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H∞ Switching Filter Design for LPV Systems in Finite Frequency Domain
Heng Wang,He-Hua Ju,Yu-Long Wang 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.3
This article studies the problem of finite frequency H∞ filter design for switching linear parameter varying (LPV) systems with disturbance frequency affected by system parameters. A set of switching filters are designed, each suitable for a specific parameter subregion and a specific finite frequency performance index. A hysteresis switching logic is adopted, and the design problem is finally formulated into linear matrix inequality (LMI) which can be solved efficiently with LMI Control Tool-box. A numerical example is given to illustrate the effectiveness of the proposed method.
Ju-Hua Wang,Xiu-Heng Xue,Jie Zhou,Cai-Yun Fan,Qian-Qian Xie,Pan Wang 대한기생충학열대의학회 2015 The Korean Journal of Parasitology Vol.53 No.3
Cryptosporidium andersoni ATP-binding cassette (CaABC) is an important membrane protein involved in substrate transport across the membrane. In this research, the nucleotide binding domain (NBD) of CaABC gene was amplified by PCR, and the eukaryotic expression vector of pEGFP-C1-CaNBD was reconstructed. Then, the recombinant plasmid of pEGFP-C1-CaNBD was transformed into the mouse intestinal epithelial cells (IECs) to study the iron transportation function of CaABC. The results indicated that NBD region of CaABC gene can significantly elevate the transport efficiency of Ca<SUP>2+</SUP>, Mg<SUP>2+</SUP>, K<SUP>+</SUP>, and HCO₃<SUP>-</SUP> in IECs (P<0.05). The significance of this study is to find the ATPase inhibitors for NBD region of CaABC gene and to inhibit ATP binding and nutrient transport of CaABC transporter. Thus, C. andersoni will be killed by inhibition of nutrient uptake. This will open up a new way for treatment of cryptosporidiosis.
Xu, Heng,Tian, Yan-Na,Dun, Bo-Ying,Liu, Hai-Tao,Dong, Guang-Kuo,Wang, Jin-Hua,Lu, Shang-Su,Chen, Bo,She, Jin-Xiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.
A New Triterpenoid from Brucea javanica
Jian Hua Liu,Jiang Jiang Qin,Hui Zi Jin,Xiao Jia Hu,Ming Chen,Yun Heng Shen,Shi Kai Yan,Wei Dong Zhang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.5
A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-α-L-arabinopyranosylpregn- 5-ene-3β,20-diol (8), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
Social Network Partition Method based on Concentricity-Controllable Routing
Huang Jian-Heng,Yu Jun-Qi,Zhao Min-Hua 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.4
In allusion to issues that partitioning algorithm of traditional social network community is generally lacking in comprehensive consideration of node and link attributes as well as full expression of model and mechanism using attributes of node and link. This paper presents a social network community partitioning algorithm fusing node and link attributes. The algorithm has blended similarity of node properties, link weights between nodes and link attribute information, making definition of the similar weights, and on this basis, social networking community division is realized combined with condensation algorithms. Experiments show that the algorithm has remarkable effects on community partition with obvious attributes in social network.
Research on Gateway Deployment Solving Model Applied in the Wireless Mesh Network
HUANG Jian-Heng,YU Jun-Qi,ZHAO Min-Hua 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.3
In order to solve gateway deployment of geometry K center in the wireless network and improve the service quality of network, this paper proposes the gateway deployment solving model and algorithm. This paper transforms center problem of the geometric K into center problem of node K and solves problem. This paper proposes a gateway node alternative selection algorithm combination of network topology properties and maximum cover area related theory, and according to the relevant features select an alternative area, each alternative area abstract for a virtual node and is inserted into the original network topology structure, thus forming the new network topology. Solving new problem of the network topology and looking for the optimal deployment scheme use the improved genetic algorithm. The experimental results show that the model and algorithm proposed in this paper can well solve the wireless network gateway deployment problem of geometric K center and improve the network service quality.
Aquaporin 8 Involvement in Human Cervical Cancer SiHa Migration via the EGFR-Erk1/2 Pathway
Shi, Yong-Hua,Tuokan, Talaf,Lin, Chen,Chang, Heng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Overexpression of aquaporins (AQPs) has been reported in several human cancers. Epidermal growth factor receptor (EGFR)-extracellular signal-regulated kinases 1/2 (Erk1/2) are associated with tumorigenesis and cancer progression and may upregulate AQP expression. In this study, we demonstrated that EGF (epidermal growth factor) induces SiHa cells migration and AQP8 expression. Wound healing results showed that cell migration was increased by 2.79-1.50-fold at 24h and 48h after EGF treatment. AQP8 expression was significantly increased (3.33-fold) at 48h after EGF treatment in SiHa cells. An EGFR kinase inhibitor, PD153035, blocked EGF-induced AQP8 expression and cell migration and AQP8 expression was decreased from 1.59-fold (EGF-treated) to 0.43-fold (PD153035-treated) in SiHa. Furthermore, the MEK (MAPK (mitogen-activated protein kinase)/Erk (extracellular signal regulated kinase)/Erk inhibitor U0126 also inhibited EGF-induced AQP8 expression and cell migration. AQP8 expression was decreased from 1.21-fold (EGF-treated) to 0.43-fold (U0126-treated). Immunofluorescence microscopy further confirmed the results. Collectively, our findings show that EGF induces AQP8 expression and cell migration in human cervical cancer SiHa cells via the EGFR/Erk1/2 signal transduction pathway.
Li-Ying Wang,Xiu-Hua Wang,Jia-Lian Tan,Shuai Xia,Heng-Zhi Sun,Jin-Wen Shi,Ming-Dong Jiang,Liang Fang,Hua Zuo,Gautam Dupati,장기완,신동수 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.11
A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.