고온가열처리에 의한 바다방석고둥 ( Omphalius pfeifferi capenteri ) 의 식품성분 변화

하진환(Jin Hwan Ha),송대진(Dae Jin Song),김풍호(Poong Ho Kim),허민수(Min Soo Heu),조문래(Moon Lae Cho),심효도(Hyo Do Sim),김혜숙(Hey Suk Kim),김진수(Jin Soo Kim) 한국수산과학회 2002 한국수산과학회지 Vol.35 No.2

바다방석고둥을 원료로 한 신제품 개발에 관한 일련의 기초 연구로 저장성 부여를 위하여 시도하는 고온가열처리 조건 (F_0 5분, F_0 10분, F_0 15분 및 F_0 20분)에 따른 바다방석고둥의 성분변화에 대하여 살펴보았다. 바다방석고둥 통조림은 살균을 5분 이상 처리하는 경우 저장 중 팽창관이 발생하지 않았고, 또한 생균수가 검출되지 않아 저장성이 있었다. 고온가열처리 정도가 증가할수록 바다방석고둥의 일반성분 중 수분함량은 감소하였고, 조단백질 함량은 증가하였으며, 조지방 및 조회분 함량은 거의 변화가 없었다. 또한 바다방석 통조림은 고온가열처리 정도가 증가할수록 이취에 관여하는 휘발성염기질소 함량, pH와 색조에 관여하는 갈변도는 증가하였고, 영양에 관여하는 구성아미노산, 무기질과 맛에 관여하는 유리아미노산, TMAO, total creatinine 및 수율 둥은 감소하였다. 이들을 색조, 조직감 및 맛에 대하여 관능검사한 결과 자숙 처리한 시료에 비하여 모든 항목에서 F_0 10분까지는 차이가 없었으나, 그 이상 가열처리한 경우 품질이 저하하였다고 인지되었다. 이상의 결과로 미루어 보아 바다방석고둥을 고온가열처리하여 신제품을 개발하고자 하는 경우 F_0 값이 10분 이상이면 바람직하지 않은 것으로 판단되었다. The top shell, Omphalius pfeifferi capenteri meat vacuum-packed in can (diameter× height, 74.1 ㎜ × 50.7 ㎜) were heated at 115℃ up to F_0 values of 5 min, 10 min, 15 min and 20 min, and the changes in food components were studied. After 14 days storage at 37℃ and 55℃, no growth of microorganism and panelling were recognized from the canned meats which were sterlized at 115℃ with F_0 value of 5 min and over. In the case of proximate composition of the canned meats, the moisture content decreased with the increase of F_0 value, while crude protein increased. The increase of volatile basic nitrogen content, pH and degree of browning and the decrease of mineral, total amino acid, free amino add, trimethylamine oxide, total creatinine contents and yields were observed during thermal processing. In sensory evaluation on color, texture and taste in the canned meats, no significant difference was observed among a boiled sample and the canned meats heated at F_0 value of 10 min and below. But, in the canned meats heated at F_0 value of over 15 min, its sensory scores decreased with the increase of F_0 value. From these results, the reasonable F_0 value for preparation of the heat-treated top shell meats was in the range of 5∼10 min.

심한 정신병적 증상을 나타낸 전신성 홍반성 루푸스 3례

문혜원,강민희,송정수,박원,김철응,이정섭,배재남 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

전신성 홍반성 루푸스(systemic lupus erythematosus, 이하 SLE)는 원인을 알 수 없는 자가항체 및 면역복합체로 인하여 여러 장기의 손상을 초래하는 질환이다. SLE의 신경정신의학적 증상에 대하여는 1872년 Kaposi에 의해 처음 기술되었다. 이때에 나타나는 임상적 양상은 상당히 다양하여 정신증, 우울증, 뇌졸증과 인지기능장애등을 포함한다. 이들은 종합적인 정신과적 평가를 위해 종종 협의진료가 의뢰되고 있다. SLE의 정신병적 증상은 환자의 사망률을 높이고 좋지 않은 예후를 시사하는 지표가 될 수 있기 때문에 조기 진단 및 치료가 요구된다. 그러나 SLE의 중추신경계 침범에 대한 명확한 진단기준이 마련되어있지 않고, 증상의 다양성과 변동성은 진단을 더욱 어렵게한다. 저자들이 경험한 심한 정신병적 증상을 보인 SLE 3례의 경우, 이들은 지남력 장애, 환시, 환청, 망상, 불안정한 기분을 보였고 자주 충동적이 되거나 난폭해져 자신 또는 타인에게 위험을 초래할 수 있었다. 현재까지 SLE의 정신병적 증상에 대하여 잘 알려져 있지는 않지만, 문헌고찰을 통해 발병기전, 분류진단, 임사양상, 치료등에 대하여 알아보았다. Systemic lupus erythematosus(SLE) is a disease of unknown etiology in which multiple organs are damaged by pathogenic autoantibodies and immune complexes. Neuropsychiatric manifestations in SLE were first described by Kaposi in 1872. These are so diverse that they include psychosis, depression, stroke, seizure and cognitive dysfunction etc.These patients are frequently consulted for psychiatric evaluation. Neuropsychiatric manifestations in SEL re also among the leading causes of morbidity and mortality and associated with poor long-term outcome. So it is essential to recognize and intervene these symptoms early. But the clear diagnostic criteria for CNS involvement in SLE have not been formulated, and diversity and fluctuation of illness make it difficult to confirm it. The authors reported three cases of SLE with severe neuropsychiatric manifestation. These patients showed symptoms such as disorientation, auditory and visual hallucibation, delusion and mood instability. They became frequently impulsive and violent and had risks to injure themselves or others. Although CNS involvement in SLE is not well known, we reviewed the pathogenesis, classification, diagnosis, clinical manifestation and treatment of them.

