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      • SCISCIESCOPUS

        Coulomb blockade behaviors in individual Au nanoparticles as observed through noncontact atomic force spectroscopy at room temperature

        Hattori, Shigeki,Kano, Shinya,Azuma, Yasuo,Tanaka, Daisuke,Sakamoto, Masanori,Teranishi, Toshiharu,Majima, Yutaka IOP Pub 2012 Nanotechnology Vol.23 No.18

        <P>Coulomb blockade behaviors in individual Au nanoparticles of 2 nm core diameter in double-barrier structures have been studied by means of noncontact atomic force spectroscopy (NC-AFS) at room temperature. The Au nanoparticles with a 1-decanethiol ligand were chemisorbed by 1,10-decanedithiol molecules of a mixed 1-octanethiol/1,10-decanedithiol self-assembled monolayer coated on a Au(111) surface; these particles were observed through NC-AFS. NC-AFS measurements of the cantilever frequency shift–sample voltage (&Dgr;f–V<SUB>S</SUB>) curves were sequentially conducted on three Au nanoparticles under the same experimental conditions; the &Dgr;f–V<SUB>S</SUB> curves were found to deviate from the parabolic (&Dgr;f<SUB>N</SUB>) curve in the cases where no extra charge existed on the Au core. The experimental &Dgr;f<SUB>CB</SUB>(=&Dgr;f − &Dgr;f<SUB>N</SUB>) and &Dgr;f<SUB>CB</SUB>/V curves agree well with the theoretical curves obtained using a golden-rule calculation and the same parabolic parameters. All the results, through NC-AFS, suggest Coulomb blockade behaviors in the Au nanoparticles at room temperature.</P>

      • KCI등재
      • SCOPUS

        Effect of Plastic Working on Fatigue Properties of Ti-6Al-4V Alloy with Notch

        Hattori, Nobusuke,Nishida, Shinichi,Hara, Masahiro,Son, Sun Young Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.297 No.-

        <P>This study is focused to the effects of plastic working on the fatigue strength of Ti-6Al-4V alloy with notch. In general, the fatigue strength of plastic worked specimen is higher than that of non-worked one. However, the potential of hardening ability of Ti-6Al-4V alloy is very limited. Accordingly, the effect of work hardening on fatigue strength about this material is very small. In addition, the surface of the worked part becomes rougher with increasing plastic deformed value and the fatigue cracks initiate at this part. Consequently, the fatigue limit of the plastic worked specimen is lower than that of the non-plastic-worked one.</P>

      • Development of Anti-viral Agents from Natural Sources

        Hattori, Masao The Plant Resources Society of Korea 2001 Plant Resources Vol.4 No.3

        Human immunodeficiency virus (HIV), the causative agent of AIDS, still continues to spread rapidly in the world population, especially in Africa and Southeast Asia. At present, two kinds of therapeutic approaches are used for treatment of AIDS. One is to target HIV reverse transcriptase, which is responsible for the viral genome transcription. The other is to inhibit HIV pretense PR, which is essential for the processing of viral proteins. Drug combinations based on these approaches can reduce the blood virus to an undetectable level. However, a small amount of virus may lurk inside the immune cells in a dormant state. Another major obstacle of long-term treatment of the disease is remarkable mutation in HIV. Most of the clinical chemotherapeutic agents have one or more of these problems. High cost and harmful side-effects further reduced the desirability of these drugs. In the course our studies on development of anti-HIV agents from natural products, we investigated various crude drugs for their inhibitory activity against HIV-induced cytopathic effects (CPE) in culture cells, HIV-pretense (PR), HIV-reverse transcriptase (RT) including ribonuclease H (RNase H), and HIV integrase (INT). In the present paper, some inhibitory substances relating to the development of anti-HIV agents are reported.

      • KCI등재

        플레이스테이션 3 상에서 수행되는 멀티플렛 식별자의 최적화

        Hattori, Masami,Mizuno, Takashi Korean Society of Earth and Exploration Geophysici 2010 지구물리와 물리탐사 Vol.13 No.1

        To enable high-performance computing (HPC) for applications with large datasets using a $Sony^{(R)}$ $PLAYSTATION^{(R)}$ 3 ($PS3^{TM}$) video game console, we configured a hybrid system consisting of a $Windows^{(R)}$ PC and a $PS3^{TM}$. To validate this system, we implemented the real-time multiplet identifier (RTMI) application, which identifies multiplets of microearthquakes in terms of the similarity of their waveforms. The cross-correlation computation, which is a core algorithm of the RTMI application, was optimised for the $PS3^{TM}$ platform, while the rest of the computation, including data input and output remained on the PC. With this configuration, the core part of the algorithm ran 69 times faster than the original program, accelerating total computation speed more than five times. As a result, the system processed up to 2100 total microseismic events, whereas the original implementation had a limit of 400 events. These results indicate that this system enables high-performance computing for large datasets using the $PS3^{TM}$, as long as data transfer time is negligible compared with computation time.

