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- 저자 : Hirsch (검색결과 51 건)
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In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment
Hadassa Hirschfield,C Billie Bian,Takaaki Higashi,Shigeki Nakagawa,Tizita Z Zeleke,Venugopalan D Nair,Bryan C Fuchs,Yujin Hoshida 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Tractable experimental model that accounts for inter-tumor molecular heterogeneity is a key element of anti-cancer drug development. Hepatocellular carcinoma is known to exhibit highly heterogeneous molecular aberrations across the tumors, including somatic genetic and epigenetic alterations. Previous studies showed that molecular tumor subtypes determined by transcriptome, as a comprehensive functional readout, are reproducibly observed across global patient populations irrespective of geographic and etiological variations. Here we demonstrate that transcriptomic hepatocellular carcinoma subtypes, S1 and S2, determined by our previous transcriptome meta-analysis of multiple clinical hepatocellular carcinoma cohorts, are presented in a panel of hepatoma cell lines widely used by the research community. Interestingly, cell line that resembles gene expression pattern of S3 subtype, representing less aggressive tumors, was not identified in the panel. MYC pathway-activated S2-like cell lines showed higher sensitivity to a small molecule BET bromodomain inhibitor, (+)-JQ1, which has anti-MYC activity. These results support the use of hepatoma cell lines as models to evaluate molecular subtype-specific drug response, which is expected to lead to development of tailored, precision care of the patients with hepatocellular carcinoma.
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Hirsch, Viola,Kohli, Meetu R.,Kim, Syngcuk The Korean Academy of Conservative Dentistry 2016 Restorative Dentistry & Endodontics Vol.41 No.4
Two case reports describing a new technique of creating a repositionable piezoelectric bony window osteotomy during apicoectomy in order to preserve bone and act as an autologous graft for the surgical site are described. Endodontic microsurgery of anterior teeth with an intact cortical plate and large periapical lesion generally involves removal of a significant amount of healthy bone in order to enucleate the diseased tissue and manage root ends. In the reported cases, apicoectomy was performed on the lateral incisors of two patients. A piezoelectric device was used to create and elevate a bony window at the surgical site, instead of drilling and destroying bone while making an osteotomy with conventional burs. Routine microsurgical procedures - lesion enucleation, root-end resection, and filling - were carried out through this window preparation. The bony window was repositioned to the original site and the soft tissue sutured. The cases were re-evaluated clinically and radiographically after a period of 12 - 24 months. At follow-up, radiographic healing was observed. No additional grafting material was needed despite the extent of the lesions. The indication for this procedure is when teeth present with an intact or near-intact buccal cortical plate and a large apical lesion to preserve the bone and use it as an autologous graft.
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Trends in the use of radiation for meningioma across the United States
Hirsch Matani,Stephen Abel,Alexander Yu,Stephen M. Karlovits,Rodney E. Wegner 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.1
Purpose: Meningiomas are tumors originating from arachnoid cap cells on the surface of the brain or spinal cord. Treatment differs by grade but can consist of observation, surgery, radiation therapy or both. We utilized the National Cancer Database (NCDB) to compare trends in the use stereotactic radiosurgery (SRS) and external beam radiation therapy (EBRT) in the management of meningioma. Materials and Methods: We queried the NCDB from 2004-2015 for meningioma patients (grade 1-3) treated with radiation therapy, either SRS or EBRT. Multivariable logistic regression was used to identify predictors of each treatment and to generate a propensity score. Propensity adjusted Kaplan-Meier survival curve analysis and multivariable Cox hazards ratios were used to identify predictors of survival. Results: We identified 5,406 patients with meningioma meeting above criteria with 45%, 44%, and 11% having World Health Organization (WHO) grade 1, 2, and 3 disease, respectively. Median follow up was 43 months. Predictors for SRS were grade 1 disease, distance from treatment facility, and histology. The only predictor of EBRT was grade 3 disease. Treatment year, histology, race and female sex were associated with improved survival. Five- and 10-year survival rates were 89.2% versus 72.6% (p < 0.0001) and 80.3% versus 61.4% (p = 0.29) for SRS and EBRT respectively. After propensity matching 226 pairs were generated. For SRS, 5-year survival was not significantly improved at 88.2% compared with EBRT (p = 0.056). Conclusion: In the present analysis, predictors of SRS utilization in management of meningioma include WHO grade 1 disease, distance from treatment facility and histology whereas conventional EBRT utilization was associated with grade 2 and 3 disease. Future studies need to be performed in order to optimize management of atypical and malignant meningioma.
