Association between High Diffusion-Weighted Imaging-Derived Functional Tumor Burden of Peritoneal Carcinomatosis and Overall Survival in Patients with Advanced Ovarian Carcinoma

An He,Perucho Jose AU,Chiu Keith WH,Hui Edward S,Chu Mandy MY,Ngu Siew Fei,Ngan Hextan YS,Lee Elaine YP 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.5

Objective: To investigate the association between functional tumor burden of peritoneal carcinomatosis (PC) derived from diffusion-weighted imaging (DWI) and overall survival in patients with advanced ovarian carcinoma (OC). Materials and Methods: This prospective study was approved by the local research ethics committee, and informed consent was obtained. Fifty patients (mean age ± standard deviation, 57 ± 12 years) with stage III–IV OC scheduled for primary or interval debulking surgery (IDS) were recruited between June 2016 and December 2021. DWI (b values: 0, 400, and 800 s/mm2) was acquired with a 16-channel phased-array torso coil. The functional PC burden on DWI was derived based on K-means clustering to discard fat, air, and normal tissue. A score similar to the surgical peritoneal cancer index was assigned to each abdominopelvic region, with additional scores assigned to the involvement of critical sites, denoted as the functional peritoneal cancer index (fPCI). The apparent diffusion coefficient (ADC) of the largest lesion was calculated. Patients were dichotomized by immediate surgical outcome into high- and low-risk groups (with and without residual disease, respectively) with subsequent survival analysis using the Kaplan-Meier curve and log-rank test. Multivariable Cox proportional hazards regression was used to evaluate the association between DWI-derived results and overall survival. Results: Fifteen (30.0%) patients underwent primary debulking surgery, and 35 (70.0%) patients received neoadjuvant chemotherapy followed by IDS. Complete tumor debulking was achieved in 32 patients. Patients with residual disease after debulking surgery had reduced overall survival (p = 0.043). The fPCI/ADC was negatively associated with overall survival when accounted for clinicopathological information with a hazard ratio of 1.254 for high fPCI/ADC (95% confidence interval, 1.007–1.560; p = 0.043). Conclusion: A high DWI-derived functional tumor burden was associated with decreased overall survival in patients with advanced OC.

물체의 수중낙하에 대한 아동 및 청소년의 사전생각과 사후생각 형성

김헤라,유안진 대한가정학회 2002 Family and Environment Research Vol.40 No.5

The purpose of this study is to investigate prior thinking and posterior thinking formation of children and adolescents in sinking objects. The subjects consisted of twenty eight, 9- and 11-year old children and fourteen, 13-year old adolescents selected from one elementary school and two middle schools. The transcripts were analyzed to classify children and adolescents' prior thinking and posterior thinking frequency, reasoning response(evidence based response, idea based response) and reasoning method(valid method, invalid method). The data were analyzed by frequency, percentile, mean and standard deviation, t test, ANOVA. Major findings were as followings: 1. Children and adolescents have already had prior thinking in sinking objects. 2. Children and adolescents applies their prior thinking to posterior thinking formation process. 3. There were significant differences in children and adolescents' posterior thinking formation process, especially choices in objects and reasoning methods depending on age. 4. There were significant differences in children and adolescents' reasoning response depending on presented evidences types. 5. Through the experimentation, children and adolescents' prior thinking was different from their posterior thinking. There were significant differences in differences between the prior thinking and posterior thinking depending on age.

