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Boron nitride nanotube-CREKA peptide as an effective target system to metastatic breast cancer
Ferreira Tiago Hilário,de Oliveira Freitas Luiza Baptista,Fernandes Renata Salgado,dos Santos Virgílio Mateus,Resende Jarbas Magalhães,Cardoso Valbert Nascimento,de Barros André Luís Branco,de Sousa E 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.5
Purpose The development of nanomaterials that are capable of recognizing disease-specific biomarkers with high sensitivity and specificity is related to several advances in the field of nanomedicine. Furthermore, the targeted delivery of anticancer agents to tumor tissues enhances their efficiency and reduces their toxic side effects. Boron nitride nanotubes (BNNTs) are nanostructured materials, analog to carbon nanotubes, which present good biocompatibility and morphology suitable for tumor cell internalization. CREKA is a pentapeptide that has a high affinity to fibrin, a protein found in the new tumor vessels in the early stages of metastasis and in thrombosis regions. Methods In this study BNNTs were chemically functionalized with the peptide CREKA, and this system was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), zeta potential, scanning electron microscopy, and transmission electron microscopy. Results After the mentioned chemical steps, the FTIR analysis shows an organic phase related to the CREKA, TGA indicates that about 10% of the peptide is firmly attached to BNNT surface. In addition, the radiolabeling process was successful, achieving the purity required for the biodistribution study. In vivo experiments showed that a considerable amount of BNNTCREKA was accumulated at the tumor and metastasis sites. Conclusion The present results indicate an effective targeting of the system to tumor and metastasis sites. Further studies can reveal potential applications of functionalized BNNTs in cancer treatment.
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The Effect of Self-Healing Agent Fraction on CFRP Mechanical Behavior: Statistical Analysis Approach
Yuri Pereira Chuves,Francisco Maciel Monticeli,Allana Azevedo do Nascimento,Ana Paula Cysne Barbosa,Herman Jacobus Cornelis Voorwald,Maria Odila Hilário Cioffi 한국섬유공학회 2023 Fibers and polymers Vol.24 No.2
The self-healing application in structural composites aims to recover component properties, control damage propagation,and increase component life. In this way, this study proposes to characterize and predict the inter-laminar shear behaviorof polymer composites (5HS carbon/epoxy) with different fractions of self-healing agent. In addition, this work aims tomeasure the influence of self-healing content on the mechanical response. The ANOVA evidenced that the healing agentfraction influences on mechanical properties more than the internal dispersion for the same laminate before the healingcycle. Weibull distribution evidenced a linear decrease in shear stresses for higher EMAA (poly(ethylene-co-methacrylicacid)) content, regarding stiffness decrease as a response to ductile thermoplastic behavior. Ineffective healing effects wereobserved for the translaminar and intra-laminar damage, once most particles were concentrated in inter-laminar sections. However, the healing efficiency reached an average of 62% for shear stress and 106% for toughness behavior, provided bythe closing shear cracks, i.e., up to 57% of reduced area related to the initial crack size. The predictive approach beforeand after healing action in the mechanical behavior provides the appropriate self-healing level to meet the specific projectrequirements, thus saving time and cost.
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