      • SCOPUSKCI등재

        Electrochemical Synthesis of TiO<sub>2</sub> Photocatalyst with Anodic Porous Alumina

        Hattori, Takanori,Fujino, Takayoshi,Ito, Seishiro Materials Research Society of Korea 2007 한국재료학회지 Vol.17 No.11

        Aluminum was anodized in a $H_2SO_4$ solution, and titanium (IV) oxide ($TiO_2$) was electrodeposited into nanopores of anodic porous alumina in a mixed solution of $TiOSO_4$ and $(COOH)_2$. The photocatalytic activity of the prepared film was analyzed for photodegradation of methylene blue aqueous solution. Consequently, we found it was possible to electrodeposit $TiO_2$ onto anodic porous alumina, and synthesized it into the nanopores by hydrolysis of a titanium complex ion under AC 8-9 V when film thickness was about $15-20{\mu}m$. The photocatalytic activity of $TiO_2$-loaded anodic porous alumina ($TiO_2/Al_2O_3$) at an impressed voltage of 9 V was the highest in every condition, being about 12 times as high as sol-gel $TiO_2$ on anodic porous alumina. The results revealed that anodic porous alumina is effective as a substrate for photocatalytic film and that high-activity $TiO_2$ film can be prepared at low cost.

      • SCIESCOPUSKCI등재

        A GRADIENT-T SZE

        HATTORI MAKOTO,OKABE NOBUHIRO The Korean Astronomical Society 2004 Journal of The Korean Astronomical Society Vol.37 No.5

        The inverse Compton scattering of the cosmic microwave background (CMB) radiation with electrons in the intracluster medium which has a temperature gradient, was examined by the third-order perturbation theory of the Compton scattering. A new type of the spectrum distortion of the CMB was found and named as gradient T Sunyaev-Zel'dovich effect (gradT SZE). The spectrum has an universal shape. There is a zero distortion point, the cross over frequency, at 326GHz. When the hotter region locates closer to an observer, the intensity becomes brighter than the CMB in the frequency region lower than the cross over frequency and fainter than the CMB in the frequency region higher than the cross over frequency. When the cooler region locates closer to an observer, the distorted part of the spectrum has an opposite sign to the above case. The amplitude of the spectrum distortion does not de-pend on the electron density and depends on the heat conductivity and the total temperature variation along a line of sight. Therefore, the gradT SZE provides an unique opportunity to measure thermally nonequilibrium electron momentum distribution function in the ICM and combined with the X-ray measurements of the electron temperature distribution provides an opportunity of direct measurement of the heat conductivity in the ICM.

      • SCIESCOPUSKCI등재

        Accuracy of Current Delivery System in Current Source Data-Driver IC for AM-OLED

        Hattori, Reiji The Institute of Electronics and Information Engin 2004 Journal of semiconductor technology and science Vol.4 No.4

        Current delivery system, in which the analog current produced by a unique DAC circuit is stored into a current-memory circuit and delivered in a time-divided sequence, shows variation of output current as low as 4% in a current source data-driver IC for AM-OLED driven by a current-programmed method without any fuse repairing after fabrication. This driver IC has 54 outputs and can sink constant current as low as 3 ${\mu}A$ with 6-bit analog levels. Such a low current level without variation can hardly be obtained by an ordinary MOS transistor because the current level is in the sub-threshold region and changes exponentially with threshold voltage variation. Thus we adopted a current mirror circuit composed of bipolar transistors to supply well-controlled current within a nano-ampere range.

      • KCI등재

        In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats

        Tsuyoshi Hattori,Kimio Sugaya,Saori Nishijima,Katsumi Kadekawa,Tomoyuki Ueda,Hideyuki Yamamoto 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.4

        Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that in the urinary bladder remains unknown. To clarify the direct effects of naftopidil on this organ, activities were assessed in the isolated rat whole urinary bladder. Methods: A total of 30 female rats were used. In Experiment 1, bladder activity was measured during a cumulative administration of 2.5–75μM naftopidil (n=7). In Experiment 2, rats were divided into 2 groups: control (n=10) and naftopidil (5 mg/ animal/day, oral gavage, once-daily for 2 weeks) (n=13). After the treatment period, plasma was obtained from each rat. The urinary bladders were harvested from the control rats. Isovolumetric rhythmic bladder contractions were induced at above the threshold volume, and intravesical pressure was recorded. Control plasma was added to the organ bath; after subsequent wash-out, plasma collected from rats administered naftopidil was added. In Experiment 3, the plasma levels of monoamines and amino acids were quantified using the individual plasma prepared in the Experiment 2. Results: Cumulative dosing with naftopidil did not change the interval between spontaneous contractions compared to the interval at baseline. After adding control plasma, the interval was shortened compared to the baseline (P=0.008). The plasma collected from rats administered naftopidil suppressed the shortening of the interval compared to the control plasma (P=0.041). Naftopidil resulted in a decrease in the level of noradrenaline (P=0.009) and an increase in that of glycine (P=0.014). Conclusions: Although naftopidil did not directly act on the interval between spontaneous contractions of the urinary bladder, the plasma collected from rats administered naftopidil, with changing levels of monoamines and amino acids, may suppressed shortening the interval.

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