Molecular Cloning of Two Genes Encoding Cinnamate 4-Hydroxylase (C4H) from Oilseed Rape (Brassica napus)

( An He Chen ),( You Rong Chai ),( Jia Na Li ),( Li Chen ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.2

<i>Yersinia pseudotuberculosis</i> Exploits CD209 Receptors for Promoting Host Dissemination and Infection

He, Ying-Xia,Ye, Cheng-Lin,Zhang, Pei,Li, Qiao,Park, Chae Gyu,Yang, Kun,Jiang, Ling-Yu,Lv, Yin,Ying, Xiao-Ling,Ding, Hong-Hui,Huang, Hong-Ping,Mambwe Tembo, John,Li, An-Yi,Cheng, Bing,Zhang, Shu-Sheng American Society for Microbiology 2019 Infection and immunity Vol.87 No.1

<P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals.</P><P><I>Yersinia pseudotuberculosis</I> is a Gram-negative enteropathogen and causes gastrointestinal infections. It disseminates from gut to mesenteric lymph nodes (MLNs), spleen, and liver of infected humans and animals. Although the molecular mechanisms for dissemination and infection are unclear, many Gram-negative enteropathogens presumably invade the small intestine via Peyer’s patches to initiate dissemination. In this study, we demonstrate that <I>Y. pseudotuberculosis</I> utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages. These <I>Y. pseudotuberculosis</I>-CD209 interactions result in bacterial dissemination to MLNs, spleens, and livers of both wild-type and Peyer’s patch-deficient mice. The blocking of the <I>Y. pseudotuberculosis</I>-CD209 interactions by expression of O-antigen and with oligosaccharides reduces infectivity. Based on the well-documented studies in which HIV-CD209 interaction leads to viral dissemination, we therefore propose an infection route for <I>Y. pseudotuberculosis</I> where this pathogen, after penetrating the intestinal mucosal membrane, hijacks the <I>Y. pseudotuberculosis</I>-CD209 interaction antigen-presenting cells to reach their target destinations, MLNs, spleens, and livers.</P>

A Corpus Analysis of Pedagogical Monologues in a Content-based EFL Context

He An E,Elizabeth Walker 아시아영어교육학회 2009 The Journal of Asia TEFL Vol.6 No.1

The Efficacy Analysis of Endoscopic Third Ventriculostomy in Infantile Hydrocephalus

He, Zhenhua,An, Caixia,Zhang, Xinding,He, Xiaodong,Li, Qiang The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.2

Objective : To investigate the efficacy of endoscopic third ventriculostomy (ETV) for infantile hydrocephalus. Methods : Retrospectively reviewed the 17 infantile hydrocephalus cases who were treated with ETV between July 2009 and June 2013. The study includes 17 patients (4 Han and 13 Hui) between the ages of 51 and 337 days. Five cases with encephalitis history and 2 cases with cerebral hemorrhage, with the remaining 10 cases congenital hydrocephalus. ETVs were performed for all patients with 1 case failing because the severe ventricle inflammatory adhesion, excessive exudation, and vague basilar artery. Results : Among the 16 successful cases 7 cases improved remarkably : heads and ventricles reduced and cerebral cortexes thickening morphologically. The ventricles of the remaining cases were unchanged. Conclusion : The ethnic minority account for the majority of the patients in this study. ETV is effective for infantile obstructive hydrocephalus.

In Situ Growth of FeCo-selenide on Ni Foam as High-Performance Electrode for Electrochemical Energy Storage Devices

An Ye,Jiqiu Qi,Yanwei Sui,Fei Yang,Fuxiang Wei,Yezeng He,Qingkun Meng,Zhi Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.7

A solid-state energy storage device has been fabricated using FeCo-selenide nanosheet arrays as positive electrode and Fe2O3 nanorod as negative electrode. As an electrode material, the ternary FeCo-selenide nanosheet arrays supported by Ni foam show a highest specific capacitance of 978 F/g (specific capacity of 163 mAh/g) at 1 A/g and a superior cycle behavior of 81.2% are obtained after 5000 cycles at current density of 4 A/g. The asymmetric supercapacitor achieves the maximum energy density of 34.6Wh/kg at the power density of 759.6 W/kg. Furthermore, the superior cycling stability with 83% retention of initial capacitance after 5000 cycles further verify the practical applications of FeCo-selenide//Fe2O3 asymmetric supercapacitor. Meanwhile, the LED bulb and the light board of "CUMT" are lighted by connecting several capacitors to form a series circuit.

