody level in diseased mice, while the bone erosion and joint destruction were not affected. These results indicate that moxibustion could prevent the incidence and attenuates the development of murine CIA.

Inhibitory Effect of Electroacupuncture on Murine Collagen Arthritis and its Possible Mechanisms

Fang, Jian-Qiao,Aoki, Eri,Yu, Ying,Sohma, Toshimitsu,Kasahara, Takako,Hisamitsu, Tadashi KOREAN PHARMACOPUNCTURE INSTITUTE 2001 Journal of pharmacopuncture Vol.4 No.1

The influence of electroacupuncture (EA), a traditional Chinese medical treatment, on type Ⅱ collagen-induced arthritis (CIA) was examined in DBA/1J mice in vivo. Mice were immunized intradermally twice at the 3-week interval with bovine type Ⅱ collagen(C Ⅱ). EA stimulation, begun on the 21 simultaneously with the second immunization, was applied at the acupoint equivalent to GV4 three times a week for 3 weeks. The results showed that EA delayed the onset, attenuated the severity of arthritis, and reduced the anti-collagen antibody level. Furthermore, we investigated the impact of EA on the productions of endogenous $interleukin-1{\Beta}$ (IL-1 beta) and prostaglandin E2 (PGE2), and the levels of IL-1 beta mRNA in splenocytes and synovial tissues from C Ⅱ immunized mice on the 45 and cyclooxygenase-2 (COX-2) mRNA in lipopolysaccharide (LPS)-stimulated macrophages of normal mice by using reverse transcriptase-polymerase chain reaction (RT-PCR). EA stimulation significant inhibited the concentrations of splenic endogenous IL-1 beta and serum PGE2. The expression of IL-1 beta mRNA in spleen cells was obviously down-regulated and that in synovial tissues was modestly affected by EA. COX-2 mRNA was highly expressed in cultured peritoneal macrophages when stimulated with LPS. Previous treatment with EA also reduced LPS-stimulated induction of COX-2 mRNA. These data suggest that EA has an inhibitory effect on murine CIA, and the partial mechanism of its therapeutic result may be attributed to inhibiting the productions of IL-1 beta and PGE2 by suppression the IL-1 beta and COX-2 gene activations.