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Emerging Issues In Southeast Asian Geography: Local, Non-Local and Collaborative Scholarship
Philip Hirsch 서강대학교 동아연구소 2013 TRaNS(Trans –Regional and –National Studies of Sou Vol.1 No.1
This paper reviews several prominent journals to identify key trends and issues in Southeast Asian geography. The review identifies the locus of articles’ geographical scholarship, the balance between issue-based versus other types of articles, and the trends in the subject matter of the issue-based publications. The paper considers the meaning of an ‘issue-based’ approach to geography in local and non-local geographical scholarship on and in Southeast Asia. Geography as taught and practiced in Southeast Asia has followed a largely idiographic tradition based on description oflandscapes, regions, settlement patterns, and so on. At an applied level, geography in some Southeast Asian countries has tended toward regional planning rather than engaging more centrally with the social sciences. Geography as a critical social science has only a loose purchase in the inherently geographical debates around development, environment, globalisation, and regionalisation in Southeast Asia. On the other hand, geographers from outside the region have engaged in more critical study, and geographical teaching and research on Southeast Asia in Australasia, North America, and Europe tends to take an issue-based approach and to be situated broadly within the realm of ‘development geography’. The paper also concludes with the question of how the discipline can better serve an issue-based agenda without being dominated by western critical social science.
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Andrew Hirsch,Sophan Chhin,Jianwei Zhang,Michael Premer 강원대학교 산림과학연구소 2023 Journal of Forest Science Vol.39 No.2
Due to the multiple ecosystem benefits that iconic large, old growth trees provide, forest managers are applying thinning treatments around these legacy trees to improve their vigor and reduce mortality, especially in the face of climate change and other forest health threats. One objectives of this study was to analyze sub-hourly stem fluctuations of legacy ponderosa (Pinus ponderosa Dougl. Ex P. & C. Laws) and sugar pines (Pinus lambertiana Dougl.) in the mixed-conifer forests of the Sierra Nevada in multiple different radius thinning treatments to assess the short-term effects of these treatments. Thinning treatments applied were: R30C0 (9.1 m radius), R30C2 (9.1 m radius leaving 2 competitors), and RD1.2 (radius equaling DBH multiplied by 1 ft/in multiplied by 1.25). The other objective was to assess climatic drivers of hourly stem fluctuations. Using the dendrometeR package, we gathered daily statistics (i.e. daily amplitude) of the stem fluctuations, as well as stem cycle statistics such as duration and magnitude of contraction, expansion, and stem radial increment. We then performed correlation analyses to assess the climatic drivers of stem fluctuations and to determine which radial thinning treatment was most effective at improving growth. We found an important role that mean solar radiation, air temperature, and relative humidity play in stem variations of both species. One of the main findings from a management perspective was that the RD1.2 treatment group allowed both species to contract less on warmer and higher solar radiation days. Furthermore, sugar pine put on more stem radial increment on higher solar radiation days. These findings suggest that the extended radius RD1.2 thinning treatment may be the most effective at releasing legacy sugar and ponderosa pine trees compared to the other forest management treatments applied.
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Viola Hirsch,Meetu R. Kohli,Syngcuk Kim 대한치과보존학회 2016 Restorative Dentistry & Endodontics Vol.41 No.4
Two case reports describing a new technique of creating a repositionable piezoelectric bony window osteotomy during apicoectomy in order to preserve bone and act as an autologous graft for the surgical site are described. Endodontic microsurgery of anterior teeth with an intact cortical plate and large periapical lesion generally involves removal of a significant amount of healthy bone in order to enucleate the diseased tissue and manage root ends. In the reported cases, apicoectomy was performed on the lateral incisors of two patients. A piezoelectric device was used to create and elevate a bony window at the surgical site, instead of drilling and destroying bone while making an osteotomy with conventional burs. Routine microsurgical procedures - lesion enucleation, root-end resection, and filling - were carried out through this window preparation. The bony window was repositioned to the original site and the soft tissue sutured. The cases were re-evaluated clinically and radiographically after a period of 12 - 24 months. At follow-up, radiographic healing was observed. No additional grafting material was needed despite the extent of the lesions. The indication for this procedure is when teeth present with an intact or near-intact buccal cortical plate and a large apical lesion to preserve the bone and use it as an autologous graft.
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