福祉서비스센터의 施設環境分析에 關한 硏究

李相正,權寧敏,金惠蘭 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

The purpose of this study is to establish the handicapped provision on service centers. Because of the architectural barriers on existing welfare facilities, the disabled elderly people have to be restricted or inconvenienced in their of such buildings. For the establishment of physical environmental criteria for the handicapped, focus to present the architectural standards and recommendations considering to the handicapped. Eventually aim to equip the architectural environment and provided guide for designing of welfare facilities.

Actual situation and prescribing patterns of opioids by pain physicians in South Korea

Min Jung Kim,Ji Yeon Kim,Yun Hee Lim,Sung Jun Hong,Jae Hun Jeong,Hey Ran Choi,Sun Kyung Park,김정은,Min Ki Lee,Jae Hun Kim 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4

Background: Use of opioids for chronic intractable pain is increasing globally, and their proper use can improve patients’ quality of life. In contrast, opioid use disorders, such as abuse or addiction, caused by prescribing opioids, are a worldwide issue. This study aimed to understand current opioid prescribing patterns and pain physicians’ experiences with opioid use in South Korea. Methods: Pain physicians in 42 university hospitals in South Korea were asked to complete anonymous questionnaires regarding opioid prescriptions. Results: A total of 69 surveys were completed. Most pain physicians started prescribing opioids at a pain score of 7/10 and aimed to reduce pain by 50%. Most physicians (73.1%) actively explained the prescribed medications and possible side effects, and 61.2% of physicians preferred the prescription interval of 4 weeks. Immediate-release opioids were the most popular treatment for breakthrough pain (92.6%). The most common side effect encountered by physicians was constipation (43.3%), followed by nausea/vomiting (34.3%). Of the physicians, 56.5% replied that addiction and misuse prevalences were less than 5%. However, the most concerning side effect was addiction (33.0%). Conclusions: The survey results showed that the prescribing patterns of pain physicians generally followed Korean guidelines. Physicians were most interested in the safety and effectiveness of opioid prescriptions. They were most concerned about respiratory depression and abuse or addiction. A significant number of physicians agreed that the NHIS regulations needed improvement for patient convenience and safe and effective treatment, though there were pros and cons of the NHIS restrictions on prescription conditions.

Bioinformatics and Systems Biology : Intracellular signaling pathway and protein analysis of the cardiac hypertrophy induced by endothelin-1 and isoproterenol

( Hey Min Hong ),( Noh Young Lee ),( Eun Joo Song ),( Young Sook Yoo ) 한국생화학분자생물학회 (구 한국생화학회) 2008 생화학분자생물학회 춘계학술발표논문집 Vol.2008 No.-

LSTM을 이용한 한반도 근해 이상수온 예측모델

최혜민 ( Hey Min Choi ),김민규 ( Min-kyu Kim ),양현 ( Hyun Yang ) 대한원격탐사학회 2022 大韓遠隔探査學會誌 Vol.38 No.3