Effect of inlet particle arrangement on separating property of a cyclone separator

An-Lin Liu,Yan-Hong Zhang,Liang Ma,Yi-Mou Wang,Meng-Ya He 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.6

Different arrangements of particles on the inlet section exert different effects on the separation property of a cyclone separator. Sorting classifier with different heights was connected in series with a conventional cyclone, positive rotation cyclone, and reverse rotation cyclone respectively, to investigate the effect of particle arrangement on the separation property and inner flow field. Results indicate that the implementation of a sorting classifier increases the pressure drop and energy consumption of a cyclone separator. The taller the sorting classifier, the larger the flow is. The energy consumption in positive rotation cyclone is closer to that in reverse rotation cyclone. Meanwhile, the tangential velocity in inner flow field is higher and the separating property is enhanced. The reverse rotation cyclone relieves the fishhook effect, whereas the positive rotation cyclone eliminates such effect. The reverse and positive rotation cyclones demonstrate an improved separating property for particles smaller and greater than 1 m, respectively. Moreover, the reverse rotation cyclone demonstrates superior overall separation, but the positive rotation cyclone demonstrates a greater classification effect than the reverse rotation cyclone.

Metabotyping of the <i>C. elegans sir-2.1</i> Mutant Using <i>in Vivo</i> Labeling and ¹³C-Heteronuclear Multidimensional NMR Metabolomics

An, Yong Jin,Xu, Wen Jun,Jin, Xing,Wen, He,Kim, Hyesook,Lee, Junho,Park, Sunghyouk American Chemical Society 2012 ACS chemical biology Vol.7 No.12

<P>The roles of <I>sir-2.1</I> in <I>C. elegans</I> lifespan extension have been subjects of recent public and academic debates. We applied an efficient workflow for <I>in vivo</I><SUP>13</SUP>C-labeling of <I>C. elegans</I> and <SUP>13</SUP>C-heteronuclear NMR metabolomics to characterizing the metabolic phenotypes of the <I>sir-2.1</I> mutant. Our method delivered sensitivity 2 orders of magnitude higher than that of the unlabeled approach, enabling 2D and 3D NMR experiments. Multivariate analysis of the NMR data showed distinct metabolic profiles of the mutant, represented by increases in glycolysis, nitrogen catabolism, and initial lipolysis. The metabolomic analysis defined the <I>sir-2.1</I> mutant metabotype as the decoupling between enhanced catabolic pathways and ATP generation. We also suggest the relationship between the metabotypes, especially the branched chain amino acids, and the roles of <I>sir-2.1</I> in the worm lifespan. Our results should contribute to solidifying the roles of <I>sir-2.1</I>, and the described workflow can be applied to studying many other proteins in metabolic perspectives.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/acbcct/2012/acbcct.2012.7.issue-12/cb3004226/production/images/medium/cb-2012-004226_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cb3004226'>ACS Electronic Supporting Info</A></P>

Fast 3D reconstruction method based on UAV photography

Jiang-An Wang,Huang‐Te Ma,Chun-Mei Wang,Yong-Jie He 한국전자통신연구원 2018 ETRI Journal Vol.40 No.6

3D reconstruction of urban architecture, land, and roads is an important part of building a “digital city.” Unmanned aerial vehicles (UAVs) are gradually replacing other platforms, such as satellites and aircraft, in geographical image collection; the reason for this is not only lower cost and higher efficiency, but also higher data accuracy and a larger amount of obtained information. Recent 3D reconstruction algorithms have a high degree of automation, but their computation time is long and the reconstruction models may have many voids. This paper decomposes the object into multiple regional parallel reconstructions using the clustering principle, to reduce the computation time and improve the model quality. It is proposed to detect the planar area under low resolution, and then reduce the number of point clouds in the complex area.