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양은경 ( Eun Kyung Yang ),윤희훈 ( Hee Hoon Yoon ),박정극 ( Jung Keug Park ),박수남 ( Soo Nam Park ),고강일 ( Kang-ii Ko ),김기호 ( Ki Ho Kim ) 대한화장품학회 2000 대한화장품학회지 Vol.26 No.1
Cytotoxicity assays using artificial skins have been proposed as in vitro alternatives to minimize animal ocular and dermal irritation testing. Accordingly, the responses of artificial skins to the well- characterized chemical irritants toluene, glutaraldehyde, and sodium lauryl sulfate (SLS), and the non- irritant polyethylene glycol were studied. The evaluation of the irritating and non-irritating test chemicals was also compared with the responses observed in human dermal fibroblasts and human epidermal keratinocytes grown in a monolayer culture. The responses monitored included an MTT mitochondrial functionality assay. In order to better understand the local mechanisms involved in skin damage and repair, the production of several mitogenic proinflammatory mediators, interleukin-lα, 12-HETE,and 15-HETE, was also investigated. Dose-dependent increases in the levels of II,la and the HETEs were observed in the underlying medium of the skin systems exposed to the two skin irritants, glutaraldehyde and SLS. The results of the present study show that both human artificial skins can be used as efficient in vitro testing models for the evaluation of skin toxicity and for screening contact skin irritancy.
Application of Nutrient Enriched Media on Organ Culture of Human Scalp Hair Follicle
Bo-Young Yoo(유보영),Hee-Hoon Yoon(윤희훈),Doo-Hoon Lee(이두훈),Young-Kwon Seo(서영권),Youn-Ho Shin(신연호),Kye-Yong Song(송계용),Sung-Joo Hwang(황성주),Young-Jin Kim(김영진),Eun-Kyung Yang(양은경),Chang-Seo Park(박장서),Ih-Seop C 한국생물공학회 2004 한국생물공학회 학술대회 Vol.2004 No.4