해수면 온도(Sea surface temperature, SST)는 지구시스템에서 해양의 순환과 생태계에 큰 영향을 주는 요소이다. 지구온난화로 한반도 근해 해수면 온도에 변화가 생기면서 이상 수온(고수온, 저수온) 현상이 발생하여 해양생태계와 수산업 피해를 지속적으로 발생시키고 있다. 따라서 본 연구는 한반도 근해 해수면 온도를 예측하여 이상 수온 현상 예측으로 피해를 예방하는 방법론을 제안한다. 연구 지역은 한반도 근해로 설정하여 동시간대 해수면 온도 데이터를 사용하기 위해 Europe Centre for Medium-Range Weather Forecasts (ECMWF)의 ERA5 자료를 사용하였다. 연구방법으로는 해수면 온도 데이터의 시계열 특징을 고려하여 딥러닝 모델 중 시계열 데이터 예측에 특화된 Long Short-Term Memory (LSTM) 알고리즘을 이용하였다. 예측 모델은 1~7일 이후 한반도 근해 해수면 온도를 예측하고 고수온(High water temperature, HWT) 혹은 저수온(Low water temperature, LWT) 현상을 예측한다. 해수면 온도 예측 정확도 평가를 위해 결정계수(Coefficient of determination, R²), 평균 제곱근 편차(Root Mean Squared Error, RMSE), 평균 절대 백분율 오차(Mean Absolute Percentage Error, MAPE) 지표를 사용하였다. 예측 모델의 여름철(JAS) 1일 예측 결과는 R²=0.996, RMSE=0.119℃, MAPE=0.352% 이고, 겨울철(JFM) 1일 예측 결과는 R²=0.999, RMSE=0.063℃, MAPE=0.646% 이었다. 예측한 해수면 온도를 이용하여 이상 수온 예측 정확도 평가를 F1 Score로 수행하였다(여름철(2021/08/05) 고수온 예측 결과 F1 Score=0.98, 겨울철(2021/02/19) 저수온 예측 결과 F1 Score=1.0). 예측 기간이 증가하면서 예측 모델이 해수면 온도를 과소 추정하는 경향을 보여주었고, 이로 인해 이상 수온 예측 정확도 또한 낮아졌다. 따라서, 향후 예측 모델의 과소 추정 원인을 분석하고 예측 정확도 향상을 위한 연구가 필요할 것으로 판단된다. Sea surface temperature (SST) is a factor that greatly influences ocean circulation and ecosystems in the Earth system. As global warming causes changes in the SST near the Korean Peninsula, abnormal water temperature phenomena (high water temperature, low water temperature) occurs, causing continuous damage to the marine ecosystem and the fishery industry. Therefore, this study proposes a methodology to predict the SST near the Korean Peninsula and prevent damage by predicting abnormal water temperature phenomena. The study area was set near the Korean Peninsula, and ERA5 data from the European Center for Medium-Range Weather Forecasts (ECMWF) was used to utilize SST data at the same time period. As a research method, Long Short-Term Memory (LSTM) algorithm specialized for time series data prediction among deep learning models was used in consideration of the time series characteristics of SST data. The prediction model predicts the SST near the Korean Peninsula after 1- to 7-days and predicts the high water temperature or low water temperature phenomenon. To evaluate the accuracy of SST prediction, Coefficient of determination (R²), Root Mean Squared Error (RMSE), and Mean Absolute Percentage Error (MAPE) indicators were used. The summer (JAS) 1-day prediction result of the prediction model, R²=0.996, RMSE=0.119℃, MAPE=0.352% and the winter (JFM) 1-day prediction result is R²=0.999, RMSE=0.063℃, MAPE=0.646%. Using the predicted SST, the accuracy of abnormal sea surface temperature prediction was evaluated with an F1 Score (F1 Score=0.98 for high water temperature prediction in summer (2021/08/05), F1 Score=1.0 for low water temperature prediction in winter (2021/02/19)). As the prediction period increased, the prediction model showed a tendency to underestimate the SST, which also reduced the accuracy of the abnormal water temperature prediction. Therefore, it is judged that it is necessary to analyze the cause of underestimation of the predictive model in the future and study to improve the prediction accuracy.

초법에 따른 당귀의 항산화 및 항혈전 효과

김민영 ( Min Yeong Kim ),권오준 ( O Jun Kown ),추병길 ( Byung Kil Choo ),이가위 ( Chia Wei Lee ),박은혜 ( Eun Hey Park ),김홍준 ( Hong Jun Kim ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.3

Objectives:Arachidonic acid is control the thromboxane A2 (TXA2) and prostacycline (PGI2) synthesis, TXA2 increase lead to thrombus produced by induces platelet aggregation and vasoconstriction. Angelicae gigantis radix (RAR) is mainly used blood deficiency and stagnation. In previous studies, RAR has been reported that a vasodilating and blood clotting delay effects. In this study, investigate that anti-oxidant and anti-thrombotic effects of RAR by heat-process. Methods:The heated angelicae gigantis radix sample were made by 140, 180, and 220 ℃ and 4, 6, 9 and 12 min using water or 30% ethanol. The anti-oxidant effects were measured by total polyphenol, total flavonoid, DPPH and ABTS radical scavening activation. Anti-thrombotic effect conducted in samples that are determined to be effective through the anti-oxidant experiment such as angelicae gigantis radix roasted 180℃, and 220℃ and angelicae gigantis radix roasted with 30% ethanol 180℃, and 220℃. Results:Anti-oxidant parameters were efficacious in high temperature roasted AR. Also AR and EAR increased a inhibitory activity of FXa compared with RAR. The blood coagulation time of administration groups were significantly increased compare with control group. The TXB2 was significantly decreased in AR and EAR. Conclusions : We confirmed that whether AR and EAR administration has anti-oxidant and anti-thrombotic effect or not. As the results, AR and EAR were improved anti-oxidant effects and blood biochemistry compare with control group. This study provides scientific evidence that AR and EAR are have an anti-oxidant effect and anti-thrombotic effect, it expected that there is no difference between the two.

Astrogliosis Is a Possible Player in Preventing Delayed Neuronal Death

Jeong, Hey-Kyeong,Ji, Kyung-Min,Min, Kyoung-Jin,Choi, Insup,Choi, Dong-Joo,Jou, Ilo,Joe, Eun-Hye Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.4

Mitigating secondary delayed neuronal injury has been a therapeutic strategy for minimizing neurological symptoms after several types of brain injury. Interestingly, secondary neuronal loss appeared to be closely related to functional loss and/or death of astrocytes. In the brain damage induced by agonists of two glutamate receptors, N-ethyl-D-aspartic acid (NMDA) and kainic acid (KA), NMDA induced neuronal death within 3 h, but did not increase further thereafter. However, in the KA-injected brain, neuronal death was not obviously detectable even at injection sites at 3 h, but extensively increased to encompass the entire hemisphere at 7 days. Brain inflammation, a possible cause of secondary neuronal damage, showed little differences between the two models. Importantly, however, astrocyte behavior was completely different. In the NMDA-injected cortex, the loss of glial fibrillary acidic protein-expressing ($GFAP^+$) astrocytes was confined to the injection site until 7 days after the injection, and astrocytes around the damage sites showed extensive gliosis and appeared to isolate the damage sites. In contrast, in the KA-injected brain, $GFAP^+$ astrocytes, like neurons, slowly, but progressively, disappeared across the entire hemisphere. Other markers of astrocytes, including $S100{\beta}$, glutamate transporter EAAT2, the potassium channel Kir4.1 and glutamine synthase, showed patterns similar to that of GFAP in both NMDA- and KA-injected cortexes. More importantly, astrocyte disappearance and/or functional loss preceded neuronal death in the KA-injected brain. Taken together, these results suggest that loss of astrocyte support to neurons may be a critical cause of delayed neuronal death in the injured brain.

결혼이주여성 가족 건강성에 영향을 미치는 경로

전혜정 ( Hey Jung Jun ),민성혜 ( Sung Hye Min ),이민영 ( Min Young Lee ),최혜영 ( Hye Young Choi ) 한국가족복지학회 2009 한국가족복지학 Vol.14 No.2

본 연구는 결혼이주여성 가족의 건강성에 영향을 미치는 변인들의 영향경로를 살펴보고자 하였다. 전국적으로 143명의 결혼 이주여성을 대상으로 하였으며, 그들을 대상으로 한국어수준, 사회적 지지, 부부관계만족도, 우울과 적응유연성, 가족건강성을 측정하였다. 경로분석 결과는 다음과 같다. 첫째, 결혼 이주여성의 한국어 수준이 가족건강성에 직접 영향을 미치고, 적응유연성과 결혼만족도를 통해 가족건강성에 간접적으로 영향을 미쳤다. 둘째, 결혼이주여성의 한국어 수준은 사회적 지지, 결혼만족도를 통해 가족건강성에 간접적으로 영향을 미쳤다. 이러한 연구결과에 근거하여 볼 때 결혼 이주 여성의 한국어수준은 결혼이주여성 가족의 건강성에 영향을 미치는 주요 변인이었다. The purpose of this study is to analyze the path model about the family health of multicultural families. Migrant women (N=143)were administered questionnaires on their Korean language level, social support, marital satisfaction, depression and resilience, and family health. Path analysis indicates three things. First, immigrant women`s Korean language level directly affects family health, but indirectly affects family health through resilience and marital satisfaction. Immigrant women`s Korean language level indirectly affects family health through social support and marital satisfaction. In conclusion, Korean immigrant women`s Korean level is an important variable to a multicultural family`s health.

텃밭활동 프로그램이 지역아동센터 이용 초등학생의 분노 및공격성에 미치는 영향

박혜민(Hey-min Park):김한나(Han-na Kim),한다경(Da-kyung Han),한경희(Kyoung-hee Han) 인간식물환경학회 2015 인간식물환경학회 학술대회 Vol.2015 No.추계